Integrative lipidomic features identify plasma lipid signatures in chronic urticaria

Chronic urticaria (CU) is a chronic inflammatory skin disease mainly mediated by mast cells. Lipids exert essential functions in biological processes; however, the role of lipids in CU remains unclear. Nontargeted lipidomics was performed to investigate the differential lipid profiles between CU pat...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in immunology Vol. 13; p. 933312
Main Authors Li, Jie, Li, Liqiao, Liu, Runqiu, Zhu, Lei, Zhou, Bingjing, Xiao, Yi, Hou, Guixue, Lin, Liang, Chen, Xiang, Peng, Cong
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 28.07.2022
Subjects
chronic urticaria
glycerophospholipid
Immunology
lipidomic signatures
mast cell
phosphatidylcholine
Online AccessGet full text

Cover

Abstract Chronic urticaria (CU) is a chronic inflammatory skin disease mainly mediated by mast cells. Lipids exert essential functions in biological processes; however, the role of lipids in CU remains unclear. Nontargeted lipidomics was performed to investigate the differential lipid profiles between CU patients and healthy control (HC) subjects. Functional validation studies were performed in vitro and in vivo including β-hexosaminidase release examination from mast cells and passive cutaneous anaphylaxis (PCA) mouse model. We detected dramatically altered glycerophospholipids in CU patients compared with HCs. Phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylglycerol (PG) were increased, while phosphatidylcholine (PC) was reduced in CU patients. The reduction in PC was related to a high weekly urticaria activity score (UAS7), while PS was positively associated with the dermatology life quality index (DLQI). We also identified the differential lipid profiles between chronic spontaneous urticaria (CSU), symptomatic dermographism (SD), and CSU coexist with SD. CU patients were classified into two subtypes (subtype 1 and subtype 2) based on consensus clustering of lipid profiling. Compared with patients in subtype 2, patients in subtype 1 had elevated levels of PC (18:0e/18:2) and PE (38:2), and lower urticaria control test (UCT) scores indicated worse clinical efficiency of secondary generation H1 antihistamines treatment. Importantly, we found that supplementation with PC could attenuate IgE-induced immune responses in mast cells. In general, We described the landscape of plasma lipid alterations in CU patients and provided novel insights into the role of PC in mast cells.
AbstractList Chronic urticaria (CU) is a chronic inflammatory skin disease mainly mediated by mast cells. Lipids exert essential functions in biological processes; however, the role of lipids in CU remains unclear. Nontargeted lipidomics was performed to investigate the differential lipid profiles between CU patients and healthy control (HC) subjects. Functional validation studies were performed in vitro and in vivo including β-hexosaminidase release examination from mast cells and passive cutaneous anaphylaxis (PCA) mouse model. We detected dramatically altered glycerophospholipids in CU patients compared with HCs. Phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylglycerol (PG) were increased, while phosphatidylcholine (PC) was reduced in CU patients. The reduction in PC was related to a high weekly urticaria activity score (UAS7), while PS was positively associated with the dermatology life quality index (DLQI). We also identified the differential lipid profiles between chronic spontaneous urticaria (CSU), symptomatic dermographism (SD), and CSU coexist with SD. CU patients were classified into two subtypes (subtype 1 and subtype 2) based on consensus clustering of lipid profiling. Compared with patients in subtype 2, patients in subtype 1 had elevated levels of PC (18:0e/18:2) and PE (38:2), and lower urticaria control test (UCT) scores indicated worse clinical efficiency of secondary generation H1 antihistamines treatment. Importantly, we found that supplementation with PC could attenuate IgE-induced immune responses in mast cells. In general, We described the landscape of plasma lipid alterations in CU patients and provided novel insights into the role of PC in mast cells.
Chronic urticaria (CU) is a chronic inflammatory skin disease mainly mediated by mast cells. Lipids exert essential functions in biological processes; however, the role of lipids in CU remains unclear. Nontargeted lipidomics was performed to investigate the differential lipid profiles between CU patients and healthy control (HC) subjects. Functional validation studies were performed in vitro and in vivo including β-hexosaminidase release examination from mast cells and passive cutaneous anaphylaxis (PCA) mouse model. We detected dramatically altered glycerophospholipids in CU patients compared with HCs. Phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylglycerol (PG) were increased, while phosphatidylcholine (PC) was reduced in CU patients. The reduction in PC was related to a high weekly urticaria activity score (UAS7), while PS was positively associated with the dermatology life quality index (DLQI). We also identified the differential lipid profiles between chronic spontaneous urticaria (CSU), symptomatic dermographism (SD), and CSU coexist with SD. CU patients were classified into two subtypes (subtype 1 and subtype 2) based on consensus clustering of lipid profiling. Compared with patients in subtype 2, patients in subtype 1 had elevated levels of PC (18:0e/18:2) and PE (38:2), and lower urticaria control test (UCT) scores indicated worse clinical efficiency of secondary generation H1 antihistamines treatment. Importantly, we found that supplementation with PC could attenuate IgE-induced immune responses in mast cells. In general, We described the landscape of plasma lipid alterations in CU patients and provided novel insights into the role of PC in mast cells.
