Epigenetics: Recent Advances and Its Role in the Treatment of Alzheimer's Disease

Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease (AD) and provides therapeutic strategies for AD. Methods: We searched the following keywords: “genetics,” “epigenetics,” “Alzheimer's disease,” “DNA methylation,” “DNA hydroxymethylation,” “histone...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in neurology Vol. 11; p. 538301
Main Authors Xiao, Xuewen, Liu, Xixi, Jiao, Bin
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 15.10.2020
Subjects
Alzheiemer's disease
DNA hydroxymethylation
DNA methylation
epigenetic
histone modifications
Neurology
non-coding RNA (ncRNA)
Online AccessGet full text

Cover

Abstract Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease (AD) and provides therapeutic strategies for AD. Methods: We searched the following keywords: “genetics,” “epigenetics,” “Alzheimer's disease,” “DNA methylation,” “DNA hydroxymethylation,” “histone modifications,” “non-coding RNAs,” and “therapeutic strategies” in PubMed. Results: In this review, we summarizes recent studies of epigenetics in AD, including DNA methylation/hydroxymethylation, histone modifications, and non-coding RNAs. There are no consistent results of global DNA methylation/hydroxymethylation in AD. Epigenetic genome-wide association studies show that many differentially methylated sites exist in AD. Several studies investigate the role of histone modifications in AD; for example, histone acetylation decreases, whereas H3 phosphorylation increases significantly in AD. In addition, non-coding RNAs, such as microRNA-16 and BACE1-antisense transcript ( BACE1-AS ), are associated with the pathology of AD. These epigenetic changes provide us with novel insights into the pathogenesis of AD and may be potential therapeutic strategies for AD. Conclusion: Epigenetics is associated with the pathogenesis of AD, including DNA methylation/hydroxymethylation, histone modifications, and non-coding RNAs, which provide potential therapeutic strategies for AD.
AbstractList Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease (AD) and provides therapeutic strategies for AD.Methods: We searched the following keywords: “genetics,” “epigenetics,” “Alzheimer's disease,” “DNA methylation,” “DNA hydroxymethylation,” “histone modifications,” “non-coding RNAs,” and “therapeutic strategies” in PubMed.Results: In this review, we summarizes recent studies of epigenetics in AD, including DNA methylation/hydroxymethylation, histone modifications, and non-coding RNAs. There are no consistent results of global DNA methylation/hydroxymethylation in AD. Epigenetic genome-wide association studies show that many differentially methylated sites exist in AD. Several studies investigate the role of histone modifications in AD; for example, histone acetylation decreases, whereas H3 phosphorylation increases significantly in AD. In addition, non-coding RNAs, such as microRNA-16 and BACE1-antisense transcript (BACE1-AS), are associated with the pathology of AD. These epigenetic changes provide us with novel insights into the pathogenesis of AD and may be potential therapeutic strategies for AD.Conclusion: Epigenetics is associated with the pathogenesis of AD, including DNA methylation/hydroxymethylation, histone modifications, and non-coding RNAs, which provide potential therapeutic strategies for AD.
Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease (AD) and provides therapeutic strategies for AD. Methods: We searched the following keywords: “genetics,” “epigenetics,” “Alzheimer's disease,” “DNA methylation,” “DNA hydroxymethylation,” “histone modifications,” “non-coding RNAs,” and “therapeutic strategies” in PubMed. Results: In this review, we summarizes recent studies of epigenetics in AD, including DNA methylation/hydroxymethylation, histone modifications, and non-coding RNAs. There are no consistent results of global DNA methylation/hydroxymethylation in AD. Epigenetic genome-wide association studies show that many differentially methylated sites exist in AD. Several studies investigate the role of histone modifications in AD; for example, histone acetylation decreases, whereas H3 phosphorylation increases significantly in AD. In addition, non-coding RNAs, such as microRNA-16 and BACE1-antisense transcript ( BACE1-AS ), are associated with the pathology of AD. These epigenetic changes provide us with novel insights into the pathogenesis of AD and may be potential therapeutic strategies for AD. Conclusion: Epigenetics is associated with the pathogenesis of AD, including DNA methylation/hydroxymethylation, histone modifications, and non-coding RNAs, which provide potential therapeutic strategies for AD.
Author Liu, Xixi
Jiao, Bin
Xiao, Xuewen
AuthorAffiliation 1 Department of Neurology, Xiangya Hospital, Central South University , Changsha , China
2 National Clinical Research Center for Geriatric Disorders, Central South University , Changsha , China
3 Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University , Changsha , China
AuthorAffiliation_xml – name: 3 Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University , Changsha , China
– name: 1 Department of Neurology, Xiangya Hospital, Central South University , Changsha , China
– name: 2 National Clinical Research Center for Geriatric Disorders, Central South University , Changsha , China
Author_xml – sequence: 1
  givenname: Xuewen
  surname: Xiao
  fullname: Xiao, Xuewen
– sequence: 2
  givenname: Xixi
  surname: Liu
  fullname: Liu, Xixi
– sequence: 3
  givenname: Bin
  surname: Jiao
  fullname: Jiao, Bin
BookMark eNpVkU1vEzEQhi1URD_oD-DmG1wS_L02B6SotBCpEqIqZ8trjxNXu3awN5Xg17NpKkTnMqOZV8_M6D1HJ7lkQOgdJUvOtfkYM-zrkhFGlpJrTugrdEaVEgvGjDz5rz5Fl609kDm4MVzxN-iUc9ppYswZ-nG9SxvIMCXfPuE78JAnvAqPLnto2OWA11PDd2UAnDKetoDvK7hpPMhKxKvhzxbSCPV9w19SA9fgLXod3dDg8jlfoJ831_dX3xa337-ur1a3Cy8Emxa9pF67QGnQQUWqSHTckY4F4U0fFYX58mgEpURGD71kumOcRyMBggdh-AVaH7mhuAe7q2l09bctLtmnRqkb6-r81gBWaAOq7yiEKEWgUUcKknVMG9mrAHJmfT6ydvt-PPDzVN3wAvpyktPWbsqj7aQRkrEZ8OEZUMuvPbTJjql5GAaXoeybZUIRohkVfJbSo9TX0lqF-G8NJfbgrH1y1h6ctUdn-V_OxJgY
CitedBy_id crossref_primary_10_1038_s41392_021_00748_4
crossref_primary_10_1021_acs_estlett_4c00154
crossref_primary_10_1002_jbt_23741
crossref_primary_10_3390_biology11010090
crossref_primary_10_1016_j_neuint_2021_105184
crossref_primary_10_1111_ejn_16336
crossref_primary_10_1038_s41398_024_02958_0
crossref_primary_10_1038_s41598_023_31117_6
crossref_primary_10_3390_pharmaceutics13091397
crossref_primary_10_3389_fcell_2021_825729
crossref_primary_10_3390_metabo12060475
crossref_primary_10_1007_s10571_023_01408_7
crossref_primary_10_3389_fnagi_2024_1332845
crossref_primary_10_1093_gerona_glac138
crossref_primary_10_2478_cdem_2021_0010
crossref_primary_10_1016_j_arr_2023_102174
crossref_primary_10_3390_ijms24097955
crossref_primary_10_3390_ijms222212280
crossref_primary_10_3390_life12091439
Cites_doi 10.1038/s41593-018-0291-1
10.1093/brain/awt237
10.1007/s00018-019-03074-9
10.3390/ijms20051134
10.1038/nrd3674
10.1016/j.neurobiolaging.2015.07.015
10.1016/j.omtn.2020.02.008
10.1136/jnnp-2019-321913
10.2174/1567202617666200117103931
10.1016/j.pneurobio.2017.03.004
10.1007/s00702-019-02134-5
10.1016/j.pharmthera.2018.11.001
10.1007/s00401-018-1880-5
10.3389/fncel.2018.00224
10.1371/journal.pone.0015367
10.3389/fncel.2020.00028
10.1038/nn.3786
10.1007/s00011-020-01364-8
10.1074/jbc.M807530200
10.1093/hmg/ddt451
10.1093/ije/dyr184
10.1074/jbc.M113.518241
10.1016/S1474-4422(16)30229-0
10.1016/j.nbd.2014.11.023
10.1038/s41582-018-0070-3
10.1016/j.bbr.2015.06.004
10.3233/JAD-141452
10.1007/s12031-019-01364-2
10.1111/j.1601-5215.2012.00662.x
10.3233/JAD-141989
10.1007/s12264-019-00361-0
10.1186/s12929-019-0609-7
10.1126/sciadv.aaw2880
10.1038/s41593-019-0501-5
10.1001/jamaneurol.2013.1443
10.1038/s41380-019-0610-2
10.1016/j.jpsychires.2016.02.010
10.1016/j.nepig.2015.10.002
10.1016/j.cell.2019.09.001
10.1073/pnas.0701532104
10.18632/aging.102558
10.1186/s13024-018-0277-1
10.1093/hmg/ddz273
10.1016/j.neurobiolaging.2018.09.024
10.1002/jcb.28276
10.1016/j.neulet.2015.06.009
10.1186/s13148-016-0202-9
10.1016/j.neurobiolaging.2013.02.021
10.2174/1567205012666150710114256
10.3389/fgene.2018.00579
10.1016/j.bbi.2014.11.002
10.1159/000309657
10.1093/brain/awy354
10.1016/j.neulet.2015.08.012
10.3233/JAD-2010-100339
10.1016/j.euroneuro.2020.01.015
10.1016/j.neulet.2017.09.043
10.1016/j.neurobiolaging.2013.10.082
10.1038/nn.3607
10.1086/504729
10.1186/s13148-019-0672-7
10.1089/dna.2017.4012
10.1038/s41419-018-0840-2
10.3892/etm.2018.6359
10.3389/fbioe.2019.00222
10.1016/j.arr.2013.05.003
10.3389/fnagi.2019.00365
10.18632/aging.102529
10.1186/s13072-017-0150-4
10.1016/0169-328X(94)90125-2
10.3892/mmr.2018.9424
10.1038/s41593-019-0339-x
10.1097/00002093-200107000-00008
10.15252/embj.201387576
10.1007/s00401-019-01966-5
10.1016/j.neurobiolaging.2008.12.005
10.3233/JAD-130428
10.1016/j.bbrc.2016.08.037
10.1126/science.8346443
10.1007/s12035-014-8751-4
10.1016/j.brainres.2005.10.006
10.1074/jbc.M112.366336
10.3233/JAD-2012-111223
10.1016/j.omtn.2020.01.010
10.1007/s12035-016-0357-6
10.1038/ng.2802
10.1371/journal.pgen.1006987
10.1080/15592294.2020.1722917
10.3233/JAD-143060
10.1038/nm1784
10.1186/s13148-019-0755-5
10.1016/j.neulet.2014.02.046
10.1186/s13195-016-0183-0
10.1002/pmic.201200010
10.1016/j.brainres.2018.08.006
10.1007/978-1-4939-7315-6_11
10.1016/j.neurobiolaging.2014.02.002
10.1016/j.jalz.2016.03.001
10.1177/1533317508325094
10.1074/jbc.M112.426536
10.1074/jbc.M110.112664
10.1182/blood-2003-03-0687
10.1016/j.mad.2016.04.003
10.3233/JAD-170664
10.1002/ana.410280117
10.1006/geno.1994.1393
10.1038/s41380-020-0824-3
10.1038/s41598-019-48471-z
