Gut Microbiota-Derived Metabolites in Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is the most common functional bowel disorder worldwide and is associated with visceral hypersensitivity, gut motility, immunomodulation, gut microbiota alterations, and dysfunction of the brain-gut axis; however, its pathophysiology remains poorly understood. Gut micro...

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Published inFrontiers in cellular and infection microbiology Vol. 11; p. 729346
Main Authors Xiao, Lin, Liu, Qin, Luo, Mei, Xiong, Lishou
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 23.09.2021
Subjects
amino acids
bile acids
Cellular and Infection Microbiology
gut microbiota
irritable bowel syndrome
SCFAs
tryptophan
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Abstract Irritable bowel syndrome (IBS) is the most common functional bowel disorder worldwide and is associated with visceral hypersensitivity, gut motility, immunomodulation, gut microbiota alterations, and dysfunction of the brain-gut axis; however, its pathophysiology remains poorly understood. Gut microbiota and its metabolites are proposed as possible etiological factors of IBS. The aim of our study was to investigate specific types of microbiota-derived metabolites, especially bile acids, short-chain fatty acids, vitamins, amino acids, serotonin and hypoxanthine, which are all implicated in the pathogenesis of IBS. Metabolites-focused research has identified multiple microbial targets relevant to IBS patients, important roles of microbiota-derived metabolites in the development of IBS symptoms have been established. Thus, we provide an overview of gut microbiota and their metabolites on the different subtypes of IBS (constipation-predominant IBS-C, diarrhea-predominant IBS-D) and present controversial views regarding the role of microbiota in IBS.
AbstractList Irritable bowel syndrome (IBS) is the most common functional bowel disorder worldwide and is associated with visceral hypersensitivity, gut motility, immunomodulation, gut microbiota alterations, and dysfunction of the brain-gut axis; however, its pathophysiology remains poorly understood. Gut microbiota and its metabolites are proposed as possible etiological factors of IBS. The aim of our study was to investigate specific types of microbiota-derived metabolites, especially bile acids, short-chain fatty acids, vitamins, amino acids, serotonin and hypoxanthine, which are all implicated in the pathogenesis of IBS. Metabolites-focused research has identified multiple microbial targets relevant to IBS patients, important roles of microbiota-derived metabolites in the development of IBS symptoms have been established. Thus, we provide an overview of gut microbiota and their metabolites on the different subtypes of IBS (constipation-predominant IBS-C, diarrhea-predominant IBS-D) and present controversial views regarding the role of microbiota in IBS.
Author Liu, Qin
Xiong, Lishou
Xiao, Lin
Luo, Mei
AuthorAffiliation Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat-sen University , Guangzhou , China
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Cites_doi 10.1146/annurev-food-041715-033159
10.1136/gutjnl-2017-315136
10.1111/j.1572-0241.2004.04139
10.1126/science.1070477
10.3389/fmicb.2018.01600
10.1152/ajpgi.00242.2016
10.1038/ajg.2011.86
10.1016/j.cell.2014.11.047
10.1080/17474124.2017.1288096
10.1136/gutjnl-2020-320919
10.1002/med.21752
10.1054/tice.2002.0217
10.1136/gutjnl-2011-301501
10.1097/00005176-199610000-00013
10.1016/j.chom.2014.09.001
10.1002/ajmg.a.37659
10.1038/s41564-018-0337-x
10.1021/pr400263n
10.1038/ejcn.2010.107
10.1093/jn/nxz302
10.1111/jgh.13471
10.3748/wjg.v17.i12.1519
10.1038/nrendo.2010.226
10.1038/s41579-020-0438-4
10.1177/0964528420922232
10.1371/journal.pbio.2004248
10.1016/j.brainres.2018.03.015
10.1111/nmo.12829
10.1016/j.imbio.2015.11.003
