Dose-dependent reduction of lymphocyte count and heart rate after multiple administration of LC51-0255, a novel sphingosine-1-phosphate receptor 1 modulator, in healthy subjects

• Published in: Frontiers in pharmacology Vol. 13; p. 930615
• Main Authors: Hwang, Inyoung, Lee, Sang Won, Oh, Jaeseong, Lee, SeungHwan, Jang, In-Jin, Yu, Kyung-Sang
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 22.08.2022
• Subjects: autoimmune disease; immunosuppression; lymphocyte count; Pharmacology; phase I; randomized controlled trial; sphingosine-1-phosphate receptor modulator

Aim: Sphingosine-1-phosphate receptor mediates the egress of lymphocytes from lymphoid organs, and its inhibition results in a decreased number of circulating lymphocytes. The aim of the current study was to investigate the safety and pharmacodynamic and pharmacokinetic characteristics of a novel sp...