Plasma metabolomics analyses highlight the multifaceted effects of noise exposure and the diagnostic power of dysregulated metabolites for noise-induced hearing loss in steel workers
Noise exposure can lead to various kinds of disorders. Noise-induced hearing loss (NIHL) is one of the leading disorders confusing the noise-exposed workers. It is essential to identify NIHL markers for its early diagnosis and new therapeutic targets for its treatment. In this study, a total of 90 p...
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Published in | Frontiers in molecular biosciences Vol. 9; p. 907832 |
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Abstract | Noise exposure can lead to various kinds of disorders. Noise-induced hearing loss (NIHL) is one of the leading disorders confusing the noise-exposed workers. It is essential to identify NIHL markers for its early diagnosis and new therapeutic targets for its treatment. In this study, a total of 90 plasma samples from 60 noise-exposed steel factory male workers (the noise group) with (NIHL group,
n
= 30) and without NIHL (non-NIHL group,
n
= 30) and 30 male controls without noise exposure (control group) were collected. Untargeted human plasma metabolomic profiles were determined with HPLC-MS/MS. The levels of the metabolites in the samples were normalized to total peak intensity, and the processed data were subjected to multivariate data analysis. The Wilcoxon test and orthogonal partial least square-discriminant analysis (OPLS-DA) were performed. With the threshold of
p
< 0.05 and the variable importance of projection (VIP) value >1, 469 differential plasma metabolites associated with noise exposure (DMs-NE) were identified, and their associated 58 KEGG pathways were indicated. In total, 33 differential metabolites associated with NIHL (DMs-NIHL) and their associated 12 KEGG pathways were identified. There were six common pathways associated with both noise exposure and NIHL. Through multiple comparisons, seven metabolites were shown to be dysregulated in the NIHL group compared with the other two groups. Through LASSO regression analysis, two risk models were constructed for NIHL status predication which could discriminate NIHL from non-NIHL workers with the area under the curve (AUC) values of 0.840 and 0.872, respectively, indicating their efficiency in NIHL diagnosis. To validate the results of the metabolomics, cochlear gene expression comparisons between susceptible and resistant mice in the GSE8342 dataset from Gene Expression Omnibus (GEO) were performed. The immune response and cell death-related processes were highlighted for their close relations with noise exposure, indicating their critical roles in noise-induced disorders. We concluded that there was a significant difference between the metabolite’s profiles between NIHL cases and non-NIHL individuals. Noise exposure could lead to dysregulations of a variety of biological pathways, especially immune response and cell death-related processes. Our results might provide new clues for noise exposure studies and NIHL diagnosis. |
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AbstractList | Noise exposure can lead to various kinds of disorders. Noise-induced hearing loss (NIHL) is one of the leading disorders confusing the noise-exposed workers. It is essential to identify NIHL markers for its early diagnosis and new therapeutic targets for its treatment. In this study, a total of 90 plasma samples from 60 noise-exposed steel factory male workers (the noise group) with (NIHL group, n = 30) and without NIHL (non-NIHL group, n = 30) and 30 male controls without noise exposure (control group) were collected. Untargeted human plasma metabolomic profiles were determined with HPLC-MS/MS. The levels of the metabolites in the samples were normalized to total peak intensity, and the processed data were subjected to multivariate data analysis. The Wilcoxon test and orthogonal partial least square-discriminant analysis (OPLS-DA) were