Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers

• Published in: Biochemical journal Vol. 402; no. 3; pp. 459 - 470
• Main Authors: Senda, Motohiro, Ito, Akihiro, Tsuchida, Akiko, Hagiwara, Tomoko, Kaneda, Tsuguhiro, Nakamura, Yoko, Kasama, Kenji, Kiso, Makoto, Yoshikawa, Kazuhiro, Katagiri, Yoko, Ono, Yoshinari, Ogiso, Manabu, Urano, Takeshi, Furukawa, Keiko, Oshima, Shinichi, Furukawa, Koichi
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 15.03.2007
• Subjects: Cell Line; DNA, Complementary - genetics; Down-Regulation; Gangliosides - biosynthesis; Gene Expression; Gene Expression Regulation, Neoplastic; Glycosphingolipids - metabolism; Humans; Immunohistochemistry; In Situ Hybridization; Isoenzymes - classification; Isoenzymes - genetics; Isoenzymes - metabolism; Kidney - enzymology; Kidney Neoplasms - enzymology; Kidney Neoplasms - genetics; Kidney Neoplasms - pathology; Kinetics; Organ Specificity; RNA, Messenger - genetics; Sialyltransferases - classification; Sialyltransferases - genetics; Sialyltransferases - metabolism

Although disialyl glycosphingolipids such as GD3 and GD2 have been considered to be associated with malignant tumours, whether branched-type disialyl glycosphingolipids show such an association is not well understood. We investigated the sialyltransferases responsible for the biosynthesis of DSGG (d...