Fra-1 Inhibits Cell Growth and the Warburg Effect in Cervical Cancer Cells via STAT1 Regulation of the p53 Signaling Pathway

• Published in: Frontiers in cell and developmental biology Vol. 8; p. 579629
• Main Authors: Zhang, Manying, Liang, Lin, He, Junyu, He, Zhengxi, Yue, Chunxue, Jin, Xi, Gao, Mengxiang, Xiao, Songshu, Zhou, Yanhong
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 30.09.2020
• Subjects: Cell and Developmental Biology; cell growth; cervical cancer; Fra-1; STAT1; Warburg effect

The oncogenesis of cervical cancer is a multi-factor and multi-step process, and major risk factors include oncogene activation with tumor suppressor gene inactivation, viral factors, and immune factors. For example, the human papillomavirus (HPV) has been linked to the occurrence of cervical cancer...