A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects

• Published in: CNS drugs Vol. 32; no. 11; pp. 1053 - 1067
• Main Authors: Taylor, Lesley, Gidal, Barry, Blakey, Graham, Tayo, Bola, Morrison, Gilmour
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2018
• Subjects: Administration, Oral; Cannabidiol - administration & dosage; Cannabidiol - adverse effects; Cannabidiol - pharmacokinetics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Food-Drug Interactions; Half-Life; Healthy Volunteers; Humans; Male; Medicine; Medicine & Public Health; Neurology; Neurosciences; Original; Original Research Article; Pharmacotherapy; Psychiatry; Psychopharmacology; Young Adult

Background A formal single ascending and multiple dose pharmacokinetic (PK) trial of cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD, the maximum tolerated dose, and to examine the effect of food on CBD PK parameters. Objective This trial assessed the saf...