Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults

Depression and related neurobehavioral symptoms are common features of Alzheimer’s disease and other dementias. The presence of these potentially modifiable neurobehavioral symptoms in cognitively intact older adults may represent an early indication of pathophysiological processes in the brain. Tau...

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Published inFrontiers in psychology Vol. 12; p. 774049
Main Authors Hall, James R., Petersen, Melissa, Johnson, Leigh, O’Bryant, Sid E.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 05.11.2021
Subjects
anxiety
apathy
daytime sleepiness
depression
plasma tau
Psychology
worry
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Abstract Depression and related neurobehavioral symptoms are common features of Alzheimer’s disease and other dementias. The presence of these potentially modifiable neurobehavioral symptoms in cognitively intact older adults may represent an early indication of pathophysiological processes in the brain. Tau pathology is a key feature of a number of dementias. A number of studies have found an association between tau and neurobehavioral symptoms. The current study investigated the relationship of a blood-based biomarker of tau and symptoms of depression, anxiety, worry, and sleep disturbances in 538 community based, cognitively normal older adults. Logistic regression revealed no significant relationship between plasma total tau and any measures of neurobehavioral symptoms. To assess the impact of level of tau on these relationships, participants were divided into those in the highest quintile of tau and those in the lower four quintiles. Regression analyses showed a significant relationship between level of plasma total tau and measures of depression, apathy, anxiety, worry and sleep. The presence of higher levels of plasma tau and elevated neurobehavioral symptoms may be an early indicator of cognitive decline and prodromal Alzheimer’s disease. Longitudinal research is needed to evaluate the impact of these factors on the development of dementia and may suggest areas for early intervention.
AbstractList Depression and related neurobehavioral symptoms are common features of Alzheimer’s disease and other dementias. The presence of these potentially modifiable neurobehavioral symptoms in cognitively intact older adults may represent an early indication of pathophysiological processes in the brain. Tau pathology is a key feature of a number of dementias. A number of studies have found an association between tau and neurobehavioral symptoms. The current study investigated the relationship of a blood-based biomarker of tau and symptoms of depression, anxiety, worry, and sleep disturbances in 538 community based, cognitively normal older adults. Logistic regression revealed no significant relationship between plasma total tau and any measures of neurobehavioral symptoms. To assess the impact of level of tau on these relationships, participants were divided into those in the highest quintile of tau and those in the lower four quintiles. Regression analyses showed a significant relationship between level of plasma total tau and measures of depression, apathy, anxiety, worry and sleep. The presence of higher levels of plasma tau and elevated neurobehavioral symptoms may be an early indicator of cognitive decline and prodromal Alzheimer’s disease. Longitudinal research is needed to evaluate the impact of these factors on the development of dementia and may suggest areas for early intervention.
Author Petersen, Melissa
Johnson, Leigh
O’Bryant, Sid E.
Hall, James R.
AuthorAffiliation 2 Department of Pharmacology and Neuroscience, University of North Texas Health Science Center , Fort Worth, TX , United States
1 Institute for Translational Research, University of North Texas Health Science Center , Fort Worth, TX , United States
3 Department of Family Medicine, University of North Texas Health Science Center , Fort Worth, TX , United States
AuthorAffiliation_xml – name: 3 Department of Family Medicine, University of North Texas Health Science Center , Fort Worth, TX , United States
– name: 1 Institute for Translational Research, University of North Texas Health Science Center , Fort Worth, TX , United States
– name: 2 Department of Pharmacology and Neuroscience, University of North Texas Health Science Center , Fort Worth, TX , United States
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  givenname: Leigh
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  fullname: Johnson, Leigh
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  givenname: Sid E.
  surname: O’Bryant
  fullname: O’Bryant, Sid E.