10.1053/j.gastro.2005.09.031
10.1159/000171397
10.1097/01.meg.0000252627.50302
10.1007/s00018-020-03645-1
10.1016/j.cell.2020.08.007
10.5056/jnm17100
10.1016/j.cgh.2013.04.020
10.1080/19490976.2015.1134082
10.1186/1471-230X-9-6
10.1186/s12915-017-0462-7
10.1186/s12876-020-01577-5
10.1111/jgh.15225
10.1126/scitranslmed.3006438
10.1016/j.neuroscience.2016.05.017
10.1186/1471-230X-9-95
10.1111/1462-2920.1427
10.1053/j.gastro.2021.06.024
10.1038/ajg.2015.220
10.1152/ajpgi.1999.277.5.G935
10.3748/wjg.v20.i17.4934
10.3389/fmicb.2016.01934
10.1016/j.mam.2017.06.002
10.3109/00365521.2014.936034
10.1038/nrdp.2016.14
10.1007/s00253-021-11264-4
10.1016/j.isci.2020.101226
10.3389/fgene.2015.00148
10.3748/wjg.v21.i40.11353
10.1186/s12876-016-0446-z
10.14309/ajg.0000000000000696
10.1016./j.copbio.2012.08.005
10.1016/j.cmet.2013.01.003
10.1093/ajcn/56.2.410
10.1016/j.biotechadv.2016.11.004
10.3389/fphar.2012.00090
10.1079/PNS2002207
10.1111/j.1365-2036.2006.02938
10.1111/apt.13227
10.1111/j.1365-2982.2009.01427
10.1053/j.gastro.2019.03.049
10.1128/CMR.00014-14
10.1172/JCI130976
10.1038/s41575-020-0286-8
10.1016/j.cgh.2012.05.006
10.1053/j.gastro.2016.02.028
10.3748/wjg.v26.i45.7153
10.12659/MSM.889068
10.1111/j.1572-0241.2002.05841
10.3390/ijms21165823
10.1152/ajpcell.00261.2017
10.1038/nrd2619
10.1111/apt.15141
10.1111/nmo.12421
10.2353/ajpath.2010.090998
10.1016/j.envpol.2019.113357
10.1096/fj.13-244640
10.1111/j.1365-2982.2012.01893
10.1038/nrgastro.2013.105
10.1128/mSystems.00130-17
10.1016/j.bbrc.2015.03.125
10.1177/1099800415594251
10.1016/j.cgh.2009.10.020
10.1136/gutjnl-2015-311240
10.1016/j.chom.2019.07.008
10.1007/s00394-021-02633-w
10.1038/nature12820
10.1016/j.cell.2015.02.047
10.1196/annals.1326.017
10.1126/science.1078197
10.1038/ajg.2014.427
10.1074/jbc.RA117.000269
10.1111/j.1462-2920.2009.02066
10.1111/j.1365-2672.1996
10.1161/HYPERTENSIONAHA.114.04035
10.1053/j.gastro.2006.11.002
10.1016/j.nutres.2011.04.001
10.1016/j.chom.2018.05.003
10.1001/archpsyc.64.3.327
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Reviewed by: Nicholas Zachos, Johns Hopkins University, United States; Jane Adair Mullaney, AgResearch Ltd, New Zealand
Edited by: Sarah C. Pearce, Agricultural Research Service (USDA), United States
These authors have contributed equally to this work and share first authorship
This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology
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References Ringel-Kulka (B78) 2015; 110
Mahé (B58) 1992; 56
Krautkramer (B43) 2021; 19
Lee (B47) 2018; 293
Treem (B93) 1996; 23
Walther (B98) 2003; 299
Liu (B52) 2021; 78
Aggarwal (B2) 2018; 24
Reich (B77) 2014; 20
Mazzoli (B63) 2016; 7
Bruewer (B12) 2006; 1072
Joyce (B41) 2016; 7
Enck (B29) 2016; 2
Wong (B102) 2012; 10
Makker (B60) 2015; 21
Baumgartner (B6) 2021
(B400) 2020; 40
Mete (B7) 2013; 19
Slattery (B84) 2015; 42
Adeghate (B1) 2002; 34
Dunlop (B28) 2007; 64
Tack (B89) 2006; 24
Barbara (B5) 2016
Camilleri (B16) 2014; 26
Cremon (B23) 2011; 106
Cellini (B19) 2020; 21
Strandwitz (B87) 2018; 1693
Long (B53) 2017; 56
Sayin (B81) 2013; 17
James (B38) 2020; 150
Magnúsdóttir (B57) 2015; 6
Rosenberg (B79) 2017; 35
Sadik (B80) 2004; 99
Krogius-Kurikka (B44) 2009; 9
Sciavilla (B82) 2021; 105
Ilmer (B37) 2014; 28
Mawe (B62) 2013; 10
Yano (B106) 2015; 161
Zhuang (B113) 2018; 9
Chen (B20) 2015; 460
Keshteli (B42) 2019; 49
Huang (B36) 2010; 64
Wei (B99) 2020; 26
Dior (B26) 2016; 28
Pata (B71) 2002; 97
Mars (B61) 2020; 182
Valles-Colomer (B94) 2019; 4
Lagier (B45) 2015; 28
LeBlanc (B46) 2013; 24
Gershon (B33) 2007; 132
Rajilić-Stojanović (B75) 2015; 110
Black (B11) 2020; 17
Camilleri (B14) 2017; 11
Agus (B3) 2018; 23
Zhang (B108) 2021; 41
Zhao (B8) 2013; 12
Zhou (B110) 2019; 68
Wadhwa (B97) 2016; 170
David (B24) 2014; 505
Morrison (B67) 2016; 7
Vujkovic-Cvijin (B96) 2013; 5
Mitsi (B65) 2016; 338
Miura (B66) 2021; 36
Zheng (B109) 2017; 15
