Efficacy and treatment tolerance in older patients with NSCLC: a meta-analysis of five phase III randomized trials conducted by the Hellenic Oncology Research Group
Approximately 50% of newly diagnosed cases of non-small-cell lung cancer (NSCLC) are observed in patients >65 years, while 30%–40% of cases occur in patients >70 years. The objective of the current study was to determine (i) the number of elderly (>70 years) patients with advanced/metastati...
Saved in:
Published in | Annals of oncology Vol. 22; no. 11; pp. 2448 - 2455 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
01.11.2011
Oxford University Press |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Approximately 50% of newly diagnosed cases of non-small-cell lung cancer (NSCLC) are observed in patients >65 years, while 30%–40% of cases occur in patients >70 years.
The objective of the current study was to determine (i) the number of elderly (>70 years) patients with advanced/metastatic NSCLC enrolled in phase III trials of the Hellenic Oncology Research Group, (ii) the treatment-related toxicity observed in these patients compared with their younger counterparts, and (iii) the differences in terms of response rate, time to tumor progression (TTP), and overall survival (OS) between younger and older patients.
Pooled data from five clinical trials including 1845 patients were analyzed; 1421 (77%) and 424 (23%) were <70 years and ≥70 years, respectively. No difference was observed in terms of the overall response rate and TTP. There was an OS difference between young and older patients, with higher risk for death in older patients. However, when the analysis was carried out after omitting a trial that showed a different trend, no difference was observed. Older patients experienced higher toxicity.
This report supports the feasibility of chemotherapy treatment for older NSCLC patients. Optimization of treatment of older NSCLC patients requires the design of prospective older-specific phase III trials for these patients. |
---|---|
AbstractList | Background: Approximately 50% of newly diagnosed cases of non-small-cell lung cancer (NSCLC) are observed in patients >65 years, while 30%-40% of cases occur in patients >70 years.
Patients and methods: The objective of the current study was to determine (i) the number of elderly (>70 years) patients with advanced/metastatic NSCLC enrolled in phase III trials of the Hellenic Oncology Research Group, (ii) the treatment-related toxicity observed in these patients compared with their younger counterparts, and (iii) the differences in terms of response rate, time to tumor progression (TTP), and overall survival (OS) between younger and older patients.
Results: Pooled data from five clinical trials including 1845 patients were analyzed; 1421 (77%) and 424 (23%) were <70 years and ≥70 years, respectively. No difference was observed in terms of the overall response rate and TTP. There was an OS difference between young and older patients, with higher risk for death in older patients. However, when the analysis was carried out after omitting a trial that showed a different trend, no difference was observed. Older patients experienced higher toxicity.
Conclusions: This report supports the feasibility of chemotherapy treatment for older NSCLC patients. Optimization of treatment of older NSCLC patients requires the design of prospective older-specific phase III trials for these patients. Approximately 50% of newly diagnosed cases of non-small-cell lung cancer (NSCLC) are observed in patients >65 years, while 30%-40% of cases occur in patients >70 years. The objective of the current study was to determine (i) the number of elderly (>70 years) patients with advanced/metastatic NSCLC enrolled in phase III trials of the Hellenic Oncology Research Group, (ii) the treatment-related toxicity observed in these patients compared with their younger counterparts, and (iii) the differences in terms of response rate, time to tumor progression (TTP), and overall survival (OS) between younger and older patients. Pooled data from five clinical trials including 1845 patients were analyzed; 1421 (77%) and 424 (23%) were <70 years and ≥70 years, respectively. No difference was observed in terms of the overall response rate and TTP. There was an OS difference between young and older patients, with higher risk for death in older patients. However, when the analysis was carried out after omitting a trial that showed a different trend, no difference was observed. Older patients experienced higher toxicity. This report supports the feasibility of chemotherapy treatment for older NSCLC patients. Optimization of treatment of older NSCLC patients requires the design of prospective older-specific phase III trials for these patients. |
Author | Vardakis, N. Georgoulias, V. Hatzidaki, D. Kotsakis, A. Mavroudis, D. Pallis, A.G. Vamvakas, L. Karampeazis, A. Kalykaki, A. Bozionelou, V. |
Author_xml | – sequence: 1 givenname: A.G. surname: Pallis fullname: Pallis, A.G. email: georgsec@med.uoc.gr – sequence: 2 givenname: A. surname: Karampeazis fullname: Karampeazis, A. – sequence: 3 givenname: L. surname: Vamvakas fullname: Vamvakas, L. – sequence: 4 givenname: N. surname: Vardakis fullname: Vardakis, N. – sequence: 5 givenname: A. surname: Kotsakis fullname: Kotsakis, A. – sequence: 6 givenname: V. surname: Bozionelou fullname: Bozionelou, V. – sequence: 7 givenname: A. surname: Kalykaki fullname: Kalykaki, A. – sequence: 8 givenname: D. surname: Hatzidaki fullname: Hatzidaki, D. – sequence: 9 givenname: D. surname: Mavroudis fullname: Mavroudis, D. – sequence: 10 givenname: V. surname: Georgoulias fullname: Georgoulias, V. |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24735897$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21393380$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkU1v1DAQhi1URLeFI1c0FyQuoU7sfHFDq9KutKISH-do4oxZo8QOtrco_B5-KF6lwAlxsjzzzGv5mQt2Zp0lxp7n_HXOW3GFNhXU1TR8q-viEdvkZdVmDZf5GdvwthBZXQp5zi5C-Mo5r9qifcLOi1y0QjR8w35ea20UqgXQDhA9YZzIRohuJI9WERgLbhzIw4zRpFaA7yYe4P3H7X77BhAmipihxXEJJoDToM09wXzAQLDb7SClDG4yP-gUb3AMoJwdjiqmQr9APBDc0jiSNQrurHKj-7LABwqEXh3gxrvj_JQ91mmQnj2cl-zzu-tP29tsf3ez277dZ0rKImYtlgXvVV-0-SB6TrIi3pdaYqXqsuVYaC5QVRplw_NGUrpRLftSlnnPldbikmVrrvIuBE-6m72Z0C9dzruT7W613a22E_9i5edjP9Hwh_6tNwEvHwAMCkd9MmrCX07WomzaOnGvVi599r9v1itKScS9Id8FldaiaDCeVOwGZ_4x-QvdebBS |