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CitedBy_id crossref_primary_10_3390_ijms242316908
crossref_primary_10_1111_psyg_13016
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Cites_doi 10.1016/j.nbd.2020.105031
10.3233/JAD-170578
10.1212/WNL.0000000000004767
10.1016/j.jalz.2014.08.099
10.1080/13825585.2017.1416057
10.1136/jnnp-2020-323092
10.1037//0022-006x.56.6.893
10.1017/S0033291712001870
10.1016/j.janxdis.2014.07.005
10.3389/fphar.2020.00279
10.1212/WNL.0000000000008866
10.1097/JGP.0b013e3182107e24
10.1093/sleep/14.6.540
10.1016/j.dadm.2019.05.001
10.1016/j.jagp.2016.05.015
10.3390/ijerph17207475
10.1155/2011/396958
10.1080/07317110903362127
10.1016/j.jad.2015.09.069
10.1016/j.neubiorev.2019.09.014
10.1212/WNL.0000000000008979
10.1001/jamaneurol.2018.0049
10.1016/j.jagp.2014.02.007
10.1176/appi.ajp.2014.13060821
10.1186/s13195-020-00604-7
10.1016/B978-0-12-802395-2.00025-0
10.1016/0005-7967(90)90135-6
10.1002/dad2.12202
10.1093/geront/gnp019
10.1016/j.jalz.2018.02.018
10.1176/appi.ps.201700439
10.3389/fnagi.2021.595758
10.1007/s11065-020-09437-5
10.1001/jamaneurol.2018.4666
10.1159/000137671
10.1001/jamaneurol.2017.1359
10.3233/JAD-191078
10.3389/fnagi.2020.00009
10.1002/gps.5418
10.2174/156720510793611592
10.1016/j.sleep.2012.02.003
10.1017/S1355617719000158
10.1016/0022-3956(82)90033-4
10.1080/13607863.2017.1387760
10.1002/gps.4715
10.1002/hbm.22390
10.3390/jcm9061791
10.1192/bjp.bp.112.118307
10.1038/nrneurol.2013.269
10.1126/scitranslmed.aau6550
10.1002/gps.4991
10.1016/j.jalz.2011.05.2410
10.1001/jamaneurol.2013.4258
10.1002/da.22360
10.1212/WNL.0000000000003246
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Reviewed by: Beatriz Navarro Bravo, University of Castilla–La Mancha, Spain; Elodie Bertrand, Université de Paris, France
This article was submitted to Psychopathology, a section of the journal Frontiers in Psychology
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References Ma (B36) 2020; 12
Johns (B25) 1991; 14
Diefenbach (B14) 2009; 49
Spira (B50) 2013; 70
Arenaza-Urquijo (B1) 2020; 94
Babulal (B2) 2020; 74
Olariu (B43) 2015; 32
Burke (B9) 2018; 22
Keage (B27) 2012; 13
Kuo (B29) 2020; 17
Mattsson (B38) 2016; 87
Fossati (B17) 2019; 28
Linnemann (B32) 2020; 11
Bower (B8) 2019; 25
Banning (B3) 2019; 107
Benedict (B6) 2020; 94
Pase (B45) 2019; 76
Owusu (B44) 2019; 34
Beck (B5) 1988; 56
Diniz (B15) 2013; 202
Liew (B31) 2020; 12
Bhattacharjee (B7) 2018; 69
Hall (B21) 2011; 2011
Yesavage (B54) 1982; 17
Jack (B24) 2018; 14
Donovan (B16) 2014; 22
Marshall (B37) 2019; 67
van Dalen (B52) 2018; 90
O’Bryant (B42) 2021; 13
O’Bryant (B41) 2015; 11
Laudisio (B30) 2018; 33
Banning (B4) 2021; 36
Chiu (B11) 2014; 35
Mielke (B40) 2017; 74
Hudon (B22) 2020; 30
Ju (B26) 2014; 10
Lyketsos (B35) 2011; 7
Pietrzak (B46) 2012; 20
Meyer (B39) 1990; 28
Wuthrich (B53) 2014; 28
Skogseth (B49) 2008; 25
Tay (B51) 2020; 91
Zhao (B55) 2016; 15
Lucey (B33) 2020; 144
de Vito (B13) 2019; 26
Iqbal (B23) 2010; 7
Geda (B18) 2014; 171
Hall (B20) 2010; 33
Cotta Ramusino (B12) 2021; 5
Gulpers (B19) 2016; 24
Santabárbara (B48) 2020; 9
Kovacs (B28) 2017; 145
Carvalho (B10) 2018; 75
Lucey (B34) 2019; 11
Ramakers (B47) 2013; 43
References_xml – volume: 144
  year: 2020
  ident: B33
  article-title: It’s complicated: The relationship between sleep and Alzheimer’s disease in humans.
