A Novel Model to Estimate Key Obstructive Sleep Apnea Endotypes from Standard Polysomnography and Clinical Data and Their Contribution to Obstructive Sleep Apnea Severity

• Published in: Annals of the American Thoracic Society Vol. 18; no. 4; pp. 656 - 667
• Main Authors: Dutta, Ritaban, Delaney, Gary, Toson, Barbara, Jordan, Amy S., White, David P., Wellman, Andrew, Eckert, Danny J.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.04.2021
• Subjects: Airway management; Arousal; Body Mass Index; Endoscopy; Humans; Original Research; Polysomnography; Sleep; Sleep apnea; Sleep Apnea, Obstructive - diagnosis; Tomography; lung; precision medicine; upper airway; sleep-disordered breathing; phenotyping

There are at least four key pathophysiological endotypes that contribute to obstructive sleep apnea (OSA) pathophysiology. These include ) upper-airway collapsibility (Pcrit); ) arousal threshold; ) loop gain; and ) pharyngeal muscle responsiveness. However, an easily interpretable model to examine...