CitedBy_id | crossref_primary_10_1007_s00280_014_2548_z crossref_primary_10_1002_14651858_CD010463_pub2 crossref_primary_10_1111_ijcp_12167 crossref_primary_10_1200_JCO_2013_49_6125 crossref_primary_10_4155_cli_13_6 crossref_primary_10_1097_CCO_0b013e32834ea6ea crossref_primary_10_1002_onco_13527 crossref_primary_10_1378_chest_12_2361 crossref_primary_10_1016_j_jgo_2014_11_001 crossref_primary_10_1007_s00280_015_2957_7 crossref_primary_10_1016_j_jgo_2022_04_016 |
Cites_doi | 10.1200/JCO.2005.04.016 10.1111/j.1532-5415.1993.tb02054.x 10.1016/S0959-8049(00)00169-6 10.1200/jco.2010.28.18_suppl.2 10.1200/JCO.2007.13.1144 10.1200/JCO.2007.15.2280 10.1634/theoncologist.5-3-224 10.1200/jco.2009.27.15_suppl.8050 10.1046/j.1532-5415.2002.50157.x 10.1016/j.lungcan.2007.07.021 10.1200/JCO.2005.07.172 10.1097/JTO.0b013e31816b4b32 10.1016/S0140-6736(00)04644-4 10.1056/NEJM199912303412706 10.1200/JCO.2005.01.2781 10.1200/JCO.2006.06.7835 10.1016/j.ejca.2010.01.006 10.1016/S0169-5002(03)00230-7 10.1634/theoncologist.2007-0043 10.1016/S0959-8049(97)10050-8 10.1016/j.ctrv.2009.12.013 10.1002/cncr.11548 10.1093/jnci/95.5.362 10.1200/JCO.2005.00.141 10.3322/caac.20006 10.1200/JCO.2005.06.742 10.1093/annonc/mdp360 10.1200/JCO.2007.12.5435 10.1200/JCO.2004.11.004 10.1002/cncr.21495 10.1200/JCO.2006.10.3085 10.1001/jama.1992.03490010059030 10.1016/j.ctrv.2009.04.011 10.1200/JCO.2006.09.2759 10.1093/jnci/91.1.66 10.1200/JCO.2004.02.175 10.1002/1097-0142(19941001)74:7+<2101::AID-CNCR2820741718>3.0.CO;2-M 10.1016/j.ejca.2010.02.022 10.1200/JCO.2003.08.010 10.1016/j.yexmp.2005.11.004 10.1200/JCO.2005.00.224 10.1016/S0169-5002(01)00392-0 10.1200/JCO.2004.05.031 10.1200/JCO.2001.19.6.1728 10.1093/jnci/94.3.173 |
ContentType | Journal Article |
Copyright | 2011 European Society for Medical Oncology The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com 2011 2015 INIST-CNRS |
Copyright_xml | – notice: 2011 European Society for Medical Oncology – notice: The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com 2011 – notice: 2015 INIST-CNRS |
DBID | 6I. AAFTH IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION |
DOI | 10.1093/annonc/mdq772 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1569-8041 |
EndPage | 2455 |
ExternalDocumentID | 10_1093_annonc_mdq772 21393380 24735897 10.1093/annonc/mdq772 S0923753419377038 |
Genre | Research Support, Non-U.S. Gov't Meta-Analysis Journal Article |
GroupedDBID | --- -E4 .2P .86 .I3 .XZ .ZR 08P 0R~ 0U7 1TH 23M 2WC 4.4 482 48X 53G 5GY 5VS 5WA 6.Y 6I. 6J9 70D AABJS AABMN AAEDW AAESY AAFTH AAIAV AAIYJ AAJKP AAJQQ AAKAS AAKUH AAMVS AAOGV AAPNW AAUQX AAXUO ABEUO ABIXL ABJNI ABKDP ABLJU ABNKS ABOCM ABQLI ABQTQ ABSAR ABSMQ ABVKL ABZBJ ACGFO ACGFS ACIMA ACMRT ACPQN ACPRK ACUFI ACUTO ADBBV ADEIU ADEYI ADHKW ADHZD ADJQC ADOCK ADORX ADQLU ADRIX ADRTK ADYVW ADZCM ADZXQ AEGPL AEGXH AEJOX AEKPW AEKSI AEMDU AENEX AENZO AEPUE AEWNT AFIYH AFOFC AFXEN AGINJ AGKEF AGKRT AGSYK AHMBA AHXPO AIAGR AIJHB AIKOY AITUG ALMA_UNASSIGNED_HOLDINGS ALUQC AMRAJ APIBT APWMN AQKUS ASMCH ASPBG ATTQO AVWKF AWCFO AXUDD AZFZN AZQFJ BAWUL BAYMD BEYMZ BGNMA BGYMP BHONS BTRTY BVRKM BZKNY C1A CAG CASEJ CDBKE CKLRP COF CS3 CZ4 DAKXR DIK DILTD DL5 DPORF DPPUQ D~K E3Z EBS EE~ EJD EX3 F9B FDB FEDTE GJXCC GX1 H5~ HAR HVGLF HW0 HZ~ I09 IH2 IHE IOX J21 KAQDR KC5 KDC KOM KOP KQ8 KSI KSN LAK M-Z M41 M49 M4Y MBLQV MHKGH N9A NCXOZ NGC NOYVH NTWIH NU- NU0 NVLIB O9- OAWHX ODMLO OJQWA OK1 OVD P2P P6G PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD R44 RD5 RNI ROL ROX ROZ RPX RW1 RXO RZC RZE RZF RZO SDH TCURE TEORI TJX TMA TR2 U2A W8F WOQ WOW X7H YAYTL YFH YKOAZ ZKX ZXP ~91 0SF AALRI ADVLN AFETI AFSHK AKRWK H13 AANRK AAPBV ABPTK IQODW AEHUL AFJKZ CGR CUY CVF ECM EIF NPM AAYXX CITATION |
ID | FETCH-LOGICAL-c442t-9a520bcb291d3b0e46e0b5f4a6c7590a2f03ac6fa480184e03ae74b5451b0cff3 |
IEDL.DBID | ABVKL |
ISSN | 0923-7534 |
IngestDate | Thu Sep 26 16:21:51 EDT 2024 Sat Sep 28 08:30:40 EDT 2024 Sun Oct 22 16:06:17 EDT 2023 Wed Sep 11 05:00:19 EDT 2024 Fri Feb 23 02:45:48 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 11 |
Keywords | meta-analysis geriatric oncology older NSCLC Human Phase III trial Lung disease Respiratory disease Lung cancer Treatment efficiency Tolerance Research Malignant tumor non-small cell lung carcinoma Metaanalysis Chemotherapy Randomization Cancerology Treatment Bronchus disease Elderly Age Cancer Geriatrics |
Language | English |
License | http://www.elsevier.com/open-access/userlicense/1.0 CC BY 4.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c442t-9a520bcb291d3b0e46e0b5f4a6c7590a2f03ac6fa480184e03ae74b5451b0cff3 |
OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0923753419377038 |
PMID | 21393380 |
PageCount | 8 |
ParticipantIDs | crossref_primary_10_1093_annonc_mdq772 pubmed_primary_21393380 pascalfrancis_primary_24735897 oup_primary_10_1093_annonc_mdq772 elsevier_sciencedirect_doi_10_1093_annonc_mdq772 |
PublicationCentury | 2000 |
PublicationDate | 2011-11-01 |
PublicationDateYYYYMMDD | 2011-11-01 |
PublicationDate_xml | – month: 11 year: 2011 text: 2011-11-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | Oxford |
PublicationPlace_xml | – name: Oxford – name: England |
PublicationTitle | Annals of oncology |
PublicationTitleAlternate | Ann Oncol |
PublicationYear | 2011 |
Publisher | Elsevier Ltd Oxford University Press |
Publisher_xml | – name: Elsevier Ltd – name: Oxford University Press |
