MicroRNA-135a Protects Against Ethanol-Induced Apoptosis in Neural Crest Cells and Craniofacial Defects in Zebrafish by Modulating the Siah1/p38/p53 Pathway

MicroRNAs (miRNAs) are small non-coding RNAs that are involved in various biological processes, including apoptosis, by regulating gene expression. This study was designed to test the hypothesis that ethanol-induced downregulation of miR-135a contributes to ethanol-induced apoptosis in neural crest...

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Published inFrontiers in cell and developmental biology Vol. 8; p. 583959
Main Authors Yuan, Fuqiang, Yun, Yang, Fan, Huadong, Li, Yihong, Lu, Lanhai, Liu, Jie, Feng, Wenke, Chen, Shao-yu
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 02.10.2020
Subjects
apoptosis
Cell and Developmental Biology
craniofacial defects
ethanol
miRNA-135a
neural crest cells
Siah1
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Abstract MicroRNAs (miRNAs) are small non-coding RNAs that are involved in various biological processes, including apoptosis, by regulating gene expression. This study was designed to test the hypothesis that ethanol-induced downregulation of miR-135a contributes to ethanol-induced apoptosis in neural crest cells (NCCs) by upregulating Siah1 and activating the p38 mitogen-activated protein kinase (MAPK)/p53 pathway. We found that treatment with ethanol resulted in a significant decrease in miR-135a expression in both NCCs and zebrafish embryos. Ethanol-induced downregulation of miR-135a resulted in the upregulation of Siah1 and the activation of the p38 MAPK/p53 pathway and increased apoptosis in NCCs and zebrafish embryos. Ethanol exposure also resulted in growth retardation and developmental defects that are characteristic of fetal alcohol spectrum disorders (FASD) in zebrafish. Overexpression of miRNA-135a significantly reduced ethanol-induced upregulation of Siah1 and the activation of the p38 MAPK/p53 pathway and decreased ethanol-induced apoptosis in NCCs and zebrafish embryos. In addition, ethanol-induced growth retardation and craniofacial defects in zebrafish larvae were dramatically diminished by the microinjection of miRNA-135a mimics. These results demonstrated that ethanol-induced downregulation of miR-135a contributes to ethanol-induced apoptosis in NCCs by upregulating Siah1 and activating the p38 MAPK/p53 pathway and that the overexpression of miRNA-135a can protect against ethanol-induced apoptosis in NCCs and craniofacial defects in a zebrafish model of FASD.
AbstractList MicroRNAs (miRNAs) are small non-coding RNAs that are involved in various biological processes, including apoptosis, by regulating gene expression. This study was designed to test the hypothesis that ethanol-induced downregulation of miR-135a contributes to ethanol-induced apoptosis in neural crest cells (NCCs) by upregulating Siah1 and activating the p38 mitogen-activated protein kinase (MAPK)/p53 pathway. We found that treatment with ethanol resulted in a significant decrease in miR-135a expression in both NCCs and zebrafish embryos. Ethanol-induced downregulation of miR-135a resulted in the upregulation of Siah1 and the activation of the p38 MAPK/p53 pathway and increased apoptosis in NCCs and zebrafish embryos. Ethanol exposure also resulted in growth retardation and developmental defects that are characteristic of fetal alcohol spectrum disorders (FASD) in zebrafish. Overexpression of miRNA-135a significantly reduced ethanol-induced upregulation of Siah1 and the activation of the p38 MAPK/p53 pathway and decreased ethanol-induced apoptosis in NCCs and zebrafish embryos. In addition, ethanol-induced growth retardation and craniofacial defects in zebrafish larvae were dramatically diminished by the microinjection of miRNA-135a mimics. These results demonstrated that ethanol-induced downregulation of miR-135a contributes to ethanol-induced apoptosis in NCCs by upregulating Siah1 and activating the p38 MAPK/p53 pathway and that the overexpression of miRNA-135a can protect against ethanol-induced apoptosis in NCCs and craniofacial defects in a zebrafish model of FASD.
Author Liu, Jie
Li, Yihong
Yun, Yang
Feng, Wenke
Yuan, Fuqiang
Chen, Shao-yu
Fan, Huadong
Lu, Lanhai
AuthorAffiliation 1 Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center , Louisville, KY , United States
3 College of Environment and Resource, Research Center of Environment and Health, Shanxi University , Taiyuan , China
2 University of Louisville Alcohol Research Center , Louisville, KY , United States
4 Department of Medicine, University of Louisville , Louisville, KY , United States
AuthorAffiliation_xml – name: 4 Department of Medicine, University of Louisville , Louisville, KY , United States
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– name: 3 College of Environment and Resource, Research Center of Environment and Health, Shanxi University , Taiyuan , China
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Edited by: Christian Kirschneck, University Medical Center Regensburg, Germany
Reviewed by: Sabrina Kathrin Schulze, University of Potsdam, Germany; Guido Artemio Marañón-Vásquez, Federal University of Rio de Janeiro, Brazil
This article was submitted to Cell Growth and Division, a section of the journal Frontiers in Cell and Developmental Biology
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Snippet MicroRNAs (miRNAs) are small non-coding RNAs that are involved in various biological processes, including apoptosis, by regulating gene expression. This study...
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SubjectTerms apoptosis
Cell and Developmental Biology
craniofacial defects
ethanol
miRNA-135a
neural crest cells
Siah1
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Title MicroRNA-135a Protects Against Ethanol-Induced Apoptosis in Neural Crest Cells and Craniofacial Defects in Zebrafish by Modulating the Siah1/p38/p53 Pathway
URI https://search.proquest.com/docview/2456853606
https://pubmed.ncbi.nlm.nih.gov/PMC7561719
https://doaj.org/article/9eab041735554b34b4f595d65fd70e55
Volume 8
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