Author Zhu, Lei
Li, Liqiao
Lin, Liang
Liu, Runqiu
Li, Jie
Hou, Guixue
Peng, Cong
Zhou, Bingjing
Xiao, Yi
Chen, Xiang
AuthorAffiliation 2 Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University , Changsha , China
4 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , China
5 BGI-Shenzhen , Shenzhen, Guangdong , China
3 Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University , Changsha , China
1 Department of Dermatology, Xiangya Hospital, Central South University , Changsha , China
AuthorAffiliation_xml – name: 2 Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University , Changsha , China
– name: 1 Department of Dermatology, Xiangya Hospital, Central South University , Changsha , China
– name: 5 BGI-Shenzhen , Shenzhen, Guangdong , China
– name: 3 Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University , Changsha , China
– name: 4 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , China
Author_xml – sequence: 1
  givenname: Jie
  surname: Li
  fullname: Li, Jie
– sequence: 2
  givenname: Liqiao
  surname: Li
  fullname: Li, Liqiao
– sequence: 3
  givenname: Runqiu
  surname: Liu
  fullname: Liu, Runqiu
– sequence: 4
  givenname: Lei
  surname: Zhu
  fullname: Zhu, Lei
– sequence: 5
  givenname: Bingjing
  surname: Zhou
  fullname: Zhou, Bingjing
– sequence: 6
  givenname: Yi
  surname: Xiao
  fullname: Xiao, Yi
– sequence: 7
  givenname: Guixue
  surname: Hou
  fullname: Hou, Guixue
– sequence: 8
  givenname: Liang
  surname: Lin
  fullname: Lin, Liang
– sequence: 9
  givenname: Xiang
  surname: Chen
  fullname: Chen, Xiang
– sequence: 10
  givenname: Cong
  surname: Peng
  fullname: Peng, Cong
BookMark eNpVkcFu3CAQhlGVqknTPEBvPvayWxiwMZdKVdS0K0XqJT2jMR42RDZswY6Ut68dp1XDAUbwzQfof8_OYorE2EfB91K25rMP4zjvgQPsjZRSwBt2IZpG7SSAOvuvPmdXpTzwZagVrN-xc1mbRivFL9jdIU50zDiFR6qGcAp9GoOrPOE0ZypV6ClOwT9VpwHLiBtSlXCMf4FYufuc4tI05yk4zAE_sLceh0JXL-sl-3Xz7e76x-725_fD9dfbnVMKpp0h1WtDHAnNMkGnOkfGeVFD22FjTN9jrUA2iEvZagmI2DsP2HXScSMv2WHz9gkf7CmHEfOTTRjs80bKR4vrmwayUrcaOuKAyqtG14akaQRvOq2V9wYW15fNdZq7kXq3fDvj8Er6-iSGe3tMj9ZIzet6FXx6EeT0e6Yy2TEUR8OAkdJcLGgOqtUCxIKKDXU5lZLJ_7tGcLuGa5_DtWu4dgtX_gHG-JvS
CitedBy_id crossref_primary_10_2147_CCID_S424478
crossref_primary_10_1038_s41467_023_44373_x
crossref_primary_10_1111_jdv_20157
crossref_primary_10_1002_ansa_202300009
crossref_primary_10_1186_s12967_024_05274_9
crossref_primary_10_2147_CCID_S426451
crossref_primary_10_1111_ijd_17102
crossref_primary_10_1039_D3FO04068B
crossref_primary_10_1111_exd_15103
crossref_primary_10_3390_ijms232113583
Cites_doi 10.1111/all.15090
10.1158/0008-5472.Can-19-4035
10.1016/j.ejphar.2009.09.012
10.1021/acs.jafc.0c06383
10.1111/j.1346-8138.1989.tb01249.x
10.1111/all.12884
10.1155/2016/3831071
10.1111/all.14757
10.1016/j.bbamem.2017.04.006
10.3389/fimmu.2019.01174
10.1002/jbmr.4240
10.1016/j.jaci.2013.12.1076
10.4196/kjpp.2013.17.3.209
10.1016/0091-6749(91)90178-q
10.1111/all.14502
10.1111/j.1398-9995.1996.tb04545.x
10.1002/jbt.20037
10.1111/all.12313
10.1093/nar/gkl838
10.1021/bi016022v
10.1073/pnas.2026583118
10.1039/c8an01046c
10.1111/bjd.16655
10.1016/j.chemphyslip.2020.104914
10.1007/s12035-018-1177-7
10.1142/s0219720005001375
10.3389/fcimb.2020.00024
10.1074/jbc.M704408200
10.1038/cdd.2016.11
10.1194/jlr.E400004-JLR200
10.1186/ar2651
10.1093/gigascience/gix087
10.1111/imr.12632
10.1021/pr5007069
10.3390/membranes11120944
10.1111/bjd.19561
10.1097/SHK.0b013e31816f204a
10.1111/bjd.13621
10.1111/bjd.15454
10.55563/clinexprheumatol/ye2ua5
10.1146/annurev-immunol-071719-094903
10.1016/j.ahj.2008.08.010
10.1038/ni1550
10.3390/cells10071759
10.1016/j.bbadis.2019.165572
10.1021/bi00013a029
10.1016/j.jaci.2016.10.017
10.1515/cclm-2012-0897
10.2340/00015555-1443
10.1038/279250a0
10.1016/j.jaci.2014.12.1362
10.1111/j.0022-202X.2005.23621.x
10.1042/CS20120602
10.1111/bjd.14768
10.1016/s0006-291x(02)00586-7
10.1093/nar/gkab382
10.1046/j.1365-2230.2003.01264.x
10.1186/s12859-017-1579-y
10.3390/cells9020511
ContentType Journal Article
Copyright Copyright © 2022 Li, Li, Liu, Zhu, Zhou, Xiao, Hou, Lin, Chen and Peng 2022 Li, Li, Liu, Zhu, Zhou, Xiao, Hou, Lin, Chen and Peng
Copyright_xml – notice: Copyright © 2022 Li, Li, Liu, Zhu, Zhou, Xiao, Hou, Lin, Chen and Peng 2022 Li, Li, Liu, Zhu, Zhou, Xiao, Hou, Lin, Chen and Peng
DBID AAYXX
CITATION
7X8
5PM
DOA
DOI 10.3389/fimmu.2022.933312
DatabaseName CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE - Academic
DatabaseTitleList

CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1664-3224
EndPage 933312
ExternalDocumentID oai_doaj_org_article_37872be02a4f46759e396106b774ff92
10_3389_fimmu_2022_933312
GrantInformation_xml – fundername: ;