References | Gridelli, Perrone, Monfardini (bb0015) 1997; 33 Owonikoko, Ragin, Belani (bb0065) 2007; 25 Pallis, Fortpied, Wedding (bb0220) 2010; 46 Quoix, Oster, Westeel (bb0040) 2010; 28 Ramsey, Howlader, Etzioni (bb0060) 2004; 22 Gridelli, Langer, Maione (bb0215) 2007; 25 Belani, Fossella (bb0155) 2005; 104 Weiss, Langer, Rosell (bb0195) 2006; 24 Langer, Vangel, Schiller (bb0145) 2003; 22 Frasci, Lorusso, Panza (bb0030) 2001; 34 Pallis, Gridelli (bb0135) 2010; 36 (bb0025) 1999; 91 De Martinis, Franceschi, Monti (bb0230) 2006; 80 Hutchins, Unger, Crowley (bb0115) 1999; 341 Lara, Higdon, Lim (bb0125) 2001; 19 Ansari, Gonin, Socinski (bb0175) 2007; 25 Pallis, Gridelli, van Meerbeeck (bb0045) 2010; 21 Gridelli, Perrone, Gallo (bb0035) 2003; 95 Lilenbaum, Herndon, List (bb0160) 2005; 23 Leighl, Zatloukal, Mezger (bb0190) 2009; 27 Balducci, Extermann (bb0225) 2000; 5 Georgoulias, Ardavanis, Tsiafaki (bb0095) 2005; 23 Talarico, Chen, Pazdur (bb0055) 2004; 22 Ershler (bb0235) 1993; 41 Georgoulias, Ardavanis, Agelidou (bb0090) 2004; 22 Janssen-Heijnen, Coebergh (bb0075) 2003; 41 Pallis, Wedding, Lacombe (bb0245) 2010; 46 Georgoulias, Papadakis, Alexopoulos (bb0085) 2001; 357 Townsley, Selby, Siu (bb0120) 2005; 23 Kelly, Giarritta, Akerley (bb0150) 2001; 20 Gridelli, Aapro, Ardizzoni (bb0050) 2005; 23 Pallis, Polyzos, Boukovinas (bb0200) 2008; 3 Kohne, Folprecht, Goldberg (bb0255) 2008; 13 Havlik, Yancik, Long (bb0020) 1994; 74 Georgoulias, Androulakis, Kotsakis (bb0100) 2008; 59 Goto, Nishiwaki, Saijo (bb0170) 2006; 24 Wheatley-Price, Ding, Seymour (bb0185) 2008; 26 Townsley, Pond, Peloza (bb0070) 2005; 23 Hunter, Frelick, Feldman (bb0130) 1987; 71 Jemal, Siegel, Ward (bb0010) 2009; 59 Lewis, Kilgore, Goldman (bb0110) 2003; 21 Balducci (bb0080) 2000; 36 Hensing, Peterman, Schell (bb0165) 2003; 98 Langer, Manola, Bernardo (bb0140) 2002; 94 Sederholm, Hillerdal, Lamberg (bb0180) 2005; 23 Gridelli, Maione, Rossi (bb0205) 2009; 35 Christman, Muss, Case (bb0250) 1992; 268 Kumar, Soares, Balducci (bb0105) 2007; 25 Ramalingam, Dahlberg, Langer (bb0210) 2008; 26 Reuben, Cheh, Harris (bb0240) 2002; 50 Lilenbaum (10.1093/annonc/mdq772_bb0160) 2005; 23 Gridelli (10.1093/annonc/mdq772_bb0015) 1997; 33 Lewis (10.1093/annonc/mdq772_bb0110) 2003; 21 Pallis (10.1093/annonc/mdq772_bb0220) 2010; 46 Reuben (10.1093/annonc/mdq772_bb0240) 2002; 50 Balducci (10.1093/annonc/mdq772_bb0080) 2000; 36 Owonikoko (10.1093/annonc/mdq772_bb0065) 2007; 25 Ansari (10.1093/annonc/mdq772_bb0175) 2007; 25 Georgoulias (10.1093/annonc/mdq772_bb0085) 2001; 357 Goto (10.1093/annonc/mdq772_bb0170) 2006; 24 Jemal (10.1093/annonc/mdq772_bb0010) 2009; 59 Lara (10.1093/annonc/mdq772_bb0125) 2001; 19 Gridelli (10.1093/annonc/mdq772_bb0050) 2005; 23 Georgoulias (10.1093/annonc/mdq772_bb0100) 2008; 59 Langer (10.1093/annonc/mdq772_bb0140) 2002; 94 Quoix (10.1093/annonc/mdq772_bb0040) 2010; 28 Kumar (10.1093/annonc/mdq772_bb0105) 2007; 25 De Martinis (10.1093/annonc/mdq772_bb0230) 2006; 80 Gridelli (10.1093/annonc/mdq772_bb0035) 2003; 95 Georgoulias (10.1093/annonc/mdq772_bb0090) 2004; 22 Hutchins (10.1093/annonc/mdq772_bb0115) 1999; 341 Gridelli (10.1093/annonc/mdq772_bb0205) 2009; 35 Pallis (10.1093/annonc/mdq772_bb0245) 2010; 46 Kohne (10.1093/annonc/mdq772_bb0255) 2008; 13 Townsley (10.1093/annonc/mdq772_bb0120) 2005; 23 Ramalingam (10.1093/annonc/mdq772_bb0210) 2008; 26 Kelly (10.1093/annonc/mdq772_bb0150) 2001; 20 Langer (10.1093/annonc/mdq772_bb0145) 2003; 22 Frasci (10.1093/annonc/mdq772_bb0030) 2001; 34 Wheatley-Price (10.1093/annonc/mdq772_bb0185) 2008; 26 Leighl (10.1093/annonc/mdq772_bb0190) 2009; 27 Hensing (10.1093/annonc/mdq772_bb0165) 2003; 98 Sederholm (10.1093/annonc/mdq772_bb0180) 2005; 23 Townsley (10.1093/annonc/mdq772_bb0070) 2005; 23 Pallis (10.1093/annonc/mdq772_bb0200) 2008; 3 Havlik (10.1093/annonc/mdq772_bb0020) 1994; 74 Pallis (10.1093/annonc/mdq772_bb0045) 2010; 21 Belani (10.1093/annonc/mdq772_bb0155) 2005; 104 Georgoulias (10.1093/annonc/mdq772_bb0095) 2005; 23 Janssen-Heijnen (10.1093/annonc/mdq772_bb0075) 2003; 41 Ramsey (10.1093/annonc/mdq772_bb0060) 2004; 22 Christman (10.1093/annonc/mdq772_bb0250) 1992; 268 Balducci (10.1093/annonc/mdq772_bb0225) 2000; 5 (10.1093/annonc/mdq772_bb0025) 1999; 91 Hunter (10.1093/annonc/mdq772_bb0130) 1987; 71 Weiss (10.1093/annonc/mdq772_bb0195) 2006; 24 Talarico (10.1093/annonc/mdq772_bb0055) 2004; 22 Ershler (10.1093/annonc/mdq772_bb0235) 1993; 41 Gridelli (10.1093/annonc/mdq772_bb0215) 2007; 25 Pallis (10.1093/annonc/mdq772_bb0135) 2010; 36 |
References_xml | – volume: 23 start-page: 2937 year: 2005 end-page: 2945 ident: bb0095 article-title: Vinorelbine plus cisplatin versus docetaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III randomized trial publication-title: J Clin Oncol contributor: fullname: Tsiafaki – volume: 22 year: 2003 ident: bb0145 article-title: Age-specific subanalysis of ECOG 1594: fit elderly patients (70-80 YRS) with NSCLC do as well as younger pts (<70) publication-title: Proc Am Soc Clin Oncol contributor: fullname: Schiller – volume: 268 start-page: 57 year: 1992 end-page: 62 ident: bb0250 article-title: Chemotherapy of metastatic breast cancer in the elderly. The Piedmont Oncology Association experience [see comment] publication-title: JAMA contributor: fullname: Case – volume: 74 start-page: 2101 year: 1994 end-page: 2106 ident: bb0020 article-title: The National Institute on Aging and the National Cancer Institute SEER collaborative study on comorbidity and early diagnosis of cancer in the elderly publication-title: Cancer contributor: fullname: Long – volume: 25 start-page: 5570 year: 2007 end-page: 5577 ident: bb0065 article-title: Lung cancer in elderly patients: an analysis of the surveillance, epidemiology, and end results database publication-title: J Clin Oncol contributor: fullname: Belani – volume: 59 start-page: 57 year: 2008 end-page: 63 ident: bb0100 article-title: Docetaxel versus docetaxel plus gemcitabine as front-line treatment of patients with advanced non-small cell lung cancer: a randomized, multicenter phase III trial publication-title: Lung Cancer contributor: fullname: Kotsakis – volume: 23 start-page: 8380 year: 2005 end-page: 8388 ident: bb0180 article-title: Phase III trial of gemcitabine plus