Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness

Development of novel treatments and diagnostic tools for psychiatric illness has been hindered by the absence of cellular models of disease. With the advent of cellular reprogramming, it may be possible to recapitulate the disease biology of psychiatric disorders using patient skin cells transdiffer...

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Published inTranslational psychiatry Vol. 4; no. 8; p. e428
Main Authors Wang, J L, Shamah, S M, Sun, A X, Waldman, I D, Haggarty, S J, Perlis, R H
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.08.2014
Nature Publishing Group
Subjects
631/378/87
631/80/2373
692/699/476/1333
Affect - drug effects
Behavioral Sciences
Biological Psychology
Bipolar Disorder - drug therapy
Bipolar Disorder - genetics
Bipolar Disorder - physiopathology
Cellular Reprogramming - drug effects
Cellular Reprogramming - physiology
Genome-Wide Association Study
Humans
Lithium Carbonate - pharmacology
Lithium Carbonate - therapeutic use
Medicine
Medicine & Public Health
Neurosciences
Optical Imaging
Original
original-article
Pharmacogenetics
Pharmacotherapy
Psychiatry
Sodium-Bicarbonate Symporters - genetics
Treatment Outcome
Online AccessGet full text

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Abstract Development of novel treatments and diagnostic tools for psychiatric illness has been hindered by the absence of cellular models of disease. With the advent of cellular reprogramming, it may be possible to recapitulate the disease biology of psychiatric disorders using patient skin cells transdifferentiated to neurons. However, efficiently identifying and characterizing relevant neuronal phenotypes in the absence of well-defined pathophysiology remains a challenge. In this study, we collected fibroblast samples from patients with bipolar 1 disorder, characterized by their lithium response ( n =12), and healthy control subjects ( n =6). We identified a cellular phenotype in reprogrammed neurons using a label-free imaging assay based on a nanostructured photonic crystal biosensor and found that an optical measure of cell adhesion was associated with clinical response to lithium treatment. This cellular phenotype may represent a useful biomarker to evaluate drug response and screen for novel therapeutics.
AbstractList Development of novel treatments and diagnostic tools for psychiatric illness has been hindered by the absence of cellular models of disease. With the advent of cellular reprogramming, it may be possible to recapitulate the disease biology of psychiatric disorders using patient skin cells transdifferentiated to neurons. However, efficiently identifying and characterizing relevant neuronal phenotypes in the absence of well-defined pathophysiology remains a challenge. In this study, we collected fibroblast samples from patients with bipolar 1 disorder, characterized by their lithium response (n=12), and healthy control subjects (n=6). We identified a cellular phenotype in reprogrammed neurons using a label-free imaging assay based on a nanostructured photonic crystal biosensor and found that an optical measure of cell adhesion was associated with clinical response to lithium treatment. This cellular phenotype may represent a useful biomarker to evaluate drug response and screen for novel therapeutics.
Development of novel treatments and diagnostic tools for psychiatric illness has been hindered by the absence of cellular models of disease. With the advent of cellular reprogramming, it may be possible to recapitulate the disease biology of psychiatric disorders using patient skin cells transdifferentiated to neurons. However, efficiently identifying and characterizing relevant neuronal phenotypes in the absence of well-defined pathophysiology remains a challenge. In this study, we collected fibroblast samples from patients with bipolar 1 disorder, characterized by their lithium response (n=12), and healthy control subjects (n=6). We identified a cellular phenotype in reprogrammed neurons using a label-free imaging assay based on a nanostructured photonic crystal biosensor and found that an optical measure of cell adhesion was associated with clinical response to lithium treatment. This cellular phenotype may represent a useful biomarker to evaluate drug response and screen for novel therapeutics.Development of novel treatments and diagnostic tools for psychiatric illness has been hindered by the absence of cellular models of disease. With the advent of cellular reprogramming, it may be possible to recapitulate the disease biology of psychiatric disorders using patient skin cells transdifferentiated to neurons. However, efficiently identifying and characterizing relevant neuronal phenotypes in the absence of well-defined pathophysiology remains a challenge. In this study, we collected fibroblast samples from patients with bipolar 1 disorder, characterized by their lithium response (n=12), and healthy control subjects (n=6). We identified a cellular phenotype in reprogrammed neurons using a label-free imaging assay based on a nanostructured photonic crystal biosensor and found that an optical measure of cell adhesion was associated with clinical response to lithium treatment. This cellular phenotype may represent a useful biomarker to evaluate drug response and screen for novel therapeutics.