performed. With the threshold of p < 0.05 and the variable importance of projection (VIP) value >1, 469 differential plasma metabolites associated with noise exposure (DMs-NE) were identified, and their associated 58 KEGG pathways were indicated. In total, 33 differential metabolites associated with NIHL (DMs-NIHL) and their associated 12 KEGG pathways were identified. There were six common pathways associated with both noise exposure and NIHL. Through multiple comparisons, seven metabolites were shown to be dysregulated in the NIHL group compared with the other two groups. Through LASSO regression analysis, two risk models were constructed for NIHL status predication which could discriminate NIHL from non-NIHL workers with the area under the curve (AUC) values of 0.840 and 0.872, respectively, indicating their efficiency in NIHL diagnosis. To validate the results of the metabolomics, cochlear gene expression comparisons between susceptible and resistant mice in the GSE8342 dataset from Gene Expression Omnibus (GEO) were performed. The immune response and cell death-related processes were highlighted for their close relations with noise exposure, indicating their critical roles in noise-induced disorders. We concluded that there was a significant difference between the metabolite’s profiles between NIHL cases and non-NIHL individuals. Noise exposure could lead to dysregulations of a variety of biological pathways, especially immune response and cell death-related processes. Our results might provide new clues for noise exposure studies and NIHL diagnosis. Noise exposure can lead to various kinds of disorders. Noise-induced hearing loss (NIHL) is one of the leading disorders confusing the noise-exposed workers. It is essential to identify NIHL markers for its early diagnosis and new therapeutic targets for its treatment. In this study, a total of 90 plasma samples from 60 noise-exposed steel factory male workers (the noise group) with (NIHL group, n = 30) and without NIHL (non-NIHL group, n = 30) and 30 male controls without noise exposure (control group) were collected. Untargeted human plasma metabolomic profiles were determined with HPLC-MS/MS. The levels of the metabolites in the samples were normalized to total peak intensity, and the processed data were subjected to multivariate data analysis. The Wilcoxon test and orthogonal partial least square-discriminant analysis (OPLS-DA) were performed. With the threshold of p < 0.05 and the variable importance of projection (VIP) value >1, 469 differential plasma metabolites associated with noise exposure (DMs-NE) were identified, and their associated 58 KEGG pathways were indicated. In total, 33 differential metabolites associated with NIHL (DMs-NIHL) and their associated 12 KEGG pathways were identified. There were six common pathways associated with both noise exposure and NIHL. Through multiple comparisons, seven metabolites were shown to be dysregulated in the NIHL group compared with the other two groups. Through LASSO regression analysis, two risk models were constructed for NIHL status predication which could discriminate NIHL from non-NIHL workers with the area under the curve (AUC) values of 0.840 and 0.872, respectively, indicating their efficiency in NIHL diagnosis. To validate the results of the metabolomics, cochlear gene expression comparisons between susceptible and resistant mice in the GSE8342 dataset from Gene Expression Omnibus (GEO) were performed. The immune response and cell death-related processes were highlighted for their close relations with noise exposure, indicating their critical roles in noise-induced disorders. We concluded that there was a significant difference between the metabolite’s profiles between NIHL cases and non-NIHL individuals. Noise exposure could lead to dysregulations of a variety of biological pathways, especially immune response and cell death-related processes. Our results might provide new clues for noise exposure studies and NIHL diagnosis. |
