Swainsonine Triggers Paraptosis via ER Stress and MAPK Signaling Pathway in Rat Primary Renal Tubular Epithelial Cells

• Published in: Frontiers in pharmacology Vol. 12; p. 715285
• Main Authors: Wang, Shuai, Guo, Yazhou, Yang, Chen, Huang, Ruijie, Wen, Yuting, Zhang, Chunyan, Wu, Chenchen, Zhao, Baoyu
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 10.08.2021
• Subjects: er stress; MAPK; paraptosis; Pharmacology; swainsonine; vacuolation

Swainsonine (SW), an indolizidine alkaloid extracted from locoweeds, was shown toxic effects in multiple studies, but the underlying action mechanism remains unclear. SW is known to cause autophagy and apoptosis, but there has been no report on paraptosis mediated cell death. Here, we showed that SW...