Development of novel treatments and diagnostic tools for psychiatric illness has been hindered by the absence of cellular models of disease. With the advent of cellular reprogramming, it may be possible to recapitulate the disease biology of psychiatric disorders using patient skin cells transdifferentiated to neurons. However, efficiently identifying and characterizing relevant neuronal phenotypes in the absence of well-defined pathophysiology remains a challenge. In this study, we collected fibroblast samples from patients with bipolar 1 disorder, characterized by their lithium response ( n =12), and healthy control subjects ( n =6). We identified a cellular phenotype in reprogrammed neurons using a label-free imaging assay based on a nanostructured photonic crystal biosensor and found that an optical measure of cell adhesion was associated with clinical response to lithium treatment. This cellular phenotype may represent a useful biomarker to evaluate drug response and screen for novel therapeutics.
Author Sun, A X
Waldman, I D
Perlis, R H
Haggarty, S J
Shamah, S M
Wang, J L
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Cites_doi 10.1016/j.biopsych.2010.01.020
10.1093/hmg/ddr532
10.1016/j.neuron.2013.06.002
10.1016/S0140-6736(10)60570-3
10.1111/j.1600-0447.2009.01454.x
10.1038/nature12630
10.4088/JCP.v63n1013
10.1016/j.tcb.2005.02.002
10.1016/j.psychres.2012.11.002
10.1016/S0301-0082(01)00011-9
10.1038/nbt.1529
10.1016/j.neubiorev.2010.10.001
10.1038/nn.3041
10.1016/S0140-6736(12)61729-2
10.1016/j.biopsych.2013.01.020
10.1038/nmeth.1972
10.1371/journal.pone.0065636
10.1261/rna.2192803
10.1136/bmj.f3646
10.1001/archpsyc.58.9.844
10.1177/1087057111399337
10.1038/417292a
10.1016/j.jpsychires.2011.10.011
10.1016/j.biopsych.2003.10.006
10.1039/c0an00899k
10.1038/nature08797
10.1111/bdi.12025
10.4088/JCP.v63n1213
10.1038/nature10323
10.1016/j.neuron.2013.01.023
10.1080/01621459.1987.10478472
10.1007/s11064-013-0977-4
10.1038/nrn2373
10.1681/ASN.V781091
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References Bova, Nguyen, Wallace, Garrido, Xu, Semko (CR13) 2011; 16
Cipriani, Hawton, Stockton, Geddes (CR22) 2013; 346
Nacher, Guirado, Castillo-Gómez (CR26) 2013; 38
Qiang, Fujita, Abeliovich (CR11) 2013; 78
Faull, Ginsberg (CR12) 1996; 7
Manchia, Adli, Akula, Ardau, Aubry, Backlund (CR16) 2013; 8
Stewart, Dykxhoorn, Palliser, Mizuno, Yu, An (CR17) 2003; 9
Cingolani, Goda (CR31) 2008; 9
Hill, Jeffries, Dobson, Price, Bray (CR29) 2012; 21
Takeichi, Abe (CR33) 2005; 15
Vos, Flaxman, Naghavi, Lozano, Michaud, Ezzati (CR2) 2012; 380
Cohen, Cohen, West, Aiken (CR18) 2002
Osby, Brandt, Correia, Ekbom, Sparen (CR1) 2001; 58
Geddes, Goodwin, Rendell, Azorin, Cipriani, Ostacher (CR4) 2010; 375
Bora, Fornito, Yücel, Pantelis (CR23) 2010; 67
Ladewig, Mertens, Kesavan, Doerr, Poppe, Glaue (CR10) 2012; 9
Varea, Guirado, Gilabert-Juan, Martí, Castillo-Gómez, Blasco-Ibáñez (CR27) 2012; 46
Han, Holder, Schaaf, Lu, Chen, Kang (CR32) 2013; 503
Grimes, Jope (CR35) 2001; 65
Shi, Kirwan, Smith, Robinson, Livesey (CR6) 2012; 15
Berk, Kapczinski, Andreazza, Dean, Giorlando, Maes (CR24) 2011; 35
Fan, Abrahamsen, Mills, Calderón, Tee, Leyton (CR25) 2013; 74
Yatham, Kennedy, Parikh, Schaffer, Beaulieu, Alda (CR3) 2013; 15
Self, Liang (CR19) 1987; 82
Vierbuchen, Ostermeier, Pang, Kokubu, Südhof, Wernig (CR8) 2010; 463
Williams, Cheng, Mudge, Harwood (CR34) 2002; 417
Shamah, Cunningham (CR14) 2011; 136
Duffy, Alda, Kutcher, Cavazzoni, Robertson, Grof (CR20) 2002; 63
Sprooten, Fleming, Thomson, Bastin, Whalley, Hall (CR28) 2013; 206
Yoo, Sun, Li, Shcheglovitov, Portmann, Li, Lee-Messer, Dolmetsch, Tsien, Crabtree (CR9) 2011; 476