carboplatin versus single-agent gemcitabine in the treatment of locally advanced or metastatic non-small-cell lung cancer: the Swedish Lung Cancer Study Group publication-title: J Clin Oncol contributor: fullname: Lamberg – volume: 24 start-page: 4405 year: 2006 end-page: 4411 ident: bb0195 article-title: Elderly patients benefit from second-line cytotoxic chemotherapy: a subset analysis of a randomized phase III trial of pemetrexed compared with docetaxel in patients with previously treated advanced non-small-cell lung cancer publication-title: J Clin Oncol contributor: fullname: Rosell – volume: 41 start-page: 176 year: 1993 end-page: 181 ident: bb0235 article-title: Interleukin-6: a cytokine for gerontologists publication-title: J Am Geriatr Soc contributor: fullname: Ershler – volume: 35 start-page: 517 year: 2009 end-page: 521 ident: bb0205 article-title: Management of unfit older patients with advanced NSCLC publication-title: Cancer Treat Rev contributor: fullname: Rossi – volume: 22 start-page: 2602 year: 2004 end-page: 2609 ident: bb0090 article-title: Docetaxel versus docetaxel plus cisplatin as front-line treatment of patients with advanced non-small-cell lung cancer: a randomized, multicenter phase III trial publication-title: J Clin Oncol contributor: fullname: Agelidou – volume: 19 start-page: 1728 year: 2001 end-page: 1733 ident: bb0125 article-title: Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment publication-title: J Clin Oncol contributor: fullname: Lim – volume: 36 start-page: 436 year: 2010 end-page: 441 ident: bb0135 article-title: Is age a negative prognostic factor for the treatment of advanced/metastatic non-small-cell lung cancer? publication-title: Cancer Treat Rev contributor: fullname: Gridelli – volume: 23 start-page: 190 year: 2005 end-page: 196 ident: bb0160 article-title: Single-agent versus combination chemotherapy in advanced non-small-cell lung cancer: the cancer and leukemia group B (study 9730) publication-title: J Clin Oncol contributor: fullname: List – volume: 98 start-page: 779 year: 2003 end-page: 788 ident: bb0165 article-title: The impact of age on toxicity, response rate, quality of life, and survival in patients with advanced, stage IIIB or IV nonsmall cell lung carcinoma treated with carboplatin and paclitaxel publication-title: Cancer contributor: fullname: Schell – volume: 23 start-page: 3125 year: 2005 end-page: 3137 ident: bb0050 article-title: Treatment of advanced non-small-cell lung cancer in the elderly: results of an international expert panel publication-title: J Clin Oncol contributor: fullname: Ardizzoni – volume: 25 year: 2007 ident: bb0175 article-title: Elderly subgroup analysis of a randomized phase 3 trial of gemcitabine (G) in combination with carboplatin (Cb) or paclitaxel (P) compared to paclitaxel plus carboplatin in advanced (stage IIIB, IV) non-small cell lung cancer publication-title: Proc Am Soc Clin Oncol contributor: fullname: Socinski – volume: 59 start-page: 225 year: 2009 end-page: 249 ident: bb0010 article-title: Cancer Statistics, 2009 publication-title: CA Cancer J Clin contributor: fullname: Ward – volume: 22 start-page: 4971 year: 2004 end-page: 4978 ident: bb0060 article-title: Chemotherapy use, outcomes, and costs for older persons with advanced non-small-cell lung cancer: evidence from surveillance, epidemiology and end results-Medicare publication-title: J Clin Oncol contributor: fullname: Etzioni – volume: 33 start-page: 2313 year: 1997 end-page: 2314 ident: bb0015 article-title: Lung cancer in the elderly publication-title: Eur J Cancer contributor: fullname: Monfardini – volume: 34 start-page: S65 year: 2001 end-page: S69 ident: bb0030 article-title: Gemcitabine plus vinorelbine yields better survival outcome than vinorelbine alone in elderly patients with advanced non-small cell lung cancer. A Southern Italy Cooperative Oncology Group (SICOG) phase III trial publication-title: Lung Cancer contributor: fullname: Panza – volume: 341 start-page: 2061 year: 1999 end-page: 2067 ident: bb0115 article-title: Underrepresentation of patients 65 years of age or older in cancer-treatment trials publication-title: N Engl J Med contributor: fullname: Crowley – volume: 94 start-page: 173 year: 2002 end-page: 181 ident: bb0140 article-title: Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: implications of Eastern Cooperative Oncology Group 5592, a randomized trial publication-title: J Natl Cancer Inst contributor: fullname: Bernardo – volume: 23 start-page: 3112 year: 2005 end-page: 3124 ident: bb0120 article-title: Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials publication-title: J Clin Oncol contributor: fullname: Siu – volume: 3 start-page: 505 year: 2008 end-page: 510 ident: bb0200 article-title: Pooled analysis of elderly patients with non-small cell lung cancer treated with front line docetaxel/gemcitabine regimen: the Hellenic Oncology Research Group experience publication-title: J Thorac Oncol contributor: fullname: Boukovinas – volume: 21 start-page: 692 year: 2010 end-page: 706 ident: bb0045 article-title: EORTC Elderly Task Force and Lung Cancer Group and International Society for Geriatric Oncology (SIOG) experts’ opinion for the treatment of non-small-cell lung cancer in an elderly population publication-title: Ann Oncol contributor: fullname: van Meerbeeck – volume: 36 start-page: 1741 year: 2000 end-page: 1754 ident: bb0080 article-title: Geriatric oncology: challenges for the new century publication-title: Eur J Cancer contributor: fullname: Balducci – volume: 20 year: 2001 ident: bb0150 article-title: Should older patients (pts) receive combination chemotherapy for advanced stage non-small cell lung cancer (NSCLC)? An analysis of Southwest Oncology trials 9509 and 9308 publication-title: Proc Am Soc Clin Oncol contributor: fullname: Akerley – volume: 21 start-page: 1383 year: 2003 end-page: 1389 ident: bb0110 article-title: Participation of patients 65 years of age or older in cancer clinical trials