Alternative Effector-Function Profiling Identifies Broad HIV-Specific T-Cell Responses in Highly HIV-Exposed Individuals Who Remain Uninfected
The characterization of host immune responses to human immunodeficiency virus (HIV) in HIV controllers and individuals with high exposure but seronegativity to HIV (HESN) is needed to guide the development of effective preventive and therapeutic vaccine candidates. However, several technical hurdles...
Saved in:
Published in | The Journal of infectious diseases Vol. 211; no. 6; pp. 936 - 946 |
---|---|
Main Authors | , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Oxford University Press
15.03.2015
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The characterization of host immune responses to human immunodeficiency virus (HIV) in HIV controllers and individuals with high exposure but seronegativity to HIV (HESN) is needed to guide the development of effective preventive and therapeutic vaccine candidates. However, several technical hurdles severely limit the definition of an effective virus-specific T-cell response. By using a toggle-peptide approach, which takes HIV sequence diversity into account, and a novel, boosted cytokine staining/flow cytometry strategy, we here describe new patterns of T-cell responses to HIV that would be missed by standard assays. Importantly, this approach also allows detection of broad and strong virus-specific T-cell responses in HESN individuals that are characterized by a T-helper type 1 cytokine-like effector profile and produce cytokines that have been associated with potential control of HIV infection, including interleukin 10, interleukin 13, and interleukin 22. These results establish a novel approach to improve the current understanding of HIV-specific T-cell immunity and identify cellular immune responses and individual cytokines as potential markers of relative HIV resistance. As such, the findings also help develop similar strategies for more-comprehensive assessments of host immune responses to other human infections and immune-mediated disorders. |
---|---|
AbstractList | The characterization of host immune responses to human immunodeficiency virus (HIV) in HIV controllers and individuals with high exposure but seronegativity to HIV (HESN) is needed to guide the development of effective preventive and therapeutic vaccine candidates. However, several technical hurdles severely limit the definition of an effective virus-specific T-cell response. By using a toggle-peptide approach, which takes HIV sequence diversity into account, and a novel, boosted cytokine staining/flow cytometry strategy, we here describe new patterns of T-cell responses to HIV that would be missed by standard assays. Importantly, this approach also allows detection of broad and strong virus-specific T-cell responses in HESN individuals that are characterized by a T-helper type 1 cytokine-like effector profile and produce cytokines that have been associated with potential control of HIV infection, including interleukin 10, interleukin 13, and interleukin 22. These results establish a novel approach to improve the current understanding of HIV-specific T-cell immunity and identify cellular immune responses and individual cytokines as potential markers of relative HIV resistance. As such, the findings also help develop similar strategies for more-comprehensive assessments of host immune responses to other human infections and immune-mediated disorders. |