Clarke (B22) 2012; 3
Camilleri (B15) 2016; 311
Sperber (B86) 2017; 66
Duboc (B27) 2012; 24
Jeffery (B39) 2020; 69
Ligaarden (B51) 2011; 31
Tierney (B92) 2019; 26
Nightingale (B69) 1993; 11
Potts (B74) 2016; 221
Smith (B85) 1996; 81
Odunsi-Shiyanbade (B70) 2010; 8
Gargari (B32) 2018; 20
Piche (B72) 2007; 19
Macfarlane (B56) 2003; 62
Camilleri (B13) 2020; 115
Biaggioni (B10) 2015; 65
Vital (B95) 2017; 2
Wu (B103) 2010; 177
Farup (B31) 2016; 16
Luo (B55) 2021; 21
Lee (B48) 2020; 23
Zhao (B107) 2020; 130
Ratzke (B76) 2018; 16
Clarke (B21) 2009; 9
Shin (B83) 2013; 11
Thomas (B91) 2008; 7
Zhuang (B112) 2017; 32
Li (B50) 2019; 316
Tana (B90) 2010; 22
Jeffery (B40) 2012; 61
Makishima (B59) 2002; 296
Canani (B17) 2011; 17
Williams (B101) 2014; 16
Louis (B54) 2010; 12
Hewison (B35) 2011; 7
Sun (B88) 2019; 255
Berstad (B9) 2014; 49
Heitkemper (B34) 2016; 18
Yan (B105) 2015; 160
Pittayanon (B73) 2019; 157
Atkinson (B4) 2006; 130
Evenepoel (B30) 1999; 277
Li (B49) 2021; 39
Williams (B100) 2021
References_xml – volume: 7
  start-page: 313
  year: 2016
  ident: B41
  article-title: Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health
  publication-title: Annu. Rev. Food Sci. Technol.
  doi: 10.1146/annurev-food-041715-033159
  contributor:
    fullname: Joyce
– volume: 68
  start-page: 996
  year: 2019
  ident: B110
  article-title: Randomised Placebo-Controlled Trial of Dietary Glutamine Supplements for Postinfectious Irritable Bowel Syndrome
  publication-title: Gut
  doi: 10.1136/gutjnl-2017-315136
  contributor:
    fullname: Zhou
– volume: 99
  start-page: 711
  year: 2004
  ident: B80
  article-title: Accelerated Regional Bowel Transit and Overweight Shown in Idiopathic Bile Acid Malabsorption
  publication-title: Am. J. Gastroenterol.
  doi: 10.1111/j.1572-0241.2004.04139
  contributor:
    fullname: Sadik
– volume: 296
  start-page: 1313
  year: 2002
  ident: B59
  article-title: Vitamin D Receptor as an Intestinal Bile Acid Sensor
  publication-title: Science
  doi: 10.1126/science.1070477
  contributor:
    fullname: Makishima
– volume: 9
  year: 2018
  ident: B113
  article-title: Fecal Microbiota Alterations Associated With Diarrhea-Predominant Irritable Bowel Syndrome
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2018.01600
  contributor:
    fullname: Zhuang
– volume: 311
  start-page: G777
  year: 2016
  ident: B15
  article-title: Chemical and Molecular Factors in Irritable Bowel Syndrome: Current Knowledge, Challenges, and Unanswered Questions
  publication-title: Am. J. Physiol. Gastrointest. Liver. Physiol.
  doi: 10.1152/ajpgi.00242.2016
  contributor:
    fullname: Camilleri
– volume: 106
  start-page: 1290
  year: 2011
  ident: B23
  article-title: Intestinal Serotonin Release, Sensory Neuron Activation, and Abdominal Pain in Irritable Bowel Syndrome
  publication-title: Am. J. Gastroenterol.
  doi: 10.1038/ajg.2011.86
  contributor:
    fullname: Cremon
– volume: 160
  start-page: 62
  year: 2015
  ident: B105
  article-title: Dopamine Controls Systemic Inflammation Through Inhibition of NLRP3 Inflammasome
  publication-title: Cell
  doi: 10.1016/j.cell.2014.11.047
  contributor:
    fullname: Yan
– volume: 11
  start-page: 303
  year: 2017
  ident: B14
  article-title: Biomarkers as a Diagnostic Tool for Irritable Bowel Syndrome: Where Are We
  publication-title: Expert Rev. Gastroenterol. Hepatol.
  doi: 10.1080/17474124.2017.1288096
  contributor:
    fullname: Camilleri
– volume: 69
  start-page: 2263
  year: 2020
  ident: B39
  article-title: Microbiome Alterations in IBS
  publication-title: Gut
  doi: 10.1136/gutjnl-2020-320919
  contributor:
    fullname: Jeffery
– volume: 41
  start-page: 1061
  year: 2021
  ident: B108
  article-title: Metabolites of Microbiota Response to Tryptophan and Intestinal Mucosal Immunity: A Therapeutic Target to Control Intestinal Inflammation
  publication-title: Med. Res. Rev.