10.1007/BF02736773
10.1186/s40035-017-0089-1
10.1001/jamaneurol.2014.3049
10.3233/JAD-2009-1134
10.1161/STROKEAHA.119.025665
10.1371/journal.pone.0110773
10.1016/j.biocel.2020.105747
10.3892/ijmm.2014.1780
10.3233/JAD-2010-091603
10.1002/wrna.1463
10.1016/j.neurobiolaging.2013.11.031
10.1186/1471-2202-11-14
10.3389/fnagi.2019.00068
10.1038/nn.3782
10.1186/s13148-019-0741-y
10.1016/j.ejmech.2019.01.077
10.3389/fphar.2019.00272
10.1038/nn.4587
10.1016/j.jalz.2016.02.009
10.1007/s00018-020-03503-0
10.3390/ijms21062220
10.3892/ijmm.2018.3957
10.1073/pnas.1012851108
10.1186/s13148-018-0547-3
10.3233/JAD-161195
10.3233/JAD-180242
10.1016/j.jconrel.2018.04.034
10.1007/s12035-018-1299-y
10.1080/15384101.2019.1629773
10.1186/1750-1326-6-70
10.3892/etm.2017.5394
10.1002/jcb.26700
10.2147/CIA.S107037
10.1016/j.jalz.2016.10.004
10.18632/oncotarget.23119
10.1038/mp.2017.218
10.1093/hmg/ddw109
10.1097/NEN.0b013e3181af2e46
10.1038/nbt.2158
10.1016/j.jpsychires.2017.04.003
10.1073/pnas.0710263105
10.1073/pnas.1707544114
10.1016/j.brainresbull.2012.05.018
10.3389/fgene.2018.00596
10.1016/j.tins.2008.12.003
10.1186/s13073-015-0258-8
10.1038/mp.2015.175
10.1038/s41467-019-10101-7
10.1371/journal.pone.0000895
10.3109/01677063.2010.503978
10.2174/156720512800618053
10.18632/aging.100906
10.1016/j.mad.2013.08.005
10.1002/jcp.28988
10.1016/S0140-6736(07)60109-3
10.12659/MSM.905524
10.1111/nan.12183
10.1038/s41593-018-0253-7
10.1016/bs.acr.2017.06.003
10.1016/j.toxlet.2011.11.032
10.1080/15476286.2020.1783487
10.1097/WAD.0000000000000329
10.3389/fncel.2017.00175
10.1038/tp.2012.55
10.1159/000440841
10.1159/000375367
10.1073/pnas.1805436115
10.1186/s13148-019-0636-y
10.1016/j.bbrc.2019.09.094
10.1038/s41586-019-1411-0
10.1016/j.expneurol.2012.10.005
10.1111/j.1460-9568.2007.05864.x
10.1186/s12864-016-2731-1
10.1038/nrn.2016.7
10.1016/j.neuint.2012.07.014
10.1016/j.neurobiolaging.2011.12.013
10.3389/fphar.2019.00806
10.1016/j.neulet.2005.03.073
10.1016/j.ajpath.2015.10.004
10.1523/JNEUROSCI.5772-12.2013
10.1155/2013/852080
10.1371/journal.pmed.1002270
10.18632/oncotarget.15149
10.1038/nn.3151
10.1016/j.jns.2020.116793
10.1007/s12035-019-1632-0
10.1016/j.neurobiolaging.2019.05.023
10.1101/cshperspect.a019133
10.1038/s41380-018-0266-3
10.1016/j.neurobiolaging.2010.04.034
10.3233/JAD-150717
10.1016/j.expneurol.2014.05.008
10.1186/s12014-015-9098-1
10.1016/j.neurobiolaging.2017.10.011
10.3389/fnmol.2014.00002
10.1038/nature10849
ContentType Journal Article
Copyright Copyright © 2020 Xiao, Liu and Jiao. 2020 Xiao, Liu and Jiao
Copyright_xml – notice: Copyright © 2020 Xiao, Liu and Jiao. 2020 Xiao, Liu and Jiao
DBID AAYXX
CITATION
7X8
5PM
DOA
DOI 10.3389/fneur.2020.538301
DatabaseName CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE - Academic
DatabaseTitleList

Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1664-2295
EndPage 538301
ExternalDocumentID oai_doaj_org_article_489e6b71edf54d1f8f1e5272895b6de5
10_3389_fneur_2020_538301
GrantInformation_xml – fundername: National Natural Science Foundation of China
  grantid: 81701134
– fundername: Provincial Technology Innovation Guidance Plan Project of Hunan
  grantid: 2108SK52601
GroupedDBID 53G
5VS
9T4
AAFWJ
AAKDD
AAYXX
ACGFO
ACGFS
ACXDI
ADBBV
ADRAZ
AENEX
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
CITATION
DIK
E3Z
EMOBN
F5P
GROUPED_DOAJ
GX1
HYE
IAO
IEA
IHR
IHW
KQ8
M48
M~E
O5R
O5S
OK1
P2P
PGMZT
RNS
RPM
7X8
ITC
5PM
ID FETCH-LOGICAL-c442t-b51c8ad11d8d6f160fa3a072d4c9bf61e295f941105fceb5287233f95eedce493
IEDL.DBID RPM
ISSN 1664-2295
IngestDate Fri Oct 04 12:50:08 EDT 2024
Tue Sep 17 21:12:15 EDT 2024
Fri Aug 16 21:30:53 EDT 2024
Thu Sep 26 17:03:36 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c442t-b51c8ad11d8d6f160fa3a072d4c9bf61e295f941105fceb5287233f95eedce493
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
This article was submitted to Dementia and Neurodegenerative Diseases, a section of the journal Frontiers in Neurology
Edited by: Keith Vossel, Mary S. Easton Center for Alzheimer's Disease Research at UCLA, United States
Reviewed by: Christian Griñán-Ferré, Bosch i Gimpera Foundation, Spain; Anderson A. Butler, University of Alabama at Birmingham, United States
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594522/
PMID 33178099
PQID 2460082143
PQPubID 23479
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_489e6b71edf54d1f8f1e5272895b6de5
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7594522
proquest_miscellaneous_2460082143
crossref_primary_10_3389_fneur_2020_538301
PublicationCentury 2000
PublicationDate 2020-10-15
PublicationDateYYYYMMDD 2020-10-15
PublicationDate_xml – month: 10
  year: 2020
  text: 2020-10-15
  day: 15
PublicationDecade 2020
PublicationTitle Frontiers in neurology
PublicationYear 2020
Publisher Frontiers Media S.A
Publisher_xml – name: Frontiers Media S.A
References Patterson (B2) 2018
Lashley (B79) 2015; 41
Chen (B136) 2019; 43
Lambert (B9) 2013; 45
Morris-Blanco (B21) 2019; 50
Hong (B155) 2020; 20
Furuya (B40) 2012; 61
Zhang (B138) 2019; 7
Gao (B70) 2018; 15
Di Francesco (B85) 2015; 45
West (B25) 1995; 6
Cao (B131) 2020
Griñán-Ferré (B167) 2019; 11
Lunnon (B39) 2014; 17
Bhatnagar (B180) 2014; 7
Blanco-Luquin (B51) 2018; 10
Long (B132) 2019; 24
Shu (B92) 2016; 17
Zhu (B119) 2012; 88
Bakulski (B36) 2012; 29
Li (B19) 2019; 22
Wang (B157) 2020; 77
Li (B29) 2018; 1676
Semick (B71) 2019; 137
El Fatimy (B126) 2018; 136
Yao (B129) 2019; 11
Corbett (B169) 2013; 288
Guo (B18) 2014; 17
Unnikrishnan (B17) 2019; 195
Cosín-Tomás (B88) 2018; 9
Schueller (B103) 2020; 33
Mani (B32) 2006; 1067
Chouliaras (B81) 2013; 34
An (B181) 2017; 8
Wang (B109) 2013; 12
Barrachina (B27) 2009; 68
Schwob (B78) 1990; 28
Yu (B11) 2020
Griñán-Ferré (B20) 2018; 62
Lai (B163) 2019; 10
Lu (B135) 2019; 35
Hebert (B110) 2009; 32
Yu (B55) 2016; 12
Hu (B59) 2017; 23
Linnebank (B188) 2010; 7
Durga (B165) 2007; 369
Cao (B156) 2019; 81
Li (B121) 2020; 413
An (B164) 2019; 11
Francis (B100) 2009; 18
Globisch (B89) 2010; 5
Lee (B183) 2019; 9
De Jager (B68) 2014; 17
Salcedo-Tacuma (B54) 2019; 33
Yamazaki (B63) 2017; 57
Marzi (B98) 2018; 21
Xu (B96) 2019; 520
Humphries (B66) 2015; 44
Arrowsmith (B207) 2012; 11
Grosser (B60) 2014; 566
Zheng (B175) 2019; 142
Brohede (B28) 2010; 24
Lanoiselee (B7) 2017; 14
Li (B154) 2020; 69
Qureshi (B16) 2013; 70
Qin (B76) 2020; 29
Barros-Viegas (B115) 2020; 19
Seritrakul (B23) 2017; 13
Siegmund (B35) 2007; 2
Kang (B127) 2017; 8
Altuna (B72) 2019; 11
Bradley-Whitman (B93) 2013; 134
Mercer (B143) 2010; 11
Delay (B133) 2011; 6
Coppieters (B83) 2014; 35
Caccamo (B197) 2010; 107
Smith (B58) 2019; 74
Nelson (B116) 2010; 21
Oliveira (B160) 2012; 15
Tulloch (B42) 2018; 1698
Kunisawa (B161) 2015; 292
Jaber (B179) 2019; 56
Nagata (B46) 2015; 5
Dyer (B105) 2019; 11
Millan (B185) 2017; 156
Issa (B189) 2004; 103
Yuan (B125) 2020; 127
Knopman (B205) 2001; 15
Liu (B178) 2014; 34
Lei (B199) 2015; 8
Banzhaf-Strathmann (B124) 2014; 33
Rogaev (B30) 1994; 22
Bernstein (B75) 2016; 25
Van den Hove (B182) 2014; 35
Janczura (B173) 2018; 115
Narayan (B101) 2015; 74
Oliveira (B187) 2016; 21
Ledoux (B31) 1994; 24
Iwata (B24) 2014; 23
Piaceri (B33) 2015; 43
Martínez-Iglesias (B87) 2020; 21
Boissonneault (B118) 2009; 284
Tannorella (B62) 2015; 600
Mastroeni (B80) 2010; 31
Corder (B8) 1993; 261
Wang (B158) 2019; 76
Volmar (B170) 2017; 114
Kumar (B191) 2015; 4
Rao (B84) 2012; 2
Parenti (B153) 2007; 26
Chatterjee (B174) 2013; 33
Fetahu (B73) 2019; 5
Luo (B147) 2016; 11
Sandi (B190) 2013; 2013
Izquierdo (B166) 2019; 20
Zhang (B148) 2019; 56
Mendioroz (B53) 2016; 8
Zhang (B99) 2012; 12
(B1) 2016; 12
Sanchez-Mut (B44) 2013; 136
Zhao (B74) 2017; 13
Watson (B67) 2016; 8
Zhou (B134) 2018; 119
Griñán-Ferré (B86) 2016; 8
Li (B141) 2020; 123
Huang (B204) 2020; 27
Knauss (B151) 2018; 9
Wang (B5) 2018; 62
Chopra (B120) 2020
Kivipelto (B12) 2018; 14
Yang (B196) 2017; 6
Celarain (B64) 2016; 8
Liu (B128) 2016; 478
Sung (B171) 2013; 239
Li (B22) 2014; 6
Tang (B4) 2016; 15
Foraker (B41) 2015; 48
Song (B194) 2016; 51
Ma (B50) 2016; 76
Plagg (B102) 2015; 12
Liu (B203) 2018; 9
Zhou (B107) 2015; 36
Remington (B206) 2009; 24
Colonna (B91) 2016; 17
Dube (B137) 2019; 22
Amin (B192) 2019; 166
Hunter (B6) 2018; 23
Fotuhi (B146) 2019; 69
Qazi (B177) 2018; 55
Waddington (B15) 2012; 41
Vilardo (B200) 2010; 285
Li (B65) 2019; 10
Ozaki (B52) 2017; 92
Klein (B106) 2019; 22
Idda (B202) 2018; 9
Mulder (B186) 2005; 386
Smith (B77) 2019; 11
Wang (B176) 2018; 279
An (B43) 1994; 33
Long (B198) 2014; 289
Modarresi (B150) 2012; 30
Fuso (B34) 2012; 9
Anderson (B104) 2015; 12
Mercorio (B57) 2018; 65
Yu (B45) 2015; 72
Moutinho (B108) 2017; 135
Silva (B61) 2014; 38
Li (B122) 2019; 120
Graff (B193) 2012; 483
Gu (B152) 2018; 37
Cheng (B90) 2015; 268
Liu (B111) 2012; 33
Griñán-Ferré (B13) 2018; 12
Ma (B123) 2017; 661
He (B130) 2020; 235
Monti (B37) 2020; 15
Carboni (B48) 2015; 605
Long (B201) 2012; 287
Xu (B56) 2018; 18
Huang (B159) 2020; 14
Xuan (B168) 2015; 51
Coppede (B49) 2017; 161
Cavalli (B14) 2019; 571
Hebert (B112) 2008; 105
Lo (B142) 2020
Long (B3) 2019; 179
Chang (B47) 2014; 9
Wang (B113) 2019; 10
Faghihi (B144) 2008; 14
Condliffe (B82) 2014; 35
Rustenhoven (B172) 2018; 13
Tan (B114) 2020; 114
Swerdlow (B94) 2010; 20
Fang (B117) 2012; 209
Quan (B184) 2017; 11
Christopher (B97) 2017; 10
Yang (B139) 2019; 18
Huang (B195) 2017; 20
Mus (B149) 2007; 104
Lardenoije (B69) 2019; 11
Hou (B26) 2013; 25
Fuso (B162) 2012; 33
Blanch (B95) 2016; 186
Diling (B140) 2019; 11
Sims (B10) 2016; 16
Flanagan (B38) 2006; 79
Zhang (B145) 2018; 16
References_xml – volume: 22
  start-page: 37
  year: 2019
  ident: B106
  article-title: Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains
  publication-title: Nat Neurosci.