  publication-title: Neurobiol. Dis
  doi: 10.1016/j.nbd.2020.105031
  contributor:
    fullname: Lucey
– volume: 67
  start-page: 757
  year: 2019
  ident: B37
  article-title: Regional tau correlates of instrumental activities of daily living and apathy in mild cognitive impairment and Alzheimer’s Dementia.
  publication-title: J. Alzheimers Dis.
  doi: 10.3233/JAD-170578
  contributor:
    fullname: Marshall
– volume: 90
  start-page: e82
  year: 2018
  ident: B52
  article-title: Apathy is associated with incident dementia in community-dwelling older people.
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000004767
  contributor:
    fullname: van Dalen
– volume: 11
  start-page: 549
  year: 2015
  ident: B41
  article-title: Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer’s disease research.
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2014.08.099
  contributor:
    fullname: O’Bryant
– volume: 26
  start-page: 161
  year: 2019
  ident: B13
  article-title: The association of anxiety, depression, and worry symptoms on cognitive performance in older adults.
  publication-title: Neuropsychol. Dev. Cogn. B Aging Neuropsychol. Cogn
  doi: 10.1080/13825585.2017.1416057
  contributor:
    fullname: de Vito
– volume: 91
  start-page: 953
  year: 2020
  ident: B51
  article-title: Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease.
  publication-title: J. Neurol. Neurosurg. Psychiatry
  doi: 10.1136/jnnp-2020-323092
  contributor:
    fullname: Tay
– volume: 56
  start-page: 893
  year: 1988
  ident: B5
  article-title: An inventory for measuring clinical anxiety: psychometric properties.
  publication-title: J. Consult. Clin. Psychol
  doi: 10.1037//0022-006x.56.6.893
  contributor:
    fullname: Beck
– volume: 43
  start-page: 911
  year: 2013
  ident: B47
  article-title: Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment.
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291712001870
  contributor:
    fullname: Ramakers
– volume: 28
  start-page: 657
  year: 2014
  ident: B53
  article-title: Comparison of the Penn State Worry Questionnaire (PSWQ) and abbreviated version (PSWQ-A) in a clinical and non-clinical population of older adults.
  publication-title: J. Anxiety Disord
  doi: 10.1016/j.janxdis.2014.07.005
  contributor:
    fullname: Wuthrich
– volume: 11
  year: 2020
  ident: B32
  article-title: Pathways connecting late-life depression and dementia.
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.00279
  contributor:
    fullname: Linnemann
– volume: 94
  start-page: e1181
  year: 2020
  ident: B6
  article-title: Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men.
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000008866
  contributor:
    fullname: Benedict
– volume: 20
  start-page: 266
  year: 2012
  ident: B46
  article-title: Mild worry symptoms predict decline in learning and memory in healthy older adults: A 2-year prospective cohort study.
  publication-title: Am J Geriatr Psychiatry
  doi: 10.1097/JGP.0b013e3182107e24
  contributor:
    fullname: Pietrzak
– volume: 14
  start-page: 540
  year: 1991
  ident: B25
  article-title: A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
  publication-title: Sleep
  doi: 10.1093/sleep/14.6.540
  contributor:
    fullname: Johns
– volume: 28
  start-page: 483
  year: 2019
  ident: B17
  article-title: Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer’s disease.
  publication-title: Alzheimers Dement.
  doi: 10.1016/j.dadm.2019.05.001
  contributor:
    fullname: Fossati
– volume: 24
  start-page: 823
  year: 2016
  ident: B19
  article-title: Anxiety as a predictor for cognitive decline and dementia: a systematic review and meta-analysis.