  grantid: 2020YFA0112904
– fundername: ;
  grantid: 1974476, 82173424, 8213000715, 82073458, 81830096
GroupedDBID 53G
5VS
9T4
AAFWJ
AAKDD
AAYXX
ACGFO
ACGFS
ACXDI
ADBBV
ADRAZ
AENEX
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
CITATION
DIK
EBS
EMOBN
GROUPED_DOAJ
GX1
HYE
IAO
IEA
IHR
IHW
KQ8
M48
M~E
OK1
PGMZT
RNS
RPM
7X8
5PM
ID FETCH-LOGICAL-c442t-9e4d79e0aea90ae2b4bce9cf1528ba699dda54236aa9dd8732aaadcf2abb3c093
IEDL.DBID RPM
ISSN 1664-3224
IngestDate Fri Oct 04 13:05:44 EDT 2024
Tue Sep 17 21:15:15 EDT 2024
Sat Oct 05 06:05:49 EDT 2024
Thu Sep 26 16:49:52 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c442t-9e4d79e0aea90ae2b4bce9cf1528ba699dda54236aa9dd8732aaadcf2abb3c093
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Edited by: Marianna Kulka, University of Alberta, Canada
These authors have contributed equally to this work and share first authorship
Reviewed by: Becky Vonakis, Johns Hopkins Medicine, United States; Nami Shrestha, University of Alberta, Canada; Zuotao Zhao, Peking University, China; Jason Meyer, Vanderbilt University Medical Center, United States
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370552/
PMID 35967440
PQID 2702487121
PQPubID 23479
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_37872be02a4f46759e396106b774ff92
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9370552
proquest_miscellaneous_2702487121
crossref_primary_10_3389_fimmu_2022_933312
PublicationCentury 2000
PublicationDate 2022-07-28
PublicationDateYYYYMMDD 2022-07-28
PublicationDate_xml – month: 07
  year: 2022
  text: 2022-07-28
  day: 28
PublicationDecade 2020
PublicationTitle Frontiers in immunology
PublicationYear 2022
Publisher Frontiers Media S.A
Publisher_xml – name: Frontiers Media S.A
References Hartmann (B46) 2009; 622
van der Veen (B43) 2017; 1859
Fahy (B9) 2005; 46
Sachdeva (B16) 2009; 157
Cao (B51) 2002; 294
Nicolson (B37) 2021; 11
Weller (B29) 2014; 133
Chang (B35) 1995; 34
Zuberbier (B55) 1996; 51
Stull (B27) 2017; 177
Kobayashi (B31) 1989; 16
Rajappa (B58) 2013; 51
Jung (B47) 2013; 17
Abbassi-Ghadi (B40) 2020; 80
Tan (B48) 2020; 68
Dilek (B57) 2016; 2016
Khalil (B26) 2015; 135
Yanase (B4) 2021; 10
Pang (B25) 2021; 49
Futschik (B24) 2005; 3
Aabdallah (B52) 2004; 18
Marquardt (B19) 1991; 88
Huang (B14) 2014; 13
Gonçalo (B1) 2021; 184
Liu (B39) 2020; 9
Kempuraj (B56) 2019; 56
Vig (B23) 2008; 9
Kay (B54) 2015; 172
Wang (B32) 2020; 10
Ghyczy (B53) 2008; 30
Galli (B17) 2020; 38
Dichlberger (B18) 2013; 125
Martin (B42) 1979; 279
Guillén-Aguinaga (B5) 2016; 175
Zuberbier (B2) 2022; 77
Bag (B36) 2021; 118
Kertys (B11) 2020; 1866
Li (B7) 2017; 139
Wang (B12) 2021; 40
Wen (B22) 2017; 18
Sud (B8) 2007; 35
Hongbo (B28) 2005; 125
Birge (B41) 2016; 23
Treede (B50) 2007; 282
Magerl (B21) 2016; 71
Raho (B59) 2003; 28
Zhang (B38) 2021; 36
Zhang (B10) 2018; 143
Zuberbier (B20) 2014; 69
Zhou (B15) 2018; 179
Jennings (B44) 2020; 230
Church (B3) 2018; 282
Zeng (B13) 2017; 6
Hagemann (B33) 2019; 10
Fok (B45) 2021; 76
Kato (B34) 2002; 41
Ye (B30) 2013; 93
Mao (B6) 2021; 76
Eros (B49) 2009; 11
References_xml – volume: 77
  year: 2022
  ident: B2
  article-title: The international EAACI/GA(2)LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria
  publication-title: Allergy
  doi: 10.1111/all.15090
  contributor:
    fullname: Zuberbier
– volume: 80
  year: 2020
  ident: B40
  article-title: De novo lipogenesis alters the phospholipidome of esophageal adenocarcinoma
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.Can-19-4035
  contributor:
    fullname: Abbassi-Ghadi
– volume: 622
  start-page: 58
  year: 2009
  ident: B46
  article-title: Anti-inflammatory effects of phosphatidylcholine in neutrophil leukocyte-dependent acute arthritis in rats
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2009.09.012
  contributor:
    fullname: Hartmann
– volume: 68
  year: 2020
  ident: B48
  article-title: Phosphatidylcholine ameliorates LPS-induced systemic inflammation and cognitive impairments via mediating the gut-brain axis balance
  publication-title: J Agric Food Chem
  doi: 10.1021/acs.jafc.0c06383
  contributor:
    fullname: Tan
– volume: 16
  start-page: 196
  year: 1989
  ident: B31
  article-title: Investigation of the roles of the substances in serum lipids and their constitutive fatty acids in chronic urticaria
  publication-title: J Dermatol
  doi: 10.1111/j.1346-8138.1989.tb01249.x
  contributor:
    fullname: Kobayashi
– volume: 71
  start-page: 780
  year: 2016
  ident: B21
  article-title: The definition, diagnostic testing, and management of chronic inducible urticarias - the EAACI/GA(2) LEN/EDF/UNEV consensus recommendations 2016 update and revision
