Membrane-Associated α-Tubulin Is Less Acetylated in Postmortem Prefrontal Cortex from Depressed Subjects Relative to Controls: Cytoskeletal Dynamics, HDAC6, and Depression

• Published in: The Journal of neuroscience Vol. 40; no. 20; pp. 4033 - 4041
• Main Authors: Singh, Harinder, Chmura, Justyna, Bhaumik, Runa, Pandey, Ghanshyam N., Rasenick, Mark M.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 13.05.2020
• Subjects: Acetylation; Adenylate cyclase; Adenylyl Cyclases - metabolism; Adolescent; Adult; Aged; Antidepressants; Cell Membrane - metabolism; Cyclic AMP; Cyclic AMP - biosynthesis; Cytoskeleton; Cytoskeleton - metabolism; Deacetylation; Depression - metabolism; Disorders; Domains; Emotional disorders; Female; Histone Deacetylase 6 - metabolism; Humans; Lipid rafts; Lipids; Male; Membrane Microdomains - metabolism; Membranes; Mental depression; Middle Aged; Mood; Mood disorders; Post-translation; Postmortem Changes; Prefrontal cortex; Prefrontal Cortex - metabolism; Proteins; Rafts; Suicide; Tissues; Translation; Tubulin; Tubulin - metabolism; Young Adult; G-protein; GPCR; cAMP; cytoskeleton; antidepressant; lipid-raft

Cytoskeletal proteins and post-translational modifications play a role in mood disorders. Post-translational modifications of tubulin also alter microtubule dynamics. Furthermore, tubulin interacts closely with Gα s , the G-protein responsible for activation of adenylyl cyclase. Postmortem tissue de...