  doi: 10.1002/med.21752
  contributor:
    fullname: Zhang
– volume: 34
  start-page: 1
  year: 2002
  ident: B1
  article-title: GABA in the Endocrine Pancreas: Cellular Localization and Function in Normal and Diabetic Rats
  publication-title: Tissue Cell.
  doi: 10.1054/tice.2002.0217
  contributor:
    fullname: Adeghate
– volume: 61
  start-page: 997
  year: 2012
  ident: B40
  article-title: An Irritable Bowel Syndrome Subtype Defined by Species-Specific Alterations in Faecal Microbiota
  publication-title: Gut
  doi: 10.1136/gutjnl-2011-301501
  contributor:
    fullname: Jeffery
– volume: 23
  start-page: 280
  year: 1996
  ident: B93
  article-title: Fecal Short-Chain Fatty Acids in Patients With Diarrhea-Predominant Irritable Bowel Syndrome: In Vitro Studies of Carbohydrate Fermentation
  publication-title: J. Pediatr. Gastroenterol. Nutr.
  doi: 10.1097/00005176-199610000-00013
  contributor:
    fullname: Treem
– volume: 16
  start-page: 495
  year: 2014
  ident: B101
  article-title: Discovery and Characterization of Gut Microbiota Decarboxylases That can Produce the Neurotransmitter Tryptamine
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2014.09.001
  contributor:
    fullname: Williams
– volume: 170
  start-page: 2078
  year: 2016
  ident: B97
  article-title: Gastroschisis and Maternal Intake of Phytoestrogens
  publication-title: Am. J. Med. Genet. A.
  doi: 10.1002/ajmg.a.37659
  contributor:
    fullname: Wadhwa
– volume: 4
  start-page: 623
  year: 2019
  ident: B94
  article-title: The Neuroactive Potential of the Human Gut Microbiota in Quality of Life and Depression
  publication-title: Nat. Microbiol.
  doi: 10.1038/s41564-018-0337-x
  contributor:
    fullname: Valles-Colomer
– volume: 12
  start-page: 2987
  year: 2013
  ident: B8
  article-title: Gut Microbiota Composition Modifies Fecal Metabolic Profiles in Mice
  publication-title: J. Proteome Res.
  doi: 10.1021/pr400263n
  contributor:
    fullname: Zhao
– volume: 64
  start-page: 1007
  year: 2010
  ident: B36
  article-title: Vitamin B (6) Supplementation Improves Pro-Inflammatory Responses in Patients With Rheumatoid Arthritis
  publication-title: Eur. J. Clin. Nutr.
  doi: 10.1038/ejcn.2010.107
  contributor:
    fullname: Huang
– volume: 150
  start-page: 1012
  year: 2020
  ident: B38
  article-title: Gut Microbial Metabolites and Biochemical Pathways Involved in Irritable Bowel Syndrome: Effects of Diet and Nutrition on the Microbiome
  publication-title: J. Nutr.
  doi: 10.1093/jn/nxz302
  contributor:
    fullname: James
– volume: 32
  start-page: 28
  year: 2017
  ident: B112
  article-title: Alterations of Gut Microbiota in Patients With Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis
  publication-title: J. Gastroen. Hepatol.
  doi: 10.1111/jgh.13471
  contributor:
    fullname: Zhuang
– volume: 17
  start-page: 1519
  year: 2011
  ident: B17
  article-title: Potential Beneficial Effects of Butyrate in Intestinal and Extraintestinal Diseases
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v17.i12.1519
  contributor:
    fullname: Canani
– volume: 7
  start-page: 337
  year: 2011
  ident: B35
  article-title: Antibacterial Effects of Vitamin D
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2010.226
  contributor:
    fullname: Hewison
– volume: 19
  start-page: 77
  year: 2021
  ident: B43
  article-title: Gut Microbial Metabolites as Multi-Kingdom Intermediates
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/s41579-020-0438-4
  contributor:
    fullname: Krautkramer
– volume: 39
  start-page: 208
  year: 2021
  ident: B49
  article-title: Electroacupuncture Alleviates Intestinal Inflammation and Barrier Dysfunction by Activating Dopamine in a Rat Model of Intestinal Ischaemia
  publication-title: Acupunct. Med.
  doi: 10.1177/0964528420922232
  contributor:
    fullname: Li
– volume: 16
  start-page: e2004248
  year: 2018
  ident: B76
  article-title: Modifying and Reacting to the Environmental pH can Drive Bacterial Interactions
  publication-title: PloS Biol.
  doi: 10.1371/journal.pbio.2004248
  contributor:
    fullname: Ratzke
– volume: 1693
  start-page: 128
  year: 2018
  ident: B87
  article-title: Neurotransmitter Modulation by the Gut Microbiota
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2018.03.015
  contributor:
    fullname: Strandwitz
– volume: 28
  start-page: 1330
  year: 2016
  ident: B26
  article-title: Interplay Between Bile Acid Metabolism and Microbiota in Irritable Bowel Syndrome
  publication-title: Neurogastroenterol. Motil.
