Effects of Kappa opioid receptor blockade by LY2444296 HCl, a selective short-acting antagonist, during chronic extended access cocaine self-administration and re-exposure in rat - Valenza, Marta; Windisch, Kyle A; Butelman, Eduardo R.; Reed, Brian; Kreek, Mary Jeanne (Psychopharmacology, 2020)
Keywords: Addictions; Animals; Antagonists; Behavior, Addictive - drug therapy; Behavior, Addictive - metabolism; Biomedical and Life Sciences; Biomedicine; Brain - drug effects; Brain - metabolism; Cocaine; Cocaine - administration & dosage; Cocaine-Related Disorders - drug therapy; Cocaine-Related Disorders - metabolism; Conditioning, Operant - drug effects; Conditioning, Operant - physiology; Dopamine Uptake Inhibitors - administration & dosage; Drug abuse; Drug addiction; Drug self-administration; Intravenous administration; Male; Mood; Narcotic Antagonists - pharmacology; Narcotic Antagonists - therapeutic use; Narcotics; Neurosciences; Opioid receptors (type kappa); Original Investigation; Pharmacology/Toxicology; Psychiatry; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa - antagonists & inhibitors; Receptors, Opioid, kappa - metabolism; Reinforcement; Self Administration; Substance Withdrawal Syndrome - drug therapy; Substance Withdrawal Syndrome - metabolism; Withdrawal; Relapse; LY2444296; KOP-r; Cocaine self-administration; Pattern of intake; Kappa opioid receptor; LY2540240; Cocaine addiction; Extended access self-administration; KOR