Blanpied, Ehlers (CR30) 2004; 55
Chambers, Fasano, Papapetrou, Tomishima, Sadelain, Studer (CR5) 2009; 27
Wang, Dolmetsch (CR7) 2013; 77
Grof, Duffy, Alda, Hajek (CR21) 2009; 120
Grof, Duffy, Cavazzoni, Grof, Garnham, MacDougall (CR15) 2002; 63
MJ Hill (BFtp201472_CR29) 2012; 21
MP Bova (BFtp201472_CR13) 2011; 16
M Takeichi (BFtp201472_CR33) 2005; 15
RJ Faull (BFtp201472_CR12) 1996; 7
TA Blanpied (BFtp201472_CR30) 2004; 55
E Bora (BFtp201472_CR23) 2010; 67
CA Grimes (BFtp201472_CR35) 2001; 65
A Cipriani (BFtp201472_CR22) 2013; 346
Y Wang (BFtp201472_CR7) 2013; 77
J Ladewig (BFtp201472_CR10) 2012; 9
SG Self (BFtp201472_CR19) 1987; 82
Andrew S. Yoo (BFtp201472_CR9) 2011; 476
U Osby (BFtp201472_CR1) 2001; 58
SM Chambers (BFtp201472_CR5) 2009; 27
LN Yatham (BFtp201472_CR3) 2013; 15
SM Shamah (BFtp201472_CR14) 2011; 136
T Vos (BFtp201472_CR2) 2012; 380
L Qiang (BFtp201472_CR11) 2013; 78
M Manchia (BFtp201472_CR16) 2013; 8
E Sprooten (BFtp201472_CR28) 2013; 206
M Berk (BFtp201472_CR24) 2011; 35
A Duffy (BFtp201472_CR20) 2002; 63
SA Stewart (BFtp201472_CR17) 2003; 9
P Grof (BFtp201472_CR15) 2002; 63
E Varea (BFtp201472_CR27) 2012; 46
K Han (BFtp201472_CR32) 2013; 503
RSB Williams (BFtp201472_CR34) 2002; 417
J Cohen (BFtp201472_CR18) 2002
Y Fan (BFtp201472_CR25) 2013; 74
Y Shi (BFtp201472_CR6) 2012; 15
P Grof (BFtp201472_CR21) 2009; 120
LA Cingolani (BFtp201472_CR31) 2008; 9
J Nacher (BFtp201472_CR26) 2013; 38
JR Geddes (BFtp201472_CR4) 2010; 375
T Vierbuchen (BFtp201472_CR8) 2010; 463
11545667 - Arch Gen Psychiatry. 2001 Sep;58(9):844-50
22099865 - J Psychiatr Res. 2012 Feb;46(2):189-97
23814104 - BMJ. 2013;346:f3646
20934453 - Neurosci Biobehav Rev. 2011 Jan;35(3):804-17
8866399 - J Am Soc Nephrol. 1996 Aug;7(8):1091-7
23840348 - PLoS One. 2013 Jun 19;8(6):e65636
20303066 - Biol Psychiatry. 2010 Jun 1;67(11):1097-105
23245607 - Lancet. 2012 Dec 15;380(9859):2163-96
19252484 - Nat Biotechnol. 2009 Mar;27(3):275-80
23482246 - Biol Psychiatry. 2013 Sep 15;74(6):418-26
18425089 - Nat Rev Neurosci. 2008 May;9(5):344-56
15817378 - Trends Cell Biol. 2005 Apr;15(4):216-21
20107439 - Nature. 2010 Feb 25;463(7284):1035-41
19807719 - Acta Psychiatr Scand. 2009 Nov;120(5):378-85
23354722 - Neurochem Res. 2013 Jun;38(6):1122-33
24153177 - Nature. 2013 Nov 7;503(7474):72-7
22306606 - Nat Neurosci. 2012 Mar;15(3):477-86, S1
12015604 - Nature. 2002 May 16;417(6886):292-5
21406619 - J Biomol Screen. 2011 Jun;16(5):536-44
23237061 - Bipolar Disord. 2013 Feb;15(1):1-44
22484851 - Nat Methods. 2012 Jun;9(6):575-8
21279202 - Analyst. 2011 Mar 21;136(6):1090-102
12523878 - J Clin Psychiatry. 2002 Dec;63(12):1171-8
20092882 - Lancet. 2010 Jan 30;375(9712):385-95
12649500 - RNA. 2003 Apr;9(4):493-501
15184030 - Biol Psychiatry. 2004 Jun 15;55(12):1121-7
23218918 - Psychiatry Res. 2013 Apr 30;206(2-3):223-31
23791192 - Neuron. 2013 Jun 19;78(6):957-69
22080834 - Hum Mol Genet. 2012 Mar 1;21(5):1018-24
23395367 - Neuron. 2013 Feb 6;77(3):379-81
12416605 - J Clin Psychiatry. 2002 Oct;63(10):942-7
21753754 - Nature. 2011 Aug 11;476(7359):228-31
11527574 - Prog Neurobiol. 2001 Nov;65(4):391-426
References_xml – volume: 67
  start-page: 1097
  year: 2010
  end-page: 1105
  ident: CR23
  article-title: Voxelwise meta-analysis of gray matter abnormalities in bipolar disorder
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2010.01.020
– volume: 21
  start-page: 1018
  year: 2012
  end-page: 1024
  ident: CR29
  article-title: Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddr532
– volume: 78
  start-page: 957
  year: 2013
  end-page: 969
