Protective effect of 5-hydroxymethylfurfural derived from processed Fructus Corni on human hepatocyte LO2 injured by hydrogen peroxide and its mechanism

The aim of the present study was to evaluate the putative protective effect of 5-hydroxymethylfurfural (5-HMF) derived from processed Fructus Corni on human hepatocyte cell line (LO2) injured by hydrogen peroxide in vitro and the mechanism of its protection. The percentage of cell viability was eval...

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Published inJournal of ethnopharmacology Vol. 128; no. 2; pp. 373 - 376
Main Authors Ding, Xia, Wang, Ming-Yan, Yao, Yun-Xiang, Li, Guan-Ye, Cai, Bao-Chang
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 24.03.2010
Amsterdam; New York: Elsevier
Subjects
5-Hydroxymethylfurfural
apoptosis
Apoptosis - drug effects
Biphenyl Compounds
Caspase 3 - metabolism
Caspase-3
Cell cycle
Cell Division - drug effects
Cell Line
Cell Survival - drug effects
Cornus - metabolism
Cornus officinalis
cultured cells
cysteine proteinases
enzyme activity
Fructus Corni
Fruit - metabolism
fruits (plant anatomy)
Furaldehyde - analogs & derivatives
Furaldehyde - pharmacology
furfural
hepatocytes
Hepatocytes - metabolism
Hepatoprotective effect
herbal medicines
human cell lines
Humans
hydrogen peroxide
Hydrogen Peroxide - pharmacology
mechanism of action
medicinal plants
medicinal properties
Nitric oxide
Nitric Oxide - metabolism
plant extracts
Protective Agents - pharmacology
Tetrazolium Salts - metabolism
viability
PBS
FCM
5-Hydroxymethylfurfural
Nitric oxide
Cell cycle
5-HMF
PI
Fructus Corni
Hepatoprotective effect
MTT
Caspase-3
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Abstract The aim of the present study was to evaluate the putative protective effect of 5-hydroxymethylfurfural (5-HMF) derived from processed Fructus Corni on human hepatocyte cell line (LO2) injured by hydrogen peroxide in vitro and the mechanism of its protection. The percentage of cell viability was evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. The hepatocyte cell apoptosis and cell cycle were detected by flow cytometric analysis. The content of nitric oxide and caspase-3 activity were quantified spectrophotometrically by enzyme-linked immunoassay. The study showed that incubation with 5-HMF caused significant increase in the viability of LO2 cell, decrease of cell apoptosis and recovery of cell cycle in LO2 cell injured by hydrogen peroxide, which was accompanied with the decreased nitric oxide level and caspase-3 activity. Our data suggest that 5-HMF protects LO2 cell against damage induced by hydrogen peroxide through inhibiting effect of cell apoptosis caused by promoting S phase to G2/M phase and the decreased caspase-3 activity and nitric oxide level. 5-HMF is one of the active principles in processed Fructus Corni.
AbstractList The aim of the present study was to evaluate the putative protective effect of 5-hydroxymethylfurfural (5-HMF) derived from processed Fructus Corni on human hepatocyte cell line (LO2) injured by hydrogen peroxide in vitro and the mechanism of its protection. The percentage of cell viability was evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. The hepatocyte cell apoptosis and cell cycle were detected by flow cytometric analysis. The content of nitric oxide and caspase-3 activity were quantified spectrophotometrically by enzyme-linked immunoassay. The study showed that incubation with 5-HMF caused significant increase in the viability of LO2 cell, decrease of cell apoptosis and recovery of cell cycle in LO2 cell injured by hydrogen peroxide, which was accompanied with the decreased nitric oxide level and caspase-3 activity. Our data suggest that 5-HMF protects LO2 cell against damage induced by hydrogen peroxide through inhibiting effect of cell apoptosis caused by promoting S phase to G2/M phase and the decreased caspase-3 activity and nitric oxide level. 5-HMF is one of the active principles in processed Fructus Corni.
AIM OF THE STUDYThe aim of the present study was to evaluate the putative protective effect of 5-hydroxymethylfurfural (5-HMF) derived from processed Fructus Corni on human hepatocyte cell line (LO2) injured by hydrogen peroxide in vitro and the mechanism of its protection.MATERIALS AND METHODSThe percentage of cell viability was evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. The hepatocyte cell apoptosis and cell cycle were detected by flow cytometric analysis. The content of nitric oxide and caspase-3 activity were quantified spectrophotometrically by enzyme-linked immunoassay.RESULTThe study showed that incubation with 5-HMF caused significant increase in the viability of LO2 cell, decrease of cell apoptosis and recovery of cell cycle in LO2 cell injured by hydrogen peroxide, which was accompanied with the decreased nitric oxide level and caspase-3 activity.CONCLUSIONSOur data suggest that 5-HMF protects LO2 cell against damage induced by hydrogen peroxide through inhibiting effect of cell apoptosis caused by promoting S phase to G2/M phase and the decreased caspase-3 activity and nitric oxide level. 5-HMF is one of the active principles in processed Fructus Corni.
