In Patients With Obesity, the Number of Adipose Tissue Mast Cells Is Significantly Lower in Subjects With Type 2 Diabetes

• Published in: Frontiers in immunology Vol. 12; p. 664576
• Main Authors: Lopez-Perez, David, Redruello-Romero, Anaïs, Garcia-Rubio, Jesús, Arana, Carlos, Garcia-Escudero, Luis A., Tamayo, Francisco, Puentes-Pardo, Jose D., Moreno-SanJuan, Sara, Salmeron, Javier, Blanco, Armando, Galvez, Julio, Leon, Josefa, Carazo, Ángel
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 21.05.2021
• Subjects: adipose tissue; angiogenesis; flow cytometry; Immunology; mast cell; obesity; T2D

Type 2 diabetes (T2D) is a rising global health problem mainly caused by obesity and a sedentary lifestyle. In healthy individuals, white adipose tissue (WAT) has a relevant homeostatic role in glucose metabolism, energy storage, and endocrine signaling. Mast cells contribute to these functions prom...