Blood-stage Plasmodium infection induces CD8⁺ T lymphocytes to parasite-expressed antigens, largely regulated by CD8α⁺ dendritic cells

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 38; pp. 14509 - 14514
• Main Authors: Lundie, Rachel J, de Koning-Ward, Tania F, Davey, Gayle M, Nie, Catherine Q, Hansen, Diana S, Lau, Lei Shong, Mintern, Justine D, Belz, Gabrielle T, Schofield, Louis, Carbone, Francis R, Villadangos, Jose A, Crabb, Brendan S, Heath, William R
• Format: Journal Article
• Language: English
• Published: National Academy of Sciences 23.09.2008; National Acad Sciences
• Subjects: Antigens; Biological Sciences; Cerebral malaria; Dendritic cells; Epitopes; Infections; Malaria; Parasites; Parasitism; T lymphocytes; Transgenic animals

Although CD8⁺ T cells do not contribute to protection against the blood stage of Plasmodium infection, there is mounting evidence that they are principal mediators of murine experimental cerebral malaria (ECM). At present, there is no direct evidence that the CD8⁺ T cells mediating ECM are parasite-...