Probability of Immobilization on Host Cell Surface Regulates Viral Infectivity

• Published in: Physical review letters Vol. 125; no. 12; p. 128101
• Main Authors: DeSantis, Michael C, Tian, Chunjuan, Kim, Jin H, Austin, Jamie L, Cheng, Wei
• Format: Journal Article
• Language: English
• Published: United States 18.09.2020
• Subjects: CD4 Antigens - metabolism; Cell Line; HIV Envelope Protein gp120 - metabolism; HIV-1 - metabolism; HIV-1 - pathogenicity; Humans; Optical Imaging; Time-Lapse Imaging; Virion - metabolism; Virion - pathogenicity

The efficiency of a virus to establish its infection in host cells varies broadly among viruses. It remains unclear if there is a key step in this process that controls viral infectivity. To address this question, we use single-particle tracking and Brownian dynamics simulation to examine human immu...