  doi: 10.1038/s41593-018-0291-1
  contributor:
    fullname: Klein
– volume: 136
  start-page: 3018
  year: 2013
  ident: B44
  article-title: DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease
  publication-title: Brain.
  doi: 10.1093/brain/awt237
  contributor:
    fullname: Sanchez-Mut
– volume: 76
  start-page: 3005
  year: 2019
  ident: B158
  article-title: NEAT1 regulates neuroglial cell mediating Aβ clearance via the epigenetic regulation of endocytosis-related genes expression
  publication-title: Cell Mol Life Sci.
  doi: 10.1007/s00018-019-03074-9
  contributor:
    fullname: Wang
– volume: 20
  start-page: 1134
  year: 2019
  ident: B166
  article-title: Maternal resveratrol supplementation prevents cognitive decline in senescent mice offspring
  publication-title: Int J Mol Sci.
  doi: 10.3390/ijms20051134
  contributor:
    fullname: Izquierdo
– volume: 11
  start-page: 384
  year: 2012
  ident: B207
  article-title: Epigenetic protein families: a new frontier for drug discovery
  publication-title: Nat Rev Drug Discov.
  doi: 10.1038/nrd3674
  contributor:
    fullname: Arrowsmith
– volume: 36
  start-page: 2925
  year: 2015
  ident: B107
  article-title: Identification of Alzheimer's disease-associated long noncoding RNAs
  publication-title: Neurobiol Aging.
  doi: 10.1016/j.neurobiolaging.2015.07.015
  contributor:
    fullname: Zhou
– volume: 20
  start-page: 140
  year: 2020
  ident: B155
  article-title: Aberrant expression profiles of lncRNAs and their associated nearby coding genes in the hippocampus of the SAMP8 mouse model with AD
  publication-title: Mol Ther Nucleic Acids.
  doi: 10.1016/j.omtn.2020.02.008
  contributor:
    fullname: Hong
– year: 2020
  ident: B11
  article-title: Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials
  publication-title: J Neurol Neurosurg Psychiatr.
  doi: 10.1136/jnnp-2019-321913
  contributor:
    fullname: Yu
– volume: 114
  start-page: 86
  year: 2020
  ident: B114
  article-title: miR-340 reduces accumulation of amyloid-beta through targeting BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) in Alzheimer' s disease
  publication-title: Curr Neurovasc Res.
  doi: 10.2174/1567202617666200117103931
  contributor:
    fullname: Tan
– volume: 156
  start-page: 1
  year: 2017
  ident: B185
  article-title: Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: an integrative review
  publication-title: Prog Neurobiol.
  doi: 10.1016/j.pneurobio.2017.03.004
  contributor:
    fullname: Millan
– volume: 127
  start-page: 339
  year: 2020
  ident: B125
  article-title: MicroRNA-425-5p promotes tau phosphorylation and cell apoptosis in Alzheimer's disease by targeting heat shock protein B8
  publication-title: J Neural Trans.
  doi: 10.1007/s00702-019-02134-5
  contributor:
    fullname: Yuan
– volume: 195
  start-page: 172
  year: 2019
  ident: B17
  article-title: The role of DNA methylation in epigenetics of aging
  publication-title: Pharmacol Ther.
  doi: 10.1016/j.pharmthera.2018.11.001
  contributor:
    fullname: Unnikrishnan
– volume: 136
  start-page: 537
  year: 2018
  ident: B126
  article-title: MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-018-1880-5
  contributor:
    fullname: El Fatimy
– volume: 12
  start-page: 224
  year: 2018
  ident: B13
  article-title: Environmental enrichment improves cognitive deficits, AD hallmarks and epigenetic alterations presented in 5xFAD mouse model
  publication-title: Front Cell Neurosci.
  doi: 10.3389/fncel.2018.00224
  contributor:
    fullname: Griñán-Ferré
– volume: 5
  start-page: e15367
  year: 2010
  ident: B89
  article-title: Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
  publication-title: PLoS ONE.
  doi: 10.1371/journal.pone.0015367
  contributor:
    fullname: Globisch
– volume: 14
  start-page: 28
  year: 2020
  ident: B159
  article-title: Depletion of LncRNA NEAT1 rescues mitochondrial dysfunction through NEDD4L-dependent PINK1 degradation in animal models of Alzheimer's disease
  publication-title: Front Cell Neurosci.
  doi: 10.3389/fncel.2020.00028
  contributor:
    fullname: Huang
– volume: 17
  start-page: 1156
  year: 2014
  ident: B68
  article-title: Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
  publication-title: Nat Neurosci.
  doi: 10.1038/nn.3786
  contributor:
    fullname: De Jager
– volume: 69
  start-page: 897
  year: 2020
  ident: B154
  article-title: Knockdown of long non-coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer's disease by elevating microRNA-15a and repressing ROCK1 expression
  publication-title: Inflamm Res.
  doi: 10.1007/s00011-020-01364-8
  contributor:
    fullname: Li
– volume: 284
  start-page: 1971
  year: 2009
  ident: B118
  article-title: MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M807530200
  contributor:
    fullname: Boissonneault
– volume: 23
  start-page: 648
  year: 2014
  ident: B24
  article-title: Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation
  publication-title: Hum Mol Genet.
  doi: 10.1093/hmg/ddt451
  contributor:
    fullname: Iwata
– volume: 41
  start-page: 10
  year: 2012
  ident: B15
  article-title: The epigenotype 1942
  publication-title: Int J Epidemiol
  doi: 10.1093/ije/dyr184
  contributor:
    fullname: Waddington
– volume: 289
  start-page: 5184
  year: 2014
  ident: B198
  article-title: MicroRNA-339-5p down-regulates protein expression of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M113.518241
  contributor:
    fullname: Long
– volume: 15
  start-page: 1317
  year: 2016
  ident: B4
  article-title: Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the dominantly inherited Alzheimer network observational study (DIAN-OBS)
  publication-title: Lancet Neurol.
  doi: 10.1016/S1474-4422(16)30229-0
  contributor:
    fullname: Tang
– volume: 74
  start-page: 281
  year: 2015
  ident: B101
  article-title: Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain
  publication-title: Neurobiol Dis.
  doi: 10.1016/j.nbd.2014.11.023
  contributor:
    fullname: Narayan
– volume: 14
  start-page: 653
  year: 2018
  ident: B12
  article-title: Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease
  publication-title: Nat Rev Neurol.
  doi: 10.1038/s41582-018-0070-3
  contributor:
    fullname: Kivipelto
– volume: 292
  start-page: 36
  year: 2015
  ident: B161
  article-title: Betaine prevents homocysteine-induced memory impairment via matrix metalloproteinase-9 in the frontal cortex
  publication-title: Behav Brain Res.
  doi: 10.1016/j.bbr.2015.06.004
  contributor:
    fullname: Kunisawa
– volume: 43
  start-page: 1169
  year: 2015
  ident: B33
  article-title: Epigenetic modifications in Alzheimer's disease: cause or effect?
  publication-title: J Alzheimers Dis.
  doi: 10.3233/JAD-141452
  contributor:
    fullname: Piaceri
– volume: 69
  start-page: 351
  year: 2019
  ident: B146
  article-title: Long non-coding RNA BACE1-AS may serve as an Alzheimer's disease blood-based biomarker
  publication-title: J Mol Neurosci.
  doi: 10.1007/s12031-019-01364-2
  contributor:
    fullname: Fotuhi
– volume: 25
  start-page: 66
  year: 2013
  ident: B26
  article-title: Changes in methylation patterns of multiple genes from peripheral blood leucocytes of Alzheimer's disease patients
  publication-title: Acta Neuropsychiatr.
  doi: 10.1111/j.1601-5215.2012.00662.x
  contributor:
    fullname: Hou
– volume: 44
  start-page: 977
  year: 2015
  ident: B66
  article-title: Integrated whole transcriptome and DNA methylation analysis identifies gene networks specific to late-onset Alzheimer's disease
  publication-title: J Alzheimers Dis.
  doi: 10.3233/JAD-141989
  contributor:
    fullname: Humphries
– volume: 35
  start-page: 877
  year: 2019
  ident: B135
  article-title: Circular HDAC9/microRNA-138/sirtuin-1 pathway mediates synaptic and amyloid precursor protein processing deficits in Alzheimer's disease
  publication-title: Neurosci Bull.