Author | Jiao, Jie Cui, Yanan Yu, Yue Chen, Guoshun Zhang, Xiuzhi Gu, Guizhen Wu, Hui Li, Ningning Zhang, Huanling Yu, Shanfa |
AuthorAffiliation | 3 Department of Occupational and Environmental Health , College of Public Health , Zhengzhou University , Zhengzhou , Henan , China 7 School of Public Health , Henan Medical College , Zhengzhou , Henan , China 2 Department of Scientific Research and Foreign Affairs , Henan Medical College , Zhengzhou , Henan , China 4 Henan Institute for Occupational Health , Zhengzhou , Henan , China 5 National Institute for Occupational Health and Poison Control , Chinese Center for Disease Control and Prevention , Beijing , China 6 Wugang Institute for Occupational Health , Wugang , Henan , China 1 Department of Pathology , Henan Medical College , Zhengzhou , Henan , China |
AuthorAffiliation_xml | – name: 1 Department of Pathology , Henan Medical College , Zhengzhou , Henan , China – name: 4 Henan Institute for Occupational Health , Zhengzhou , Henan , China – name: 3 Department of Occupational and Environmental Health , College of Public Health , Zhengzhou University , Zhengzhou , Henan , China – name: 7 School of Public Health , Henan Medical College , Zhengzhou , Henan , China – name: 5 National Institute for Occupational Health and Poison Control , Chinese Center for Disease Control and Prevention , Beijing , China – name: 2 Department of Scientific Research and Foreign Affairs , Henan Medical College , Zhengzhou , Henan , China – name: 6 Wugang Institute for Occupational Health , Wugang , Henan , China |
Author_xml | – sequence: 1 givenname: Xiuzhi surname: Zhang fullname: Zhang, Xiuzhi – sequence: 2 givenname: Ningning surname: Li fullname: Li, Ningning – sequence: 3 givenname: Yanan surname: Cui fullname: Cui, Yanan – sequence: 4 givenname: Hui surname: Wu fullname: Wu, Hui – sequence: 5 givenname: Jie surname: Jiao fullname: Jiao, Jie – sequence: 6 givenname: Yue surname: Yu fullname: Yu, Yue – sequence: 7 givenname: Guizhen surname: Gu fullname: Gu, Guizhen – sequence: 8 givenname: Guoshun surname: Chen fullname: Chen, Guoshun – sequence: 9 givenname: Huanling surname: Zhang fullname: Zhang, Huanling – sequence: 10 givenname: Shanfa surname: Yu fullname: Yu, Shanfa |
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Cites_doi | 10.3967/bes2021.098 10.3760/cma.j.issn.1001-9391.2020.02.011 10.3390/life10040046 10.1038/s41598-019-56174-8 10.1093/infdis/143.1.101 10.3760/cma.j.issn.1001-9391.2020.02.008 10.1039/c4fo00883a 10.1016/s0140-6736(13)61613-x 10.1016/j.bbalip.2021.159082 10.1158/1055-9965.epi-21-1023 10.1016/j.envint.2021.106946 10.1016/j.heares.2016.12.011 10.3389/fncel.2017.00106 10.1016/j.ecoenv.2022.113759 10.3390/ijerph16081367 10.1038/nrm.2017.107 10.1007/s11356-020-11193-1 10.1016/j.biopha.2020.111098 10.2147/jir.s338421 10.1371/journal.pntd.0010071 10.3390/ijerph19010382 10.1186/s12859-018-2487-5 10.3390/toxins13010050 10.1016/j.bbrc.2017.09.124 10.1097/aud.0000000000001194 10.1161/hypertensionaha.121.17704 10.3390/ijms22116126 10.1038/s41598-019-45385-8 10.3389/fpsyt.2021.644555 10.1186/s12989-022-00463-0 10.4049/jimmunol.1801019 10.3390/ijms20194675 10.1016/j.neuron.2012.09.020 10.1016/j.scitotenv.2022.155764 10.1002/glia.24095 10.3760/cma.j.issn.1001-9391.2020.02.009 10.1016/j.heares.2015.08.003 10.3967/bes2021.134 10.1007/s11356-021-18360-y 10.2174/0929867328666211125091811 10.1016/j.bioactmat.2020.03.010 10.3760/cma.j.cn121094-20200518-00270 10.1007/s11356-021-15468-z 10.1093/carcin/bgab089 10.1007/s00418-016-1436-5 10.1038/s41598-020-79234-w 10.1007/s00420-022-01876-2 10.3389/fnmol.2021.678510 10.1016/j.abb.2020.108279 10.1093/hmg/ddac006 10.1016/j.heares.2010.12.014 10.1211/0022357001777568 10.1016/j.envint.2018.10.046 10.1016/j.redox.2020.101506 |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Ana Cláudia Coelho, University of Trás-os-Montes and Alto Douro, Portugal Jinglong Tang, Qingdao University, China Edited by: Anna Maria Timperio, University of Tuscia, Italy Reviewed by: Meibian Zhang, National institue for occupational health and poison control, China This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences. |