  doi: 10.1111/nmo.12829
  contributor:
    fullname: Dior
– volume: 221
  start-page: 468
  year: 2016
  ident: B74
  article-title: Mast Cells and Histamine Alter Intestinal Permeability During Malaria Parasite Infection
  publication-title: Immunobiology
  doi: 10.1016/j.imbio.2015.11.003
  contributor:
    fullname: Potts
– volume: 130
  start-page: 34
  year: 2006
  ident: B4
  article-title: Altered 5-Hydroxytryptamine Signaling in Patients With Constipation- and Diarrhea-Predominant Irritable Bowel Syndrome
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2005.09.031
  contributor:
    fullname: Atkinson
– volume: 11
  start-page: 12
  year: 1993
  ident: B69
  article-title: The Short Bowel Syndrome: What's New and Old
  publication-title: Dig. Dis.
  doi: 10.1159/000171397
  contributor:
    fullname: Nightingale
– volume: 19
  start-page: 237
  year: 2007
  ident: B72
  article-title: Fatigue in Irritable Bowel Syndrome: Characterization and Putative Role of Leptin
  publication-title: Eur. J. Gastroenterol. Hepatol.
  doi: 10.1097/01.meg.0000252627.50302
  contributor:
    fullname: Piche
– volume: 78
  start-page: 909
  year: 2021
  ident: B52
  article-title: Gut Microbiota-Derived Tryptophan Metabolism Mediates Renal Fibrosis by Aryl Hydrocarbon Receptor Signaling Activation
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-020-03645-1
  contributor:
    fullname: Liu
– volume: 182
  start-page: 1460
  year: 2020
  ident: B61
  article-title: Longitudinal Multi-Omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome
  publication-title: Cell
  doi: 10.1016/j.cell.2020.08.007
  contributor:
    fullname: Mars
– volume: 24
  start-page: 422
  year: 2018
  ident: B2
  article-title: Dysregulation of GABAergic Signalling Contributes in the Pathogenesis of Diarrhea-Predominant Irritable Bowel Syndrome
  publication-title: J. Neurogastroenterol. Motil.
  doi: 10.5056/jnm17100
  contributor:
    fullname: Aggarwal
– volume: 11
  start-page: 1270
  year: 2013
  ident: B83
  article-title: Bowel Functions, Fecal Unconjugated Primary and Secondary Bile Acids, and Colonic Transit in Patients With Irritable Bowel Syndrome
  publication-title: Clin. Gastroenterol. Hepatol.
  doi: 10.1016/j.cgh.2013.04.020
  contributor:
    fullname: Shin
– volume: 40
  start-page: 803
  year: 2020
  ident: B400
  article-title: Expert Consensus on Irritable Bowel Syndrome in China in 2020
  publication-title: Chin J Dig
– volume: 7
  start-page: 189
  year: 2016
  ident: B67
  article-title: Formation of Short Chain Fatty Acids by the Gut Microbiota and Their Impact on Human Metabolism
  publication-title: Gut. Microbes
  doi: 10.1080/19490976.2015.1134082
  contributor:
    fullname: Morrison
– volume: 9
  year: 2009
  ident: B21
  article-title: Tryptophan Degradation in Irritable Bowel Syndrome: Evidence of Indoleamine 2,3-Dioxygenase Activation in a Male Cohort
  publication-title: BMC Gastroenterol.
  doi: 10.1186/1471-230X-9-6
  contributor:
    fullname: Clarke
– volume: 15
  start-page: 120
  year: 2017
  ident: B109
  article-title: Bile Acid Is a Significant Host Factor Shaping the Gut Microbiome of Diet-Induced Obese Mice
  publication-title: BMC Biol.
  doi: 10.1186/s12915-017-0462-7
  contributor:
    fullname: Zheng
– volume: 21
  start-page: 14
  year: 2021
  ident: B55
  article-title: Alterations in Short-Chain Fatty Acids and Serotonin in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis
  publication-title: BMC Gastroenterol.
  doi: 10.1186/s12876-020-01577-5
  contributor:
    fullname: Luo
– volume: 36
  start-page: 951
  year: 2021
  ident: B66
  article-title: Vitamin D Receptor Is Overexpressed in the Duodenum of Patients With Irritable Bowel Syndrome
  publication-title: J. Gastroenterol. Hepatol
  doi: 10.1111/jgh.15225
  contributor:
    fullname: Miura
– volume: 5
  start-page: 191r
  year: 2013
  ident: B96
  article-title: Dysbiosis of the Gut Microbiota Is Associated With HIV Disease Progression and Tryptophan Catabolism
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3006438
  contributor:
    fullname: Vujkovic-Cvijin
– volume: 338
  start-page: 81
  year: 2016
  ident: B65
  article-title: Modulation of Pain, Nociception, and Analgesia by the Brain Reward Center
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2016.05.017
  contributor:
    fullname: Mitsi
– volume: 9
  year: 2009
  ident: B44
  article-title: Microbial Community Analysis Reveals High Level Phylogenetic Alterations in the Overall Gastrointestinal Microbiota of Diarrhoea-Predominant Irritable Bowel Syndrome Sufferers
  publication-title: BMC Gastroenterol.