  doi: 10.1007/s12264-019-00361-0
  contributor:
    fullname: Lu
– volume: 27
  start-page: 18
  year: 2020
  ident: B204
  article-title: Clinical trials of new drugs for Alzheimer disease
  publication-title: J Biomed Sci.
  doi: 10.1186/s12929-019-0609-7
  contributor:
    fullname: Huang
– volume: 5
  start-page: eaaw2880
  year: 2019
  ident: B73
  article-title: Epigenetic signatures of methylated DNA cytosine in Alzheimer's disease
  publication-title: Sci Adv.
  doi: 10.1126/sciadv.aaw2880
  contributor:
    fullname: Fetahu
– volume: 22
  start-page: 1903
  year: 2019
  ident: B137
  article-title: An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
  publication-title: Nat Neurosci.
  doi: 10.1038/s41593-019-0501-5
  contributor:
    fullname: Dube
– volume: 70
  start-page: 703
  year: 2013
  ident: B16
  article-title: Understanding neurological disease mechanisms in the era of epigenetics
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2013.1443
  contributor:
    fullname: Qureshi
– year: 2020
  ident: B120
  article-title: MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties
  publication-title: Mol Psychiatr.
  doi: 10.1038/s41380-019-0610-2
  contributor:
    fullname: Chopra
– volume: 76
  start-page: 143
  year: 2016
  ident: B50
  article-title: Association of gene expression and methylation of UQCRC1 to the predisposition of Alzheimer's disease in a Chinese population
  publication-title: J Psychiatr Res.
  doi: 10.1016/j.jpsychires.2016.02.010
  contributor:
    fullname: Ma
– volume: 4
  start-page: 12
  year: 2015
  ident: B191
  article-title: Tet1 oxidase regulates neuronal gene transcription, active DNA hydroxy-methylation, object location memory, and threat recognition memory
  publication-title: Neuroepigenetics.
  doi: 10.1016/j.nepig.2015.10.002
  contributor:
    fullname: Kumar
– volume: 179
  start-page: 312
  year: 2019
  ident: B3
  article-title: Alzheimer disease: an update on pathobiology and treatment strategies
  publication-title: Cell.
  doi: 10.1016/j.cell.2019.09.001
  contributor:
    fullname: Long
– volume: 104
  start-page: 10679
  year: 2007
  ident: B149
  article-title: Dendritic BC200 RNA in aging and in Alzheimer's disease
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.0701532104
  contributor:
    fullname: Mus
– volume: 11
  start-page: 11591
  year: 2019
  ident: B167
  article-title: Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer's disease mouse model
  publication-title: Aging.
  doi: 10.18632/aging.102558
  contributor:
    fullname: Griñán-Ferré
– volume: 13
  start-page: 44
  year: 2018
  ident: B172
  article-title: PU.1 regulates Alzheimer's disease-associated genes in primary human microglia
  publication-title: Mol Neurodegener.
  doi: 10.1186/s13024-018-0277-1
  contributor:
    fullname: Rustenhoven
– volume: 29
  start-page: 149
  year: 2020
  ident: B76
  article-title: Ethnicity-specific and overlapping alterations of brain hydroxymethylome in Alzheimer's disease
  publication-title: Hum Mol Genet.
  doi: 10.1093/hmg/ddz273
  contributor:
    fullname: Qin
– volume: 74
  start-page: 70
  year: 2019
  ident: B58
  article-title: A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases
  publication-title: Neurobiol Aging.
  doi: 10.1016/j.neurobiolaging.2018.09.024
  contributor:
    fullname: Smith
– volume: 120
  start-page: 9936
  year: 2019
  ident: B122
  article-title: miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3beta in Alzheimer's disease
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.28276
  contributor:
    fullname: Li
– volume: 600
  start-page: 143
  year: 2015
  ident: B62
  article-title: Methylation analysis of multiple genes in blood DNA of Alzheimer's disease and healthy individuals
  publication-title: Neurosci Lett.
  doi: 10.1016/j.neulet.2015.06.009
  contributor:
    fullname: Tannorella
– volume: 8
  start-page: 37
  year: 2016
  ident: B64
  article-title: TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus
  publication-title: Clin Epigenetics.
  doi: 10.1186/s13148-016-0202-9
  contributor:
    fullname: Celarain
– volume: 34
  start-page: 2091
  year: 2013
  ident: B81
  article-title: Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
  publication-title: Neurobiol Aging.
  doi: 10.1016/j.neurobiolaging.2013.02.021
  contributor:
    fullname: Chouliaras
– volume: 12
  start-page: 752
  year: 2015
  ident: B102
  article-title: Increased acetylation of histone H4 at lysine 12 (H4K12) in monocytes of transgenic alzheimer's mice and in human patients
  publication-title: Curr Alzheimer Res.
  doi: 10.2174/1567205012666150710114256
  contributor:
    fullname: Plagg
– volume: 9
  start-page: 579
  year: 2018
  ident: B203
  article-title: The epigenetics of Alzheimer's disease: factors and therapeutic implications
  publication-title: Front Genet.
  doi: 10.3389/fgene.2018.00579
  contributor:
    fullname: Liu
– volume: 45
  start-page: 139
  year: 2015
  ident: B85
  article-title: Global changes in DNA methylation in Alzheimer's disease peripheral blood mononuclear cells
  publication-title: Brain Behav Immun.
  doi: 10.1016/j.bbi.2014.11.002
  contributor:
    fullname: Di Francesco
– volume: 7
  start-page: 373
  year: 2010
  ident: B188
  article-title: S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease
  publication-title: Neurodegener Dis.
  doi: 10.1159/000309657
  contributor:
    fullname: Linnebank
– volume: 142
  start-page: 787
  year: 2019
  ident: B175
  article-title: Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease
  publication-title: Brain.
  doi: 10.1093/brain/awy354
  contributor:
    fullname: Zheng
– volume: 605
  start-page: 44
  year: 2015
  ident: B48
  article-title: Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients
  publication-title: Neurosci Lett.
  doi: 10.1016/j.neulet.2015.08.012
  contributor:
    fullname: Carboni
– volume: 20
  start-page: S265
  year: 2010
  ident: B94
  article-title: The Alzheimer's disease mitochondrial cascade hypothesis
  publication-title: J Alzheimers Dis.
  doi: 10.3233/JAD-2010-100339
  contributor:
    fullname: Swerdlow
– volume: 33
  start-page: 101
  year: 2020
  ident: B103
  article-title: Dysregulation of histone acetylation pathways in hippocampus and frontal cortex of Alzheimer's disease patients
  publication-title: Eur Neuropsychopharmacol.
  doi: 10.1016/j.euroneuro.2020.01.015
  contributor:
    fullname: Schueller
– volume: 661
  start-page: 57
  year: 2017
  ident: B123
  article-title: MicroRNA-125b promotes neurons cell apoptosis and Tau phosphorylation in Alzheimer's disease
  publication-title: Neurosci Lett.
  doi: 10.1016/j.neulet.2017.09.043
  contributor:
    fullname: Ma
– volume: 35
  start-page: 731
  year: 2014
  ident: B182
  article-title: Epigenetically regulated microRNAs in Alzheimer's disease
  publication-title: Neurobiol Aging.
  doi: 10.1016/j.neurobiolaging.2013.10.082
  contributor:
    fullname: Van den Hove
– volume: 17
  start-page: 215
  year: 2014
  ident: B18
  article-title: Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain
  publication-title: Nat Neurosci.
  doi: 10.1038/nn.3607
  contributor:
    fullname: Guo
– volume: 79
  start-page: 67
  year: 2006
  ident: B38
  article-title: Intra- and interindividual epigenetic variation in human germ cells
  publication-title: Am J Hum Genet.
  doi: 10.1086/504729
  contributor:
    fullname: Flanagan
– volume: 11
  start-page: 91
  year: 2019
  ident: B72
  article-title: DNA methylation signature of human hippocampus in Alzheimer's disease is linked to neurogenesis
  publication-title: Clin Epigenetics.
  doi: 10.1186/s13148-019-0672-7
  contributor:
    fullname: Altuna
– volume: 37
  start-page: 220
  year: 2018
  ident: B152
  article-title: Long noncoding RNA EBF3-AS promotes neuron apoptosis in Alzheimer's disease
  publication-title: DNA Cell Biol.
  doi: 10.1089/dna.2017.4012
  contributor:
    fullname: Gu
– volume: 9
  start-page: 799
  year: 2018
  ident: B151
  article-title: Long noncoding RNA Sox2ot and transcription factor YY1 co-regulate the differentiation of cortical neural progenitors by repressing Sox2
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-018-0840-2
  contributor:
    fullname: Knauss
– volume: 16
  start-page: 2080
  year: 2018
  ident: B145
  article-title: Knockdown of BACE1-AS by siRNA improves memory and learning behaviors in Alzheimer's disease animal model
  publication-title: Exp Ther Med.
  doi: 10.3892/etm.2018.6359
  contributor:
    fullname: Zhang
– volume: 7
  start-page: 222
  year: 2019
  ident: B138
  article-title: Systematic characterization of circular RNA-associated CeRNA network identified novel circRNA biomarkers in Alzheimer's disease
  publication-title: Front Bioeng Biotechnol.
  doi: 10.3389/fbioe.2019.00222
  contributor:
    fullname: Zhang
– volume: 12
  start-page: 1024
  year: 2013
  ident: B109
  article-title: Epigenetic mechanisms in Alzheimer's disease: implications for pathogenesis and therapy
  publication-title: Ageing Res Rev.
  doi: 10.1016/j.arr.2013.05.003
  contributor:
    fullname: Wang
– volume: 11
  start-page: 365
  year: 2019
  ident: B129
  article-title: Loss of miR-369 promotes Tau phosphorylation by targeting the Fyn and serine/threonine-protein kinase 2 signaling pathways in Alzheimer's disease mice
  publication-title: Front Aging Neurosci.
  doi: 10.3389/fnagi.2019.00365
  contributor:
    fullname: Yao
– volume: 11
  start-page: 12002
  year: 2019
  ident: B140
  article-title: Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and adaptor protein 2 B1 in AD-like mice
  publication-title: Aging.
  doi: 10.18632/aging.102529
  contributor:
    fullname: Diling
– volume: 10
  start-page: 47
  year: 2017
  ident: B97
  article-title: Neuroepigenetic mechanisms in disease
  publication-title: Epigenetics Chromatin.
  doi: 10.1186/s13072-017-0150-4
  contributor:
    fullname: Christopher
– volume: 24
  start-page: 140
  year: 1994
  ident: B31
  article-title: Amyloid precursor protein gene expression in neural cell lines: influence of DNA cytosine methylation
  publication-title: Brain Res Mol Brain Res.
  doi: 10.1016/0169-328X(94)90125-2
  contributor:
    fullname: Ledoux
– volume: 18
  start-page: 4297
  year: 2018
  ident: B56
  article-title: Elevated methylation of OPRM1 and OPRL1 genes in Alzheimer's disease
  publication-title: Mol Med Rep.
  doi: 10.3892/mmr.2018.9424
  contributor:
    fullname: Xu
– volume: 22
  start-page: 534
  year: 2019
  ident: B19
  article-title: The DNA modification N6-methyl-2′-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction
  publication-title: Nat Neurosci.