  publication-title: Allergy
  doi: 10.1111/all.12884
  contributor:
    fullname: Magerl
– volume: 2016
  year: 2016
  ident: B57
  article-title: Oxidative stress in children with chronic spontaneous urticaria
  publication-title: Oxid Med Cell Longev
  doi: 10.1155/2016/3831071
  contributor:
    fullname: Dilek
– volume: 76
  year: 2021
  ident: B45
  article-title: Predictors of treatment response in chronic spontaneous urticaria
  publication-title: Allergy
  doi: 10.1111/all.14757
  contributor:
    fullname: Fok
– volume: 1859
  year: 2017
  ident: B43
  article-title: The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease
  publication-title: Biochim Biophys Acta Biomembr
  doi: 10.1016/j.bbamem.2017.04.006
  contributor:
    fullname: van der Veen
– volume: 10
  year: 2019
  ident: B33
  article-title: Modulation of mast cell reactivity by lipids: The neglected side of allergic diseases
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2019.01174
  contributor:
    fullname: Hagemann
– volume: 36
  year: 2021
  ident: B38
  article-title: Metabolomics insights into osteoporosis through association with bone mineral density
  publication-title: J Bone Miner Res
  doi: 10.1002/jbmr.4240
  contributor:
    fullname: Zhang
– volume: 133
  start-page: 1365
  year: 2014
  ident: B29
  article-title: Development and validation of the urticaria control test: a patient-reported outcome instrument for assessing urticaria control
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2013.12.1076
  contributor:
    fullname: Weller
– volume: 17
  year: 2013
  ident: B47
  article-title: Protective effect of phosphatidylcholine on lipopolysaccharide-induced acute inflammation in multiple organ injury
  publication-title: Korean J Physiol Pharmacol
  doi: 10.4196/kjpp.2013.17.3.209
  contributor:
    fullname: Jung
– volume: 88
  year: 1991
  ident: B19
  article-title: Lysophosphatidylcholine induces mast cell secretion and protein kinase c activation
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/0091-6749(91)90178-q
  contributor:
    fullname: Marquardt
– volume: 76
  year: 2021
  ident: B6
  article-title: Plasma adenosine is linked to disease activity and response to treatment in patients with chronic spontaneous urticaria
  publication-title: Allergy
  doi: 10.1111/all.14502
  contributor:
    fullname: Mao
– volume: 51
  year: 1996
  ident: B55
  article-title: Histamine releasability of basophils and skin mast cells in chronic urticaria
  publication-title: Allergy
  doi: 10.1111/j.1398-9995.1996.tb04545.x
  contributor:
    fullname: Zuberbier
– volume: 18
  year: 2004
  ident: B52
  article-title: Possible neuroprotective effects of lecithin and alpha-tocopherol alone or in combination against ischemia/reperfusion insult in rat brain
  publication-title: J Biochem Mol Toxicol
  doi: 10.1002/jbt.20037
  contributor:
    fullname: Aabdallah
– volume: 69
  year: 2014
  ident: B20
  article-title: The EAACI/GA(2) LEN/EDF/WAO guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update
  publication-title: Allergy
  doi: 10.1111/all.12313
  contributor:
    fullname: Zuberbier
– volume: 35
  year: 2007
  ident: B8
  article-title: LMSD: LIPID MAPS structure database
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkl838
  contributor:
    fullname: Sud
– volume: 41
  year: 2002
  ident: B34
  article-title: Transbilayer asymmetry of phospholipids in the plasma membrane regulates exocytotic release in mast cells
  publication-title: Biochemistry
  doi: 10.1021/bi016022v
  contributor:
    fullname: Kato
– volume: 118
  year: 2021
  ident: B36
  article-title: Lipid-based and protein-based interactions synergize transmembrane signaling stimulated by antigen clustering of IgE receptors
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2026583118
  contributor:
    fullname: Bag
– volume: 143
  year: 2018
  ident: B10
  article-title: Lipid metabolism in inflammation-related diseases
  publication-title: Analyst
  doi: 10.1039/c8an01046c
  contributor:
    fullname: Zhang
– volume: 179
  year: 2018
  ident: B15
  article-title: Lipidomics reveals skin surface lipid abnormity in acne in young men
  publication-title: Br J Dermatol
  doi: 10.1111/bjd.16655
  contributor:
    fullname: Zhou
– volume: 230
  year: 2020
  ident: B44
  article-title: CDP-diacylglycerol, a critical intermediate in lipid metabolism
  publication-title: Chem Phys Lipids
  doi: 10.1016/j.chemphyslip.2020.104914
  contributor:
    fullname: Jennings
– volume: 56
  year: 2019
  ident: B56