publication-title: J Clin Oncol contributor: fullname: Goldman – volume: 50 start-page: 638 year: 2002 end-page: 644 ident: bb0240 article-title: Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons publication-title: J Am Geriatr Soc contributor: fullname: Harris – volume: 104 start-page: 2766 year: 2005 end-page: 2774 ident: bb0155 article-title: Elderly subgroup analysis of a randomized phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for first-line treatment of advanced nonsmall cell lung carcinoma (TAX 326) publication-title: Cancer contributor: fullname: Fossella – volume: 25 start-page: 1898 year: 2007 end-page: 1907 ident: bb0215 article-title: Lung cancer in the elderly publication-title: J Clin Oncol contributor: fullname: Maione – volume: 26 start-page: 2350 year: 2008 end-page: 2357 ident: bb0185 article-title: Erlotinib for advanced non-small-cell lung cancer in the elderly: an analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21 publication-title: J Clin Oncol contributor: fullname: Seymour – volume: 28 year: 2010 ident: bb0040 article-title: Weekly paclitaxel combined with monthly carboplatin versus single agent therapy in patients aged 70 to 89: IFCT-0501 randomized phase III study in advanced non-small cell lung cancer publication-title: J Clin Oncol contributor: fullname: Westeel – volume: 22 start-page: 4626 year: 2004 end-page: 4631 ident: bb0055 article-title: Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration publication-title: J Clin Oncol contributor: fullname: Pazdur – volume: 41 start-page: 245 year: 2003 end-page: 258 ident: bb0075 article-title: The changing epidemiology of lung cancer in Europe publication-title: Lung Cancer contributor: fullname: Coebergh – volume: 26 start-page: 60 year: 2008 end-page: 65 ident: bb0210 article-title: Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group Trial 4599 publication-title: J Clin Oncol contributor: fullname: Langer – volume: 24 year: 2006 ident: bb0170 article-title: The Four-Arm Cooperative Study (FACS) for advanced non-small cell lung cancer (NSCLC): a subgroup analysis in elderly patients (pts) publication-title: Proc Am Soc Clin Oncol contributor: fullname: Saijo – volume: 5 start-page: 224 year: 2000 end-page: 237 ident: bb0225 article-title: Management of cancer in the older person: a practical approach publication-title: Oncologist contributor: fullname: Extermann – volume: 23 start-page: 3802 year: 2005 end-page: 3810 ident: bb0070 article-title: Analysis of treatment practices for elderly cancer patients in Ontario, Canada publication-title: J Clin Oncol contributor: fullname: Peloza – volume: 91 start-page: 66 year: 1999 end-page: 72 ident: bb0025 article-title: Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. The Elderly Lung Cancer Vinorelbine Italian Study Group publication-title: J Natl Cancer Inst – volume: 357 start-page: 1478 year: 2001 end-page: 1484 ident: bb0085 article-title: Platinum-based and non-platinum-based chemotherapy in advanced non-small-cell lung cancer: a randomised multicentre trial publication-title: Lancet contributor: fullname: Alexopoulos – volume: 71 start-page: 559 year: 1987 end-page: 565 ident: bb0130 article-title: Selection factors in clinical trials: results from the Community Clinical Oncology Program Physician’s Patient Log publication-title: Cancer Treat Rep contributor: fullname: Feldman – volume: 13 start-page: 390 year: 2008 end-page: 402 ident: bb0255 article-title: Chemotherapy in elderly patients with colorectal cancer publication-title: Oncologist contributor: fullname: Goldberg – volume: 46 start-page: 1502 year: 2010 end-page: 1513 ident: bb0220 article-title: EORTC elderly task force position paper: approach to the older cancer patient publication-title: Eur J Cancer contributor: fullname: Wedding – volume: 95 start-page: 362 year: 2003 end-page: 372 ident: bb0035 article-title: Chemotherapy for elderly patients with advanced non-small-cell lung cancer: the Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial publication-title: J Natl Cancer Inst contributor: fullname: Gallo – volume: 25 start-page: 1272 year: 2007 end-page: 1276 ident: bb0105 article-title: Treatment tolerance and efficacy in geriatric oncology: a systematic review of phase III randomized trials conducted by five National Cancer Institute-sponsored cooperative groups publication-title: J Clin Oncol contributor: fullname: Balducci – volume: 80 start-page: 219 year: 2006 end-page: 227 ident: bb0230 article-title: Inflammation markers predicting frailty and mortality in the elderly publication-title: Exp Mol Pathol contributor: fullname: Monti – volume: 46 start-page: 1019 year: 2010 end-page: 1025 ident: bb0245 article-title: Questionnaires and instruments for a multidimensional assessment of the older cancer patient: what clinicians need to know? publication-title: Eur J Cancer contributor: fullname: Lacombe – volume: 27 year: 2009 ident: bb0190 article-title: Efficacy and safety of first-line bevacizumab (Bv) and cisplatin/gemcitabine (CG) in elderly patients (pts) with advanced non-small cell lung cancer (NSCLC) in the BO17704 study (AVAiL) publication-title: J Clin Oncol contributor: fullname: Mezger – volume: 23 start-page: 2937 year: 2005 ident: 10.1093/annonc/mdq772_bb0095 article-title: Vinorelbine plus cisplatin versus docetaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III randomized trial publication-title: J Clin Oncol doi: 10.1200/JCO.2005.04.016 contributor: fullname: Georgoulias – volume: 41 start-page: 176 year: 1993 ident: 10.1093/annonc/mdq772_bb0235 article-title: Interleukin-6: a cytokine for gerontologists publication-title: J Am Geriatr Soc doi: 10.1111/j.1532-5415.1993.tb02054.x contributor: fullname: Ershler – volume: 36 start-page: 1741 year: 2000 ident: 10.1093/annonc/mdq772_bb0080 article-title: Geriatric oncology: challenges for the new century publication-title: Eur J Cancer doi: 10.1016/S0959-8049(00)00169-6 contributor: fullname: Balducci – volume: 28 