Inflammatory Cytokine Production by Human Neutrophils Involves C/EBP Transcription Factors

• Published in: The Journal of immunology (1950) Vol. 182; no. 1; pp. 563 - 571
• Main Authors: Cloutier, Alexandre, Guindi, Chantal, Larivee, Pierre, Dubois, Claire M, Amrani, Abdelaziz, McDonald, Patrick P
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.01.2009
• Subjects: Animals; CCAAT-Enhancer-Binding Protein-beta - genetics; CCAAT-Enhancer-Binding Protein-beta - metabolism; CCAAT-Enhancer-Binding Protein-beta - physiology; CCAAT-Enhancer-Binding Proteins - metabolism; CCAAT-Enhancer-Binding Proteins - physiology; Cell Differentiation - immunology; Cell Line, Tumor; Cells, Cultured; CHO Cells; Chromatin - metabolism; Cricetinae; Cricetulus; Cytokines - biosynthesis; Gene Expression Regulation - immunology; Humans; Inflammation Mediators - metabolism; Interleukin-8 - genetics; Interleukin-8 - metabolism; Neutrophils - immunology; Neutrophils - metabolism; Neutrophils - pathology; Phosphorylation; Promoter Regions, Genetic - immunology; Protein Binding - immunology; Transcriptional Activation - immunology

A growing number of neutrophil-derived cytokines have proven to be crucial to various inflammatory and immune processes in vivo. Whereas C/EBP (CCAAT/enhancer-binding protein) transcription factors are important for neutrophil differentiation from myeloid precursors, we report herein that they also...