A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold - Li-Zhulanov, Nikolai S.; Zakharenko, Alexandra L.; Chepanova, Arina A.; Patel, Jinal; Zafar, Ayesha; Volcho, Konstantin P.; Salakhutdinov, Nariman F.; Reynisson, Jóhannes; Leung, Ivanhoe K. H.; Lavrik, Olga I. (Molecules (Basel, Switzerland), 2018)
Keywords: anticancer agent; biochemical assay; chemical space; DNA repair enzyme; molecular modeling; structural-activity relationships; synthesis; Tdp1 inhibitor