  doi: 10.1038/s41593-019-0339-x
  contributor:
    fullname: Li
– volume: 15
  start-page: 162
  year: 2001
  ident: B205
  article-title: An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients
  publication-title: Alzheimer Dis Assoc Disord.
  doi: 10.1097/00002093-200107000-00008
  contributor:
    fullname: Knopman
– volume: 33
  start-page: 1667
  year: 2014
  ident: B124
  article-title: MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease
  publication-title: Embo J.
  doi: 10.15252/embj.201387576
  contributor:
    fullname: Banzhaf-Strathmann
– volume: 137
  start-page: 557
  year: 2019
  ident: B71
  article-title: Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-019-01966-5
  contributor:
    fullname: Semick
– volume: 31
  start-page: 2025
  year: 2010
  ident: B80
  article-title: Epigenetic changes in Alzheimer's disease: decrements in DNA methylation
  publication-title: Neurobiol Aging.
  doi: 10.1016/j.neurobiolaging.2008.12.005
  contributor:
    fullname: Mastroeni
– volume: 38
  start-page: 165
  year: 2014
  ident: B61
  article-title: Analysis of HSPA8 and HSPA9 mRNA expression and promoter methylation in the brain and blood of Alzheimer's disease patients
  publication-title: J Alzheimers Dis.
  doi: 10.3233/JAD-130428
  contributor:
    fullname: Silva
– volume: 478
  start-page: 852
  year: 2016
  ident: B128
  article-title: miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer's disease
  publication-title: Biochem Biophys Res Commun.
  doi: 10.1016/j.bbrc.2016.08.037
  contributor:
    fullname: Liu
– volume: 261
  start-page: 921
  year: 1993
  ident: B8
  article-title: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
  publication-title: Science.
  doi: 10.1126/science.8346443
  contributor:
    fullname: Corder
– volume: 51
  start-page: 300
  year: 2015
  ident: B168
  article-title: Valproic acid alleviates memory deficits and attenuates amyloid-beta deposition in transgenic mouse model of Alzheimer's disease
  publication-title: Mol Neurobiol.
  doi: 10.1007/s12035-014-8751-4
  contributor:
    fullname: Xuan
– volume: 1067
  start-page: 43
  year: 2006
  ident: B32
  article-title: In the cerebral cortex of female and male mice, amyloid precursor protein (APP) promoter methylation is higher in females and differentially regulated by sex steroids
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2005.10.006
  contributor:
    fullname: Mani
– volume: 287
  start-page: 31298
  year: 2012
  ident: B201
  article-title: MicroRNA-153 physiologically inhibits expression of amyloid-beta precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M112.366336
  contributor:
    fullname: Long
– volume: 29
  start-page: 571
  year: 2012
  ident: B36
  article-title: Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex
  publication-title: J Alzheimers Dis.
  doi: 10.3233/JAD-2012-111223
  contributor:
    fullname: Bakulski
– volume: 19
  start-page: 1219
  year: 2020
  ident: B115
  article-title: miRNA-31 improves cognition and abolishes amyloid-β pathology by targeting APP and BACE1 in an animal model of Alzheimer's disease
  publication-title: Mol Ther Nucleic Acids.
  doi: 10.1016/j.omtn.2020.01.010
  contributor:
    fullname: Barros-Viegas
– volume: 55
  start-page: 1026
  year: 2018
  ident: B177
  article-title: Epigenetics in Alzheimer's disease: perspective of DNA methylation
  publication-title: Mol Neurobiol.
  doi: 10.1007/s12035-016-0357-6
  contributor:
    fullname: Qazi
– volume: 45
  start-page: 1452
  year: 2013
  ident: B9
  article-title: Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
  publication-title: Nat Genet.
  doi: 10.1038/ng.2802
  contributor:
    fullname: Lambert
– volume: 13
  start-page: e1006987
  year: 2017
  ident: B23
  article-title: Tet-mediated DNA hydroxymethylation regulates retinal neurogenesis by modulating cell-extrinsic signaling pathways
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1006987
  contributor:
    fullname: Seritrakul
– volume: 15
  start-page: 781
  year: 2020
  ident: B37
  article-title: CpG and non-CpG Presenilin1 methylation pattern in course of neurodevelopment and neurodegeneration is associated with gene expression in human and murine brain
  publication-title: Epigenetics.
  doi: 10.1080/15592294.2020.1722917
  contributor:
    fullname: Monti
– volume: 48
  start-page: 745
  year: 2015
  ident: B41
  article-title: The APOE gene is differentially methylated in Alzheimer's disease
  publication-title: J Alzheimers Dis.
  doi: 10.3233/JAD-143060
  contributor:
    fullname: Foraker
– volume: 14
  start-page: 723
  year: 2008
  ident: B144
  article-title: Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase
  publication-title: Nat Med.
  doi: 10.1038/nm1784
  contributor:
    fullname: Faghihi
– volume: 11
  start-page: 164
  year: 2019
  ident: B69
  article-title: Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood
  publication-title: Clin Epigenetics.
  doi: 10.1186/s13148-019-0755-5
  contributor:
    fullname: Lardenoije
– volume: 566
  start-page: 241
  year: 2014
  ident: B60
  article-title: Methylation analysis of SST and SSTR4 promoters in the neocortex of Alzheimer's disease patients
  publication-title: Neurosci Lett.
  doi: 10.1016/j.neulet.2014.02.046
  contributor:
    fullname: Grosser
– volume: 8
  start-page: 15
  year: 2016
  ident: B53
  article-title: CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer's disease
  publication-title: Alzheimers Res Ther.
  doi: 10.1186/s13195-016-0183-0
  contributor:
    fullname: Mendioroz
– volume: 12
  start-page: 1261
  year: 2012
  ident: B99
  article-title: Targeted proteomics for quantification of histone acetylation in Alzheimer's disease
  publication-title: Proteomics.
  doi: 10.1002/pmic.201200010
  contributor:
    fullname: Zhang
– volume: 1698
  start-page: 179
  year: 2018
  ident: B42
  article-title: Glia-specific APOE epigenetic changes in the Alzheimer's disease brain
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2018.08.006
  contributor:
    fullname: Tulloch
– volume: 1676
  start-page: 185
  year: 2018
  ident: B29
  article-title: Detection of DNA methylation by whole-genome bisulfite sequencing
  publication-title: Methods Mol Biol.
  doi: 10.1007/978-1-4939-7315-6_11
  contributor:
    fullname: Li
– volume: 35
  start-page: 1850
  year: 2014
  ident: B82
  article-title: Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain
  publication-title: Neurobiol Aging.
  doi: 10.1016/j.neurobiolaging.2014.02.002
  contributor:
    fullname: Condliffe
– volume: 12
  start-page: 459
  year: 2016
  ident: B1
  article-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2016.03.001
– volume: 24
  start-page: 27
  year: 2009
  ident: B206
  article-title: Efficacy of a vitamin/nutriceutical formulation for moderate-stage to later-stage Alzheimer's disease: a placebo-controlled pilot study
  publication-title: Am J Alzheimers Dis Other Demen.
  doi: 10.1177/1533317508325094
  contributor:
    fullname: Remington
– volume: 288
  start-page: 8299
  year: 2013
  ident: B169
  article-title: Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M112.426536
  contributor:
    fullname: Corbett
– volume: 285
  start-page: 18344
  year: 2010
  ident: B200
  article-title: MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M110.112664
  contributor:
    fullname: Vilardo
– volume: 103
  start-page: 1635
  year: 2004
  ident: B189
  article-title: Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
  publication-title: Blood.
  doi: 10.1182/blood-2003-03-0687
  contributor:
    fullname: Issa
– volume: 161
  start-page: 105
  year: 2017
  ident: B49
  article-title: Methylation analysis of DNA repair genes in Alzheimer's disease
  publication-title: Mech Ageing Dev.
  doi: 10.1016/j.mad.2016.04.003
  contributor:
    fullname: Coppede
– volume: 62
  start-page: 943
  year: 2018
  ident: B20
  article-title: Understanding epigenetics in the neurodegeneration of Alzheimer's disease: SAMP8 mouse model
  publication-title: J Alzheimers Dis.
  doi: 10.3233/JAD-170664
  contributor:
    fullname: Griñán-Ferré
– volume: 28
  start-page: 91
  year: 1990
  ident: B78
  article-title: DNA cytosine methylation in brain of patients with Alzheimer's disease
  publication-title: Ann Neurol.
  doi: 10.1002/ana.410280117
  contributor:
    fullname: Schwob
– volume: 22
  start-page: 340
  year: 1994
  ident: B30
  article-title: George-Hyslop PH. The upstream promoter of the beta-amyloid precursor protein gene (APP) shows differential patterns of methylation in human brain
  publication-title: Genomics.
  doi: 10.1006/geno.1994.1393
  contributor:
    fullname: Rogaev
– year: 2020
  ident: B131
  article-title: MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis
  publication-title: Mol Psychiatr.
  doi: 10.1038/s41380-020-0824-3
  contributor:
    fullname: Cao
– volume: 9
  start-page: 11956
  year: 2019
  ident: B183
  article-title: Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model
  publication-title: Sci Rep.
  doi: 10.1038/s41598-019-48471-z
  contributor:
    fullname: Lee
– volume: 6
  start-page: 141
  year: 1995
  ident: B25
  article-title: Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient
  publication-title: J Mol Neurosci.
  doi: 10.1007/BF02736773
  contributor:
    fullname: West
– volume: 6
  start-page: 19
  year: 2017
  ident: B196
  article-title: The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease
  publication-title: Transl Neurodegener.
  doi: 10.1186/s40035-017-0089-1
  contributor:
    fullname: Yang
– volume: 72
  start-page: 15
  year: 2015
  ident: B45
  article-title: Association of brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2014.3049
  contributor:
    fullname: Yu
– volume: 18
  start-page: 131
  year: 2009
  ident: B100
  article-title: Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease
  publication-title: J Alzheimers Dis.
  doi: 10.3233/JAD-2009-1134
  contributor:
    fullname: Francis
– volume: 50
  start-page: 2513
  year: 2019
  ident: B21
  article-title: Induction of DNA hydroxymethylation protects the brain after stroke
  publication-title: Stroke.
  doi: 10.1161/STROKEAHA.119.025665
  contributor:
    fullname: Morris-Blanco
– volume: 9
  start-page: e110773
  year: 2014
  ident: B47
  article-title: Elevation of peripheral BDNF promoter methylation links to the risk of Alzheimer's disease
  publication-title: PLoS ONE.
  doi: 10.1371/journal.pone.0110773
  contributor:
    fullname: Chang
– volume: 123
  start-page: 105747
  year: 2020
  ident: B141
  article-title: Circular RNA expression profile of Alzheimer's disease and its clinical significance as biomarkers for the disease risk and progression
  publication-title: Int J Biochem Cell Biol.
  doi: 10.1016/j.biocel.2020.105747
  contributor:
    fullname: Li
– volume: 34
  start-page: 160
  year: 2014
  ident: B178
  article-title: MicroRNA-384 regulates both amyloid precursor protein and β-secretase expression and is a potential biomarker for Alzheimer's disease
  publication-title: Int J Mol Med.
