Endoscopy-verified occult subependymal dissemination of glioblastoma and brain metastasis undetected by MRI: prognostic significance
Although various prognostic indices exist for patients with malignant brain tumors, the prognostic significance of the subependymal spread of intracranial tumors is still a matter of debate. In this paper, we report the cases of two intraventricular lesions, a recurrent glioblastoma multiforme (GBM)...
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| Published in | OncoTargets and therapy Vol. 5; pp. 449 - 456 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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New Zealand
Dove Medical Press Limited
01.01.2012
Taylor & Francis Ltd Dove Press Dove Medical Press |
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| Abstract | Although various prognostic indices exist for patients with malignant brain tumors, the prognostic significance of the subependymal spread of intracranial tumors is still a matter of debate. In this paper, we report the cases of two intraventricular lesions, a recurrent glioblastoma multiforme (GBM) and a brain metastasis, each successfully treated with a neuroendoscopic approach. Thanks to this minimally invasive approach, we achieved good therapeutic results: we obtained a histological diagnosis; we controlled intracranial hypertension by treating the associated hydrocephalus and, above all, compared with a microsurgical approach, we reduced the risks related to dissection and brain retraction. Moreover, in both cases, neuroendoscopy enabled us to identify an initial, precocious subependymal tumor spreading below the threshold of magnetic resonance imaging (MRI) detection. This finding, undetected in pre-operative MRI scans, was then evident during follow-up neuroimaging studies. In light of these data, a neuroendoscopic approach might play a leading role in better defining the prognosis and optimally tailored management protocols for GBM and brain metastasis. |
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| AbstractList | Although various prognostic indices exist for patients with malignant brain tumors, the prognostic significance of the subependymal spread of intracranial tumors is still a matter of debate. In this paper, we report the cases of two intraventricular lesions, a recurrent glioblastoma multiforme (GBM) and a brain metastasis, each successfully treated with a neuroendoscopic approach. Thanks to this minimally invasive approach, we achieved good therapeutic results: we obtained a histological diagnosis; we controlled intracranial hypertension by treating the associated hydrocephalus and, above all, compared with a microsurgical approach, we reduced the risks related to dissection and brain retraction. Moreover, in both cases, neuroendoscopy enabled us to identify an initial, precocious subependymal tumor spreading below the threshold of magnetic resonance imaging (MRI) detection. This finding, undetected in pre-operative MRI scans, was then evident during follow-up neuroimaging studies. In light of these data, a neuroendoscopic approach might play a leading role in better defining the prognosis and optimally tailored management protocols for GBM and brain metastasis. Although various prognostic indices exist for patients with malignant brain tumors, the prognostic significance of the subependymal spread of intracranial tumors is still a matter of debate. In this paper, we report the cases of two intraventricular lesions, a recurrent glioblastoma multiforme (GBM) and a brain metastasis, each successfully treated with a neuroendoscopic approach. Thanks to this minimally invasive approach, we achieved good therapeutic results: we obtained a histological diagnosis; we controlled intracranial hypertension by treating the associated hydrocephalus and, above all, compared with a microsurgical approach, we reduced the risks related to dissection and brain retraction. Moreover, in both cases, neuroendoscopy enabled us to identify an initial, precocious subependymal tumor spreading below the threshold of magnetic resonance imaging (MRI) detection. This finding, undetected in pre- operative MRI scans, was then evident during follow-up neuroimaging studies. In light of these data, a neuroendoscopic approach might play a leading role in better defining the prognosis and optimally tailored management protocols for GBM and brain metastasis. Keywords: subependymal spreading, glioblastoma, brain metastasis, endoscopy, minimally invasive surgery, prognosis |
| Audience | Academic |
| Author | Colasanti, Roberto Di Somma, Lucia Giovanna Maria Scerrati, Massimo Scarpelli, Marina Di Rienzo, Alessandro Iacoangeli, Maurizio Zizzi, Antonio Gladi, Maurizio Alvaro, Lorenzo Nocchi, Niccolò |
| AuthorAffiliation | 2 Department of Pathology, Università Politecnica delle Marche, Umberto I General Hospital, Ancona, Italy 1 Department of Neurosurgery, Università Politecnica delle Marche, Umberto I General Hospital, Ancona, Italy |
| AuthorAffiliation_xml | – name: 2 Department of Pathology, Università Politecnica delle Marche, Umberto I General Hospital, Ancona, Italy – name: 1 Department of Neurosurgery, Università Politecnica delle Marche, Umberto I General Hospital, Ancona, Italy |
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| SubjectTerms | Brain cancer brain metastasis Care and treatment Case Report Case studies Diagnosis Endoscopic surgery Endoscopy glioblastoma Glioblastoma multiforme Health aspects Magnetic resonance imaging Metastasis minimally invasive surgery NMR Nuclear magnetic resonance prognosis subependymal spreading Tumors |
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| Title | Endoscopy-verified occult subependymal dissemination of glioblastoma and brain metastasis undetected by MRI: prognostic significance |
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