Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes

There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant d...

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Published inMolecular and cellular biochemistry Vol. 458; no. 1-2; pp. 171 - 183
Main Authors Soundararajan, Avinash, Prabu, Paramasivam, Mohan, Viswanathan, Gibert, Yann, Balasubramanyam, Muthuswamy
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2019
Springer
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Bisphenol A
Cardiology
Cardiovascular diseases
Care and treatment
Comparative analysis
Correlation analysis
Development and progression
Dextrose
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes therapy
Endocrine disruptors
Enzyme-linked immunosorbent assay
Epoxy resins
Estrogen
Estrogen receptors
Estrogens
Ethylenediaminetetraacetic acid
Etiology
Gene expression
Glucose
Glucose tolerance
Heart diseases
Inflammation
Insulin
Insulin resistance
Interleukin 6
Leukocytes (mononuclear)
Life Sciences
Markers
Medical Biochemistry
Oncology
Organic chemistry
p53 Protein
Patients
Peripheral blood mononuclear cells
Receptors
Risk factors
RNA
Senescence
Serum levels
Telomeres
Tumor necrosis factor-α
Tumor proteins
Type 2 diabetes
T2DM
Insulin resistance
Senescence
Inflammation
Bisphenol-A
ERRγ
Online AccessGet full text
ISSN0300-8177
1573-4919
1573-4919
DOI10.1007/s11010-019-03540-9

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Abstract There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Therefore, we measured systemic levels of BPA in patients with T2DM compared to individuals with normal glucose tolerance ( n  = 30 each). Serum BPA levels were estimated using ELISA kit, and biochemical determinations were done by standard protocols. Peripheral blood mononuclear cells (PBMCs) were used to profile the gene expression alterations with special reference to inflammation, estrogen receptors, and cellular senescence in these subjects. Serum levels of BPA were significantly higher in patients with T2DM compared to control individuals and positively correlated to poor glycemic control and insulin resistance. Patients with T2DM exhibited significantly elevated mRNA levels of senescence (GLB1, p16, p21, and p53) and inflammatory (IL6 and TNF-α) markers, shortened telomeres as well as elevated levels of estrogen-related receptor gamma (ERRγ), a recently identified receptor for BPA. BPA levels were positively correlated to senescence indicators, inflammatory markers and ERRγ and negatively correlated to telomere length. Our study is the first data in the clinical diabetes setting to demonstrate an association of increased BPA levels with cellular senescence, proinflammation, poor glycemic control, insulin resistance, and shortened telomeres in patients with T2DM. Graphical abstract
AbstractList There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Therefore, we measured systemic levels of BPA in patients with T2DM compared to individuals with normal glucose tolerance (n = 30 each). Serum BPA levels were estimated using ELISA kit, and biochemical determinations were done by standard protocols. Peripheral blood mononuclear cells (PBMCs) were used to profile the gene expression alterations with special reference to inflammation, estrogen receptors, and cellular senescence in these subjects. Serum levels of BPA were significantly higher in patients with T2DM compared to control individuals and positively correlated to poor glycemic control and insulin resistance. Patients with T2DM exhibited significantly elevated mRNA levels of senescence (GLB1, p16, p21, and p53) and inflammatory (IL6 and TNF-α) markers, shortened telomeres as well as elevated levels of estrogen-related receptor gamma (ERRγ), a recently identified receptor for BPA. BPA levels were positively correlated to senescence indicators, inflammatory markers and ERRγ and negatively correlated to telomere length. Our study is the first data in the clinical diabetes setting to demonstrate an association of increased BPA levels with cellular senescence, proinflammation, poor glycemic control, insulin resistance, and shortened telomeres in patients with T2DM.Graphical abstract
There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Therefore, we measured systemic levels of BPA in patients with T2DM compared to individuals with normal glucose tolerance (n = 30 each). Serum BPA levels were estimated using ELISA kit, and biochemical determinations were done by standard protocols. Peripheral blood mononuclear cells (PBMCs) were used to profile the gene expression alterations with special reference to inflammation, estrogen receptors, and cellular senescence in these subjects. Serum levels of BPA were significantly higher in patients with T2DM compared to control individuals and positively correlated to poor glycemic control and insulin resistance. Patients with T2DM exhibited significantly elevated mRNA levels of senescence (GLB1, p16, p21, and p53) and inflammatory (IL6 and TNF-[alpha]) markers, shortened telomeres as well as elevated levels of estrogen-related receptor gamma (ERR[gamma]), a recently identified receptor for BPA. BPA levels were positively correlated to senescence indicators, inflammatory markers and ERR[gamma] and negatively correlated to telomere length. Our study is the first data in the clinical diabetes setting to demonstrate an association of increased BPA levels with cellular senescence, proinflammation, poor glycemic control, insulin resistance, and shortened telomeres in patients with T2DM.
