Selective Inhibition of Phosphodiesterase 7 Enzymes Reduces Motivation for Nicotine Use through Modulation of Mesolimbic Dopaminergic Transmission - Ciccocioppo, Roberto; de Guglielmo, Giordano; Li, Hong Wu; Melis, Miriam; Caffino, Lucia; Shen, Quienwei; Domi, Ana; Fumagalli, Fabio; Demopulos, Gregory A.; Gaitanaris, George A. (The Journal of neuroscience, 2021)
Keywords: Adenosine monophosphate; Circuits; Cyclic AMP; Cyclic AMP response element-binding protein; Dopamine D1 receptors; Drug abuse; Drug addiction; Drug self-administration; Enzymes; Inhibitors; Intravenous administration; Kinases; Mesolimbic system; Neurons; Nicotine; Nucleus accumbens; Phosphodiesterase; Place preference conditioning; Potentiation; Protein kinase A; Proteins; Receptor mechanisms; Receptors; Reinstatement; Tobacco; Ventral tegmentum; Yohimbine; γ-Aminobutyric acid; treatment; nicotine; rat; relapse; self-administration; addiction