Author | Korber, Bette T. Ibarrondo, Javier Zamarreño, Jennifer Bach, Vanessa Clotet, Bonaventura Ruiz-Riol, Marta Brander, Christian Yusim, Karina Meulbroek, Michael Sanchez, Jorge Llano, Anuska Fernandez, Marco A. Cobarsi, Patricia Perez-Alvarez, Susana Leon, Agathe Requena, Gerard Ganoza, Carmela Mothe, Beatriz Pujol, Ferran Coll, Josep |
Author_xml | – sequence: 1 givenname: Marta surname: Ruiz-Riol fullname: Ruiz-Riol, Marta – sequence: 2 givenname: Anuska surname: Llano fullname: Llano, Anuska – sequence: 3 givenname: Javier surname: Ibarrondo fullname: Ibarrondo, Javier – sequence: 4 givenname: Jennifer surname: Zamarreño fullname: Zamarreño, Jennifer – sequence: 5 givenname: Karina surname: Yusim fullname: Yusim, Karina – sequence: 6 givenname: Vanessa surname: Bach fullname: Bach, Vanessa – sequence: 7 givenname: Beatriz surname: Mothe fullname: Mothe, Beatriz – sequence: 8 givenname: Susana surname: Perez-Alvarez fullname: Perez-Alvarez, Susana – sequence: 9 givenname: Marco A. surname: Fernandez fullname: Fernandez, Marco A. – sequence: 10 givenname: Gerard surname: Requena fullname: Requena, Gerard – sequence: 11 givenname: Michael surname: Meulbroek fullname: Meulbroek, Michael – sequence: 12 givenname: Ferran surname: Pujol fullname: Pujol, Ferran – sequence: 13 givenname: Agathe surname: Leon fullname: Leon, Agathe – sequence: 14 givenname: Patricia surname: Cobarsi fullname: Cobarsi, Patricia – sequence: 15 givenname: Bette T. surname: Korber fullname: Korber, Bette T. – sequence: 16 givenname: Bonaventura surname: Clotet fullname: Clotet, Bonaventura – sequence: 17 givenname: Carmela surname: Ganoza fullname: Ganoza, Carmela – sequence: 18 givenname: Jorge surname: Sanchez fullname: Sanchez, Jorge – sequence: 19 givenname: Josep surname: Coll fullname: Coll, Josep – sequence: 20 givenname: Christian surname: Brander fullname: Brander, Christian |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25249264$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkUFvEzEQhS1URNPCkSPIRy7b2rv27vqCVKK0iVQJBC0cLa89Thxt7GDvRvRP8Jtx2RLBjZOleZ_e-M07Qyc-eEDoNSUXlIjq0nlrXLrcupFX7BmaUV41RV3T6gTNCCnLgrZCnKKzlLaEEFbVzQt0WvKSibJmM_Tzqh8gejW4A-CFtaCHEIvr0evBBY8_xWBd7_warwz4wVkHCX-IQRm8XH0tvuxB55nGd8Uc-h5_hrQPPmXGebx0603_8Jtb_NiHBAavvHEHZ0bVJ_xtEzK_U5m89zlF3gzmJXpuswivnt5zdH-9uJsvi9uPN6v51W2hGSuHQrVMtdaUhIvO1qrRHa87bSkFA4wSQ00FRjWNoqqlinZWt5p0pe4E5WCYqs7R-8l3P3Y7MDpni6qX--h2Kj7IoJz8V_FuI9fhIBmjNS15Nnj3ZBDD9xHSIHcu6XwD5SGMSdJaMNFQwZv_QHnbEE75o2sxoTqGlCLY448okY91y6luOdWd-bd_xzjSf_rNwJsJ2Kbc61FnVUMEp6T6BbPzt5A |
CitedBy_id | crossref_primary_10_1371_journal_ppat_1008011 crossref_primary_10_3389_fimmu_2017_00936 crossref_primary_10_4049_jimmunol_2000933 crossref_primary_10_1186_s13063_019_3409_1 crossref_primary_10_1038_mtna_2015_29 crossref_primary_10_3389_fimmu_2020_00418 crossref_primary_10_1586_14760584_2016_1129904 crossref_primary_10_17533_udea_iatreia_216 crossref_primary_10_3390_v14030471 crossref_primary_10_3389_fimmu_2022_928039 crossref_primary_10_1016_j_ebiom_2017_11_001 crossref_primary_10_1097_QAD_0000000000000728 crossref_primary_10_1371_journal_ppat_1008607 crossref_primary_10_3389_fimmu_2022_815041 |