  doi: 10.3892/ijmm.2014.1780
  contributor:
    fullname: Liu
– volume: 21
  start-page: 75
  year: 2010
  ident: B116
  article-title: MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study
  publication-title: J Alzheimers Dis.
  doi: 10.3233/JAD-2010-091603
  contributor:
    fullname: Nelson
– volume: 9
  start-page: 1463
  year: 2018
  ident: B202
  article-title: Noncoding RNAs in Alzheimer's disease
  publication-title: Wiley Interdiscip Rev RNA.
  doi: 10.1002/wrna.1463
  contributor:
    fullname: Idda
– volume: 35
  start-page: 1334
  year: 2014
  ident: B83
  article-title: Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain
  publication-title: Neurobiol Aging.
  doi: 10.1016/j.neurobiolaging.2013.11.031
  contributor:
    fullname: Coppieters
– volume-title: World Alzheimer Report 2018. The State of the Art of Dementia Research: New Frontiers. An Analysis of Prevalence, Incidence, Cost and Trends
  year: 2018
  ident: B2
  contributor:
    fullname: Patterson
– volume: 11
  start-page: 14
  year: 2010
  ident: B143
  article-title: Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation
  publication-title: BMC Neurosci.
  doi: 10.1186/1471-2202-11-14
  contributor:
    fullname: Mercer
– volume: 11
  start-page: 68
  year: 2019
  ident: B105
  article-title: Age, but not amyloidosis, induced changes in global levels of histone modifications in susceptible and disease-resistant neurons in Alzheimer's disease model mice
  publication-title: Front Aging Neurosci.
  doi: 10.3389/fnagi.2019.00068
  contributor:
    fullname: Dyer
– volume: 17
  start-page: 1164
  year: 2014
  ident: B39
  article-title: Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
  publication-title: Nat Neurosci.
  doi: 10.1038/nn.3782
  contributor:
    fullname: Lunnon
– volume: 11
  start-page: 139
  year: 2019
  ident: B164
  article-title: Dietary intakes and biomarker patterns of folate, vitamin B(6), and vitamin B(12) can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1
  publication-title: Clin Epigenetics.
  doi: 10.1186/s13148-019-0741-y
  contributor:
    fullname: An
– volume: 166
  start-page: 369
  year: 2019
  ident: B192
  article-title: Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides
  publication-title: Eur J Med Chem.
  doi: 10.1016/j.ejmech.2019.01.077
  contributor:
    fullname: Amin
– volume: 10
  start-page: 272
  year: 2019
  ident: B163
  article-title: Alcohol extracts from ganoderma lucidum delay the progress of Alzheimer's disease by regulating DNA methylation in rodents
  publication-title: Front Pharmacol.
  doi: 10.3389/fphar.2019.00272
  contributor:
    fullname: Lai
– volume: 20
  start-page: 1052
  year: 2017
  ident: B195
  article-title: A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
  publication-title: Nat Neurosci.
  doi: 10.1038/nn.4587
  contributor:
    fullname: Huang
– volume: 12
  start-page: 942
  year: 2016
  ident: B55
  article-title: Methylation profiles in peripheral blood CD4+ lymphocytes versus brain: the relation to Alzheimer's disease pathology
  publication-title: Alzheimers Dement.
  doi: 10.1016/j.jalz.2016.02.009
  contributor:
    fullname: Yu
– volume: 77
  start-page: 3769
  year: 2020
  ident: B157
  article-title: Long non-coding RNA NEAT1-centric gene regulation
  publication-title: Cell Mol Life Sci.
  doi: 10.1007/s00018-020-03503-0
  contributor:
    fullname: Wang
– volume: 21
  start-page: 2220
  year: 2020
  ident: B87
  article-title: DNA methylation in neurodegenerative and cerebrovascular disorders
  publication-title: Int J Mol Sci.
  doi: 10.3390/ijms21062220
  contributor:
    fullname: Martínez-Iglesias
– volume: 43
  start-page: 91
  year: 2019
  ident: B136
  article-title: MicroRNA-98 reduces amyloid β-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice
  publication-title: Int J Mol Med.
  doi: 10.3892/ijmm.2018.3957
  contributor:
    fullname: Chen
– volume: 107
  start-page: 22687
  year: 2010
  ident: B197
  article-title: CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.1012851108
  contributor:
    fullname: Caccamo
– volume: 10
  start-page: 116
  year: 2018
  ident: B51
  article-title: PLD3 epigenetic changes in the hippocampus of Alzheimer's disease
  publication-title: Clin Epigenetics.
  doi: 10.1186/s13148-018-0547-3
  contributor:
    fullname: Blanco-Luquin
– volume: 57
  start-page: 171
  year: 2017
  ident: B63
  article-title: Gene expression and methylation analysis of ABCA7 in patients with Alzheimer's disease
  publication-title: J Alzheimers Dis.
  doi: 10.3233/JAD-161195
  contributor:
    fullname: Yamazaki
– volume: 65
  start-page: 283
  year: 2018
  ident: B57
  article-title: PICALM gene methylation in blood of Alzheimer's disease patients is associated with cognitive decline
  publication-title: J Alzheimers Dis.
  doi: 10.3233/JAD-180242
  contributor:
    fullname: Mercorio
– volume: 279
  start-page: 220
  year: 2018
  ident: B176
  article-title: Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer's disease
  publication-title: J Control Release.
  doi: 10.1016/j.jconrel.2018.04.034
  contributor:
    fullname: Wang
– volume: 56
  start-page: 3522
  year: 2019
  ident: B148
  article-title: Silencing of long noncoding RNA SOX21-AS1 relieves neuronal oxidative stress injury in mice with Alzheimer's disease by upregulating fzd3/5 via the Wnt signaling pathway
  publication-title: Mol Neurobiol.
  doi: 10.1007/s12035-018-1299-y
  contributor:
    fullname: Zhang
– volume: 18
  start-page: 2197
  year: 2019
  ident: B139
  article-title: Circular RNA circ_0000950 promotes neuron apoptosis, suppresses neurite outgrowth and elevates inflammatory cytokines levels via directly sponging miR-103 in Alzheimer's disease
  publication-title: Cell Cycle.
  doi: 10.1080/15384101.2019.1629773
  contributor:
    fullname: Yang
– volume: 6
  start-page: 70
  year: 2011
  ident: B133
  article-title: Alzheimer-specific variants in the 3'UTR of amyloid precursor protein affect microRNA function
  publication-title: Mol Neurodegener.
  doi: 10.1186/1750-1326-6-70
  contributor:
    fullname: Delay
– volume: 15
  start-page: 103
  year: 2018
  ident: B70
  article-title: Aberrant DNA methylation associated with Alzheimer's disease in the superior temporal gyrus
  publication-title: Exp Ther Med.
  doi: 10.3892/etm.2017.5394
  contributor:
    fullname: Gao
– volume: 119
  start-page: 5437
  year: 2018
  ident: B134
  article-title: Protective effects of microRNA-330 on amyloid β-protein production, oxidative stress, and mitochondrial dysfunction in Alzheimer's disease by targeting VAV1 via the MAPK signaling pathway
  publication-title: J Cell Biochem.
  doi: 10.1002/jcb.26700
  contributor:
    fullname: Zhou
– volume: 11
  start-page: 867
  year: 2016
  ident: B147
  article-title: Long noncoding RNAs and Alzheimer's disease
  publication-title: Clin Interv Aging.
  doi: 10.2147/CIA.S107037
  contributor:
    fullname: Luo
– volume: 13
  start-page: 674
  year: 2017
  ident: B74
  article-title: A genome-wide profiling of brain DNA hydroxymethylation in Alzheimer's disease
  publication-title: Alzheimers Dement.
  doi: 10.1016/j.jalz.2016.10.004
  contributor:
    fullname: Zhao
– volume: 8
  start-page: 114065
  year: 2017
  ident: B181
  article-title: MiR-124 acts as a target for Alzheimer's disease by regulating BACE1
  publication-title: Oncotarget.
  doi: 10.18632/oncotarget.23119
  contributor:
    fullname: An
– volume: 23
  start-page: 81
  year: 2018
  ident: B6
  article-title: Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease
  publication-title: Mol Psychiatr.
  doi: 10.1038/mp.2017.218
  contributor:
    fullname: Hunter
– volume: 25
  start-page: 2437
  year: 2016
  ident: B75
  article-title: 5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddw109
  contributor:
    fullname: Bernstein
– volume: 68
  start-page: 880
  year: 2009
  ident: B27
  article-title: DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain
  publication-title: J Neuropathol Exp Neurol.
  doi: 10.1097/NEN.0b013e3181af2e46
  contributor:
    fullname: Barrachina
– volume: 30
  start-page: 453
  year: 2012
  ident: B150
  article-title: Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation
  publication-title: Nat Biotechnol.
  doi: 10.1038/nbt.2158
  contributor:
    fullname: Modarresi
– volume: 92
  start-page: 74
  year: 2017
  ident: B52
  article-title: DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease
  publication-title: J Psychiatr Res.
  doi: 10.1016/j.jpsychires.2017.04.003
  contributor:
    fullname: Ozaki
– volume: 105
  start-page: 6415
  year: 2008
  ident: B112
  article-title: Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.0710263105
  contributor:
    fullname: Hebert
– volume: 114
  start-page: E9135
  year: 2017
  ident: B170
  article-title: M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.1707544114
  contributor:
    fullname: Volmar
– volume: 88
  start-page: 596
  year: 2012
  ident: B119
  article-title: MicroRNA-195 downregulates Alzheimer's disease amyloid-beta production by targeting BACE1
  publication-title: Brain Res Bull.
  doi: 10.1016/j.brainresbull.2012.05.018
  contributor:
    fullname: Zhu
– volume: 9
  start-page: 596
  year: 2018
  ident: B88
  article-title: Temporal integrative analysis of mRNA and microRNAs expression profiles and epigenetic alterations in female SAMP8, a model of age-related cognitive decline
  publication-title: Front Genet.
  doi: 10.3389/fgene.2018.00596
  contributor:
    fullname: Cosín-Tomás
– volume: 32
  start-page: 199
  year: 2009
  ident: B110
  article-title: Alterations of the microRNA network cause neurodegenerative disease
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2008.12.003
  contributor:
    fullname: Hebert
– volume: 8
  start-page: 5
  year: 2016
  ident: B67
  article-title: Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease
  publication-title: Genome Med.
  doi: 10.1186/s13073-015-0258-8
  contributor:
    fullname: Watson
– volume: 21
  start-page: 1130
  year: 2016
  ident: B187
  article-title: Dnmt3a2: a hub for enhancing cognitive functions
  publication-title: Mol Psychiatr.
  doi: 10.1038/mp.2015.175
  contributor:
    fullname: Oliveira
– volume: 10
  start-page: 2246
  year: 2019
  ident: B65
  article-title: Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer's disease pathology and cognitive symptoms
  publication-title: Nat Commun.
  doi: 10.1038/s41467-019-10101-7
  contributor:
    fullname: Li
– volume: 2
  start-page: e895
  year: 2007
  ident: B35
  article-title: DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
  publication-title: PLoS ONE.
  doi: 10.1371/journal.pone.0000895
  contributor:
    fullname: Siegmund
– volume: 24
  start-page: 179
  year: 2010
  ident: B28
  article-title: A DNA methylation study of the amyloid precursor protein gene in several brain regions from patients with familial Alzheimer disease
  publication-title: J Neurogenet.