  doi: 10.1186/1471-230X-9-95
  contributor:
    fullname: Krogius-Kurikka
– volume: 20
  start-page: 3201
  year: 2018
  ident: B32
  article-title: Fecal Clostridiales Distribution and Short-Chain Fatty Acids Reflect Bowel Habits in Irritable Bowel Syndrome
  publication-title: Environ. Microbiol.
  doi: 10.1111/1462-2920.1427
  contributor:
    fullname: Gargari
– year: 2021
  ident: B6
  article-title: Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2021.06.024
  contributor:
    fullname: Baumgartner
– volume: 110
  start-page: 1339
  year: 2015
  ident: B78
  article-title: Altered Colonic Bacterial Fermentation as a Potential Pathophysiological Factor in Irritable Bowel Syndrome
  publication-title: Am. J. Gastroenterol.
  doi: 10.1038/ajg.2015.220
  contributor:
    fullname: Ringel-Kulka
– volume: 277
  start-page: G935
  year: 1999
  ident: B30
  article-title: Amount and Fate of Egg Protein Escaping Assimilation in the Small Intestine of Humans
  publication-title: Am. J. Physiol.
  doi: 10.1152/ajpgi.1999.277.5.G935
  contributor:
    fullname: Evenepoel
– volume: 20
  start-page: 4934
  year: 2014
  ident: B77
  article-title: Vitamin D Improves Inflammatory Bowel Disease Outcomes: Basic Science and Clinical Review
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v20.i17.4934
  contributor:
    fullname: Reich
– volume: 7
  year: 2016
  ident: B63
  article-title: The Neuro-Endocrinological Role of Microbial Glutamate and GABA Signaling
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2016.01934
  contributor:
    fullname: Mazzoli
– volume: 56
  start-page: 54
  year: 2017
  ident: B53
  article-title: Interactions Between Gut Bacteria and Bile in Health and Disease
  publication-title: Mol. Aspects. Med.
  doi: 10.1016/j.mam.2017.06.002
  contributor:
    fullname: Long
– volume: 49
  start-page: 1493
  year: 2014
  ident: B9
  article-title: Tryptophan: 'Essential' for the Pathogenesis of Irritable Bowel Syndrome
  publication-title: Scand. J. Gastroenterol.
  doi: 10.3109/00365521.2014.936034
  contributor:
    fullname: Berstad
– volume: 2
  start-page: 16014
  year: 2016
  ident: B29
  article-title: Irritable Bowel Syndrome
  publication-title: Nat. Rev. Dis. Primers.
  doi: 10.1038/nrdp.2016.14
  contributor:
    fullname: Enck
– volume: 105
  start-page: 3277
  year: 2021
  ident: B82
  article-title: Gut Microbiota Profiles and Characterization of Cultivable Fungal Isolates in IBS Patients
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-021-11264-4
  contributor:
    fullname: Sciavilla
– volume: 23
  year: 2020
  ident: B48
  article-title: Microbiota-Sourced Purines Support Wound Healing and Mucous Barrier Function
  publication-title: iScience
  doi: 10.1016/j.isci.2020.101226
  contributor:
    fullname: Lee
– volume: 6
  year: 2015
  ident: B57
  article-title: Systematic Genome Assessment of B-Vitamin Biosynthesis Suggests Co-Operation Among Gut Microbes
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2015.00148
  contributor:
    fullname: Magnúsdóttir
– volume: 21
  start-page: 11353
  year: 2015
  ident: B60
  article-title: Genetic Epidemiology of Irritable Bowel Syndrome
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v21.i40.11353
  contributor:
    fullname: Makker
– volume: 16
  start-page: 51
  year: 2016
  ident: B31
  article-title: Faecal Short-Chain Fatty Acids - a Diagnostic Biomarker for Irritable Bowel Syndrome
  publication-title: BMC Gastroenterol.
  doi: 10.1186/s12876-016-0446-z
  contributor:
    fullname: Farup
– volume: 115
  start-page: 1596
  year: 2020
  ident: B13
  article-title: The Role of Bile Acids in Chronic Diarrhea
  publication-title: Am. J. Gastroenterol.
  doi: 10.14309/ajg.0000000000000696
  contributor:
    fullname: Camilleri
– volume: 24
  start-page: 160
  year: 2013
  ident: B46
  article-title: Bacteria as Vitamin Suppliers to Their Host: A Gut Microbiota Perspective
  publication-title: Curr. Opin. Biotechnol.
