Superoxide dismutase 2 ameliorates mitochondrial dysfunction in skin fibroblasts of Leber’s hereditary optic neuropathy patients

• Published in: Frontiers in neuroscience Vol. 16; p. 917348
• Main Authors: Zhou, Qingru, Yao, Shun, Yang, Mingzhu, Guo, Qingge, Li, Ya, Li, Lei, Lei, Bo
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 09.08.2022
• Subjects: LHON; mitochondrial dysfunction; Neuroscience; oxidative stress; retinal ganglion cell; SOD2

In Leber's hereditary optic neuropathy (LHON), mtDNA mutations mediate mitochondrial dysfunction and apoptosis of retinal ganglion cells. Mitochondrial superoxide dismutase 2 (SOD2) is a crucial antioxidase against reactive oxygen species (ROS). This study aims to investigate whether SOD2 could...