  ident: CR11
  article-title: Remodeling neurodegeneration: somatic cell reprogramming-based models of adult neurological disorders
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.06.002
– volume: 375
  start-page: 385
  year: 2010
  end-page: 395
  ident: CR4
  article-title: Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(10)60570-3
– volume: 120
  start-page: 378
  year: 2009
  end-page: 385
  ident: CR21
  article-title: Lithium response across generations
  publication-title: Acta Psychiatr Scand
  doi: 10.1111/j.1600-0447.2009.01454.x
– volume: 503
  start-page: 72
  year: 2013
  end-page: 77
  ident: CR32
  article-title: SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties
  publication-title: Nature
  doi: 10.1038/nature12630
– volume: 63
  start-page: 942
  year: 2002
  end-page: 947
  ident: CR15
  article-title: Is response to prophylactic lithium a familial trait?
  publication-title: J Clin Psychiatry
  doi: 10.4088/JCP.v63n1013
– volume: 15
  start-page: 216
  year: 2005
  end-page: 221
  ident: CR33
  article-title: Synaptic contact dynamics controlled by cadherin and catenins
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2005.02.002
– volume: 206
  start-page: 223
  year: 2013
  end-page: 231
  ident: CR28
  article-title: White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder
  publication-title: Psychiatry Res
  doi: 10.1016/j.psychres.2012.11.002
– volume: 65
  start-page: 391
  year: 2001
  end-page: 426
  ident: CR35
  article-title: The multifaceted roles of glycogen synthase kinase 3b in cellular signaling
  publication-title: Prog Neurobiol
  doi: 10.1016/S0301-0082(01)00011-9
– volume: 7
  start-page: 1091
  year: 1996
  end-page: 1097
  ident: CR12
  article-title: Inside-out signaling through integrins
  publication-title: J Am Soc Nephrol
– volume: 27
  start-page: 275
  year: 2009
  end-page: 280
  ident: CR5
  article-title: Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.1529
– volume: 35
  start-page: 804
  year: 2011
  end-page: 817
  ident: CR24
  article-title: Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2010.10.001
– volume: 15
  start-page: 477
  year: 2012
  end-page: 486
  ident: CR6
  article-title: Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3041
– volume: 380
  start-page: 2163
  year: 2012
  end-page: 2196
  ident: CR2
  article-title: Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
  publication-title: Lancet
  doi: 10.1016/S0140-6736(12)61729-2
– volume: 74
  start-page: 418
  year: 2013
  end-page: 426
  ident: CR25
  article-title: Focal adhesion dynamics are altered in schizophrenia
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2013.01.020
– year: 2002
  ident: CR18
  publication-title: Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences
– volume: 9
  start-page: 575
  year: 2012
  end-page: 578
  ident: CR10
  article-title: Small molecules enable highly efficient neuronal conversion of human fibroblasts
  publication-title: Nat Methods
  doi: 10.1038/nmeth.1972
– volume: 8
  start-page: e65636
  year: 2013
  ident: CR16
  article-title: Assessment of response to lithium maintenance treatment in bipolar disorder: a Consortium on Lithium Genetics (ConLiGen) Report
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0065636
– volume: 9
  start-page: 493
  year: 2003
  end-page: 501
  ident: CR17
  article-title: Lentivirus-delivered stable gene silencing by RNAi in primary cells
  publication-title: RNA
  doi: 10.1261/rna.2192803
– volume: 346
  start-page: f3646
  year: 2013
  ident: CR22
  article-title: Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis
  publication-title: BMJ
  doi: 10.1136/bmj.f3646
– volume: 58
  start-page: 844
  year: 2001
  end-page: 850
  ident: CR1
  article-title: Excess mortality in bipolar and unipolar disorder in Sweden
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.58.9.844
– volume: 16
  start-page: 536
  year: 2011
  end-page: 544
  ident: CR13
  article-title: A label-free approach to identify inhibitors of alpha4beta7-mediated cell adhesion to MadCAM
  publication-title: J Biomol Screen
  doi: 10.1177/1087057111399337
– volume: 417
  start-page: 292
  year: 2002
  end-page: 295
  ident: CR34
  article-title: A common mechanism of action for three mood-stabilizing drugs
  publication-title: Nature
  doi: 10.1038/417292a
– volume: 46
  start-page: 189
  year: 2012
  end-page: 197
  ident: CR27
  article-title: Expression of PSA-NCAM and synaptic proteins in the amygdala of psychiatric disorder patients
  publication-title: J Psychiatr Res
  doi: 10.1016/j.jpsychires.2011.10.011
– volume: 55
  start-page: 1121
  year: 2004
  end-page: 1127
  ident: CR30
  article-title: Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2003.10.006
– volume: 136
  start-page: 1090
  year: 2011
  end-page: 1102
  ident: CR14
  article-title: Label-free cell-based assays using photonic crystal optical biosensors
  publication-title: Analyst
  doi: 10.1039/c0an00899k
– volume: 463
  start-page: 1035
  year: 2010
  end-page: 1041
  ident: CR8
  article-title: Direct conversion of fibroblasts to functional neurons by defined factors
  publication-title: Nature
  doi: 10.1038/nature08797
– volume: 15
  start-page: 1
  year: 2013
  end-page: 44
  ident: CR3
  article-title: Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013
  publication-title: Bipolar disord
  doi: 10.1111/bdi.12025
– volume: 63
  start-page: 1171
  year: 2002
  end-page: 1178
  ident: CR20
  article-title: A prospective study of the offspring of bipolar parents responsive and nonresponsive to lithium treatment
  publication-title: J Clin Psychiatry
  doi: 10.4088/JCP.v63n1213
– volume: 476
  start-page: 228
  issue: 7359
  year: 2011
  end-page: 231
  ident: CR9
  article-title: MicroRNA-mediated conversion of human fibroblasts to neurons
  publication-title: Nature
  doi: 10.1038/nature10323
– volume: 77
  start-page: 379
  year: 2013
  end-page: 381
  ident: CR7
  article-title: human corticogenesis
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.01.023
– volume: 82
  start-page: 398
  year: 1987
  ident: CR19
  article-title: Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions
  publication-title: J Am Stat Asso
  doi: 10.1080/01621459.1987.10478472
– volume: 38
  start-page: 1122
  year: 2013
  end-page: 1133
  ident: CR26
  article-title: Structural plasticity of interneurons in the adult brain: role of PSA-NCAM and implications for psychiatric disorders
  publication-title: Neurochem Res
  doi: 10.1007/s11064-013-0977-4
– volume: 9
  start-page: 344
  year: 2008
  end-page: 356
  ident: CR31
  article-title: Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn2373
– volume: 38
  start-page: 1122
  year: 2013
  ident: BFtp201472_CR26
  publication-title: Neurochem Res
  doi: 10.1007/s11064-013-0977-4
– volume: 136
  start-page: 1090
  year: 2011
  ident: BFtp201472_CR14
  publication-title: Analyst
  doi: 10.1039/c0an00899k
– volume: 346
  start-page: f3646
  year: 2013
  ident: BFtp201472_CR22
  publication-title: BMJ
  doi: 10.1136/bmj.f3646
– volume: 21
  start-page: 1018
  year: 2012
  ident: BFtp201472_CR29
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddr532
– volume: 63
  start-page: 1171