  article-title: Mast cell proteases activate astrocytes and glia-neurons and release interleukin-33 by activating p38 and ERK1/2 MAPKs and NF-κB
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-018-1177-7
  contributor:
    fullname: Kempuraj
– volume: 3
  year: 2005
  ident: B24
  article-title: Noise-robust soft clustering of gene expression time-course data
  publication-title: J Bioinform Comput Biol
  doi: 10.1142/s0219720005001375
  contributor:
    fullname: Futschik
– volume: 10
  year: 2020
  ident: B32
  article-title: Gut microbiome and serum metabolome analyses identify unsaturated fatty acids and butanoate metabolism induced by gut microbiota in patients with chronic spontaneous urticaria
  publication-title: Front Cell Infect Microbiol
  doi: 10.3389/fcimb.2020.00024
  contributor:
    fullname: Wang
– volume: 282
  year: 2007
  ident: B50
  article-title: Anti-inflammatory effects of phosphatidylcholine
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M704408200
  contributor:
    fullname: Treede
– volume: 23
  year: 2016
  ident: B41
  article-title: Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2016.11
  contributor:
    fullname: Birge
– volume: 46
  year: 2005
  ident: B9
  article-title: A comprehensive classification system for lipids
  publication-title: J Lipid Res
  doi: 10.1194/jlr.E400004-JLR200
  contributor:
    fullname: Fahy
– volume: 11
  start-page: R43
  year: 2009
  ident: B49
  article-title: Oral phosphatidylcholine pretreatment alleviates the signs of experimental rheumatoid arthritis
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar2651
  contributor:
    fullname: Eros
– volume: 6
  start-page: 1
  year: 2017
  ident: B13
  article-title: Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis
  publication-title: Gigascience
  doi: 10.1093/gigascience/gix087
  contributor:
    fullname: Zeng
– volume: 282
  year: 2018
  ident: B3
  article-title: The role and relevance of mast cells in urticaria
  publication-title: Immunol Rev
  doi: 10.1111/imr.12632
  contributor:
    fullname: Church
– volume: 13
  year: 2014
  ident: B14
  article-title: Serum metabolomics study and eicosanoid analysis of childhood atopic dermatitis based on liquid chromatography-mass spectrometry
  publication-title: J Proteome Res
  doi: 10.1021/pr5007069
  contributor:
    fullname: Huang
– volume: 11
  year: 2021
  ident: B37
  article-title: Fundamentals of membrane lipid replacement: A natural medicine approach to repairing cellular membranes and reducing fatigue, pain, and other symptoms while restoring function in chronic illnesses and aging
  publication-title: Membranes (Basel)
  doi: 10.3390/membranes11120944
  contributor:
    fullname: Nicolson
– volume: 184
  year: 2021
  ident: B1
  article-title: The global burden of chronic urticaria for the patient and society
  publication-title: Br J Dermatol
  doi: 10.1111/bjd.19561
  contributor:
    fullname: Gonçalo
– volume: 30
  start-page: 596
  year: 2008
  ident: B53
  article-title: Oral phosphatidylcholine pretreatment decreases ischemia-reperfusion-induced methane generation and the inflammatory response in the small intestine
  publication-title: Shock
  doi: 10.1097/SHK.0b013e31816f204a
  contributor:
    fullname: Ghyczy
– volume: 172
  year: 2015
  ident: B54
  article-title: Elevations in T-helper-2-initiating cytokines (interleukin-33, interleukin-25 and thymic stromal lymphopoietin) in lesional skin from chronic spontaneous ('idiopathic') urticaria
  publication-title: Br J Dermatol
  doi: 10.1111/bjd.13621
  contributor:
    fullname: Kay
– volume: 177
  year: 2017
  ident: B27
  article-title: Analysis of disease activity categories in chronic spontaneous/idiopathic urticaria
  publication-title: Br J Dermatol
  doi: 10.1111/bjd.15454
  contributor:
    fullname: Stull
– volume: 40
  year: 2021
  ident: B12
  article-title: Untargeted lipidomics reveals specific lipid abnormalities in systemic lupus erythematosus
  publication-title: Clin Exp Rheumatol
  doi: 10.55563/clinexprheumatol/ye2ua5
  contributor:
    fullname: Wang
– volume: 38
  start-page: 49
  year: 2020
  ident: B17
  article-title: Mast cells in inflammation and disease: Recent progress and ongoing concerns
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev-immunol-071719-094903
  contributor:
    fullname: Galli
– volume: 157
  start-page: 111
  year: 2009
  ident: B16
  article-title: Lipid levels in patients hospitalized with coronary artery disease: an analysis of 136,905 hospitalizations in get with the guidelines
  publication-title: Am Heart J
  doi: 10.1016/j.ahj.2008.08.010
  contributor:
    fullname: Sachdeva
– volume: 9