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References | Fredriksson (B15) 2021; 43 Graber (B18) 1981; 143 Zheng (B54) 2017; 349 Nie (B39) 2022; 241 Wood (B52) 2017; 11 Essers (B12) 2022; 158 Gratton (B19) 2011; 277 Castillo (B5) 2012; 76 Wang (B50) 2020; 681 Liu (B33) 2021; 34 Kumakura (B29) 2021; 13 Hannun (B21) 2018; 19 Li (B31); 38 Su (B45) 2019; 20 Brantley (B3) 2022; 31 Daiber (B8) 2020; 34 Li (B30); 38 Jin (B27) 2021; 34 Wang (B49) 2022; 31 Wu (B53) 2020; 38 Nishi (B40) 2020; 10 Gamrad-Streubel (B16) 2022 Ding (B10) 2016; 333 Du (B11) 2021; 12 Cheng (B6) 2022; 19 Fernandes (B13) 2022; 837 Ji (B26) 2019; 9 Ferrigno (B14) 2020; 5 Nyarubeli (B42) 2019; 16 Tan (B46) 2016; 146 Miao (B35); 28 Huang (B25) 2018; 121 Nongonierma (B41) 2015; 6 Cai (B4) 2021; 134 Basner (B2) 2014; 383 Hough (B23) 2022; 70 Rothman (B44) 2021; 42 Tanguy (B47) 2019; 202 Ghosh (B17) 2021; 14 Groblewska (B20) 2021; 22 Picart-Armada (B43) 2018; 19 Hariganesh (B22) 2000; 52 Dhanjal (B9) 2022; 29 Wojciechowska (B51) 2022; 79 Wan (B48) 2022; 29 Hua (B24) 2022; 15 Miao (B34); 28 Banoei (B1) 2019; 9 Mizushima (B37) 2017; 493 Nari (B38) 2020; 10 Cífková (B7) 2022; 1867 Miao (B36); 19 Koplewitz (B28) 2022; 16 Liang (B32) 2021; 39 |
References_xml | – volume: 34 start-page: 705 year: 2021 ident: B33 article-title: NRN1 and CAT gene polymorphisms, complex noise, and lifestyles interactively affect the risk of noise-induced hearing loss publication-title: Biomed. Environ. Sci. doi: 10.3967/bes2021.098 contributor: fullname: Liu – volume: 38 start-page: 128 year: 2020 ident: B53 article-title: Association between PON2 gene polymorphisms and susceptibility to noise-induced hearing loss publication-title: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi doi: 10.3760/cma.j.issn.1001-9391.2020.02.011 contributor: fullname: Wu – volume: 10 start-page: E46 year: 2020 ident: B38 article-title: Association between occupational noise and vibration exposure and insomnia among workers in korea publication-title: Life (Basel) doi: 10.3390/life10040046 contributor: fullname: Nari – volume: 9 start-page: 19584 year: 2019 ident: B1 article-title: Metabolomic and metallomic profile differences between veterans and civilians with pulmonary sarcoidosis publication-title: Sci. Rep. doi: 10.1038/s41598-019-56174-8 contributor: fullname: Banoei – volume: 143 start-page: 101 year: 1981 ident: B18 article-title: Immunomodulating properties of dimethylglycine in humans publication-title: J. Infect. Dis. doi: 10.1093/infdis/143.1.101 contributor: fullname: Graber – volume: 38 start-page: 116 ident: B30 article-title: Association between GPX1 gene polymorphisms and noise-induced hearing loss publication-title: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi doi: 10.3760/cma.j.issn.1001-9391.2020.02.008 contributor: fullname: Li – volume: 6 start-page: 313 year: 2015 ident: B41 article-title: Utilisation of the isobole methodology to study dietary peptide-drug and peptide-peptide interactive effects on dipeptidyl peptidase IV (DPP-IV) inhibition publication-title: Food Funct. doi: 10.1039/c4fo00883a contributor: fullname: Nongonierma – volume: 383 start-page: 1325 year: 2014 ident: B2 article-title: Auditory and non-auditory effects of noise on health publication-title: Lancet doi: 10.1016/s0140-6736(13)61613-x contributor: fullname: Basner – volume: 1867 start-page: 159082 year: 2022 ident: B7 article-title: Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues publication-title: Biochim. Biophys. Acta. Mol. Cell Biol. Lipids doi: 10.1016/j.bbalip.2021.159082 contributor: fullname: Cífková – volume: 31 start-page: 839 year: 2022 ident: B3 article-title: Plasma metabolomics and breast cancer risk over 20 Years of follow-up among postmenopausal women in the nurses' health study publication-title: Cancer Epidemiol. Biomarkers Prev. doi: 10.1158/1055-9965.epi-21-1023 