  publication-title: Am. J. Geriatr. Psychiatry
  doi: 10.1016/j.jagp.2016.05.015
  contributor:
    fullname: Gulpers
– volume: 17
  year: 2020
  ident: B29
  article-title: Association of late life depression, (non-) modifiable risk and protective factors with dementia and Alzheimer’s disease: literature review on current evidences, preventive interventions and possible future trends in treatment of dementia.
  publication-title: Int. J. Environ. Res. Public Health
  doi: 10.3390/ijerph17207475
  contributor:
    fullname: Kuo
– volume: 2011
  year: 2011
  ident: B21
  article-title: Depressive symptom clusters and neuropsychological performance in mild Alzheimer’s and cognitively intact elderly.
  publication-title: J. Depres. Res. Treat.
  doi: 10.1155/2011/396958
  contributor:
    fullname: Hall
– volume: 33
  start-page: 39
  year: 2010
  ident: B20
  article-title: Factor structure of the Geriatric Depression Scale with cognitively impaired older adults.
  publication-title: Clin. Gerontol.
  doi: 10.1080/07317110903362127
  contributor:
    fullname: Hall
– volume: 15
  start-page: 264
  year: 2016
  ident: B55
  article-title: The prevalence of neuropsychiatric symptoms in Alzheimer’s disease: Systematic review and meta-analysis.
  publication-title: J. Affect Disord
  doi: 10.1016/j.jad.2015.09.069
  contributor:
    fullname: Zhao
– volume: 107
  start-page: 346
  year: 2019
  ident: B3
  article-title: Affective symptoms and AT(N) biomarkers in mild cognitive impairment and Alzheimer’s disease: A systematic literature review.
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2019.09.014
  contributor:
    fullname: Banning
– volume: 94
  start-page: e1571
  year: 2020
  ident: B1
  article-title: Better stress coping associated with lower tau in amyloid-positive cognitively unimpaired older adults.
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000008979
  contributor:
    fullname: Arenaza-Urquijo
– volume: 75
  start-page: 672
  year: 2018
  ident: B10
  article-title: Association of excessive daytime sleepiness with longitudinal β-amyloid accumulation in elderly persons without dementia.
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2018.0049
  contributor:
    fullname: Carvalho
– volume: 22
  start-page: 1642
  year: 2014
  ident: B16
  article-title: Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer Disease.
  publication-title: Am. J. Geriatr. Psychiatry
  doi: 10.1016/j.jagp.2014.02.007
  contributor:
    fullname: Donovan
– volume: 171
  start-page: 572
  year: 2014
  ident: B18
  article-title: Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: A population-based study.
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2014.13060821
  contributor:
    fullname: Geda
– volume: 12
  year: 2020
  ident: B31
  article-title: Neuropsychiatric symptoms in cognitively normal older persons, and the association with Alzheimer’s and non-Alzheimer’s dementia.
  publication-title: Alzheimer’s Res. Therapy
  doi: 10.1186/s13195-020-00604-7
  contributor:
    fullname: Liew
– volume: 145
  start-page: 355
  year: 2017
  ident: B28
  article-title: Tauopathies.
  publication-title: Handb. Clin. Neurol.
  doi: 10.1016/B978-0-12-802395-2.00025-0
  contributor:
    fullname: Kovacs
– volume: 28
  start-page: 487
  year: 1990
  ident: B39
  article-title: Development and validation of the Penn State Worry Questionnaire.
  publication-title: Behav. Res. Ther.
  doi: 10.1016/0005-7967(90)90135-6
  contributor:
    fullname: Meyer
– volume: 13
  year: 2021
  ident: B42
  article-title: The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics.
  publication-title: Alzheimers Dement
  doi: 10.1002/dad2.12202
  contributor:
    fullname: O’Bryant
– volume: 49
  start-page: 141
  year: 2009
  ident: B14
  article-title: Assessment of anxiety in older home care recipients.
  publication-title: Gerontologist
  doi: 10.1093/geront/gnp019
  contributor:
    fullname: Diefenbach
– volume: 14
  start-page: 535
  year: 2018
  ident: B24
  article-title: NIA-AA research framework: Toward a biological definition of Alzheimer’s disease.