The aim of the present study was to evaluate the putative protective effect of 5-hydroxymethylfurfural (5-HMF) derived from processed Fructus Corni on human hepatocyte cell line (LO2) injured by hydrogen peroxide in vitro and the mechanism of its protection. The percentage of cell viability was evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. The hepatocyte cell apoptosis and cell cycle were detected by flow cytometric analysis. The content of nitric oxide and caspase-3 activity were quantified spectrophotometrically by enzyme-linked immunoassay. The study showed that incubation with 5-HMF caused significant increase in the viability of LO2 cell, decrease of cell apoptosis and recovery of cell cycle in LO2 cell injured by hydrogen peroxide, which was accompanied with the decreased nitric oxide level and caspase-3 activity. Our data suggest that 5-HMF protects LO2 cell against damage induced by hydrogen peroxide through inhibiting effect of cell apoptosis caused by promoting S phase to G2/M phase and the decreased caspase-3 activity and nitric oxide level. 5-HMF is one of the active principles in processed Fructus Corni.
Aim of the study: The aim of the present study was to evaluate the putative protective effect of 5-hydroxymethylfurfural (5-HMF) derived from processed Fructus Corni on human hepatocyte cell line (LO2) injured by hydrogen peroxide in vitro and the mechanism of its protection. Materials and methods: The percentage of cell viability was evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. The hepatocyte cell apoptosis and cell cycle were detected by flow cytometric analysis. The content of nitric oxide and caspase-3 activity were quantified spectrophotometrically by enzyme-linked immunoassay. Result: The study showed that incubation with 5-HMF caused significant increase in the viability of LO2 cell, decrease of cell apoptosis and recovery of cell cycle in LO2 cell injured by hydrogen peroxide, which was accompanied with the decreased nitric oxide level and caspase-3 activity. Conclusions: Our data suggest that 5-HMF protects LO2 cell against damage induced by hydrogen peroxide through inhibiting effect of cell apoptosis caused by promoting S phase to G2/M phase and the decreased caspase-3 activity and nitric oxide level. 5-HMF is one of the active principles in processed Fructus Corni.
Author Cai, Bao-Chang
Yao, Yun-Xiang
Ding, Xia
Li, Guan-Ye
Wang, Ming-Yan
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/20117202$$D View this record in MEDLINE/PubMed
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Keywords PBS
FCM
5-Hydroxymethylfurfural
Nitric oxide
Cell cycle
5-HMF
PI
Fructus Corni
Hepatoprotective effect
MTT
Caspase-3
Language English
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Snippet The aim of the present study was to evaluate the putative protective effect of 5-hydroxymethylfurfural (5-HMF) derived from processed Fructus Corni on human...
Aim of the study: The aim of the present study was to evaluate the putative protective effect of 5-hydroxymethylfurfural (5-HMF) derived from processed Fructus...
The aim of the present study was to evaluate the putative protective effect of 5-hydroxymethylfurfural (5-HMF) derived from processed Fructus Corni on human...
AIM OF THE STUDYThe aim of the present study was to evaluate the putative protective effect of 5-hydroxymethylfurfural (5-HMF) derived from processed Fructus...
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SubjectTerms 5-Hydroxymethylfurfural
apoptosis
Apoptosis - drug effects
Biphenyl Compounds
Caspase 3 - metabolism
Caspase-3
Cell cycle
Cell Division - drug effects
Cell Line
Cell Survival - drug effects
Cornus - metabolism
Cornus officinalis
cultured cells
cysteine proteinases
enzyme activity
Fructus Corni
Fruit - metabolism
fruits (plant anatomy)
Furaldehyde - analogs & derivatives
Furaldehyde - pharmacology
furfural
hepatocytes
Hepatocytes - metabolism
Hepatoprotective effect
herbal medicines
human cell lines
Humans
hydrogen peroxide
Hydrogen Peroxide - pharmacology
mechanism of action
medicinal plants
medicinal properties
Nitric oxide
Nitric Oxide - metabolism
plant extracts
Protective Agents - pharmacology
Tetrazolium Salts - metabolism
viability
Title Protective effect of 5-hydroxymethylfurfural derived from processed Fructus Corni on human hepatocyte LO2 injured by hydrogen peroxide and its mechanism
URI https://dx.doi.org/10.1016/j.jep.2010.01.043
https://www.ncbi.nlm.nih.gov/pubmed/20117202
https://search.proquest.com/docview/733562716
Volume 128
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