Cites_doi | 10.4049/jimmunol.176.7.4094 10.1016/S0165-2478(01)00262-0 10.1097/QAD.0b013e32831f924c 10.4049/jimmunol.171.5.2671 10.1038/nm1520 10.1186/1479-5876-9-208 10.4049/jimmunol.164.3.1602 10.1097/QAD.0b013e3282f42412 10.1186/1742-4690-3-35 10.1128/CVI.00247-08 10.1086/597801 10.1016/j.coi.2006.05.012 10.1182/blood-2005-12-4818 10.4049/jimmunol.179.10.6638 10.1128/JVI.78.5.2187-2200.2004 10.1016/j.immuni.2012.10.021 10.1093/infdis/jis480 10.1128/JVI.02444-10 10.1371/journal.pone.0029717 10.1155/2009/360362 10.1007/s11904-010-0039-3 10.1097/01.COH.0000194108.14601.69 10.4049/jimmunol.175.9.6117 10.1128/JVI.80.6.3122-3125.2006 10.1097/COH.0b013e3280f3bfe2 10.1086/314632 10.1093/infdis/jiq028 10.1056/NEJMoa1113425 10.1097/00002030-200207050-00003 10.1038/nprot.2006.268 10.4049/jimmunol.178.1.407 10.1084/jem.20130555 10.4049/jimmunol.0902463 10.1126/science.1195271 |
ContentType | Journal Article |
Copyright | Copyright © 2015 Oxford University Press on behalf of the Infectious Diseases Society of America The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: . 2014 |
Copyright_xml | – notice: Copyright © 2015 Oxford University Press on behalf of the Infectious Diseases Society of America – notice: The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. – notice: The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: . 2014 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 7T5 7U9 H94 5PM |
DOI | 10.1093/infdis/jiu534 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic Immunology Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic AIDS and Cancer Research Abstracts Immunology Abstracts Virology and AIDS Abstracts |
DatabaseTitleList | AIDS and Cancer Research Abstracts MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Biology |
EISSN | 1537-6613 |
EndPage | 946 |
ExternalDocumentID | 10_1093_infdis_jiu534 25249264 43709510 |
Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: NIDCR NIH HHS grantid: R01 DE018925-05 – fundername: NIDCR NIH HHS grantid: R01 DE018925 |
GroupedDBID | --- -DZ -~X ..I .2P .I3 .XZ .ZR 08P 0R~ 123 1KJ 1TH 29K 2AX 2WC 36B 4.4 48X 53G 5GY 5RE 5VS 5WD 70D 85S AABJS AABMN AABZA AACGO AACZT AAESY AAHTB AAIYJ AAJKP AAJQQ AAMVS AANCE AANRK AAOGV AAPNW AAPQZ AAPXW AAQQT AAUQX AAVAP AAWTL ABBHK ABEUO ABIXL ABJNI ABKDP ABLJU ABNKS ABOCM ABPEJ ABPLY ABPPZ ABPTD ABQLI ABSAR ABTLG ABWST ABXSQ ABZBJ ACGFO ACGFS ACGOD ACIMA ACPRK ACUFI ACUTO ACYHN ADBBV ADEIU ADEYI ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADORX ADQLU ADRIX ADRTK ADULT ADVEK ADYVW ADZLD ADZXQ AEGPL AEGXH AEJOX AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEUPB AEWNT AEXZC AFFZL AFIYH AFOFC AFXAL AFXEN AGINJ AGKEF AGQXC AGSYK AGUTN AHMBA AHXPO AIAGR AIJHB AIKOY AIMBJ AJEEA ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APWMN AQVQM ASMCH AWCFO AXUDD AZQFJ BAWUL BAYMD BCRHZ BEYMZ BGYMP BHONS BR6 BTRTY BVRKM BYORX C45 CASEJ CDBKE CS3 CZ4 D-I DAKXR DCCCD DIK DILTD DNJUQ DOOOF DPORF DPPUQ DU5 DWIUU D~K EBS ECGQY EE~ EJD EMOBN ENERS ESX F5P F9B FECEO FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H5~ HAR HW0 HZ~ IH2 IOX J21 JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JSODD JST KAQDR KBUDW KOP KQ8 KSI KSN L7B LSO LU7 M49 MHKGH MJL ML0 N9A NGC NOMLY NOYVH NU- NVLIB O9- OAUYM OAWHX OCZFY ODMLO OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P PAFKI PEELM PQQKQ Q1. Q5Y QBD RD5 ROX ROZ RUSNO RW1 RXO SA0 SJN TCURE TEORI TJX TR2 W2D W8F WH7 X7H YAYTL YKOAZ YXANX ZA5 ~91 AAHBH AARHZ AAUAY ABNHQ ABQNK ABXVV ADACV ADQBN ATGXG CGR CUY CVF ECM EIF H13 IPSME NPM AASNB AAYXX CITATION 7X8 7T5 7U9 ADQXQ H94 5PM P0- |
