Exploring the structure-activity relationship of benzylidene-2,3-dihydro-1H-inden-1-one compared to benzofuran-3(2H)-one derivatives as inhibitors of tau amyloid fibers - Boukherrouba, Emeline; Larosa, Camille; Nguyen, Kim-Anh; Caburet, Jérémy; Lunven, Laurent; Bonnet, Hugues; Fortuné, Antoine; Boumendjel, Ahcène; Boucherle, Benjamin; Chierici, Sabine; Peuchmaur, Marine (European journal of medicinal chemistry, 2022)
Keywords: AcPHF6 peptide; Alzheimer Disease; Alzheimer's disease; Aurones; Benzofurans - chemistry; Benzofurans - pharmacology; Chemical Sciences; Chemistry, Medicinal; Humans; Indanones; Life Sciences; Life Sciences & Biomedicine; Medicinal Chemistry; Neurons and Cognition; Pharmacology & Pharmacy; Protein Aggregates; Science & Technology; Structure-Activity Relationship; Tau aggregation; tau Proteins - metabolism; AcPHF6 peptide; Indanones; Aurones; Alzheimer's disease; Tau aggregation; DESIGN; NATURALLY-OCCURRING AURONES; INDANONE DERIVATIVES; DISCOVERY; FILAMENTS; MUSHROOM; DISEASE; CHEMISTRY; AGGREGATION; SCAFFOLD; tau aggregation