PRELP inhibits colorectal cancer progression by suppressing epithelial-mesenchymal transition and angiogenesis via the inactivation of the FGF1/PI3K/AKT pathway - Li, Xiaoqing; Jiang, Zhongxiang; Li, Junfeng; Yang, Kun; He, Jin; Deng, Qianxi; Xu, Shuman; Jiang, Zhihang; Liu, Fuqiang; Jiang, Zheng (Apoptosis (London), 2025)
Keywords: 1-Phosphatidylinositol 3-kinase; AKT protein; Angiogenesis; Animal models; Animals; Apoptosis; Bevacizumab; Bevacizumab - pharmacology; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Cell adhesion; Cell Biology; Cell culture; Cell Line, Tumor; Cell migration; Cell Movement; Cell proliferation; Cell Proliferation - drug effects; Cholecystokinin; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Deactivation; Development and progression; Disease Progression; Effectiveness; Epithelial-Mesenchymal Transition - drug effects; Epithelial-Mesenchymal Transition - genetics; Extracellular matrix; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Female; Fibroblast growth factor 1; Fibroblast Growth Factor 1 - genetics; Fibroblast Growth Factor 1 - metabolism; Fibroblast growth factors; Gene Expression Regulation, Neoplastic; Growth factors; Humans; Immunofluorescence; In vivo methods and tests; Leucine; Male; Metastases; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; Monoclonal antibodies; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Oncology; Phenotypes; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Proteins; Proteoglycans; Proteoglycans - genetics; Proteoglycans - metabolism; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; RNA; Signal Transduction - drug effects; Stem cells; TOR protein; Tumor cell lines; Tumors; Virology; Xenograft Model Antitumor Assays; Xenografts; Xenotransplantation; Epithelial-mesenchymal transition; Angiogenesis; PRELP; FGF1; Colorectal cancer