There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Therefore, we measured systemic levels of BPA in patients with T2DM compared to individuals with normal glucose tolerance (n = 30 each). Serum BPA levels were estimated using ELISA kit, and biochemical determinations were done by standard protocols. Peripheral blood mononuclear cells (PBMCs) were used to profile the gene expression alterations with special reference to inflammation, estrogen receptors, and cellular senescence in these subjects. Serum levels of BPA were significantly higher in patients with T2DM compared to control individuals and positively correlated to poor glycemic control and insulin resistance. Patients with T2DM exhibited significantly elevated mRNA levels of senescence (GLB1, p16, p21, and p53) and inflammatory (IL6 and TNF-α) markers, shortened telomeres as well as elevated levels of estrogen-related receptor gamma (ERRγ), a recently identified receptor for BPA. BPA levels were positively correlated to senescence indicators, inflammatory markers and ERRγ and negatively correlated to telomere length. Our study is the first data in the clinical diabetes setting to demonstrate an association of increased BPA levels with cellular senescence, proinflammation, poor glycemic control, insulin resistance, and shortened telomeres in patients with T2DM.There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Therefore, we measured systemic levels of BPA in patients with T2DM compared to individuals with normal glucose tolerance (n = 30 each). Serum BPA levels were estimated using ELISA kit, and biochemical determinations were done by standard protocols. Peripheral blood mononuclear cells (PBMCs) were used to profile the gene expression alterations with special reference to inflammation, estrogen receptors, and cellular senescence in these subjects. Serum levels of BPA were significantly higher in patients with T2DM compared to control individuals and positively correlated to poor glycemic control and insulin resistance. Patients with T2DM exhibited significantly elevated mRNA levels of senescence (GLB1, p16, p21, and p53) and inflammatory (IL6 and TNF-α) markers, shortened telomeres as well as elevated levels of estrogen-related receptor gamma (ERRγ), a recently identified receptor for BPA. BPA levels were positively correlated to senescence indicators, inflammatory markers and ERRγ and negatively correlated to telomere length. Our study is the first data in the clinical diabetes setting to demonstrate an association of increased BPA levels with cellular senescence, proinflammation, poor glycemic control, insulin resistance, and shortened telomeres in patients with T2DM.
There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Therefore, we measured systemic levels of BPA in patients with T2DM compared to individuals with normal glucose tolerance ( n  = 30 each). Serum BPA levels were estimated using ELISA kit, and biochemical determinations were done by standard protocols. Peripheral blood mononuclear cells (PBMCs) were used to profile the gene expression alterations with special reference to inflammation, estrogen receptors, and cellular senescence in these subjects. Serum levels of BPA were significantly higher in patients with T2DM compared to control individuals and positively correlated to poor glycemic control and insulin resistance. Patients with T2DM exhibited significantly elevated mRNA levels of senescence (GLB1, p16, p21, and p53) and inflammatory (IL6 and TNF-α) markers, shortened telomeres as well as elevated levels of estrogen-related receptor gamma (ERRγ), a recently identified receptor for BPA. BPA levels were positively correlated to senescence indicators, inflammatory markers and ERRγ and negatively correlated to telomere length. Our study is the first data in the clinical diabetes setting to demonstrate an association of increased BPA levels with cellular senescence, proinflammation, poor glycemic control, insulin resistance, and shortened telomeres in patients with T2DM. Graphical abstract
There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Therefore, we measured systemic levels of BPA in patients with T2DM compared to individuals with normal glucose tolerance (n = 30 each). Serum BPA levels were estimated using ELISA kit, and biochemical determinations were done by standard protocols. Peripheral blood mononuclear cells (PBMCs) were used to profile the gene expression alterations with special reference to inflammation, estrogen receptors, and cellular senescence in these subjects. Serum levels of BPA were significantly higher in patients with T2DM compared to control individuals and positively correlated to poor glycemic control and insulin resistance. Patients with T2DM exhibited significantly elevated mRNA levels of senescence (GLB1, p16, p21, and p53) and inflammatory (IL6 and TNF-α) markers, shortened telomeres as well as elevated levels of estrogen-related receptor gamma (ERRγ), a recently identified receptor for BPA. BPA levels were positively correlated to senescence indicators, inflammatory markers and ERRγ and negatively correlated to telomere length. Our study is the first data in the clinical diabetes setting to demonstrate an association of increased BPA levels with cellular senescence, proinflammation, poor glycemic control, insulin resistance, and shortened telomeres in patients with T2DM.
