Genes associated with the progression of neurofibrillary tangles in Alzheimer’s disease

• Published in: Translational psychiatry Vol. 4; no. 6; p. e396
• Main Authors: Miyashita, A, Hatsuta, H, Kikuchi, M, Nakaya, A, Saito, Y, Tsukie, T, Hara, N, Ogishima, S, Kitamura, N, Akazawa, K, Kakita, A, Takahashi, H, Murayama, S, Ihara, Y, Ikeuchi, T, Kuwano, R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2014; Nature Publishing Group
• Subjects: 38; 38/39; 38/61; 38/77; 38/88; 631/378/340; Adaptor Proteins, Signal Transducing - genetics; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Basic Helix-Loop-Helix Transcription Factors - genetics; Behavioral Sciences; Biological Psychology; Brain - pathology; Cell Adhesion Molecules, Neuronal - genetics; Cyclooxygenase 2 - genetics; Disease Progression; Extracellular Matrix Proteins - genetics; Female; Gene Expression Profiling; Gene Ontology; Genes - genetics; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Humans; Intracellular Signaling Peptides and Proteins - genetics; Male; Medicine; Medicine & Public Health; Myosin Type V - genetics; Nerve Tissue Proteins - genetics; Neurofibrillary Tangles - genetics; Neurofibrillary Tangles - pathology; Neurosciences; Original; original-article; Pharmacotherapy; Psychiatry; Real-Time Polymerase Chain Reaction; Serine Endopeptidases - genetics

The spreading of neurofibrillary tangles (NFTs), intraneuronal aggregates of highly phosphorylated microtubule-associated protein tau, across the human brain is correlated with the cognitive severity of Alzheimer’s disease (AD). To identify genes relevant to NFT expansion defined by the Braak stage,...