Biomarkers and heterogeneous fibroblast phenotype associated with incisional hernia

• Published in: Molecular and cellular biochemistry Vol. 476; no. 9; pp. 3353 - 3363
• Main Authors: Thankam, Finosh G., Larsen, Nicholas K., Varghese, Ann, Bui, Thao-Nguyen, Reilly, Matthew, Fitzgibbons, Robert J., Agrawal, Devendra K.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2021; Springer; Springer Nature B.V
• Subjects: Abdominal wall; Actin; Biochemistry; Biological markers; Biomarkers; Biomedical and Life Sciences; Cadherins; Cardiology; CD34 antigen; Comparative analysis; Connective tissue; Connective tissue growth factor; Connective tissues; Extracellular matrix; Fascia; Fibroblasts; Genetic aspects; Growth factors; Hernia; Hernias; Heterogeneity; Histology; Immunofluorescence; Laparotomy; Life Sciences; Medical Biochemistry; Morphology; Muscles; Oncology; Peritoneum; Phenotypes; Proteins; Smooth muscle; Tissues; Transplantation; Incisional Hernia; Fibroblasts; Biomarkers; Wound healing; Laparotomy; ECM pathology

Development of incisional hernia (IH) is multifactorial but inflammation and abdominal wall ECM (extracellular matrix) disorganization are key pathological events. We investigated if the differential expression of fibroblast biomarkers reflects the cellular milieu and the dysregulated ECM in IH tiss...