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2018.02.018
  contributor:
    fullname: Jack
– volume: 69
  start-page: 1098
  year: 2018
  ident: B7
  article-title: Depression screening patterns, predictors, and trends among adults without a depression diagnosis in ambulatory settings in the United States.
  publication-title: Psychiat. Serv.
  doi: 10.1176/appi.ps.201700439
  contributor:
    fullname: Bhattacharjee
– volume: 5
  year: 2021
  ident: B12
  article-title: Correlation of frontal atrophy and CSF tau levels with neuropsychiatric symptoms in patients with cognitive impairment: a memory clinic experience.
  publication-title: Front. Aging Neurosci
  doi: 10.3389/fnagi.2021.595758
  contributor:
    fullname: Cotta Ramusino
– volume: 30
  start-page: 558
  year: 2020
  ident: B22
  article-title: Behavioral and psychological symptoms that predict cognitive decline or impairment in cognitively normal middle-aged or older adults: A meta-analysis.
  publication-title: Neuropsychol. Rev.
  doi: 10.1007/s11065-020-09437-5
  contributor:
    fullname: Hudon
– volume: 76
  start-page: 598
  year: 2019
  ident: B45
  article-title: Assessment of plasma total tau level as a predictive biomarker for dementia and related endophenotypes.
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2018.4666
  contributor:
    fullname: Pase
– volume: 25
  start-page: 559
  year: 2008
  ident: B49
  article-title: Neuropsychiatric correlates of cerebrospinal fluid biomarkers in Alzheimer’s disease.
  publication-title: Dement Geriatr. Cogn. Disord.
  doi: 10.1159/000137671
  contributor:
    fullname: Skogseth
– volume: 74
  start-page: 1073
  year: 2017
  ident: B40
  article-title: Association of plasma total tau level with cognitive decline and risk of mild cognitive impairment or dementia in the Mayo Clinic Study on Aging.
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2017.1359
  contributor:
    fullname: Mielke
– volume: 74
  start-page: 1045
  year: 2020
  ident: B2
  article-title: Depression is associated with tau and not amyloid positron emission tomography in cognitively normal adults.
  publication-title: J. Alzheimers Dis
  doi: 10.3233/JAD-191078
  contributor:
    fullname: Babulal
– volume: 12
  year: 2020
  ident: B36
  article-title: Depression, anxiety, and apathy in mild cognitive impairment: current perspectives.
  publication-title: Front. Aging Neurosci.
  doi: 10.3389/fnagi.2020.00009
  contributor:
    fullname: Ma
– volume: 36
  start-page: 224
  year: 2021
  ident: B4
  article-title: Alzheimer’s Disease Neuroimaging Initiative. Alzheimer’s disease biomarkers as predictors of trajectories of depression and apathy in cognitively normal individuals, mild cognitive impairment, and Alzheimer’s disease dementia.
  publication-title: Int. J. Geriatr. Psychiatry
  doi: 10.1002/gps.5418
  contributor:
    fullname: Banning
– volume: 7
  start-page: 656
  year: 2010
  ident: B23
  article-title: T-tau in Alzheimer disease and related t-tauopathies.
  publication-title: Curr. Alzheimer Res.
  doi: 10.2174/156720510793611592
  contributor:
    fullname: Iqbal
– volume: 13
  start-page: 886
  year: 2012
  ident: B27
  article-title: What sleep characteristics predict cognitive decline in the elderly?
  publication-title: Sleep Med.
  doi: 10.1016/j.sleep.2012.02.003
  contributor:
    fullname: Keage
– volume: 25
  start-page: 546
  year: 2019
  ident: B8
  article-title: effect of worry level on recall memory for odors in ApoE-ε4 carriers and non-carriers.
