Intravenous immunoglobulin treatment responsiveness depends on the degree of CD8+ T cell activation in Kawasaki disease

• Published in: Clinical immunology (Orlando, Fla.) Vol. 171; pp. 25 - 31
• Main Authors: Ye, Qing, Gong, Fang-qi, Shang, Shi-qiang, Hu, Jian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2016
• Subjects: Allergy and Immunology; CD4-Positive T-Lymphocytes - immunology; CD8 + HLA-DR + T cells; CD8-Positive T-Lymphocytes - immunology; Child; Child, Preschool; Female; Flow cytometry; Humans; Immune activation; Immunoglobulins, Intravenous - pharmacology; Immunoglobulins, Intravenous - therapeutic use; Immunologic Factors - pharmacology; Immunologic Factors - therapeutic use; Infant; Kawasaki disease; Lymphocyte Activation; Male; Mucocutaneous Lymph Node Syndrome - drug therapy; Mucocutaneous Lymph Node Syndrome - immunology; ROC curve; T-Lymphocyte Subsets - immunology; Treatment Outcome; Flow cytometry; Immune activation; Kawasaki disease; ROC curve; CD8+HLA-DR+ T cells; CD8 + HLA-DR + T cells

Kawasaki disease (KD) has become the most common cause of acquired heart disease in children and is also a risk factor for ischemic heart disease in adults. However, Kawasaki disease lacks specific laboratory diagnostic indices. Thus, this study analyzed the T cell activation profiles of Kawasaki di...