Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways - Ihn, Hye Jung; Kim, Ju Ang; Bae, Yong Chul; Shin, Hong-In; Baek, Moon-Chang; Park, Eui Kyun (BMB reports, 2017)
Keywords: Afatinib; Animals; Bone Marrow Cells - cytology; Bone Resorption - pathology; Cell Differentiation - drug effects; Down-Regulation - drug effects; ErbB Receptors - metabolism; JNK Mitogen-Activated Protein Kinases - metabolism; Macrophages - drug effects; Mice; NF-kappa B - metabolism; Osteoclasts - cytology; Phosphorylation; Quinazolines - metabolism; Quinazolines - therapeutic use; RANK Ligand - drug effects; RANK Ligand - genetics; RANK Ligand - metabolism; Receptor Activator of Nuclear Factor-kappa B - metabolism; Signal Transduction - drug effects; 화학