Molecular characterization of adenosine monophosphate deaminase 1 and its regulatory mechanism for inosine monophosphate formation in triploid crucian carp
Inosine monophosphate (IMP) is the main flavoring substance in aquatic animal, and adenosine monophosphate deaminase1 ( AMPD1 ) gene is a key gene in IMP formation. At present, the research on the mechanism of AMPD1 regulating IMP formation in aquatic animal is still blank. In this study, in order t...
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Published in | Frontiers in physiology Vol. 13; p. 970939 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Abstract | Inosine monophosphate (IMP) is the main flavoring substance in aquatic animal, and adenosine monophosphate deaminase1 (
AMPD1
) gene is a key gene in IMP formation. At present, the research on the mechanism of
AMPD1
regulating IMP formation in aquatic animal is still blank. In this study, in order to study the mechanism of
AMPD1
regulating IMP formation in fish, the full open reading frame (ORF) of
AMPD1
which was 2160bp was obtained for the first time in triploid crucian carp (
Carassius auratus
). It encoded 719 amino acids with a molecular mass of 82.97 kDa, and the theoretical isoelectric point value was 6.31. The homology analysis showed that the homology of triploid crucian carp and diploid
Carassius auratus w
as the highest, up to 99%. And the phylogenetic tree showed that triploid crucian carp was grouped with diploid
Carassius auratus
,
Culter alburnus
, and
Danio rerio
. And real-time fluorescence quantitative results showed that
AMPD1
was expressed specifically in muscle of triploid crucian carp (
p
< 0.05). The results of detection the localization of
AMPD1
in cells indicated that the
AMPD1
was mainly localized in cytoplasm and cell membrane. Further, we examined the effects of glutamate which was the promotor of IMP formation on the expression of
AMPD1
and the formation of IMP
in vivo
and
in vitro
experiments, the results showed that 3% glutamate and 2 mg/ml glutamate could significantly promote
AMPD1
expression and IMP formation in triploid crucian carp muscle tissue and muscle cells (
p
< 0.05). Then we inhibited the expression of
AMPD1 in vivo
and
in vitro
experiments, we found the formation of IMP in muscle tissue and muscle cells of triploid crucian carp all were inhibited and they affected the gene expression of AMPK-mTOR signaling pathway. The all results showed that
AMPD1
mediated glutamate through AMPK-mTOR signaling pathway to regulate the formation of fish IMP. |
---|---|
AbstractList | Inosine monophosphate (IMP) is the main flavoring substance in aquatic animal, and adenosine monophosphate deaminase1 (
AMPD1
) gene is a key gene in IMP formation. At present, the research on the mechanism of
AMPD1
regulating IMP formation in aquatic animal is still blank. In this study, in order to study the mechanism of
AMPD1
regulating IMP formation in fish, the full open reading frame (ORF) of
AMPD1
which was 2160bp was obtained for the first time in triploid crucian carp (
Carassius auratus
). It encoded 719 amino acids with a molecular mass of 82.97 kDa, and the theoretical isoelectric point value was 6.31. The homology analysis showed that the homology of triploid crucian carp and diploid
Carassius auratus w
as the highest, up to 99%. And the phylogenetic tree showed that triploid crucian carp was grouped with diploid
Carassius auratus
,
Culter alburnus
, and
Danio rerio
. And real-time fluorescence quantitative results showed that
AMPD1
was expressed specifically in muscle of triploid crucian carp (
p
< 0.05). The results of detection the localization of
AMPD1
in cells indicated that the
AMPD1
was mainly localized in cytoplasm and cell membrane. Further, we examined the effects of glutamate which was the promotor of IMP formation on the expression of
AMPD1
and the formation of IMP
in vivo
and
in vitro
experiments, the results showed that 3% glutamate and 2 mg/ml glutamate could significantly promote
AMPD1
expression and IMP formation in triploid crucian carp muscle tissue and muscle cells (
p
< 0.05). Then we inhibited the expression of
AMPD1 in vivo
and
in vitro
experiments, we found the formation of IMP in muscle tissue and muscle cells of triploid crucian carp all were inhibited and they affected the gene expression of AMPK-mTOR signaling pathway. The all results showed that
AMPD1
mediated glutamate through AMPK-mTOR signaling pathway to regulate the formation of fish IMP. Inosine monophosphate (IMP) is the main flavoring substance in aquatic animal, and adenosine monophosphate deaminase1 (AMPD1) gene is a key gene in IMP formation. At present, the research on the mechanism of AMPD1 regulating IMP formation in aquatic animal is still blank. In this study, in order to study the mechanism of AMPD1 regulating IMP formation in fish, the full open reading frame (ORF) of AMPD1 which was 2160bp was obtained for the first time in triploid crucian carp (Carassius auratus). It encoded 719 amino acids with a molecular mass of 82.97 kDa, and the theoretical isoelectric point value was 6.31. The homology analysis showed that the homology of triploid crucian carp and diploid Carassius auratus was the highest, up to 99%. And the phylogenetic tree showed that triploid crucian carp was grouped with diploid Carassius auratus, Culter alburnus, and