Protective effect of 5-hydroxymethylfurfural derived from processed Fructus Corni on human hepatocyte LO2 injured by hydrogen peroxide and its mechanism

• Published in: Journal of ethnopharmacology Vol. 128; no. 2; pp. 373 - 376
• Main Authors: Ding, Xia, Wang, Ming-Yan, Yao, Yun-Xiang, Li, Guan-Ye, Cai, Bao-Chang
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 24.03.2010; Amsterdam; New York: Elsevier
• Subjects: 5-Hydroxymethylfurfural; apoptosis; Apoptosis - drug effects; Biphenyl Compounds; Caspase 3 - metabolism; Caspase-3; Cell cycle; Cell Division - drug effects; Cell Line; Cell Survival - drug effects; Cornus - metabolism; Cornus officinalis; cultured cells; cysteine proteinases; enzyme activity; Fructus Corni; Fruit - metabolism; fruits (plant anatomy); Furaldehyde - analogs & derivatives; Furaldehyde - pharmacology; furfural; hepatocytes; Hepatocytes - metabolism; Hepatoprotective effect; herbal medicines; human cell lines; Humans; hydrogen peroxide; Hydrogen Peroxide - pharmacology; mechanism of action; medicinal plants; medicinal properties; Nitric oxide; Nitric Oxide - metabolism; plant extracts; Protective Agents - pharmacology; Tetrazolium Salts - metabolism; viability; PBS; FCM; 5-Hydroxymethylfurfural; Nitric oxide; Cell cycle; 5-HMF; PI; Fructus Corni; Hepatoprotective effect; MTT; Caspase-3

The aim of the present study was to evaluate the putative protective effect of 5-hydroxymethylfurfural (5-HMF) derived from processed Fructus Corni on human hepatocyte cell line (LO2) injured by hydrogen peroxide in vitro and the mechanism of its protection. The percentage of cell viability was eval...