Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis

• Published in: Translational psychiatry Vol. 7; no. 3; p. e1059
• Main Authors: Fries, G R, Quevedo, J, Zeni, C P, Kazimi, I F, Zunta-Soares, G, Spiker, D E, Bowden, C L, Walss-Bass, C, Soares, J C
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.03.2017; Nature Publishing Group
• Subjects: 631/208/212/2166; 692/53/2423; Adolescent; Behavioral Sciences; Biological Psychology; Bipolar Disorder - genetics; Case-Control Studies; Child; Child of Impaired Parents; DNA Methylation - genetics; Female; Gene Expression Profiling; HSP70 Heat-Shock Proteins - genetics; Humans; Male; Mediator Complex Subunit 1 - genetics; Medicine; Medicine & Public Health; Neurosciences; Original; original-article; Pharmacotherapy; Psychiatry; Risk; RNA, Messenger - metabolism; TATA-Binding Protein Associated Factors - genetics

First-degree relatives of patients with bipolar disorder (BD), particularly their offspring, have a higher risk of developing BD and other mental illnesses than the general population. However, the biological mechanisms underlying this increased risk are still unknown, particularly because most of t...