Danio rerio. And real-time fluorescence quantitative results showed that AMPD1 was expressed specifically in muscle of triploid crucian carp (p < 0.05). The results of detection the localization of AMPD1 in cells indicated that the AMPD1 was mainly localized in cytoplasm and cell membrane. Further, we examined the effects of glutamate which was the promotor of IMP formation on the expression of AMPD1 and the formation of IMP in vivo and in vitro experiments, the results showed that 3% glutamate and 2 mg/ml glutamate could significantly promote AMPD1 expression and IMP formation in triploid crucian carp muscle tissue and muscle cells (p < 0.05). Then we inhibited the expression of AMPD1 in vivo and in vitro experiments, we found the formation of IMP in muscle tissue and muscle cells of triploid crucian carp all were inhibited and they affected the gene expression of AMPK-mTOR signaling pathway. The all results showed that AMPD1 mediated glutamate through AMPK-mTOR signaling pathway to regulate the formation of fish IMP. |
Author | Qu, Fufa Zuo, Anli Cao, Shenping Zhang, Yu Yi, Zilin Zhao, Dafang Mao, Zhuangwen Liu, Zhen Zhou, Yonghua Tang, Jianzhou Li, Yingjie Jin, Junyan |
AuthorAffiliation | 2 State Key Laboratory of Freshwater Ecology and Biotechnology , Institute of Hydrobiology , Chinese Academy of Sciences , Wuhan , China 1 Hunan Provincial Key Laboratory of Nutrition and Quality Control of Aquatic Animals , Department of Biological and Environmental Engineering , Changsha University , Changsha , China |
AuthorAffiliation_xml | – name: 2 State Key Laboratory of Freshwater Ecology and Biotechnology , Institute of Hydrobiology , Chinese Academy of Sciences , Wuhan , China – name: 1 Hunan Provincial Key Laboratory of Nutrition and Quality Control of Aquatic Animals , Department of Biological and Environmental Engineering , Changsha University , Changsha , China |
Author_xml | – sequence: 1 givenname: Yonghua surname: Zhou fullname: Zhou, Yonghua – sequence: 2 givenname: Anli surname: Zuo fullname: Zuo, Anli – sequence: 3 givenname: Yingjie surname: Li fullname: Li, Yingjie – sequence: 4 givenname: Yu surname: Zhang fullname: Zhang, Yu – sequence: 5 givenname: Zilin surname: Yi fullname: Yi, Zilin – sequence: 6 givenname: Dafang surname: Zhao fullname: Zhao, Dafang – sequence: 7 givenname: Jianzhou surname: Tang fullname: Tang, Jianzhou – sequence: 8 givenname: Fufa surname: Qu fullname: Qu, Fufa – sequence: 9 givenname: Shenping surname: Cao fullname: Cao, Shenping – sequence: 10 givenname: Zhuangwen surname: Mao fullname: Mao, Zhuangwen – sequence: 11 givenname: Junyan surname: Jin fullname: Jin, Junyan – sequence: 12 givenname: Zhen surname: Liu fullname: Liu, Zhen |
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CitedBy_id | crossref_primary_10_1007_s10126_023_10270_z crossref_primary_10_1016_j_cbpb_2024_110966 |
Cites_doi | 10.1016/j.ymgmr.2013.12.004 10.1007/s10695-018-0581-2 10.1006/abbi.1995.1407 10.1016/j.gene.2015.08.008 10.1016/s1096-4959(02)00049-0 10.1111/jfbc.13946 10.1016/j.chembiol.2014.09.011 10.1002/jsfa.10618 10.1038/s41598-021-04023-y 10.1007/978-3-030-54462-1_9 10.1007/s10695-009-9358-y 10.1111/jsm.12572 10.1096/fj.11-198168 10.1080/15257770.2020.1809674 10.1016/j.foodres.2021.110349 10.1016/j.foodchem.2020.128904 10.1038/ijo.2008.116 10.1016/j.neuroscience.2015.12.008 10.1017/S0007114516001732 10.1007/s00726-014-1842-8 10.1016/j.fsi.2017.09.035 10.1007/s00726-017-2460-z 10.1021/acs.jafc.8b06047 10.1016/j.foodchem.2016.12.056 10.1152/jappl.1998.85.4.1273 10.1016/j.chembiol.2014.09.013 10.1007/s00726-020-02851-2 10.1007/s10695-015-0076-3 10.1002/fsn3.2501 10.1186/s12902-015-0010-9 10.1111/age.13025 10.1074/jbc.M116.732511 10.3382/ps/pex415 10.2337/diabetes.53.suppl_3.s67 10.1152/jappl.2001.91.1.258 10.1038/srep35970 |
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Copyright | Copyright © 2022 Zhou, Zuo, Li, Zhang, Yi, Zhao, Tang, Qu, Cao, Mao, Jin and Liu. 2022 Zhou, Zuo, Li, Zhang, Yi, Zhao, Tang, Qu, Cao, Mao, Jin and Liu |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Aquatic Physiology, a section of the journal Frontiers in Physiology Edited by: Menghong Hu, Shanghai Ocean University, China Reviewed by: Shuming Zou, Shanghai Ocean University, China Qizhi Liu, Cedars Sinai Medical Center, United States |
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Snippet | Inosine monophosphate (IMP) is the main flavoring substance in aquatic animal, and adenosine monophosphate deaminase1 (
AMPD1
) gene is a key gene in IMP... Inosine monophosphate (IMP) is the main flavoring substance in aquatic animal, and adenosine monophosphate deaminase1 (AMPD1) gene is a key gene in IMP... |
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SourceType | Open Website Open Access Repository Aggregation Database |
StartPage | 970939 |
SubjectTerms | AMPD1 glutamate inosine monophosphate Physiology regulatory triploid crucian carp |
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Title | Molecular characterization of adenosine monophosphate deaminase 1 and its regulatory mechanism for inosine monophosphate formation in triploid crucian carp |
URI | https://search.proquest.com/docview/2715445204 https://pubmed.ncbi.nlm.nih.gov/PMC9468423 https://doaj.org/article/8fac810a88864315b7f201b30d91cf41 |
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