Sensory Representations Supporting Memory Specificity: Age Effects on Behavioral and Neural Discriminability

• Published in: The Journal of neuroscience Vol. 39; no. 12; pp. 2265 - 2275
• Main Authors: Bowman, Caitlin R., Chamberlain, Jordan D., Dennis, Nancy A.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 20.03.2019
• Subjects: Activation; Adolescent; Adult; Adults; Age; Age differences; Aging - physiology; Aging - psychology; Brain - physiology; Discrimination; Discrimination, Psychological - physiology; Female; Humans; Male; Memory Disorders - etiology; Memory Disorders - physiopathology; Mental Recall - physiology; Occipital lobe; Older people; Representations; Semantics; Signal quality; Somatosensory cortex; Visual cortex; Visual Cortex - physiology; Visual discrimination; Visual signals; Young Adult; Young adults; functional MRI; aging; false memory; long-term memory; multivariate pattern analysis
• ISSN: 0270-6474; 1529-2401; 1529-2401
• DOI: 10.1523/JNEUROSCI.2022-18.2019

Older adults' difficulty in distinguishing between old and new information contributes to memory decline, which may occur because older adults are less likely than young adults to retrieve specific sensory details necessary to distinguish between similar items. In male and female human subjects, the present study measured the extent of age differences in the specificity of memory representations using a false memory paradigm in which studied items were linked to retrieval items at multiple levels of similarity. Older adults showed poorer behavioral discrimination than young adults, driven primarily by false recognition of lures that differed from targets only in perceptual details. Patterns of activation across several regions within ventral visual cortex could be used to distinguish between targets and lures when they differed in both perceptual details and a semantic label. However, of ventral visual regions, only signals in the midline occipital cortex could be used to distinguish targets from lures when they differed only in perceptual details. Although there was an overall age deficit for this neural discrimination in this region, the positive relationship between neural and behavioral discriminability did not differ across age groups. In contrast, age moderated the relationship between neural and behavioral discriminability in lateral occipital and fusiform cortices, suggesting that activation patterns within these regions represent different types of information in each age group. Therefore, the quality of perceptual signals is a key contributor to memory discrimination across age groups, with evidence that age differences in the nature of representations emerges outside early visual cortex. SIGNIFICANCE STATEMENT Age-related memory decline is due in part to older adults' difficulties in discriminating between old and new information. We tested whether this deficit arises from lack of specificity in the sensory representations underlying older adults' recognition judgments. Using pattern classification analyses in ventral visual cortices, we found that signals in a region early in the visual stream could distinguish between targets and lures at the highest level of similarity. The discriminability of targets and lures in this region was positively related to behavioral discriminability across age groups despite an overall age deficit in classification accuracy. Together, results showed that older adults' memory deficits are related to reduced discriminability of cognitive processes (old/new recognition) in portions of visual cortex.