ID | FETCH-LOGICAL-c442t-a84a8fd2059bf6a7cb56bcf11ede410d1d3eda77a1a81a1bfc8c0b2cb915ed4a3 |
ISSN | 0022-1899 |
IngestDate | Tue Sep 17 21:22:53 EDT 2024 Fri Aug 16 01:29:17 EDT 2024 Sat Oct 05 05:54:53 EDT 2024 Thu Sep 12 18:17:32 EDT 2024 Tue Oct 15 23:48:53 EDT 2024 Fri Feb 02 07:49:05 EST 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 6 |
Keywords | Th2 cytokines boosted flow cytometry T-cell responses toggled peptides highly exposed seronegative HIV infection Th1 cytokines Th17 cytokines |
Language | English |
License | The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c442t-a84a8fd2059bf6a7cb56bcf11ede410d1d3eda77a1a81a1bfc8c0b2cb915ed4a3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 M. R.-R. and A. L. contributed equally to this report. Presented in part: HIV Vaccines (X5), Keystone Symposia on Molecular and Cellular Biology, Keystone, Colorado, 21–26 March 2012. |
OpenAccessLink | https://academic.oup.com/jid/article-pdf/211/6/936/13805749/jiu534.pdf |
PMID | 25249264 |
PQID | 1658705155 |
PQPubID | 23479 |
PageCount | 11 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4416125 proquest_miscellaneous_1694971957 proquest_miscellaneous_1658705155 crossref_primary_10_1093_infdis_jiu534 pubmed_primary_25249264 jstor_primary_43709510 |
PublicationCentury | 2000 |
PublicationDate | 2015-03-15 |
PublicationDateYYYYMMDD | 2015-03-15 |
PublicationDate_xml | – month: 03 year: 2015 text: 2015-03-15 day: 15 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The Journal of infectious diseases |
PublicationTitleAlternate | J Infect Dis |
PublicationYear | 2015 |
Publisher | Oxford University Press |
Publisher_xml | – name: Oxford University Press |
References | 16501126 - J Virol. 2006 Mar;80(6):3122-5 18301057 - AIDS. 2008 Feb 19;22(4):447-56 19372885 - Curr Opin HIV AIDS. 2007 May;2(3):183-8 21288826 - J Infect Dis. 2011 Jan 15;203(2):258-62 21051598 - Science. 2010 Dec 10;330(6010):1551-7 22926009 - J Infect Dis. 2012 Oct;206(8):1299-308 16467198 - Blood. 2006 Jun 15;107(12):4781-9 9952360 - J Infect Dis. 1999 Mar;179(3):548-57 14963115 - J Virol. 2004 Mar;78(5):2187-200 24958850 - J Exp Med. 2014 Jun 30;211(7):1273-80 20425558 - Curr HIV/AIDS Rep. 2010 May;7(2):53-9 18815234 - Clin Vaccine Immunol. 2008 Nov;15(11):1745-8 17182579 - J Immunol. 2007 Jan 1;178(1):407-15 12928421 - J Immunol. 2003 Sep 1;171(5):2671-83 22475592 - N Engl J Med. 2012 Apr 5;366(14):1275-86 21265010 - Cytometry A. 2011 Feb;79(2):167-74 20124101 - J Immunol. 2010 Mar 1;184(5):2710-7 16237108 - J Immunol. 2005 Nov 1;175(9):6117-22 16792805 - Retrovirology. 2006;3:35 19114861 - AIDS. 2009 Jan 28;23(3):329-33 16547245 - J Immunol. 2006 Apr 1;176(7):4094-101 19301980 - J Infect Dis. 2009 May 1;199(9):1318-22 12131208 - AIDS. 2002 Jul 5;16(10):1319-29 17982054 - J Immunol. 2007 Nov 15;179(10):6638-50 10640781 - J Immunol. 