Cholesterol manipulation by West Nile virus perturbs the cellular immune response

• Published in: Cell host & microbe Vol. 2; no. 4; pp. 229 - 239
• Main Authors: Mackenzie, Jason M, Khromykh, Alexander A, Parton, Robert G
• Format: Journal Article
• Language: English
• Published: United States 01.10.2007
• Subjects: Animals; Cell Line, Tumor; Cercopithecus aethiops; Cholesterol - metabolism; Down-Regulation; Homeostasis - drug effects; Humans; Hydroxymethylglutaryl CoA Reductases - metabolism; Interferon-alpha - metabolism; Janus Kinase 1 - metabolism; STAT Transcription Factors - metabolism; Vero Cells; Virus Replication; West Nile Fever - immunology; West Nile Fever - metabolism; West Nile Fever - virology; West Nile virus; West Nile virus - physiology

Complex membrane structures induced by West Nile virus (WNV), an enveloped RNA virus, are required for efficient viral replication. How these membranes are induced and how they facilitate the viral life cycle are unknown. We show that WNV modulates host cell cholesterol homeostasis by upregulating c...