  doi: 10.1016./j.copbio.2012.08.005
  contributor:
    fullname: LeBlanc
– volume: 17
  start-page: 225
  year: 2013
  ident: B81
  article-title: Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-Beta-Muricholic Acid, a Naturally Occurring FXR Antagonist
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.01.003
  contributor:
    fullname: Sayin
– volume: 56
  start-page: 410
  year: 1992
  ident: B58
  article-title: Gastroileal Nitrogen and Electrolyte Movements After Bovine Milk Ingestion in Humans
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/56.2.410
  contributor:
    fullname: Mahé
– volume: 35
  start-page: 31
  year: 2017
  ident: B79
  article-title: Vitamin B6 Metabolism in Microbes and Approaches for Fermentative Production
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2016.11.004
  contributor:
    fullname: Rosenberg
– volume: 3
  year: 2012
  ident: B22
  article-title: A Distinct Profile of Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2012.00090
  contributor:
    fullname: Clarke
– volume: 62
  start-page: 67
  year: 2003
  ident: B56
  article-title: Regulation of Short-Chain Fatty Acid Production
  publication-title: Proc. Nutr. Soc
  doi: 10.1079/PNS2002207
  contributor:
    fullname: Macfarlane
– volume: 24
  start-page: 183
  year: 2006
  ident: B89
  article-title: Systematic Review: The Efficacy of Treatments for Irritable Bowel Syndrome–a European Perspective
  publication-title: Aliment. Pharmacol. Ther.
  doi: 10.1111/j.1365-2036.2006.02938
  contributor:
    fullname: Tack
– volume: 42
  start-page: 3
  year: 2015
  ident: B84
  article-title: Systematic Review With Meta-Analysis: The Prevalence of Bile Acid Malabsorption in the Irritable Bowel Syndrome With Diarrhoea
  publication-title: Aliment. Pharmacol. Ther.
  doi: 10.1111/apt.13227
  contributor:
    fullname: Slattery
– volume: 22
  start-page: 512
  year: 2010
  ident: B90
  article-title: Altered Profiles of Intestinal Microbiota and Organic Acids may be the Origin of Symptoms in Irritable Bowel Syndrome
  publication-title: Neurogastroenterol. Motil.
  doi: 10.1111/j.1365-2982.2009.01427
  contributor:
    fullname: Tana
– volume: 157
  start-page: 97
  year: 2019
  ident: B73
  article-title: Gut Microbiota in Patients With Irritable Bowel Syndrome-A Systematic Review
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2019.03.049
  contributor:
    fullname: Pittayanon
– volume: 28
  start-page: 237
  year: 2015
  ident: B45
  article-title: The Rebirth of Culture in Microbiology Through the Example of Culturomics to Study Human Gut Microbiota
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.00014-14
  contributor:
    fullname: Lagier
– volume: 130
  start-page: 438
  year: 2020
  ident: B107
  article-title: A Clostridia-Rich Microbiota Enhances Bile Acid Excretion in Diarrhea-Predominant Irritable Bowel Syndrome
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI130976
  contributor:
    fullname: Zhao
– volume: 17
  start-page: 473
  year: 2020
  ident: B11
  article-title: Global Burden of Irritable Bowel Syndrome: Trends, Predictions and Risk Factors
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-020-0286-8
  contributor:
    fullname: Black
– volume: 10
  start-page: 1009
  year: 2012
  ident: B102
  article-title: Increased Bile Acid Biosynthesis Is Associated With Irritable Bowel Syndrome With Diarrhea
  publication-title: Clin. Gastroenterol. Hepatol.
  doi: 10.1016/j.cgh.2012.05.006
  contributor:
    fullname: Wong
– year: 2016
  ident: B5
  article-title: The Intestinal Microenvironment and Functional Gastrointestinal Disorders
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2016.02.028
  contributor:
    fullname: Barbara
– volume: 26
  start-page: 7153
  year: 2020
  ident: B99
  article-title: Altered Metabolism of Bile Acids Correlates With Clinical Parameters and the Gut Microbiota in Patients With Diarrhea-Predominant Irritable Bowel Syndrome
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v26.i45.7153
  contributor:
    fullname: Wei
– volume: 19
  start-page: 762
  year: 2013
  ident: B7
  article-title: The Role of Oxidants and Reactive Nitrogen Species in Irritable Bowel Syndrome: A Potential Etiological Explanation
  publication-title: Med. Sci. Monit.
  doi: 10.12659/MSM.889068
  contributor:
    fullname: Mete
– volume: 97
  start-page: 1780
  year: 2002
  ident: B71
  article-title: Serotonin Transporter Gene Polymorphism in Irritable Bowel Syndrome
  publication-title: Am. J. Gastroenterol.
