Homing endonucleases: structure, function and evolution

• Published in: Cellular and molecular life sciences : CMLS Vol. 55; no. 10; pp. 1304 - 1326
• Main Authors: Jurica, M. S., Stoddard, B. L.
• Format: Journal Article
• Language: English
• Published: Switzerland Springer Nature B.V 15.08.1999; Birkhäuser Verlag
• Subjects: Animals; Bacteriology; Biochemistry; Biological Evolution; DNA - chemistry; DNA - genetics; DNA - metabolism; DNA Restriction Enzymes - chemistry; DNA Restriction Enzymes - metabolism; Endodeoxyribonucleases - chemistry; Endodeoxyribonucleases - metabolism; Endonuclease; Enzymes; Evolutionary biology; Genetic Engineering; Genetics; Homing; Homing behavior; Homing endonuclease; Introns; Models, Molecular; Nucleic Acid Conformation; Nucleic acids; Nucleotide sequence; Open reading frames; Protein Conformation; Proteins; Structure-function relationships

'Homing' is the lateral transfer of an intervening genetic sequence, either an intron or an intein, to a cognate allele that lacks that element. The end result of homing is the duplication of the intervening sequence. The process is initiated by site-specific endonucleases that are encoded...