  start-page: 89
  year: 2008
  ident: B23
  article-title: Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels
  publication-title: Nat Immunol
  doi: 10.1038/ni1550
  contributor:
    fullname: Vig
– volume: 10
  year: 2021
  ident: B4
  article-title: The role of coagulation and complement factors for mast cell activation in the pathogenesis of chronic spontaneous urticaria
  publication-title: Cells
  doi: 10.3390/cells10071759
  contributor:
    fullname: Yanase
– volume: 1866
  year: 2020
  ident: B11
  article-title: Plasma based targeted metabolomic analysis reveals alterations of phosphatidylcholines and oxidative stress markers in guinea pig model of allergic asthma
  publication-title: Biochim Biophys Acta Mol Basis Dis
  doi: 10.1016/j.bbadis.2019.165572
  contributor:
    fullname: Kertys
– volume: 34
  year: 1995
  ident: B35
  article-title: Alteration of lipid composition modulates fc epsilon RI signaling in RBL-2H3 cells
  publication-title: Biochemistry
  doi: 10.1021/bi00013a029
  contributor:
    fullname: Chang
– volume: 139
  start-page: 1386
  year: 2017
  ident: B7
  article-title: Association of ORAI1 gene polymorphisms with chronic spontaneous urticaria and the efficacy of the nonsedating H1 antihistamine desloratadine
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2016.10.017
  contributor:
    fullname: Li
– volume: 51
  year: 2013
  ident: B58
  article-title: Platelet oxidative stress and systemic inflammation in chronic spontaneous urticaria
  publication-title: Clin Chem Lab Med
  doi: 10.1515/cclm-2012-0897
  contributor:
    fullname: Rajappa
– volume: 93
  year: 2013
  ident: B30
  article-title: Co-Existence of chronic urticaria and metabolic syndrome: clinical implications
  publication-title: Acta Derm Venereol
  doi: 10.2340/00015555-1443
  contributor:
    fullname: Ye
– volume: 279
  year: 1979
  ident: B42
  article-title: Interactions of lysophospholipids and mast cells
  publication-title: Nature
  doi: 10.1038/279250a0
  contributor:
    fullname: Martin
– volume: 135
  year: 2015
  ident: B26
  article-title: Weekly urticaria activity score (UAS7) and dermatology life quality index (DLQI) in validation of chronic Spontaneous/Idiopathic urticaria (CSU/CIU) health states
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2014.12.1362
  contributor:
    fullname: Khalil
– volume: 125
  year: 2005
  ident: B28
  article-title: Translating the science of quality of life into practice: What do dermatology life quality index scores mean
  publication-title: J Invest Dermatol
  doi: 10.1111/j.0022-202X.2005.23621.x
  contributor:
    fullname: Hongbo
– volume: 125
  year: 2013
  ident: B18
  article-title: Mast cells: from lipid droplets to lipid mediators
  publication-title: Clin Sci (Lond)
  doi: 10.1042/CS20120602
  contributor:
    fullname: Dichlberger
– volume: 175
  year: 2016
  ident: B5
  article-title: Updosing nonsedating antihistamines in patients with chronic spontaneous urticaria: a systematic review and meta-analysis
  publication-title: Br J Dermatol
  doi: 10.1111/bjd.14768
  contributor:
    fullname: Guillén-Aguinaga
– volume: 294
  year: 2002
  ident: B51
  article-title: Dilinoleoylphosphatidylcholine decreases LPS-induced TNF-alpha generation in kupffer cells of ethanol-fed rats: respective roles of MAPKs and NF-kappaB
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/s0006-291x(02)00586-7
  contributor:
    fullname: Cao
– volume: 49
  year: 2021
  ident: B25
  article-title: MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkab382
  contributor:
    fullname: Pang
– volume: 28
  year: 2003
  ident: B59
  article-title: Over-expression of Mn-superoxide dismutase as a marker of oxidative stress in lesional skin of chronic idiopathic urticaria
  publication-title: Clin Exp Dermatol
  doi: 10.1046/j.1365-2230.2003.01264.x
  contributor:
    fullname: Raho
– volume: 18
  start-page: 183
  year: 2017
  ident: B22
  article-title: metaX: a flexible and comprehensive software for processing metabolomics data
  publication-title: BMC Bioinf
  doi: 10.1186/s12859-017-1579-y
  contributor:
    fullname: Wen
– volume: 9
  year: 2020
  ident: B39
  article-title: (R)-salbutamol improves imiquimod-induced psoriasis-like skin dermatitis by regulating the Th17/Tregs balance and glycerophospholipid metabolism
  publication-title: Cells
  doi: 10.3390/cells9020511
  contributor:
    fullname: Liu
SSID ssj0000493335
Score 2.431949
Snippet Chronic urticaria (CU) is a chronic inflammatory skin disease mainly mediated by mast cells. Lipids exert essential functions in biological processes; however,...