  year: 2002
  ident: BFtp201472_CR20
  publication-title: J Clin Psychiatry
  doi: 10.4088/JCP.v63n1213
– volume: 77
  start-page: 379
  year: 2013
  ident: BFtp201472_CR7
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.01.023
– volume: 65
  start-page: 391
  year: 2001
  ident: BFtp201472_CR35
  publication-title: Prog Neurobiol
  doi: 10.1016/S0301-0082(01)00011-9
– volume: 82
  start-page: 398
  year: 1987
  ident: BFtp201472_CR19
  publication-title: J Am Stat Asso
  doi: 10.1080/01621459.1987.10478472
– volume: 55
  start-page: 1121
  year: 2004
  ident: BFtp201472_CR30
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2003.10.006
– volume-title: Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences
  year: 2002
  ident: BFtp201472_CR18
– volume: 27
  start-page: 275
  year: 2009
  ident: BFtp201472_CR5
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.1529
– volume: 9
  start-page: 575
  year: 2012
  ident: BFtp201472_CR10
  publication-title: Nat Methods
  doi: 10.1038/nmeth.1972
– volume: 16
  start-page: 536
  year: 2011
  ident: BFtp201472_CR13
  publication-title: J Biomol Screen
  doi: 10.1177/1087057111399337
– volume: 9
  start-page: 344
  year: 2008
  ident: BFtp201472_CR31
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn2373
– volume: 206
  start-page: 223
  year: 2013
  ident: BFtp201472_CR28
  publication-title: Psychiatry Res
  doi: 10.1016/j.psychres.2012.11.002
– volume: 58
  start-page: 844
  year: 2001
  ident: BFtp201472_CR1
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.58.9.844
– volume: 380
  start-page: 2163
  year: 2012
  ident: BFtp201472_CR2
  publication-title: Lancet
  doi: 10.1016/S0140-6736(12)61729-2
– volume: 35
  start-page: 804
  year: 2011
  ident: BFtp201472_CR24
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2010.10.001
– volume: 46
  start-page: 189
  year: 2012
  ident: BFtp201472_CR27
  publication-title: J Psychiatr Res
  doi: 10.1016/j.jpsychires.2011.10.011
– volume: 7
  start-page: 1091
  year: 1996
  ident: BFtp201472_CR12
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.V781091
– volume: 8
  start-page: e65636
  year: 2013
  ident: BFtp201472_CR16
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0065636
– volume: 375
  start-page: 385
  year: 2010
  ident: BFtp201472_CR4
  publication-title: Lancet
  doi: 10.1016/S0140-6736(10)60570-3
– volume: 503
  start-page: 72
  year: 2013
  ident: BFtp201472_CR32
  publication-title: Nature
  doi: 10.1038/nature12630
– volume: 476
  start-page: 228
  issue: 7359
  year: 2011
  ident: BFtp201472_CR9
  publication-title: Nature
  doi: 10.1038/nature10323
– volume: 67
  start-page: 1097
  year: 2010
  ident: BFtp201472_CR23
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2010.01.020
– volume: 15
  start-page: 477
  year: 2012
  ident: BFtp201472_CR6
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3041
– volume: 74
  start-page: 418
  year: 2013
  ident: BFtp201472_CR25
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2013.01.020
– volume: 463
  start-page: 1035
  year: 2010
  ident: BFtp201472_CR8
  publication-title: Nature
  doi: 10.1038/nature08797
– volume: 78
  start-page: 957
  year: 2013
  ident: BFtp201472_CR11
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.06.002
– volume: 63
  start-page: 942
  year: 2002
  ident: BFtp201472_CR15
  publication-title: J Clin Psychiatry
  doi: 10.4088/JCP.v63n1013
– volume: 15
  start-page: 216
  year: 2005
  ident: BFtp201472_CR33
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2005.02.002
– volume: 9
  start-page: 493
  year: 2003
  ident: BFtp201472_CR17
