De-differentiation in cultures of organoids from luminal-type breast cancer is restored by inhibition of NOTCH signaling

• Published in: Human cell : official journal of Human Cell Research Society Vol. 36; no. 6; pp. 2099 - 2112
• Main Authors: Uematsu, Hiroyuki, Saito, Chieko, Kondo, Jumpei, Onuma, Kunishige, Coppo, Roberto, Mori, Yukiko, Muto, Manabu, Kikawa, Yuichiro, Tada, Manami, Sugie, Tomoharu, Inoue, Masahiro
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.11.2023; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Breast cancer; Cell Biology; Cell differentiation; Estrogen receptors; Gynecology; Immunohistochemistry; Life Sciences; Oncology; Organoids; Reproductive Medicine; Research Article; Stem Cells; Surgery; Transcription activation; Estrogen receptor; Organoid; Breast cancer; Differentiation; Notch

Estrogen receptor (ER) expression in breast cancer can change during progression and the treatment, but the mechanism has not been well studied. In this study, we successfully prepared organoids from samples obtained from 33 luminal-type breast cancer patients and studied their ER expression. The ex...