There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Therefore, we measured systemic levels of BPA in patients with T2DM compared to individuals with normal glucose tolerance (n = 30 each). Serum BPA levels were estimated using ELISA kit, and biochemical determinations were done by standard protocols. Peripheral blood mononuclear cells (PBMCs) were used to profile the gene expression alterations with special reference to inflammation, estrogen receptors, and cellular senescence in these subjects. Serum levels of BPA were significantly higher in patients with T2DM compared to control individuals and positively correlated to poor glycemic control and insulin resistance. Patients with T2DM exhibited significantly elevated mRNA levels of senescence (GLB1, p16, p21, and p53) and inflammatory (IL6 and TNF-[alpha]) markers, shortened telomeres as well as elevated levels of estrogen-related receptor gamma (ERR[gamma]), a recently identified receptor for BPA. BPA levels were positively correlated to senescence indicators, inflammatory markers and ERR[gamma] and negatively correlated to telomere length. Our study is the first data in the clinical diabetes setting to demonstrate an association of increased BPA levels with cellular senescence, proinflammation, poor glycemic control, insulin resistance, and shortened telomeres in patients with T2DM. Graphical abstract
Audience Academic
Author Balasubramanyam, Muthuswamy
Gibert, Yann
Prabu, Paramasivam
Soundararajan, Avinash
Mohan, Viswanathan
Author_xml – sequence: 1
  givenname: Avinash
  surname: Soundararajan
  fullname: Soundararajan, Avinash
  organization: Department of Cell and Molecular Biology, Madras Diabetes Research Foundation & Dr. Mohan’s Diabetes Specialties Centre, ICMR-Centre for Advanced Research on Diabetes, Metabolic Research Unit, Metabolic Genetic Diseases Laboratory, School of Medicine, Deakin University
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  givenname: Paramasivam
  surname: Prabu
  fullname: Prabu, Paramasivam
  organization: Department of Cell and Molecular Biology, Madras Diabetes Research Foundation & Dr. Mohan’s Diabetes Specialties Centre, ICMR-Centre for Advanced Research on Diabetes
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  givenname: Viswanathan
  surname: Mohan
  fullname: Mohan, Viswanathan
  organization: Department of Cell and Molecular Biology, Madras Diabetes Research Foundation & Dr. Mohan’s Diabetes Specialties Centre, ICMR-Centre for Advanced Research on Diabetes
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  givenname: Yann
  surname: Gibert
  fullname: Gibert, Yann
  organization: Metabolic Research Unit, Metabolic Genetic Diseases Laboratory, School of Medicine, Deakin University, Department of Cell and Molecular Biology, The University of Mississippi Medical Center
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  surname: Balasubramanyam
  fullname: Balasubramanyam, Muthuswamy
  email: balusignal@gmail.com, baluglobaldiab@gmail.com
  organization: Department of Cell and Molecular Biology, Madras Diabetes Research Foundation & Dr. Mohan’s Diabetes Specialties Centre, ICMR-Centre for Advanced Research on Diabetes
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31004310$$D View this record in MEDLINE/PubMed
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ID FETCH-LOGICAL-c442t-b85ab27c6094dbc7ce8cb61b0756def43b353cfb14dd3ff063a1690df02af93c3
IEDL.DBID 7X7
ISSN 0300-8177
1573-4919
IngestDate Fri Jul 11 07:42:49 EDT 2025
Fri Jul 25 19:01:40 EDT 2025
Tue Jun 17 21:33:37 EDT 2025
Tue Jun 10 20:51:01 EDT 2025
Mon Jul 21 05:45:55 EDT 2025
Tue Jul 01 02:21:01 EDT 2025
Thu Apr 24 23:07:48 EDT 2025
Fri Feb 21 02:39:13 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 1-2
Keywords T2DM
Insulin resistance
Senescence
Inflammation
Bisphenol-A
ERRγ
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c442t-b85ab27c6094dbc7ce8cb61b0756def43b353cfb14dd3ff063a1690df02af93c3
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  day: 01
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PublicationSubtitle An International Journal for Chemical Biology in Health and Disease
PublicationTitle Molecular and cellular biochemistry
PublicationTitleAbbrev Mol Cell Biochem
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PublicationYear 2019
Publisher Springer US
Springer
Springer Nature B.V
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Snippet There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like...
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StartPage 171
SubjectTerms Biochemistry
Biomedical and Life Sciences
Bisphenol A
Cardiology
Cardiovascular diseases
Care and treatment
Comparative analysis
Correlation analysis
Development and progression
Dextrose
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes therapy
Endocrine disruptors
Enzyme-linked immunosorbent assay
Epoxy resins
Estrogen
Estrogen receptors
Estrogens
Ethylenediaminetetraacetic acid
Etiology
Gene expression
Glucose
Glucose tolerance
Heart diseases
Inflammation
Insulin
Insulin resistance
Interleukin 6
Leukocytes (mononuclear)
Life Sciences
Markers
Medical Biochemistry
Oncology
Organic chemistry
p53 Protein
Patients
Peripheral blood mononuclear cells
Receptors
Risk factors
RNA
Senescence
Serum levels
Telomeres
Tumor necrosis factor-α
Tumor proteins
Type 2 diabetes
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Title Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes
URI https://link.springer.com/article/10.1007/s11010-019-03540-9
https://www.ncbi.nlm.nih.gov/pubmed/31004310
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https://www.proquest.com/docview/2211948934
Volume 458
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