2000 Feb 1;164(3):1602-11 23395677 - Immunity. 2013 Feb 21;38(2):373-83 21270166 - J Virol. 2011 Apr;85(7):3507-16 11595286 - Immunol Lett. 2001 Nov 1;79(1-2):21-7 17406442 - Nat Protoc. 2006;1(3):1507-16 16777397 - Curr Opin Immunol. 2006 Aug;18(4):430-7 19372780 - Curr Opin HIV AIDS. 2006 Jan;1(1):28-33 17173051 - Nat Med. 2007 Jan;13(1):46-53 19893207 - Dis Markers. 2009;27(3):105-20 22152067 - J Transl Med. 2011;9:208 22238642 - PLoS One. 2012;7(1):e29717 ( key 20170425180515_JIU534C6) 2001; 79 ( key 20170425180515_JIU534C10) 2003; 171 ( key 20170425180515_JIU534C32) 2011; 85 ( key 20170425180515_JIU534C26) 2008; 22 ( key 20170425180515_JIU534C2) 2008; 15 ( key 20170425180515_JIU534C11) 2005; 175 ( key 20170425180515_JIU534C22) 2012; 206 ( key 20170425180515_JIU534C3) 1999; 179 ( key 20170425180515_JIU534C24) 2006; 1 ( key 20170425180515_JIU534C20) 2007; 2 ( key 20170425180515_JIU534C36) 2007; 178 ( key 20170425180515_JIU534C28) 2006; 80 ( key 20170425180515_JIU534C25) 2011; 79 ( key 20170425180515_JIU534C33) 2002; 16 ( key 20170425180515_JIU534C16) 2011; 9 ( key 20170425180515_JIU534C23) 2006; 176 ( key 20170425180515_JIU534C17) 2012; 7 ( key 20170425180515_JIU534C19) 2006; 18 ( key 20170425180515_JIU534C5) 2000; 164 ( key 20170425180515_JIU534C12) 2009; 27 ( key 20170425180515_JIU534C9) 2009; 199 ( key 20170425180515_JIU534C14) 2006; 107 ( key 20170425180515_JIU534C18) 2004; 78 ( key 20170425180515_JIU534C21) 2007; 179 ( key 20170425180515_JIU534C29) 2014; 211 ( key 20170425180515_JIU534C31) 2009 ( key 20170425180515_JIU534C30) 2013; 38 ( key 20170425180515_JIU534C13) 2010; 330 ( key 20170425180515_JIU534C27) 2007; 13 ( key 20170425180515_JIU534C34) 2010; 184 ( key 20170425180515_JIU534C8) 2006; 3 ( key 20170425180515_JIU534C15) 2006; 1 ( key 20170425180515_JIU534C1) 2010; 7 ( key 20170425180515_JIU534C7) 2011; 203 ( key 20170425180515_JIU534C35) 2012; 366 ( key 20170425180515_JIU534C4) 2009; 23 |
References_xml | – volume: 176 start-page: 4094 year: 2006 ident: key 20170425180515_JIU534C23 article-title: Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses publication-title: J Immunol doi: 10.4049/jimmunol.176.7.4094 – volume: 79 start-page: 21 year: 2001 ident: key 20170425180515_JIU534C6 article-title: Immune defence against HIV-1 infection in HIV-1-exposed seronegative persons publication-title: Immunol Lett doi: 10.1016/S0165-2478(01)00262-0 – volume: 23 start-page: 329 year: 2009 ident: key 20170425180515_JIU534C4 article-title: Oral HIV-exposure elicits mucosal HIV-neutralizing antibodies in uninfected men who have sex with men publication-title: AIDS doi: 10.1097/QAD.0b013e32831f924c – volume: 171 start-page: 2671 year: 2003 ident: key 20170425180515_JIU534C10 article-title: Most highly exposed seronegative men lack HIV-1-specific, IFN-gamma-secreting T cells publication-title: J Immunol doi: 10.4049/jimmunol.171.5.2671 – volume: 13 start-page: 46 year: 2007 ident: key 20170425180515_JIU534C27 article-title: CD8+ T-cell responses to different HIV proteins have discordant associations with viral load publication-title: Nat Med doi: 10.1038/nm1520 – volume: 9 start-page: 208 year: 2011 ident: key 20170425180515_JIU534C16 article-title: Definition of the viral targets of protective