  publication-title: RNA
  doi: 10.1261/rna.2192803
– volume: 417
  start-page: 292
  year: 2002
  ident: BFtp201472_CR34
  publication-title: Nature
  doi: 10.1038/417292a
– volume: 15
  start-page: 1
  year: 2013
  ident: BFtp201472_CR3
  publication-title: Bipolar disord
  doi: 10.1111/bdi.12025
– volume: 120
  start-page: 378
  year: 2009
  ident: BFtp201472_CR21
  publication-title: Acta Psychiatr Scand
  doi: 10.1111/j.1600-0447.2009.01454.x
– reference: 23245607 - Lancet. 2012 Dec 15;380(9859):2163-96
– reference: 23218918 - Psychiatry Res. 2013 Apr 30;206(2-3):223-31
– reference: 21406619 - J Biomol Screen. 2011 Jun;16(5):536-44
– reference: 8866399 - J Am Soc Nephrol. 1996 Aug;7(8):1091-7
– reference: 22099865 - J Psychiatr Res. 2012 Feb;46(2):189-97
– reference: 21753754 - Nature. 2011 Aug 11;476(7359):228-31
– reference: 20107439 - Nature. 2010 Feb 25;463(7284):1035-41
– reference: 23395367 - Neuron. 2013 Feb 6;77(3):379-81
– reference: 23482246 - Biol Psychiatry. 2013 Sep 15;74(6):418-26
– reference: 18425089 - Nat Rev Neurosci. 2008 May;9(5):344-56
– reference: 23354722 - Neurochem Res. 2013 Jun;38(6):1122-33
– reference: 20303066 - Biol Psychiatry. 2010 Jun 1;67(11):1097-105
– reference: 15184030 - Biol Psychiatry. 2004 Jun 15;55(12):1121-7
– reference: 21279202 - Analyst. 2011 Mar 21;136(6):1090-102
– reference: 19807719 - Acta Psychiatr Scand. 2009 Nov;120(5):378-85
– reference: 22306606 - Nat Neurosci. 2012 Mar;15(3):477-86, S1
– reference: 11527574 - Prog Neurobiol. 2001 Nov;65(4):391-426
– reference: 23791192 - Neuron. 2013 Jun 19;78(6):957-69
– reference: 23814104 - BMJ. 2013;346:f3646
– reference: 15817378 - Trends Cell Biol. 2005 Apr;15(4):216-21
– reference: 20934453 - Neurosci Biobehav Rev. 2011 Jan;35(3):804-17
– reference: 12416605 - J Clin Psychiatry. 2002 Oct;63(10):942-7
– reference: 22484851 - Nat Methods. 2012 Jun;9(6):575-8
– reference: 23840348 - PLoS One. 2013 Jun 19;8(6):e65636
– reference: 19252484 - Nat Biotechnol. 2009 Mar;27(3):275-80
– reference: 20092882 - Lancet. 2010 Jan 30;375(9712):385-95
– reference: 24153177 - Nature. 2013 Nov 7;503(7474):72-7
– reference: 12015604 - Nature. 2002 May 16;417(6886):292-5
– reference: 12523878 - J Clin Psychiatry. 2002 Dec;63(12):1171-8
– reference: 11545667 - Arch Gen Psychiatry. 2001 Sep;58(9):844-50
– reference: 12649500 - RNA. 2003 Apr;9(4):493-501
– reference: 23237061 - Bipolar Disord. 2013 Feb;15(1):1-44
– reference: 22080834 - Hum Mol Genet. 2012 Mar 1;21(5):1018-24
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Snippet Development of novel treatments and diagnostic tools for psychiatric illness has been hindered by the absence of cellular models of disease. With the advent of...
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SubjectTerms 631/378/87
631/80/2373
692/699/476/1333
Affect - drug effects
Behavioral Sciences
Biological Psychology
Bipolar Disorder - drug therapy
Bipolar Disorder - genetics
Bipolar Disorder - physiopathology
Cellular Reprogramming - drug effects
Cellular Reprogramming - physiology
Genome-Wide Association Study
Humans
Lithium Carbonate - pharmacology
Lithium Carbonate - therapeutic use
Medicine
Medicine & Public Health
Neurosciences
Optical Imaging
Original
original-article
Pharmacogenetics
Pharmacotherapy
Psychiatry
Sodium-Bicarbonate Symporters - genetics
Treatment Outcome
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Title Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness
URI https://link.springer.com/article/10.1038/tp.2014.72
https://www.ncbi.nlm.nih.gov/pubmed/25158003
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