SourceID doaj
pubmedcentral
proquest
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
StartPage 933312
SubjectTerms chronic urticaria
glycerophospholipid
Immunology
lipidomic signatures
mast cell
phosphatidylcholine
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA4iCF7EJ64vIngSqm0e3eSooqigJwVvYfLCilsX3T347500u7I9efFSShNI-k2a-abJfCHkxFntlFCiqDnIInmoAoSLhffo0Etvo-iSwh4e69tncf8iXxaO-kp7wrI8cAbunOOIYjaUDETEj1rqwDW6_Noib4lR59m3kgvB1FvmvZxzmZcxMQrT57EZjaYYDzJ2looq1nNEnV5_j2T2t0gu-JybdbI2I4v0IndygyyFdpOs5OMjv7fI091M6wFnLPrejBufUoxpDJ1Y5xdtuiTc-E3HSJFHkKvQtGNjXqGlLovj0mlqA-Nm2CbPN9dPV7fF7JSEwgnBJoUOwg91KCGAxguzwrqgXUTHrCzUWnsPEklTDYC3asgZAHgXGVjLXan5DlluP9qwS2hKWuUyqjooLZC6gAtSeRWjk2iCig3I6RwyM85iGAaDiISv6fA1CV-T8R2QywTqb8WkY909QOuamXXNX9YdkOO5SQyO-7SYAW34mH6ZlEeHwVbFqgEZ9mzVa7Ff0javnYI2crJSSrb3H13cJ6vprdP_XqYOyPLkcxoOkahM7FE3Jn8A0ATpPA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LaxRBEG5CRMlF1ERcX7TgSZg424_Z7oOICQlRiKcs5NZUv3QkO7vuA9x_b9XMbMhATrkMw_SLqX7UV91dXzH2MXgbjDKqqCTogjRUASrkIkZU6GX0WbVOYZc_q4up-nGtr_fYLrxVL8DVvaYdxZOaLm-O__3dfsUJ_4UsTtS3n3M9m23Q1BPiGM1zSTGHHwklFQ34yx7t_-nAMCbr7mzz_pIH7InUtiLWvIGiavn8ByB0eIXyjk46f8ae9mCSf-t6_znbS80L9rgLL7k9ZFffey4IXNH4Tb2oI7kg85xaMs8Vr1sn3bzlC4TQM-iycLrRscvQ8NCR5_INtYF2NRyx6fnZ1elF0UdRKIJSYl3YpOLEphISWHwIr3xINmRU3MZDZW2MoBFUVQD4aiZSAEAMWYD3MpRWvmT7zbxJrxgnp1aps6mSsQqhDYSkTTQ5By18GosR-7QTmVt0ZBkOjQwStWtF7UjUrhP1iJ2QUG8zEs91-2G-_OX6aeMkridYdSlAZVzStU3SIuCrPKLWnC1W8mHXJQ7nBR12QJPmm5UjPzs0xsZiPGKTQV8NWhymNPXvlmEbMVuptXj94JJv2AH9Km0CC_OW7a-Xm_QO0cvav2_H5H9ww_M2
  priority: 102
  providerName: Scholars Portal
Title Integrative lipidomic features identify plasma lipid signatures in chronic urticaria
URI https://search.proquest.com/docview/2702487121
https://pubmed.ncbi.nlm.nih.gov/PMC9370552
https://doaj.org/article/37872be02a4f46759e396106b774ff92
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZJoNBLafqgmzZBhZ4K3rX18ErHNiRNC1t6SGBvYvRqXWLvkuwe8u87ku0QX3sRxpIlezRovrFmPhHyyVntlFCiqDnIIlmoAoSLhfdo0Etvo8hJYauf9dWN-LGW6wMix1yYHLTvbDPvbtt51_zJsZXb1i3GOLHFr9U5mtRSSrY4JIdLzp-46H97yMs5l_0OJjpgehGbtt2jK8jYPFVV6QQbLnWduPEm5iiz9k-g5jRQ8onluXxJXgyQkX7pX-2YHITuFXnWHyL58Jpcfx8YH3DdorfNtvEp0ZjGkCk772mTU3HjA90iUG6hb0JT3MbYoKOup8il-zQGes_whtxcXlyfXxXDWQmFE4LtCh2EX-pQQgCNBbPCuqBdRPOsLNRaew8SoVMNgJdqyRkAeBcZWMtdqflbctRtuvCO0JS6ymVUdVBaIIABF6TyKkYnmQ0Vm5HPo8jMtqfEMOhKJFGbLGqTRG16Uc_I1yTUx4aJzTrf2Nz9NsOcGo6rBnZdMhARF26pA9cI62qL2DRGjZ18HKfEoPanLQ3owmZ_b1I2HbpcFatmZDmZq8mI0xpUq8yjPajRyX8_-Z48T5-afvUy9YEc7e724RQxys6eZd8ey2_rCsuVUGdZS_8B9iTttQ