year: 2010 ident: 10.1093/annonc/mdq772_bb0040 article-title: Weekly paclitaxel combined with monthly carboplatin versus single agent therapy in patients aged 70 to 89: IFCT-0501 randomized phase III study in advanced non-small cell lung cancer publication-title: J Clin Oncol doi: 10.1200/jco.2010.28.18_suppl.2 contributor: fullname: Quoix – volume: 26 start-page: 60 year: 2008 ident: 10.1093/annonc/mdq772_bb0210 article-title: Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group Trial 4599 publication-title: J Clin Oncol doi: 10.1200/JCO.2007.13.1144 contributor: fullname: Ramalingam – volume: 26 start-page: 2350 year: 2008 ident: 10.1093/annonc/mdq772_bb0185 article-title: Erlotinib for advanced non-small-cell lung cancer in the elderly: an analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21 publication-title: J Clin Oncol doi: 10.1200/JCO.2007.15.2280 contributor: fullname: Wheatley-Price – volume: 5 start-page: 224 year: 2000 ident: 10.1093/annonc/mdq772_bb0225 article-title: Management of cancer in the older person: a practical approach publication-title: Oncologist doi: 10.1634/theoncologist.5-3-224 contributor: fullname: Balducci – volume: 27 year: 2009 ident: 10.1093/annonc/mdq772_bb0190 article-title: Efficacy and safety of first-line bevacizumab (Bv) and cisplatin/gemcitabine (CG) in elderly patients (pts) with advanced non-small cell lung cancer (NSCLC) in the BO17704 study (AVAiL) publication-title: J Clin Oncol doi: 10.1200/jco.2009.27.15_suppl.8050 contributor: fullname: Leighl – volume: 50 start-page: 638 year: 2002 ident: 10.1093/annonc/mdq772_bb0240 article-title: Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons publication-title: J Am Geriatr Soc doi: 10.1046/j.1532-5415.2002.50157.x contributor: fullname: Reuben – volume: 59 start-page: 57 year: 2008 ident: 10.1093/annonc/mdq772_bb0100 article-title: Docetaxel versus docetaxel plus gemcitabine as front-line treatment of patients with advanced non-small cell lung cancer: a randomized, multicenter phase III trial publication-title: Lung Cancer doi: 10.1016/j.lungcan.2007.07.021 contributor: fullname: Georgoulias – volume: 23 start-page: 190 year: 2005 ident: 10.1093/annonc/mdq772_bb0160 article-title: Single-agent versus combination chemotherapy in advanced non-small-cell lung cancer: the cancer and leukemia group B (study 9730) publication-title: J Clin Oncol doi: 10.1200/JCO.2005.07.172 contributor: fullname: Lilenbaum – volume: 3 start-page: 505 year: 2008 ident: 10.1093/annonc/mdq772_bb0200 article-title: Pooled analysis of elderly patients with non-small cell lung cancer treated with front line docetaxel/gemcitabine regimen: the Hellenic Oncology Research Group experience publication-title: J Thorac Oncol doi: 10.1097/JTO.0b013e31816b4b32 contributor: fullname: Pallis – volume: 357 start-page: 1478 year: 2001 ident: 10.1093/annonc/mdq772_bb0085 article-title: Platinum-based and non-platinum-based chemotherapy in advanced non-small-cell lung cancer: a randomised multicentre trial publication-title: Lancet doi: 10.1016/S0140-6736(00)04644-4 contributor: fullname: Georgoulias – volume: 341 start-page: 2061 year: 1999 ident: 10.1093/annonc/mdq772_bb0115 article-title: Underrepresentation of patients 65 years of age or older in cancer-treatment trials publication-title: N Engl J Med doi: 10.1056/NEJM199912303412706 contributor: fullname: Hutchins – volume: 23 start-page: 8380 year: 2005 ident: 10.1093/annonc/mdq772_bb0180 article-title: Phase III trial of gemcitabine plus carboplatin versus single-agent gemcitabine in the treatment of locally advanced or metastatic non-small-cell lung cancer: the Swedish Lung Cancer Study Group publication-title: J Clin Oncol doi: 10.1200/JCO.2005.01.2781 contributor: fullname: Sederholm – volume: 24 start-page: 4405 year: 2006 ident: 10.1093/annonc/mdq772_bb0195 article-title: Elderly patients benefit from second-line cytotoxic chemotherapy: a subset analysis of a randomized phase III trial of pemetrexed compared with docetaxel in patients with previously treated advanced non-small-cell lung cancer publication-title: J Clin Oncol doi: 10.1200/JCO.2006.06.7835 contributor: fullname: Weiss – volume: 46 start-page: 1019 year: 2010 ident: 10.1093/annonc/mdq772_bb0245 article-title: Questionnaires and instruments for a multidimensional assessment of the older cancer patient: what clinicians need to know? publication-title: Eur J Cancer doi: 10.1016/j.ejca.2010.01.006 contributor: fullname: Pallis – volume: 41 start-page: 245 year: 2003 ident: 10.1093/annonc/mdq772_bb0075 article-title: The changing epidemiology of lung cancer in Europe publication-title: Lung Cancer doi: 10.1016/S0169-5002(03)00230-7 contributor: fullname: Janssen-Heijnen – volume: 13 start-page: 390 year: 2008 ident: 10.1093/annonc/mdq772_bb0255 article-title: Chemotherapy in elderly patients with colorectal cancer publication-title: Oncologist doi: 10.1634/theoncologist.2007-0043 contributor: fullname: Kohne – volume: 33 start-page: 2313 year: 1997 ident: 10.1093/annonc/mdq772_bb0015 article-title: Lung cancer in the elderly publication-title: Eur J Cancer doi: 10.1016/S0959-8049(97)10050-8 contributor: fullname: Gridelli – volume: 24 year: 2006 ident: 10.1093/annonc/mdq772_bb0170 article-title: The Four-Arm Cooperative Study (FACS) for advanced non-small cell lung cancer (NSCLC): a subgroup analysis in elderly patients (pts) publication-title: Proc Am Soc Clin Oncol contributor: fullname: Goto – volume: 36 start-page: 436 year: 2010 ident: 10.1093/annonc/mdq772_bb0135 article-title: Is age a negative prognostic factor for the treatment of advanced/metastatic non-small-cell lung cancer? publication-title: Cancer Treat Rev doi: 10.1016/j.ctrv.2009.12.013 contributor: fullname: Pallis – volume: 25 year: 2007 ident: 10.1093/annonc/mdq772_bb0175 article-title: Elderly subgroup analysis of a randomized phase 3 trial of gemcitabine (G) in combination with carboplatin (Cb) or paclitaxel (P) compared to paclitaxel plus carboplatin in advanced (stage IIIB, IV) non-small cell lung cancer publication-title: Proc Am Soc Clin Oncol contributor: fullname: Ansari – volume: 98 start-page: 779 year: 2003 ident: 10.1093/annonc/mdq772_bb0165 article-title: The impact of age on toxicity, response rate, quality of life, and survival in patients with advanced, stage IIIB or IV nonsmall cell lung carcinoma treated with carboplatin and paclitaxel publication-title: Cancer doi: 10.1002/cncr.11548 contributor: fullname: Hensing – volume: 95 start-page: 362 year: 2003 ident: 10.1093/annonc/mdq772_bb0035 article-title: Chemotherapy for elderly patients with advanced non-small-cell lung cancer: the Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial publication-title: J Natl Cancer Inst doi: 10.1093/jnci/95.5.362 contributor: fullname: Gridelli – volume: 23 start-page: 3112 year: 2005 ident: 10.1093/annonc/mdq772_bb0120 article-title: Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials publication-title: J Clin Oncol doi: 10.1200/JCO.2005.00.141 contributor: fullname: Townsley – volume: 59 start-page: 225 year: 2009 ident: 10.1093/annonc/mdq772_bb0010 article-title: Cancer Statistics, 2009 publication-title: CA Cancer J Clin doi: 10.3322/caac.20006 contributor: fullname: Jemal – volume: 23 start-page: 3802 year: 2005 ident: 10.1093/annonc/mdq772_bb0070 article-title: Analysis of treatment practices for elderly cancer patients in Ontario, Canada publication-title: J Clin Oncol doi: 10.1200/JCO.2005.06.742 contributor: fullname: Townsley – volume: 21 start-page: 692 year: 2010 ident: 10.1093/annonc/mdq772_bb0045 article-title: EORTC Elderly Task Force and Lung Cancer Group and International Society for Geriatric Oncology (SIOG) experts’ opinion for the treatment of non-small-cell lung cancer in an elderly population publication-title: Ann Oncol doi: 10.1093/annonc/mdp360 contributor: fullname: Pallis – volume: 25 start-page: 5570 year: 2007 ident: 10.1093/annonc/mdq772_bb0065 article-title: Lung cancer in elderly patients: an analysis of the surveillance, epidemiology, and end results database publication-title: J Clin Oncol doi: 10.1200/JCO.2007.12.5435 contributor: fullname: Owonikoko – volume: 22 start-page: 2602 year: 2004 ident: 10.1093/annonc/mdq772_bb0090 article-title: Docetaxel versus docetaxel plus cisplatin as front-line treatment of patients with advanced non-small-cell lung cancer: a randomized, multicenter phase III trial publication-title: J Clin Oncol doi: 10.1200/JCO.2004.11.004 contributor: fullname: Georgoulias – volume: 22 year: 2003 ident: 10.1093/annonc/mdq772_bb0145 article-title: Age-specific subanalysis of ECOG 1594: fit elderly patients (70-80 YRS) with NSCLC do as well as younger pts (<70) publication-title: Proc Am Soc Clin Oncol contributor: fullname: Langer – volume: 104 start-page: 2766 year: 2005 ident: 10.1093/annonc/mdq772_bb0155 article-title: Elderly subgroup analysis of a randomized phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for first-line treatment of advanced nonsmall cell lung carcinoma (TAX 326) publication-title: Cancer doi: 10.1002/cncr.21495 contributor: fullname: Belani – volume: 25 start-page: 1898 year: 2007 ident: 10.1093/annonc/mdq772_bb0215 article-title: Lung cancer in the elderly publication-title: J Clin Oncol doi: 10.1200/JCO.2006.10.3085 contributor: fullname: Gridelli – volume: 268 start-page: 57 year: 1992 ident: 10.1093/annonc/mdq772_bb0250 article-title: Chemotherapy of metastatic breast cancer in the elderly. The Piedmont Oncology Association experience [see comment] publication-title: JAMA doi: 10.1001/jama.1992.03490010059030 contributor: fullname: Christman – volume: 35 start-page: 517 year: 2009 ident: 10.1093/annonc/mdq772_bb0205 article-title: Management of unfit older patients with advanced NSCLC publication-title: Cancer Treat Rev doi: 10.1016/j.ctrv.2009.04.011 contributor: fullname: Gridelli – volume: 25 start-page: 1272 year: 2007 ident: 10.1093/annonc/mdq772_bb0105 article-title: Treatment tolerance and efficacy in geriatric oncology: a systematic review of phase III randomized trials conducted by five National Cancer Institute-sponsored cooperative groups publication-title: J Clin Oncol doi: 10.1200/JCO.2006.09.2759 contributor: fullname: Kumar – volume: 91 start-page: 66 year: 1999 ident: 10.1093/annonc/mdq772_bb0025 article-title: Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. The Elderly Lung Cancer Vinorelbine Italian Study Group publication-title: J Natl Cancer Inst doi: 10.1093/jnci/91.1.66 – volume: 22 start-page: 4626 year: 2004 ident: 10.1093/annonc/mdq772_bb0055 article-title: Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration publication-title: J Clin Oncol doi: 10.1200/JCO.2004.02.175 contributor: fullname: Talarico – volume: 20 year: 2001 ident: 10.1093/annonc/mdq772_bb0150 article-title: Should older patients (pts) receive combination chemotherapy for advanced stage non-small cell lung cancer (NSCLC)? An analysis of Southwest Oncology trials 9509 and 9308 publication-title: Proc Am Soc Clin Oncol contributor: fullname: Kelly – volume: 74 start-page: 2101 year: 1994 ident: 10.1093/annonc/mdq772_bb0020 article-title: The National Institute on Aging and the National Cancer Institute SEER collaborative study on comorbidity and early diagnosis of cancer in the elderly publication-title: Cancer doi: 10.1002/1097-0142(19941001)74:7+<2101::AID-CNCR2820741718>3.0.CO;2-M contributor: fullname: Havlik – volume: 46 start-page: 1502 year: 2010 ident: 10.1093/annonc/mdq772_bb0220 article-title: EORTC elderly task force position paper: approach to the older cancer patient publication-title: Eur J Cancer doi: 10.1016/j.ejca.2010.02.022 contributor: fullname: Pallis – volume: 21 start-page: 1383 year: 2003 ident: 10.1093/annonc/mdq772_bb0110 article-title: Participation of patients 65 years of age or older in cancer clinical trials publication-title: J Clin Oncol doi: 10.1200/JCO.2003.08.010 contributor: fullname: Lewis – volume: 80 start-page: 219 year: 2006 ident: 