HIV-1-specific T cell responses publication-title: J Transl Med doi: 10.1186/1479-5876-9-208 – volume: 164 start-page: 1602 year: 2000 ident: key 20170425180515_JIU534C5 article-title: HIV-1-specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi publication-title: J Immunol doi: 10.4049/jimmunol.164.3.1602 – volume: 22 start-page: 447 year: 2008 ident: key 20170425180515_JIU534C26 article-title: Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity publication-title: AIDS doi: 10.1097/QAD.0b013e3282f42412 – volume: 3 start-page: 35 year: 2006 ident: key 20170425180515_JIU534C8 article-title: Reduced CD4T cell activation and in-vitro susceptibility to HIV-1 infection in exposed uninfected Central Africans publication-title: Retrovirology doi: 10.1186/1742-4690-3-35 – volume: 15 start-page: 1745 year: 2008 ident: key 20170425180515_JIU534C2 article-title: Potentially exposed but uninfected individuals produce cytotoxic and polyfunctional human immunodeficiency virus type 1-specific CD8(+) T-cell responses which can be defined to the epitope level publication-title: Clin Vaccine Immunol doi: 10.1128/CVI.00247-08 – volume: 199 start-page: 1318 year: 2009 ident: key 20170425180515_JIU534C9 article-title: Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells publication-title: J Infect Dis doi: 10.1086/597801 – volume: 18 start-page: 430 year: 2006 ident: key 20170425180515_JIU534C19 article-title: The challenges of host and viral diversity in HIV vaccine design publication-title: Curr Opin Immunol doi: 10.1016/j.coi.2006.05.012 – volume: 107 start-page: 4781 year: 2006 ident: key 20170425180515_JIU534C14 article-title: HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells publication-title: Blood doi: 10.1182/blood-2005-12-4818 – volume: 179 start-page: 6638 year: 2007 ident: key 20170425180515_JIU534C21 article-title: Increased sequence diversity coverage improves detection of HIV-specific T cell responses publication-title: J Immunol doi: 10.4049/jimmunol.179.10.6638 – volume: 78 start-page: 2187 year: 2004 ident: key 20170425180515_JIU534C18 article-title: Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities publication-title: J Virol doi: 10.1128/JVI.78.5.2187-2200.2004 – volume: 38 start-page: 373 year: 2013 ident: key 20170425180515_JIU534C30 article-title: Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults publication-title: Immunity doi: 10.1016/j.immuni.2012.10.021 – volume: 206 start-page: 1299 year: 2012 ident: key 20170425180515_JIU534C22 article-title: Quantifying ongoing HIV-1 exposure in HIV-1-serodiscordant couples to identify individuals with potential host resistance to HIV-1 publication-title: J Infect Dis doi: 10.1093/infdis/jis480 – volume: 85 start-page: 3507 year: 2011 ident: key 20170425180515_JIU534C32 article-title: Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals publication-title: J Virol doi: 10.1128/JVI.02444-10 – volume: 7 start-page: e29717 year: 2012 ident: key 20170425180515_JIU534C17 article-title: CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control publication-title: PLoS One doi: 10.1371/journal.pone.0029717 – volume: 27 start-page: 105 year: 2009 ident: key 20170425180515_JIU534C12 article-title: Virological, immune and host genetics markers in the