contributor: fullname: Brantley – volume: 158 start-page: 106946 year: 2022 ident: B12 article-title: Environmental noise exposure and emotional, aggressive, and attention-deficit/hyperactivity disorder-related symptoms in children from two European birth cohorts publication-title: Environ. Int. doi: 10.1016/j.envint.2021.106946 contributor: fullname: Essers – volume: 349 start-page: 182 year: 2017 ident: B54 article-title: Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development? publication-title: Hear. Res. doi: 10.1016/j.heares.2016.12.011 contributor: fullname: Zheng – volume: 11 start-page: 106 year: 2017 ident: B52 article-title: The contribution of immune infiltrates to ototoxicity and cochlear hair cell loss publication-title: Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00106 contributor: fullname: Wood – volume: 241 start-page: 113759 year: 2022 ident: B39 article-title: Combined multi-omics analysis reveals oil mist particulate matter-induced lung injury in rats: Pathological damage, proteomics, metabolic disturbances, and lung dysbiosis publication-title: Ecotoxicol. Environ. Saf. doi: 10.1016/j.ecoenv.2022.113759 contributor: fullname: Nie – volume: 16 start-page: E1367 year: 2019 ident: B42 article-title: Prevalence of noise-induced hearing loss among Tanzanian iron and steel workers: A cross-sectional study publication-title: Int. J. Environ. Res. Public Health doi: 10.3390/ijerph16081367 contributor: fullname: Nyarubeli – volume: 19 start-page: 175 year: 2018 ident: B21 article-title: Sphingolipids and their metabolism in physiology and disease publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2017.107 contributor: fullname: Hannun – volume: 28 start-page: 8626 ident: B34 article-title: CARD8 polymorphism rs2043211 protects against noise-induced hearing loss by causing the dysfunction of CARD8 protein publication-title: Environ. Sci. Pollut. Res. Int. doi: 10.1007/s11356-020-11193-1 contributor: fullname: Miao – volume: 134 start-page: 111098 year: 2021 ident: B4 article-title: Lindera aggregata intervents adenine-induced chronic kidney disease by mediating metabolism and TGF-β/Smad signaling pathway publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2020.111098 contributor: fullname: Cai – volume: 15 start-page: 381 year: 2022 ident: B24 article-title: A novel inflammatory-nutritional prognostic scoring system for patients with early-stage breast cancer publication-title: J. Inflamm. Res. doi: 10.2147/jir.s338421 contributor: fullname: Hua – volume: 16 start-page: e0010071 year: 2022 ident: B28 article-title: Predicting dengue incidence leveraging internet-based data sources. A case study in 20 cities in Brazil publication-title: PLoS Negl. Trop. Dis. doi: 10.1371/journal.pntd.0010071 contributor: fullname: Koplewitz – volume: 19 start-page: 382 ident: B36 article-title: TMT-based quantitative proteomics reveals cochlear protein profile Alterations in mice with noise-induced hearing loss publication-title: Int. J. Environ. Res. Public Health doi: 10.3390/ijerph19010382 contributor: fullname: Miao – volume: 19 start-page: 538 year: 2018 ident: B43 article-title: Fella: an R package to enrich metabolomics data publication-title: BMC Bioinforma. doi: 10.1186/s12859-018-2487-5 contributor: fullname: Picart-Armada – volume: 13 start-page: 50 year: 2021 ident: B29 article-title: Nicotinamide attenuates the progression of renal failure in a mouse model of adenine-induced chronic kidney disease publication-title: Toxins (Basel) doi: 10.3390/toxins13010050 contributor: fullname: Kumakura – volume: 493 start-page: 894 year: 2017 ident: B37 article-title: Macrophage recruitment, but not interleukin 1 beta activation, enhances noise-induced hearing damage publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2017.09.124 contributor: fullname: Mizushima – volume: 43 start-page: 1366 year: 2021 ident: B15 article-title: The impact of occupational noise exposure on hyperacusis: A longitudinal population study