10.1093/annonc/mdq772_bb0230 article-title: Inflammation markers predicting frailty and mortality in the elderly publication-title: Exp Mol Pathol doi: 10.1016/j.yexmp.2005.11.004 contributor: fullname: De Martinis – volume: 23 start-page: 3125 year: 2005 ident: 10.1093/annonc/mdq772_bb0050 article-title: Treatment of advanced non-small-cell lung cancer in the elderly: results of an international expert panel publication-title: J Clin Oncol doi: 10.1200/JCO.2005.00.224 contributor: fullname: Gridelli – volume: 34 start-page: S65 issue: Suppl 4 year: 2001 ident: 10.1093/annonc/mdq772_bb0030 article-title: Gemcitabine plus vinorelbine yields better survival outcome than vinorelbine alone in elderly patients with advanced non-small cell lung cancer. A Southern Italy Cooperative Oncology Group (SICOG) phase III trial publication-title: Lung Cancer doi: 10.1016/S0169-5002(01)00392-0 contributor: fullname: Frasci – volume: 22 start-page: 4971 year: 2004 ident: 10.1093/annonc/mdq772_bb0060 article-title: Chemotherapy use, outcomes, and costs for older persons with advanced non-small-cell lung cancer: evidence from surveillance, epidemiology and end results-Medicare publication-title: J Clin Oncol doi: 10.1200/JCO.2004.05.031 contributor: fullname: Ramsey – volume: 19 start-page: 1728 year: 2001 ident: 10.1093/annonc/mdq772_bb0125 article-title: Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment publication-title: J Clin Oncol doi: 10.1200/JCO.2001.19.6.1728 contributor: fullname: Lara – volume: 94 start-page: 173 year: 2002 ident: 10.1093/annonc/mdq772_bb0140 article-title: Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: implications of Eastern Cooperative Oncology Group 5592, a randomized trial publication-title: J Natl Cancer Inst doi: 10.1093/jnci/94.3.173 contributor: fullname: Langer – volume: 71 start-page: 559 year: 1987 ident: 10.1093/annonc/mdq772_bb0130 article-title: Selection factors in clinical trials: results from the Community Clinical Oncology Program Physician’s Patient Log publication-title: Cancer Treat Rep contributor: fullname: Hunter |
SSID | ssj0006929 |
Score | 2.1772003 |
SecondaryResourceType | review_article |
Snippet | Approximately 50% of newly diagnosed cases of non-small-cell lung cancer (NSCLC) are observed in patients >65 years, while 30%–40% of cases occur in patients... Background: Approximately 50% of newly diagnosed cases of non-small-cell lung cancer (NSCLC) are observed in patients >65 years, while 30%-40% of cases occur... Approximately 50% of newly diagnosed cases of non-small-cell lung cancer (NSCLC) are observed in patients >65 years, while 30%-40% of cases occur in patients... |
SourceID | crossref pubmed pascalfrancis oup elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 2448 |
SubjectTerms | Age Factors Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Cisplatin - administration & dosage Cisplatin - adverse effects Clinical Trials, Phase III as Topic - methods Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Docetaxel Female geriatric oncology Humans Lung Neoplasms - drug therapy Male Medical sciences meta-analysis Multicenter Studies as Topic NSCLC older Pharmacology. Drug treatments Pneumology Randomized Controlled Trials as Topic - methods Survival Rate Taxoids - administration & dosage Taxoids - adverse effects Taxoids - therapeutic use Tumors of the respiratory system and mediastinum Vinblastine - administration & dosage Vinblastine - adverse effects Vinblastine - analogs & derivatives Vinorelbine |
Title | Efficacy and treatment tolerance in older patients with NSCLC: a meta-analysis of five phase III randomized trials conducted by the Hellenic Oncology Research Group |
URI | https://dx.doi.org/10.1093/annonc/mdq772 https://www.ncbi.nlm.nih.gov/pubmed/21393380 |
Volume | 22 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEBbpBkohlL6zaRumUHozq5Vl2eotNQm7bbI5pClLL0bSSsTQ2JvEOWx_T39oR5Z2Swqh9GT80CBrhplv9PiGkPdcagQFUiaa2iLhRulEGesS6xaUp0q61Ph5yJOZmJzzz_NsvkXK9VkYv60y-v7g03tvHZ-M4miOlnU9OqOITRBsc4QgOdpt8YBsM7_MNCDbB5--fTneOGQhWaDcY2niG0SqTczlfa2XtjGY_F_lObsvNIWTbztLdYPD5kK9i79QaB-Njp6QxxFGwkHo6VOyZZtn5OFJXCh_Tn4demoIZVagmgVsdpND1_6wXrSFuoHWV-iGyKx6A35KFmZn5XH5ERRc2k4lKlKWQOvAoV-E5QVGPZhOp4BSFu1l_dN68d6IATNrTx6LD_QKEFfCxC8KNLWB06bnxl7Bep8f9FNeL8j50eHXcpLEggyJ4Zx1iVQZo9poJseLFJXLhaU6c1wJk2eSKuZoqoxwynPSFNzinc25RpA21tQ4l74kAxxvu0tA8CwVzglaKMaFUAr9DOO5pC61xmXjIfmw1kW1DLwbVVgvT6ugtCoobUjoWlPVHcOpMCbc1-Qd_uO_xO7f0ffma-ZrNRcyH5JXwQD-vEEwjQk_3fv_Hr0mj_q56v6M4xsy6K5v7VsEO53ej8aM11k5P_3-G_alBIw |
link.rule.ids | 315,786,790,27600,27955,27956,45696 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELfGJgESQnwNysc4JMSbVddxnJi3UW1qWVsetqG9RbZri0gsKSw8lL-HP5Rz7BYNaUI8xolPju909_PZ_h0hb4UyCAqUooa5kgqrDdXWeer8kolMK5_ZkIecL-TkXHy8yC92yHhzFyYcq0y-P_r03lunlmGazeGqroenDLEJgm2BEKRAuy1vkT1EAwrNfO_ww-eT2dYhS8Uj5R7PaOiQqDZxLR9qvbSNxcX_t6LgN4WmePPt3kpf4bT5WO_iLxTaR6PjB-R-gpFwGEf6kOy45hG5PU8b5Y_Jr6NADaHtGnSzhO1pcujary6IdlA30IYK3ZCYVa8gpGRhcTqejd-DhkvXaaoTZQm0Hjz6RVh9wagH0-kUUMqyvax_uiA-GDHgyjqQx2KDWQPiSpiETYGmtvCp6bmx17A55wd9yusJOT8-OhtPaCrIQK0QvKNK55wZa7gaLTNUrpCOmdwLLW2RK6a5Z5m20uvASVMKh0-uEAZB2sgw6322T3Zxvt0zAlLkmfReslJzIaXW6Ge4KBTzmbM-Hw3Iu40uqlXk3ajifnlWRaVVUWkDwjaaqq4ZToUx4aYub_Af_yX24Jq-t1_zUKu5VMWAPI0G8OcNgmlc8LPn_z-i1-TO5Gw-q2bTxckLcrfPW_f3HV-S3e77D_cKgU9nDpJh_wZHwwXQ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficacy+and+treatment+tolerance+in+older+patients+with+NSCLC%3A+a+meta-analysis+of+five+phase+III+randomized+trials+conducted+by+the+Hellenic+Oncology+Research+Group&rft.jtitle=Annals+of+oncology&rft.au=Pallis%2C+A+G&rft.au=Karampeazis%2C+A&rft.au=Vamvakas%2C+L&rft.au=Vardakis%2C+N&rft.date=2011-11-01&rft.eissn=1569-8041&rft.volume=22&rft.issue=11&rft.spage=2448&rft_id=info:doi/10.1093%2Fannonc%2Fmdq772&rft_id=info%3Apmid%2F21393380&rft.externalDocID=21393380 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0923-7534&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0923-7534&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0923-7534&client=summon |