  doi: 10.3109/01677063.2010.503978
  contributor:
    fullname: Brohede
– volume: 9
  start-page: 527
  year: 2012
  ident: B34
  article-title: PSEN1 promoter demethylation in hyperhomocysteinemic TgCRND8 mice is the culprit, not the consequence
  publication-title: Curr Alzheimer Res.
  doi: 10.2174/156720512800618053
  contributor:
    fullname: Fuso
– volume: 8
  start-page: 664
  year: 2016
  ident: B86
  article-title: Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice
  publication-title: Aging (Albany NY).
  doi: 10.18632/aging.100906
  contributor:
    fullname: Griñán-Ferré
– volume: 134
  start-page: 486
  year: 2013
  ident: B93
  article-title: Epigenetic changes in the progression of Alzheimer's disease
  publication-title: Mech Ageing Dev.
  doi: 10.1016/j.mad.2013.08.005
  contributor:
    fullname: Bradley-Whitman
– volume: 235
  start-page: 480
  year: 2020
  ident: B130
  article-title: MicroRNA-326 decreases tau phosphorylation and neuron apoptosis through inhibition of the JNK signaling pathway by targeting VAV1 in Alzheimer's disease
  publication-title: J Cell Physiol.
  doi: 10.1002/jcp.28988
  contributor:
    fullname: He
– volume: 369
  start-page: 208
  year: 2007
  ident: B165
  article-title: Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial
  publication-title: Lancet.
  doi: 10.1016/S0140-6736(07)60109-3
  contributor:
    fullname: Durga
– volume: 23
  start-page: 5851
  year: 2017
  ident: B59
  article-title: ATP binding cassette subfamily A member 2 (ABCA2) expression and methylation are associated with Alzheimer's disease
  publication-title: Med Sci Monit.
  doi: 10.12659/MSM.905524
  contributor:
    fullname: Hu
– volume: 33
  start-page: 835
  year: 1994
  ident: B43
  article-title: mRNA levels and methylation patterns of the 2-5A synthetase gene in control and Alzheimer's disease (AD) fibroblasts
  publication-title: Biochem Mol Biol Int.
  contributor:
    fullname: An
– volume: 41
  start-page: 497
  year: 2015
  ident: B79
  article-title: Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease
  publication-title: Neuropathol Appl Neurobiol.
  doi: 10.1111/nan.12183
  contributor:
    fullname: Lashley
– volume: 21
  start-page: 1618
  year: 2018
  ident: B98
  article-title: A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex
  publication-title: Nat Neurosci.
  doi: 10.1038/s41593-018-0253-7
  contributor:
    fullname: Marzi
– volume: 135
  start-page: 189
  year: 2017
  ident: B108
  article-title: MicroRNAs and epigenetics
  publication-title: Adv Cancer Res.
  doi: 10.1016/bs.acr.2017.06.003
  contributor:
    fullname: Moutinho
– volume: 209
  start-page: 94
  year: 2012
  ident: B117
  article-title: The miR-124 regulates the expression of BACE1/beta-secretase correlated with cell death in Alzheimer's disease
  publication-title: Toxicol Lett.
  doi: 10.1016/j.toxlet.2011.11.032
  contributor:
    fullname: Fang
– year: 2020
  ident: B142
  article-title: Linking the association between circRNAs and Alzheimer's disease progression by multi-tissue circular RNA characterization
  publication-title: RNA Biol.
  doi: 10.1080/15476286.2020.1783487
  contributor:
    fullname: Lo
– volume: 33
  start-page: 321
  year: 2019
  ident: B54
  article-title: Differential methylation levels in CpGs of the BIN1 gene in individuals with Alzheimer disease
  publication-title: Alzheimer Dis Assoc Disord.
  doi: 10.1097/WAD.0000000000000329
  contributor:
    fullname: Salcedo-Tacuma
– volume: 8
  start-page: 1565
  year: 2015
  ident: B199
  article-title: Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer's disease
  publication-title: Int J Clin Exp Pathol.
  contributor:
    fullname: Lei
– volume: 11
  start-page: 175
  year: 2017
  ident: B184
  article-title: Regulatory roles of long non-coding RNAs in the central nervous system and associated neurodegenerative diseases
  publication-title: Front Cell Neurosci.
  doi: 10.3389/fncel.2017.00175
  contributor:
    fullname: Quan
– volume: 2
  start-page: e132
  year: 2012
  ident: B84
  article-title: Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients
  publication-title: Transl Psychiatry.
  doi: 10.1038/tp.2012.55
  contributor:
    fullname: Rao
– volume: 16
  start-page: 6
  year: 2016
  ident: B10
  article-title: Defining the genetic architecture of Alzheimer's disease: where next
  publication-title: Neurodegener Dis.
  doi: 10.1159/000440841
  contributor:
    fullname: Sims
– volume: 5
  start-page: 64
  year: 2015
  ident: B46
  article-title: Association between DNA methylation of the BDNF promoter region and clinical presentation in Alzheimer's disease
  publication-title: Dement Geriatr Cogn Dis Extra.
  doi: 10.1159/000375367
  contributor:
    fullname: Nagata
– volume: 115
  start-page: E11148
  year: 2018
  ident: B173
  article-title: Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.1805436115
  contributor:
    fullname: Janczura
– volume: 11
  start-page: 52
  year: 2019
  ident: B77
  article-title: Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease
  publication-title: Clin Epigenetics.
  doi: 10.1186/s13148-019-0636-y
  contributor:
    fullname: Smith
– volume: 520
  start-page: 41
  year: 2019
  ident: B96
  article-title: Altered mitochondrial DNA methylation and mitochondrial DNA copy number in an APP/PS1 transgenic mouse model of Alzheimer disease
  publication-title: Biochem Biophys Res Commun.
  doi: 10.1016/j.bbrc.2019.09.094
  contributor:
    fullname: Xu
– volume: 571
  start-page: 489
  year: 2019
  ident: B14
  article-title: Advances in epigenetics link genetics to the environment and disease
  publication-title: Nature.
  doi: 10.1038/s41586-019-1411-0
  contributor:
    fullname: Cavalli
– volume: 239
  start-page: 192
  year: 2013
  ident: B171
  article-title: Mercaptoacetamide-based class II HDAC inhibitor lowers Aβ levels and improves learning and memory in a mouse model of Alzheimer's disease
  publication-title: Exp Neurol.
  doi: 10.1016/j.expneurol.2012.10.005
  contributor:
    fullname: Sung
– volume: 26
  start-page: 2444
  year: 2007
  ident: B153
  article-title: A natural antisense transcript against Rad18, specifically expressed in neurons and upregulated during beta-amyloid-induced apoptosis
  publication-title: Eur J Neurosci.
  doi: 10.1111/j.1460-9568.2007.05864.x
  contributor:
    fullname: Parenti
– volume: 17
  start-page: 381
  year: 2016
  ident: B92
  article-title: Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease
  publication-title: BMC Genomics.
  doi: 10.1186/s12864-016-2731-1
  contributor:
    fullname: Shu
– volume: 17
  start-page: 201
  year: 2016
  ident: B91
  article-title: TREM2 variants: new keys to decipher Alzheimer disease pathogenesis
  publication-title: Nat Rev Neurosci.
  doi: 10.1038/nrn.2016.7
  contributor:
    fullname: Colonna
– volume: 61
  start-page: 973
  year: 2012
  ident: B40
  article-title: SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's disease
  publication-title: Neurochem Int.
  doi: 10.1016/j.neuint.2012.07.014
  contributor:
    fullname: Furuya
– volume: 33
  start-page: 1482.e1481
  year: 2012
  ident: B162
  article-title: S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice
  publication-title: Neurobiol Aging.
  doi: 10.1016/j.neurobiolaging.2011.12.013
  contributor:
    fullname: Fuso
– volume: 10
  start-page: 806
  year: 2019
  ident: B113
  article-title: MicroRNA-200a-3p mediates neuroprotection in Alzheimer-related deficits and attenuates amyloid-beta overproduction and tau hyperphosphorylation via coregulating BACE1 and PRKACB
  publication-title: Front Pharmacol.
  doi: 10.3389/fphar.2019.00806
  contributor:
    fullname: Wang
– volume: 386
  start-page: 69
  year: 2005
  ident: B186
  article-title: The transmethylation cycle in the brain of Alzheimer patients
  publication-title: Neurosci Lett.
  doi: 10.1016/j.neulet.2005.03.073
  contributor:
    fullname: Mulder
– volume: 186
  start-page: 385
  year: 2016
  ident: B95
  article-title: Altered mitochondrial DNA methylation pattern in Alzheimer disease-related pathology and in Parkinson disease
  publication-title: Am J Pathol.
  doi: 10.1016/j.ajpath.2015.10.004
  contributor:
    fullname: Blanch
– volume: 33
  start-page: 10698
  year: 2013
  ident: B174
  article-title: A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice
  publication-title: J Neurosci.
  doi: 10.1523/JNEUROSCI.5772-12.2013
  contributor:
    fullname: Chatterjee
– volume: 2013
  start-page: 852080
  year: 2013
  ident: B190
  article-title: Epigenetics in friedreich's ataxia: challenges and opportunities for therapy
  publication-title: Genet Res Int.
  doi: 10.1155/2013/852080
  contributor:
    fullname: Sandi
– volume: 14
  start-page: e1002270
  year: 2017
  ident: B7
  article-title: APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: a genetic screening study of familial and sporadic cases
  publication-title: PLoS Med.
  doi: 10.1371/journal.pmed.1002270
  contributor:
    fullname: Lanoiselee
– volume: 8
  start-page: 24314
  year: 2017
  ident: B127
  article-title: MiR-124-3p attenuates hyperphosphorylation of Tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3β pathway in N2a/APP695swe cells
  publication-title: Oncotarget.
  doi: 10.18632/oncotarget.15149
  contributor:
    fullname: Kang
– volume: 15
  start-page: 1111
  year: 2012
  ident: B160
  article-title: Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities
  publication-title: Nat Neurosci.
  doi: 10.1038/nn.3151
  contributor:
    fullname: Oliveira
– volume: 413
  start-page: 116793
  year: 2020
  ident: B121
  article-title: miR-34a-5p and miR-125b-5p attenuate Aβ-induced neurotoxicity through targeting BACE1
  publication-title: J Neurol Sci.
  doi: 10.1016/j.jns.2020.116793
  contributor:
    fullname: Li
– volume: 56
  start-page: 8101
  year: 2019
  ident: B179
  article-title: Addressing Alzheimer's disease (AD) neuropathology using anti-microRNA (AM) strategies
  publication-title: Mol Neurobiol.
  doi: 10.1007/s12035-019-1632-0
  contributor:
    fullname: Jaber
– volume: 81
  start-page: 116
  year: 2019
  ident: B156
  article-title: Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer's disease
  publication-title: Neurobiol Aging.
  doi: 10.1016/j.neurobiolaging.2019.05.023
  contributor:
    fullname: Cao
– volume: 6
  start-page: a019133
  year: 2014
  ident: B22
  article-title: DNA methylation in mammals
  publication-title: Cold Spring Harb Perspect Biol.
  doi: 10.1101/cshperspect.a019133
  contributor:
    fullname: Li
– volume: 24
  start-page: 345
  year: 2019
  ident: B132
  article-title: Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer's disease
  publication-title: Mol Psychiatr.
  doi: 10.1038/s41380-018-0266-3
  contributor:
    fullname: Long
– volume: 33
  start-page: 522
  year: 2012
  ident: B111
  article-title: MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice
  publication-title: Neurobiol Aging.
  doi: 10.1016/j.neurobiolaging.2010.04.034
  contributor:
    fullname: Liu
– volume: 51
  start-page: 591
  year: 2016
  ident: B194
  article-title: A mercaptoacetamide-based class II histone deacetylase inhibitor increases dendritic spine density via RasGRF1/ERK pathway
  publication-title: J Alzheimers Dis.
  doi: 10.3233/JAD-150717
  contributor:
    fullname: Song
– volume: 268
  start-page: 3
  year: 2015
  ident: B90
  article-title: 5-Hydroxymethylcytosine: a new player in brain disorders?