link.rule.ids 230,315,733,786,790,870,891,2115,24346,27955,27956,53825,53827
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwELVKEYIL5atioYCROCElm_VH1j5CRbWFbsVhi3qzbMeGlCa7ajeH8usZ2wlquMElimInjvOczJt45hmhd9ZIK5hgWUk1z4KFyjSzPqsqMOhFZTyLSWHL03Jxxj6f8_MdxIdcmBi0b02dt5dN3tY_YmzlprHTIU5s-nV5CCa14JxM76C78L4SfstJv0ikl1LK0xwmuGBy6uum6cAZJCQPRbOwhg3lsgzqeCODFHX7R2RzHCp5y_Yc7aFvw12nkJOfebc1uf31l6DjP3frEXrYs1H8IRU_RjuufYLupfUpb56i1XEvJgGfRHxZb-oq5DBj76Ia6DWuY5avv8Eb4OCNTlVwCAkZKrTYJvVd3IU2wDHXz9DZ0afV4SLrl2HILGNkm0nHqrl0hXZawoYYZqyT1oPlF0aXUlaV5sDKSq1hV8wp0VpX1hNtDLWFpPtot1237jnCISuWci9KJyQDbqSt46IS3ltOjJuRCXo_YKE2SW1DgZcSMFQRQxUwVAnDCfoY0PpTMQhlxwPrq--qf66KwgcJLl0QzTzYBC4dlcAYSwO013sJF3k7YK3gxQqzJbp16-5ahUQ98OZmZDZB89EgGLU4LgFoo0R3D-WL_z7zDbq_WC1P1Mnx6ZeX6EHodvijTMQB2t1ede4VUKGteR0H_m_hNAz5
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagCMSFN-pSHkHihJTH-pGNj6WwaoFWPbRSxcXyk6ZtslG7OZRfz9hO0IZjL1GUTOIkX-z5Jpn5jNAnrbiuaEXTkkiWeg-VSqpdagw49MIoR0NR2OFRuX9Kv5-xs42pvkLSvlZ11l41WVufh9zKrtH5mCeWHx_ugUstGMN5Z1x-Hz2APosXG4H6RSS-hBAW_2NCGMZzVzdNDwEhxpnfNffz2BDGS6-QN3FKQbt_Qjin6ZIb_mf5FP0arzymnVxm_Vpl-s9_oo53urVn6MnASpPdaPIc3bPtC_QwzlN5-xKdHAyiEjA0Jld1Vxtfy5w4G1RBb5I6VPu626QDLt7IaJL41JDRoE10VOFNet8GBOjyFTpdfjvZ20-H6RhSTSlep9xSs-C2kFZyWGBFlbZcO2AAlZIl58ZIBuyslBJWqwXBUkqjHZZKEV1w8hpttavWbqPEV8cS5qrSVpwCR5LasspUzmmGlZ3jGfo84iG6qLohIFrxOIqAo_A4iojjDH3xiP0z9ILZYcPq-rcYnq0gMDDBqQssqQPfwLglHJhjqYD-OsfhJB9HvAV0MP_XRLZ21d8IX7AHUd0cz2doMXkRJi1O9wC8Qap7gPPNnY_8gB4df12KnwdHP3bQY3_X_sMyrt6irfV1b98BI1qr9-Hd_wsyxQ95
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Integrative+lipidomic+features+identify+plasma+lipid+signatures+in+chronic+urticaria&rft.jtitle=Frontiers+in+immunology&rft.au=Li%2C+Jie&rft.au=Li%2C+Liqiao&rft.au=Liu%2C+Runqiu&rft.au=Zhu%2C+Lei&rft.date=2022-07-28&rft.pub=Frontiers+Media+S.A&rft.eissn=1664-3224&rft.volume=13&rft_id=info:doi/10.3389%2Ffimmu.2022.933312&rft_id=info%3Apmid%2F35967440&rft.externalDBID=PMC9370552
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-3224&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-3224&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-3224&client=summon