control of HIV infection publication-title: Dis Markers doi: 10.1155/2009/360362 – volume: 7 start-page: 53 year: 2010 ident: key 20170425180515_JIU534C1 article-title: Systems biology-based approaches to understand HIV-exposed uninfected women publication-title: Curr HIV/AIDS Rep doi: 10.1007/s11904-010-0039-3 – volume-title: HIV molecular immunology year: 2009 ident: key 20170425180515_JIU534C31 article-title: How to optimally define optimal cytotoxic T lymphocyte epitopes in HIV infection? – volume: 1 start-page: 28 year: 2006 ident: key 20170425180515_JIU534C15 article-title: Qualitative host factors associated with immunological control of HIV infection by CD8T cells publication-title: Curr Opin HIV AIDS doi: 10.1097/01.COH.0000194108.14601.69 – volume: 175 start-page: 6117 year: 2005 ident: key 20170425180515_JIU534C11 article-title: Low-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infection publication-title: J Immunol doi: 10.4049/jimmunol.175.9.6117 – volume: 80 start-page: 3122 year: 2006 ident: key 20170425180515_JIU534C28 article-title: Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control publication-title: J Virol doi: 10.1128/JVI.80.6.3122-3125.2006 – volume: 2 start-page: 183 year: 2007 ident: key 20170425180515_JIU534C20 article-title: Capturing viral diversity for in-vitro test reagents and HIV vaccine immunogen design publication-title: Curr Opin HIV AIDS doi: 10.1097/COH.0b013e3280f3bfe2 – volume: 179 start-page: 548 year: 1999 ident: key 20170425180515_JIU534C3 article-title: Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects publication-title: J Infect Dis doi: 10.1086/314632 – volume: 203 start-page: 258 year: 2011 ident: key 20170425180515_JIU534C7 article-title: Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals publication-title: J Infect Dis doi: 10.1093/infdis/jiq028 – volume: 366 start-page: 1275 year: 2012 ident: key 20170425180515_JIU534C35 article-title: Immune-correlates analysis of an HIV-1 vaccine efficacy trial publication-title: N Engl J Med doi: 10.1056/NEJMoa1113425 – volume: 16 start-page: 1319 year: 2002 ident: key 20170425180515_JIU534C33 article-title: Activation of HIV-1 specific CD4 and CD8T cells by human dendritic cells: roles for cross-presentation and non-infectious HIV-1 virus publication-title: AIDS doi: 10.1097/00002030-200207050-00003 – volume: 1 start-page: 1507 year: 2006 ident: key 20170425180515_JIU534C24 article-title: Intracellular cytokine optimization and standard operating procedure publication-title: Nat Protoc doi: 10.1038/nprot.2006.268 – volume: 178 start-page: 407 year: 2007 ident: key 20170425180515_JIU534C36 article-title: IL-22 participates in an innate anti-HIV-1 host-resistance network through acute-phase protein induction publication-title: J Immunol doi: 10.4049/jimmunol.178.1.407 – volume: 211 start-page: 1273 year: 2014 ident: key 20170425180515_JIU534C29 article-title: Proteome-wide analysis of HIV-specific naive and memory CD4+ T cells in unexposed blood donors publication-title: J Exp Med doi: 10.1084/jem.20130555 – volume: 184 start-page: 2710 year: 2010 ident: key 20170425180515_JIU534C34 article-title: TLR activation pathways in HIV-1-exposed seronegative individuals publication-title: J Immunol doi: 10.4049/jimmunol.0902463 – volume: 330 start-page: 1551 year: 2010 ident: key 20170425180515_JIU534C13 article-title: The major genetic determinants of HIV-1 control affect HLA class I peptide presentation publication-title: Science doi: 10.1126/science.1195271 – volume: 79 start-page: 167 year: 2011 ident: key 20170425180515_JIU534C25 article-title: SPICE: Exploration and analysis of post-cytometric complex multivariate datasets publication-title: Cytometry A |