  publication-title: J. Int. Neuropsychol.
  doi: 10.1017/S1355617719000158
  contributor:
    fullname: Bower
– volume: 17
  start-page: 37
  year: 1982
  ident: B54
  article-title: Development and validation of a geriatric depression screening scale: A preliminary report.
  publication-title: J. Psychiatric Res.
  doi: 10.1016/0022-3956(82)90033-4
  contributor:
    fullname: Yesavage
– volume: 22
  start-page: 1577
  year: 2018
  ident: B9
  article-title: Psychosocial risk factors and Alzheimer’s disease: the associative effect of depression, sleep disturbance, and anxiety.
  publication-title: Aging Ment. Health
  doi: 10.1080/13607863.2017.1387760
  contributor:
    fullname: Burke
– volume: 33
  start-page: e58
  year: 2018
  ident: B30
  article-title: Definition of a Geriatric Depression Scale cutoff based upon quality of life: a population-based study.
  publication-title: Int. J. Geriatr. Psychiatry
  doi: 10.1002/gps.4715
  contributor:
    fullname: Laudisio
– volume: 35
  start-page: 3132
  year: 2014
  ident: B11
  article-title: Plasma tau as a windowto the brain-negative associations with brain volume and memory function in mild cognitive impairment and early Alzheimer’s disease.
  publication-title: Human Brain Mapp.
  doi: 10.1002/hbm.22390
  contributor:
    fullname: Chiu
– volume: 9
  year: 2020
  ident: B48
  article-title: Does anxiety increase the risk of all-cause dementia? An updated meta-analysis of prospective cohort studies.
  publication-title: J. Clin. Med
  doi: 10.3390/jcm9061791
  contributor:
    fullname: Santabárbara
– volume: 202
  start-page: 329
  year: 2013
  ident: B15
  article-title: Late-life depression and risk of vascular dementia and Alzheimer’s disease: Systematic review and meta-analysis of community-based cohort studies.
  publication-title: Br. J. Psychiatry
  doi: 10.1192/bjp.bp.112.118307
  contributor:
    fullname: Diniz
– volume: 10
  start-page: 115
  year: 2014
  ident: B26
  article-title: Sleep and Alzheimer disease pathology—a bidirectional relationship.
  publication-title: Nat. Rev. Neurol
  doi: 10.1038/nrneurol.2013.269
  contributor:
    fullname: Ju
– volume: 11
  year: 2019
  ident: B34
  article-title: Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease.
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aau6550
  contributor:
    fullname: Lucey
– volume: 34
  start-page: 87
  year: 2019
  ident: B44
  article-title: Napping characteristics and cognitive performance in older adults.
  publication-title: Int. J. Geriatr. Psychiatry
  doi: 10.1002/gps.4991
  contributor:
    fullname: Owusu
– volume: 7
  start-page: 532
  year: 2011
  ident: B35
  article-title: Neuropsychiatric symptoms in Alzheimer’s disease.
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2011.05.2410
  contributor:
    fullname: Lyketsos
– volume: 70
  start-page: 1537
  year: 2013
  ident: B50
  article-title: Self-reported sleep and β-amyloid deposition in community-dwelling older adults.
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2013.4258
  contributor:
    fullname: Spira
– volume: 32
  start-page: 471
  year: 2015
  ident: B43
  article-title: Detection of anxiety disorders in primary care: A meta-analysis of assisted and unassisted diagnoses.
  publication-title: Depress. Anxiety
  doi: 10.1002/da.22360
  contributor:
    fullname: Olariu
– volume: 87
  start-page: 1827
  year: 2016
  ident: B38
  article-title: Plasma tau in Alzheimer disease.
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000003246
  contributor:
    fullname: Mattsson
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Snippet Depression and related neurobehavioral symptoms are common features of Alzheimer’s disease and other dementias. The presence of these potentially modifiable...
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SubjectTerms anxiety
apathy
daytime sleepiness
depression
plasma tau
Psychology
worry
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Title Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults
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Volume 12
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