of female workers in Sweden publication-title: Ear Hear. doi: 10.1097/aud.0000000000001194 contributor: fullname: Fredriksson – volume: 79 start-page: 325 year: 2022 ident: B51 article-title: Blood pressure and arterial stiffness in association with aircraft noise exposure:long-term observation and potential effect of COVID-19 lockdown publication-title: Hypertension doi: 10.1161/hypertensionaha.121.17704 contributor: fullname: Wojciechowska – volume: 22 start-page: 6126 year: 2021 ident: B20 article-title: Pro- and antiangiogenic factors in gliomas: Implications for novel therapeutic possibilities publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms22116126 contributor: fullname: Groblewska – volume: 9 start-page: 9273 year: 2019 ident: B26 article-title: Auditory metabolomics, an approach to identify acute molecular effects of noise trauma publication-title: Sci. Rep. doi: 10.1038/s41598-019-45385-8 contributor: fullname: Ji – volume: 12 start-page: 644555 year: 2021 ident: B11 article-title: Plasma metabolomics profiling of metabolic pathways affected by major depressive disorder publication-title: Front. Psychiatry doi: 10.3389/fpsyt.2021.644555 contributor: fullname: Du – volume: 19 start-page: 20 year: 2022 ident: B6 article-title: Circulatory metabolites trigger ex vivo arterial endothelial cell dysfunction in population chronically exposed to diesel exhaust publication-title: Part. Fibre Toxicol. doi: 10.1186/s12989-022-00463-0 contributor: fullname: Cheng – volume: 202 start-page: 2971 year: 2019 ident: B47 article-title: Regulation of phospholipase D by Arf6 during FcγR-mediated phagocytosis publication-title: J. Immunol. doi: 10.4049/jimmunol.1801019 contributor: fullname: Tanguy – volume: 20 start-page: E4675 year: 2019 ident: B45 article-title: Hyperbaric oxygen treatment ameliorates hearing loss and auditory cortex injury in noise exposed mice by repressing local ceramide accumulation publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20194675 contributor: fullname: Su – volume: 76 start-page: 70 year: 2012 ident: B5 article-title: Endocannabinoid signaling and synaptic function publication-title: Neuron doi: 10.1016/j.neuron.2012.09.020 contributor: fullname: Castillo – volume: 837 start-page: 155764 year: 2022 ident: B13 article-title: The toxicological profile of polychlorinated naphthalenes (PCNs) publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2022.155764 contributor: fullname: Fernandes – volume: 70 start-page: 219 year: 2022 ident: B23 article-title: Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss publication-title: Glia doi: 10.1002/glia.24095 contributor: fullname: Hough – volume: 38 start-page: 120 ident: B31 article-title: Association between GSTP1 gave polymorphisms and susceptibility to noise-induced hearing loss publication-title: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi doi: 10.3760/cma.j.issn.1001-9391.2020.02.009 contributor: fullname: Li – volume: 333 start-page: 275 year: 2016 ident: B10 article-title: Analysis of plasma microRNA expression profiles in male textile workers with noise-induced hearing loss publication-title: Hear. Res. doi: 10.1016/j.heares.2015.08.003 contributor: fullname: Ding – volume: 34 start-page: 992 year: 2021 ident: B27 article-title: Positive associations between bilateral high-frequency hearing loss and hypertension risk in short-term occupational noise exposure publication-title: Biomed. Environ. Sci. doi: 10.3967/bes2021.134 contributor: fullname: Jin – volume: 29 start-page: 32947 year: 2022 ident: B48 article-title: Association between UBAC2 gene polymorphism and the risk of noise-induced hearing loss: A cross-sectional study publication-title: Environ. Sci. Pollut. Res. Int. doi: 10.1007/s11356-021-18360-y contributor: fullname: Wan – volume: 29 start-page: 2632 year: 2022 ident: B9 article-title: Millennium nutrient N, N-dimethylglycine (DMG) and its effectiveness in autism spectrum disorders publication-title: Curr. Med. Chem. doi: 