Identification of Trichomonas vaginalis Cysteine Proteases That Induce Apoptosis in Human Vaginal Epithelial Cells

• Published in: The Journal of biological chemistry Vol. 280; no. 25; pp. 23853 - 23860
• Main Authors: Sommer, Ulf, Costello, Catherine E., Hayes, Gary R., Beach, David H., Gilbert, Robert O., Lucas, John J., Singh, Bibhuti N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.06.2005; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Sequence; Animals; Apoptosis - physiology; Cells, Cultured; Cysteine Endopeptidases - chemistry; Cysteine Endopeptidases - metabolism; Cysteine Endopeptidases - physiology; Epithelial Cells - cytology; Female; Humans; Molecular Sequence Data; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trichomonas vaginalis; Trichomonas vaginalis - enzymology; Vagina - cytology

A secreted cysteine protease (CP) fraction from Trichomonas vaginalis is shown here to induce apoptosis in human vaginal epithelial cells (HVEC) and is analyzed by mass spectrometry. The trichomonad parasite T. vaginalis causes one of the most common non-viral sexually transmitted infection in human...