Response to Ursodeoxycholic Acid May Be Assessed Earlier to Allow Second-Line Therapy in Patients with Unresponsive Primary Biliary Cholangitis

• Published in: Digestive diseases and sciences Vol. 68; no. 2; pp. 514 - 520
• Main Authors: Cançado, Guilherme Grossi Lopes, Couto, Cláudia Alves, Terrabuio, Debora Raquel Benedita, Cançado, Eduardo Luiz Rachid, Villela-Nogueira, Cristiane Alves, Ferraz, Maria Lucia Gomes, Braga, Michelle Harriz, Nardelli, Mateus Jorge, Faria, Luciana Costa, de Faria Gomes, Nathalia Mota, Oliveira, Elze Maria Gomes, Rotman, Vivian, Oliveira, Maria Beatriz, da Cunha, Simone Muniz Carvalho Fernandes, Cunha-Silva, Marlone, Mendes, Liliana Sampaio Costa, Ivantes, Claudia Alexandra Pontes, Codes, Liana, de Almeida e Borges, Valéria Ferreira, de Lima Pace, Fabio Heleno, Pessoa, Mario Guimarães, Guedes, Laura Vilar, Signorelli, Izabelle Venturini, Coral, Gabriela Perdomo, Levy, Cynthia, Bittencourt, Paulo Lisboa
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2023; Springer; Springer Nature B.V
• Subjects: Acids; Adult; Aged; Antibodies; Biochemistry; Cholagogues and Choleretics - therapeutic use; Cholangitis; Consortia; Drug dosages; Enzymes; Female; Gallbladder diseases; Gastroenterology; Hepatology; Histology; Humans; Laboratories; Liver; Liver cirrhosis; Liver Cirrhosis, Biliary - drug therapy; Liver diseases; Male; Medical prognosis; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Article; Patient compliance; Phosphatase; Phosphatases; Retrospective Studies; Statistical analysis; Transplant Surgery; Transplants & implants; Ursodeoxycholic Acid - therapeutic use; Ursodiol; Variables; Primary biliary cholangitis; Treatment; Second-line therapy; Ursodeoxycholic acid

Background Response to ursodeoxycholic acid (UDCA) in primary biliary cholangitis (PBC) has been traditionally assessed 1 to 2 years after treatment initiation. With the development of new drugs, some patients may benefit from an earlier introduction of second-line therapies. Aims This study aims to...