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2014.05.008
  contributor:
    fullname: Cheng
– volume: 12
  start-page: 26
  year: 2015
  ident: B104
  article-title: Histone post-translational modifications in frontal cortex from human donors with Alzheimer's disease
  publication-title: Clin Proteomics.
  doi: 10.1186/s12014-015-9098-1
  contributor:
    fullname: Anderson
– volume: 62
  start-page: 244.e215
  year: 2018
  ident: B5
  article-title: Genetic screening in two Iranian families with early-onset Alzheimer's disease identified a novel PSEN1 mutation
  publication-title: Neurobiol Aging.
  doi: 10.1016/j.neurobiolaging.2017.10.011
  contributor:
    fullname: Wang
– volume: 7
  start-page: 2
  year: 2014
  ident: B180
  article-title: Increased microRNA-34c abundance in Alzheimer's disease circulating blood plasma
  publication-title: Front Mol Neurosci.
  doi: 10.3389/fnmol.2014.00002
  contributor:
    fullname: Bhatnagar
– volume: 483
  start-page: 222
  year: 2012
  ident: B193
  article-title: An epigenetic blockade of cognitive functions in the neurodegenerating brain
  publication-title: Nature.
  doi: 10.1038/nature10849
  contributor:
    fullname: Graff
SSID ssj0000399363
Score 2.3858683
SecondaryResourceType review_article
Snippet Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease (AD) and provides therapeutic strategies for AD. Methods: We...
Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease (AD) and provides therapeutic strategies for AD.Methods: We...
SourceID doaj
pubmedcentral
proquest
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
StartPage 538301
SubjectTerms Alzheiemer's disease
DNA hydroxymethylation
DNA methylation
epigenetic
histone modifications
Neurology
non-coding RNA (ncRNA)
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1dS-QwFA3ig_iyrF_srB9EEAShOvls49uoM6ig4KLgW2iaXBzQjtjxxV_vTdNZpk_7sq9tSZNz09xzuOkJIUdQ6twJJrKA4iOTTvPM5MAyP4TKM1wSfesze3evr5_k7bN6XjrqK-4JS_bACbgzWZigXc6CByU9gwJYUDxHnaCc9iG5lzK1JKbaNTjmXS1SGRNVmDmD6A-JepAPT_EbF90hMItE1Pr190hmf4vkUs6Z_CQ_OrJIR6mTG2Ql1Jtk7a4rh2-Rh_F7NNOM_yE25xQZIDZDR6mq39Cy9vRm3tA_s9dApzVFqkcfF_vK6Qzo6PXrJUzfwsdxQ69SoWabPE3Gj5fXWXdGQlZJyeeZU6wqSs-YL7wGpodQinKYcy8r40CzwI0CIzHJK6iCUyiQuBBgVIhjk0bskNV6VodfhBoDvEI2ZKoiSAXSVYCNO8GNNNqX-YCcLACz78kKw6KEiOjaFl0b0bUJ3QG5iJD-fTC6WLcXMLa2i639V2wH5HAREIuzPpYyyjrMPhvLpY7kBcnegOS9SPXe2L9TT19a_-xcmegj__t_dHGXrMdRx2zG1B5ZnX98hn2kKXN30M7Ibyo85zE
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fa9RAEF5KBfFF6i88q7KCIAiptz-TFURObanCCUoP-rZkszv24Jq0lytU__rOJDkx0AdfkzBhv93Z-YbZ_Yax11DaPCihsoTJR6aDlZnLQWRxClUUuCXGTmd2_t0eL_S3U3O6w7btrQYA21tTO-ontVivDq4vf39Eh_9AGSfG23dA0o-Y6snpAbqvottcd6RWmhb8fGD73cZMwbjrrSas1Rk1su7rnLdbGUWqTtB_xELHZyj_CUpHe-z-wCb5rJ_-B2wn1Q_Z3flQL3_EfhxekNomXVRs33OkiGiGz_qyf8vLOvKvm5b_bFaJL2uOXJCfbA-e8wb4bPXnLC3P0_pNy7_0lZzHbHF0ePL5OBuaKGSV1nKTBSOqooxCxCJaEHYKpSqnuYy6cgGsSIgCOI0swECVgsEMSioFziQam3bqCdutmzo9Zdw5kBXSJVcVSRvQoQI0HpR02tlY5hP2dguYv-i1MjzmGISu79D1hK7v0Z2wTwTp3w9J5rp70Kx_-cFrvC5csiEXKYLRUUABIhmZY5Jogo3JTNir7YR4dAuqdZR1aq5aL7UldoNscMLy0UyN_jh-Uy_POoHt3DgSmn_2H9b32T0aFEUzYZ6z3c36Kr1AmrIJL7vFdwMDk-Yl
  priority: 102
  providerName: Scholars Portal
Title Epigenetics: Recent Advances and Its Role in the Treatment of Alzheimer's Disease
URI https://search.proquest.com/docview/2460082143
https://pubmed.ncbi.nlm.nih.gov/PMC7594522
https://doaj.org/article/489e6b71edf54d1f8f1e5272895b6de5
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZJDiGX0ifdtgkKFAoF71pPW7lt04SksKUtCeQmrFeysGsv682lv74j2W7jay8--CFLo7Hm-5jRZ4Q-hkoWhhGWeSAfGTeSZqoIJHN5sI7AkuiSzuziu7y65d_uxN0eEsNemFS0b81yWq_W03r5kGorN2s7G-rEZj8W54VQUQh8to_2C8aeUPS0_MaQK1mXwQQCpmYhSkMCFaT5FD5v8OgjdMggbpZ5Unz9F46Sav8Iao4LJZ9Ensvn6FkPGfG869oLtOfrl-hw0SfFX6GfF5soqRl3I7ZnGHAgNIPnXW6_xVXt8PWuxb-alcfLGgPgwzdDdTluAp6vfj_45dpvP7X4a5eueY1uLy9uzq-y_k8JmeWc7jIjiC0rR4grnQxE5qFiVV5Qx60yQRJPlQiKQ6gXwXojgCZRxoISPo6NK_YGHdRN7d8irFSgFjCRsqXnInBjAzRuGFVcSVcVE_R5MJjedIIYGohENLROhtbR0Loz9AR9iSb9e2PUsk4nmu297mdU81J5aQriXRDckVAG4gUtgAkKI50XE3Q6TIgG348Jjar2zWOrKZcRwgDkm6BiNFOjN46vgFMlFe3eid7995Pv0VEcagxkRHxAB7vtoz8GhLIzJ4nZw3HBy5PknX8Ah_PpNQ
link.rule.ids 230,315,733,786,790,870,891,2115,24346,27955,27956,53825,53827
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbGkMZexnWijIuRkJCQksaO7cS8lbGpg3UC1KG9RfGNVbRJ1aQv-_Uc5wILb_Aax4ntz_b5js7xZ4TeuFwkKiZxYMH5CJgSNJCJI4GJnDYEtkTT6MzOLsT0kn264lc7iPdnYZqkfa0WYbFchcXiusmtXK_0uM8TG3-ZHSdceiHw8R10F9Yr5bec9GYD9kZXxG0ME1wwOXZeHBKcQRqFUAHm9D7ai8FyplGj-frHIDW6_QOyOUyVvGV7Tu-j732r25STn-G2VqG--UvQ8Z-79QAddGwUT9rih2jHFo_Q3qyLtz9GX0_WXq3TH3Ss3mOgmNA-PGnTBiqcFwaf1RX-Vi4tXhQYuCSe94nruHR4sry5touV3byt8Mc2EvQEXZ6ezI-nQXcJQ6AZo3WgONFpbggxqRGOiMjlcR4l1DAtlRPEUsmdZMAiuNNWcfDAaBw7ya0fNCbjQ7RblIV9irCUjmqgW1KnlnHHlHbwcRVTyaQweTJC73oksnWrtZGBj-IRzBoEM49g1iI4Qh88Vr9f9DLZzYNy8yPrRjVjqbRCJcQax5khLnXEcpqAk8mVMJaP0Ose6QyWlY-V5IUtt1VGmfDsCNjkCCWDKTD447AEgG0Eujsgn_13zVfo3nQ-O8_Ozy4-H6F9321vLwl_jnbrzda-ACJUq5fNtP8FvhAJbQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgSNVeuCO6cTESEhJSLnZsJ-atbKs2oNNAmzTxEsU3VtEmVZO-7NdznAu0PO41sRPbn-3zHZ3jzwi9d4VIVUKSwILzETAlaCBTRwITO20IbImm1ZmdnYvTK_blml9vXfXVJu1rNQ_LxTIs5zdtbuVqqaMhTyy6mB2lXHoh8GhlXHQfPYA1S9MtR73dhL3hFUkXxwQ3TEbOC0SCQ0jjECrAvN5HowSsZxa3uq__jFKr3b9DOHfTJbfsz_QR-jm0vEs7-R1uGhXq2_9EHe_UtcfoYc9K8aQr8gTds-VTNJr1cfdn6PvJyqt2-gOP9ScMVBPaiCdd-kCNi9Lgs6bGP6qFxfMSA6fEl0MCO64cnixub-x8adcfanzcRYSeo6vpyeXRadBfxhBoxmgTKE50VhhCTGaEIyJ2RVLEKTVMS-UEsVRyJxmwCe60VRw8MZokTnLrB47J5AXaK6vSvkRYSkc10C6pM8u4Y0o7-LhKqGRSmCIdo48DGvmq09zIwVfxKOYtirlHMe9QHKPPHq-_Bb1cdvugWv_K-5HNWSatUCmxxnFmiMscsZym4GxyJYzlY_RuQDuH5eVjJkVpq02dUyY8SwJWOUbpzjTY-ePuGwC3FeruwTy4c823aHRxPM2_nZ1_PUT7vtfebBL-Cu016419DXyoUW_amf8HDDEL7Q
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Epigenetics%3A+Recent+Advances+and+Its+Role+in+the+Treatment+of+Alzheimer%27s+Disease&rft.jtitle=Frontiers+in+neurology&rft.au=Xiao%2C+Xuewen&rft.au=Liu%2C+Xixi&rft.au=Jiao%2C+Bin&rft.date=2020-10-15&rft.issn=1664-2295&rft.eissn=1664-2295&rft.volume=11&rft.spage=538301&rft.epage=538301&rft_id=info:doi/10.3389%2Ffneur.2020.538301&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-2295&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-2295&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-2295&client=summon