10.2174/0929867328666211125091811 contributor: fullname: Dhanjal – volume: 5 start-page: 468 year: 2020 ident: B14 article-title: Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration publication-title: Bioact. Mat. doi: 10.1016/j.bioactmat.2020.03.010 contributor: fullname: Ferrigno – volume: 39 start-page: 511 year: 2021 ident: B32 article-title: Health survey and analysis of workers exposed to noise and dust in a candy manufacturing enterprise publication-title: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi doi: 10.3760/cma.j.cn121094-20200518-00270 contributor: fullname: Liang – volume: 28 start-page: 68539 ident: B35 article-title: Plasma metabolomic profiling in workers with noise-induced hearing loss: A pilot study publication-title: Environ. Sci. Pollut. Res. Int. doi: 10.1007/s11356-021-15468-z contributor: fullname: Miao – volume: 42 start-page: 1326 year: 2021 ident: B44 article-title: Metabolome-wide association study of occupational exposure to benzene publication-title: Carcinogenesis doi: 10.1093/carcin/bgab089 contributor: fullname: Rothman – volume: 146 start-page: 219 year: 2016 ident: B46 article-title: Characterisation of cochlear inflammation in mice following acute and chronic noise exposure publication-title: Histochem. Cell Biol. doi: 10.1007/s00418-016-1436-5 contributor: fullname: Tan – volume: 10 start-page: 22110 year: 2020 ident: B40 article-title: Alteration of serum amino acid profiles by dietary adenine supplementation inhibits fatty liver development in rats publication-title: Sci. Rep. doi: 10.1038/s41598-020-79234-w contributor: fullname: Nishi – year: 2022 ident: B16 article-title: Underground salt and potash workers exposed to nitrogen oxides and diesel exhaust: Assessment of specific effect biomarkers publication-title: Int. Arch. Occup. Environ. Health doi: 10.1007/s00420-022-01876-2 contributor: fullname: Gamrad-Streubel – volume: 14 start-page: 678510 year: 2021 ident: B17 article-title: Cannabinoid signaling in auditory function and development publication-title: Front. Mol. Neurosci. doi: 10.3389/fnmol.2021.678510 contributor: fullname: Ghosh – volume: 681 start-page: 108279 year: 2020 ident: B50 article-title: A urinary metabolomic study from subjects after long-term occupational exposure to low concentration acrylamide using UPLC-QTOF/MS publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2020.108279 contributor: fullname: Wang – volume: 31 start-page: 2109 year: 2022 ident: B49 article-title: Associations of genetic variation in E3 SUMO-protein ligase CBX4 with noise-induced hearing loss publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddac006 contributor: fullname: Wang – volume: 277 start-page: 211 year: 2011 ident: B19 article-title: Noise-induced changes in gene expression in the cochleae of mice differing in their susceptibility to noise damage publication-title: Hear. Res. doi: 10.1016/j.heares.2010.12.014 contributor: fullname: Gratton – volume: 52 start-page: 1519 year: 2000 ident: B22 article-title: Effect of dimethylglycine on gastric ulcers in rats publication-title: J. Pharm. Pharmacol. doi: 10.1211/0022357001777568 contributor: fullname: Hariganesh – volume: 121 start-page: 1243 year: 2018 ident: B25 article-title: The modification of indoor PM(2.5) exposure to chronic obstructive pulmonary disease in Chinese elderly people: A meet-in-metabolite analysis publication-title: Environ. Int. doi: 10.1016/j.envint.2018.10.046 contributor: fullname: Huang – volume: 34 start-page: 101506 year: 2020 ident: B8 article-title: Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitric oxide synthases publication-title: Redox Biol. doi: 10.1016/j.redox.2020.101506 contributor: fullname: Daiber |
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Title | Plasma metabolomics analyses highlight the multifaceted effects of noise exposure and the diagnostic power of dysregulated metabolites for noise-induced hearing loss in steel workers |
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