Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies

Colorectal cancer (CRC) is a common gastrointestinal tumor with a high degree of malignancy, and most clinical cases are diagnosed at an advanced stage, which has unfortunately missed an opportunity for surgery; therefore, elucidation of the crucial pathways of CRC development and discovery of targe...

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Published inFrontiers in oncology Vol. 12; p. 1007509
Main Authors Qiang, Liming, Li, Hongpeng, Wang, Zhaohui, Wan, Lin, Jiang, Guangfu
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 12.09.2022
Subjects
autophagy
colorectal cancer (CRC)
crucial pathway
Oncology
targeted therapy
therapeutic strategy
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Abstract Colorectal cancer (CRC) is a common gastrointestinal tumor with a high degree of malignancy, and most clinical cases are diagnosed at an advanced stage, which has unfortunately missed an opportunity for surgery; therefore, elucidation of the crucial pathways of CRC development and discovery of targeted therapeutic strategies should be anticipated. Autophagy, which is an evolutionarily highly conserved catabolic process, may promote tumorigenesis and development of CRC. On the contrary, autophagy can trigger programmed cell death to inhibit CRC progression. Correspondingly, several targeted therapeutic strategies have been reported in CRC, including small-molecule compounds, polypeptides, non-coding RNAs, photodynamic, and adjuvant therapies. Thus, in this review, we focus on summarizing the crucial pathways of autophagy in CRC, and further discuss the current therapeutic strategies targeting autophagy. Together, these findings may shed light on the key regulatory mechanisms of autophagy and provide more promising therapeutic approaches for the future CRC therapies.
AbstractList Colorectal cancer (CRC) is a common gastrointestinal tumor with a high degree of malignancy, and most clinical cases are diagnosed at an advanced stage, which has unfortunately missed an opportunity for surgery; therefore, elucidation of the crucial pathways of CRC development and discovery of targeted therapeutic strategies should be anticipated. Autophagy, which is an evolutionarily highly conserved catabolic process, may promote tumorigenesis and development of CRC. On the contrary, autophagy can trigger programmed cell death to inhibit CRC progression. Correspondingly, several targeted therapeutic strategies have been reported in CRC, including small-molecule compounds, polypeptides, non-coding RNAs, photodynamic, and adjuvant therapies. Thus, in this review, we focus on summarizing the crucial pathways of autophagy in CRC, and further discuss the current therapeutic strategies targeting autophagy. Together, these findings may shed light on the key regulatory mechanisms of autophagy and provide more promising therapeutic approaches for the future CRC therapies.
Author Li, Hongpeng
Wan, Lin
Jiang, Guangfu
Wang, Zhaohui
Qiang, Liming
AuthorAffiliation 1 Department of Gastroenterology Ward, Guang’an People’s Hospital , Guang’an , China
2 Department of Gastrointestinal Surgery, Guang’an People’s Hospital , Guang’an , China
AuthorAffiliation_xml – name: 1 Department of Gastroenterology Ward, Guang’an People’s Hospital , Guang’an , China
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  givenname: Guangfu
  surname: Jiang
  fullname: Jiang, Guangfu
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Reviewed by: Lingjuan Zhu, Shenyang Pharmaceutical University, China; Haiyang Yu, Tianjin University of Traditional Chinese Medicine, China
These authors have contributed equally to this work
This article was submitted to Pharmacology of Anti-Cancer Drugs, a section of the journal Frontiers in Oncology
Edited by: Bo Liu, Sichuan University, China
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Snippet Colorectal cancer (CRC) is a common gastrointestinal tumor with a high degree of malignancy, and most clinical cases are diagnosed at an advanced stage, which...
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SubjectTerms autophagy
colorectal cancer (CRC)
crucial pathway
Oncology
targeted therapy
therapeutic strategy
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Title Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies
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