Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells

• Published in: Archives of toxicology Vol. 92; no. 5; pp. 1751 - 1765
• Main Authors: Müller, S. M., Finke, H., Ebert, F., Kopp, J. F., Schumacher, F., Kleuser, B., Francesconi, K. A., Raber, G., Schwerdtle, T.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2018; Springer Nature B.V
• Subjects: Alcohols; Algae; Arsenic; Arsenic - pharmacokinetics; Arsenic - toxicity; Autophagy; Biomedical and Life Sciences; Biomedicine; Biotransformation; Cell death; Cell lines; Cellular stress response; Chromatography, High Pressure Liquid; Culture Media - analysis; Culture Media - chemistry; Cytosine; Deoxyribonucleic acid; DNA; DNA methylation; DNA Methylation - drug effects; DNA repair; DNA Repair - drug effects; DNA Repair - genetics; Dose-Response Relationship, Drug; Endonuclease; Energy levels; Environmental Health; Epigenesis, Genetic - drug effects; Epigenetics; Fatty acids; FEN1 protein; Gene expression; Gene Expression Regulation - drug effects; Hep G2 Cells; Hepatocytes; High-performance liquid chromatography; Humans; Hydrocarbons; Hydrocarbons - administration & dosage; Hydrocarbons - chemistry; Hydrocarbons - pharmacokinetics; Hydrocarbons - toxicity; Liquid chromatography; Liver; Mass spectrometry; Mass spectroscopy; Metabolites; Methyltransferase; Mode of action; Molecular Toxicology; Occupational Medicine/Industrial Medicine; Phagocytosis; Pharmacology/Toxicology; Spectrometry, Mass, Electrospray Ionization; Stability analysis; Subgroups; Tandem Mass Spectrometry; Toxicity; Xeroderma pigmentosum; Arsenic speciation; Gene expression; Metabolism; Arsenolipids; Global DNA methylation; Arsenic-containing hydrocarbons

Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found in fish and algae, elicit substantial toxic effects in various human cell lines and have a considerable impact on cellular energy levels. The underlying mode of action, however, is still unknown. The present study analyzes the...