Synthesis and Evaluation of Coumarin-Chalcone Derivatives as α-Glucosidase Inhibitors

• Published in: Frontiers in chemistry Vol. 10; p. 926543
• Main Authors: Hu, Chun-Mei, Luo, Yong-Xin, Wang, Wen-Jing, Li, Jian-Ping, Li, Meng-Yue, Zhang, Yu-Fei, Xiao, Di, Lu, Li, Xiong, Zhuang, Feng, Na, Li, Chen
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 27.06.2022
• Subjects: chalcone; Chemistry; coumarin; docking; enzyme inhibitor; α-glucosidase

Coumarin and chalcone, two important kinds of natural product skeletons, both exhibit α-glucosidase inhibitory activity. In this work, coumarin-chalcone derivatives 3 ( a∼v ) were synthesized, and their α-glucosidase inhibitory activity was screened. The results showed that all synthetic derivatives...