SSID | ssj0004367 |
Score | 2.287683 |
Snippet | The characterization of host immune responses to human immunodeficiency virus (HIV) in HIV controllers and individuals with high exposure but seronegativity to... |
SourceID | pubmedcentral proquest crossref pubmed jstor |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 936 |
SubjectTerms | Cells, Cultured Cytokines - metabolism Cytokines - secretion Disease Resistance HIV - immunology HIV/AIDS Human immunodeficiency virus Humans Immunity, Cellular Major and Brief Reports T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - secretion T-Lymphocytes, Helper-Inducer - virology |
Title | Alternative Effector-Function Profiling Identifies Broad HIV-Specific T-Cell Responses in Highly HIV-Exposed Individuals Who Remain Uninfected |
URI | https://www.jstor.org/stable/43709510 https://www.ncbi.nlm.nih.gov/pubmed/25249264 https://search.proquest.com/docview/1658705155 https://search.proquest.com/docview/1694971957 https://pubmed.ncbi.nlm.nih.gov/PMC4416125 |
Volume | 211 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLXKEIgXBION8iUjIV6qbE1i5-Nxmlo61A00tdC3yLEdLdCl09oith_BT-E3cu2bpCmd0OAlqlzXrnRO7Ovrc-8l5K3HNFcpDxwF5jQcUIR20m4qnSjjcRb40hfKxA4fnwSDMfsw4ZNW61dDtbRcpHvy-sa4kv9BFdoAVxMl-w_I1oNCA3wGfOEJCMPzVhgfTEt33nfdwTTEs0unDzuVBfWTLcdtFQEKNUF6DljOhOoMjj47tvJ8lsvOyDk0DrxTVMtagZaVf0yvbL_ej4vZXBvRcBW6Ne98OZtB_3MBPcFotXqu9Yqfq4izMikFSr6W8-pGqCGxz6-d0xwLfZmkBvU-MZyKAoNwiuX8W918lJq8kYXCKyNh9vXa-y3OjfIYf1Xpdpp-DZcbYRdGdjbiDNwIyyft6Wp5Dh2wKPzm-u2Vq3W-sRrHftDY2GP0dW7sGZhPC5qUyerQ_5oveelfXcvOffIx6Y-Hw2TUm4zukLteGHMjIX0_WUmKmB-EVXZ688_LnK4wwT4Ov4-Dr9lAKIO96YDzp063YfiMHpGHJYr0AOn3mLR0sU3uYQ3Tq21y_7hUZzwhPxt8pBt8pDUf6YqP1PKRNvlIkY-05iPNC4p8pA0-0gYfKfCRIh_pio9PybjfGx0OnLLehyMZ8xaOiJiIMuWBxZ9mgQglrCGpzFxXK83crnKVr5UIQ-GKyBVumslIdlNPprHLtWLC3yFbxazQzwj1fckDxVLu-YIFQkXaYxJIpjIVZyzibfKuQiC5wLQuCcox_AShShCqNtmx-NS9mB_aU0mbvKkAS2BFNtdsotDwHiUuGPWhLZ30tz4xi0M35mGb7CLI9Qwet1k8YepwDf66g8kIv_5NkZ_ZzPDMuCs8_vwW874gD1Zv3Uuytbhc6ldgXy_S15bUvwFkcNx3 |
link.rule.ids | 230,315,786,790,891,27955,27956 |
linkProvider | Geneva Foundation for Medical Education and Research |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Alternative+Effector-Function+Profiling+Identifies+Broad+HIV-Specific+T-Cell+Responses+in+Highly+HIV-Exposed+Individuals+Who+Remain+Uninfected&rft.jtitle=The+Journal+of+infectious+diseases&rft.au=Ruiz-Riol%2C+Marta&rft.au=Llano%2C+Anuska&rft.au=Ibarrondo%2C+Javier&rft.au=Zamarreno%2C+Jennifer&rft.date=2015-03-15&rft.issn=0022-1899&rft.eissn=1537-6613&rft.volume=211&rft.issue=6&rft.spage=936&rft.epage=946&rft_id=info:doi/10.1093%2Finfdis%2Fjiu534&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-1899&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-1899&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-1899&client=summon |