  doi: 10.1111/j.1572-0241.2002.05841
  contributor:
    fullname: Pata
– volume: 21
  start-page: 5823
  year: 2020
  ident: B19
  article-title: Pyridoxal 5'-Phosphate-Dependent Enzymes at the Crossroads of Host-Microbe Tryptophan Metabolism
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms21165823
  contributor:
    fullname: Cellini
– volume: 316
  start-page: C393
  year: 2019
  ident: B50
  article-title: Dopamine Promotes Colonic Mucus Secretion Through Dopamine D (5) Receptor in Rats
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00261.2017
  contributor:
    fullname: Li
– volume: 7
  start-page: 678
  year: 2008
  ident: B91
  article-title: Targeting Bile-Acid Signalling for Metabolic Diseases
  publication-title: Nat. Rev. Drug Discovery
  doi: 10.1038/nrd2619
  contributor:
    fullname: Thomas
– volume: 49
  start-page: 723
  year: 2019
  ident: B42
  article-title: Comparison of the Metabolomic Profiles of Irritable Bowel Syndrome Patients With Ulcerative Colitis Patients and Healthy Controls: New Insights Into Pathophysiology and Potential Biomarkers
  publication-title: Aliment. Pharmacol. Ther.
  doi: 10.1111/apt.15141
  contributor:
    fullname: Keshteli
– volume: 26
  start-page: 1677
  year: 2014
  ident: B16
  article-title: Validating Biomarkers of Treatable Mechanisms in Irritable Bowel Syndrome
  publication-title: Neurogastroenterol. Motil.
  doi: 10.1111/nmo.12421
  contributor:
    fullname: Camilleri
– volume: 177
  start-page: 686
  year: 2010
  ident: B103
  article-title: Vitamin D Receptor Negatively Regulates Bacterial-Stimulated NF-kappaB Activity in Intestine
  publication-title: Am. J. Pathol.
  doi: 10.2353/ajpath.2010.090998
  contributor:
    fullname: Wu
– volume: 255
  year: 2019
  ident: B88
  article-title: Activation of Aryl Hydrocarbon Receptor by Dioxin Directly Shifts Gut Microbiota in Zebrafish
  publication-title: Environ. Pollut.
  doi: 10.1016/j.envpol.2019.113357
  contributor:
    fullname: Sun
– volume: 28
  start-page: 2748
  year: 2014
  ident: B37
  article-title: Two Sides of the Same Coin: Stem Cells in Cancer and Regenerative Medicine
  publication-title: FASEB J.
  doi: 10.1096/fj.13-244640
  contributor:
    fullname: Ilmer
– volume: 24
  start-page: 513
  year: 2012
  ident: B27
  article-title: Increase in Fecal Primary Bile Acids and Dysbiosis in Patients With Diarrhea-Predominant Irritable Bowel Syndrome
  publication-title: Neurogastroenterol. Motil.
  doi: 10.1111/j.1365-2982.2012.01893
  contributor:
    fullname: Duboc
– volume: 10
  start-page: 473
  year: 2013
  ident: B62
  article-title: Serotonin Signalling in the Gut–Functions, Dysfunctions and Therapeutic Targets
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/nrgastro.2013.105
  contributor:
    fullname: Mawe
– volume: 2
  year: 2017
  ident: B95
  article-title: Colonic Butyrate-Producing Communities in Humans: An Overview Using Omics Data
  publication-title: mSystems
  doi: 10.1128/mSystems.00130-17
  contributor:
    fullname: Vital
– volume: 460
  start-page: 873
  year: 2015
  ident: B20
  article-title: 1,25-Dihydroxyvitamin D3 Preserves Intestinal Epithelial Barrier Function From TNF-α Induced Injury via Suppression of NF-kB P65 Mediated MLCK-P-MLC Signaling Pathway
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2015.03.125
  contributor:
    fullname: Chen
– volume: 18
  start-page: 193
  year: 2016
  ident: B34
  article-title: Serum Tryptophan Metabolite Levels During Sleep in Patients With and Without Irritable Bowel Syndrome (IBS)
  publication-title: Biol. Res. Nurs.
  doi: 10.1177/1099800415594251
  contributor:
    fullname: Heitkemper
– volume: 8
  start-page: 159
  year: 2010
  ident: B70
  article-title: Effects of Chenodeoxycholate and a Bile Acid Sequestrant, Colesevelam, on Intestinal Transit and Bowel Function
  publication-title: Clin. Gastroenterol. Hepatol.
  doi: 10.1016/j.cgh.2009.10.020
  contributor:
    fullname: Odunsi-Shiyanbade
– volume: 66
  start-page: 1075
  year: 2017
  ident: B86
  article-title: The Global Prevalence of IBS in Adults Remains Elusive Due to the Heterogeneity of Studies: A Rome Foundation Working Team Literature Review
  publication-title: Gut
  doi: 10.1136/gutjnl-2015-311240
  contributor:
    fullname: Sperber
– volume: 26
  start-page: 283
  year: 2019
  ident: B92
  article-title: The Landscape of Genetic Content in the Gut and Oral Human Microbiome
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2019.07.008
  contributor:
    fullname: Tierney
– year: 2021
  ident: B100
  article-title: Vitamin D Supplementation in People With IBS has No Effect on Symptom Severity and Quality of Life: Results of a Randomised Controlled Trial
  publication-title: Eur. J. Nutr
  doi: 10.1007/s00394-021-02633-w
  contributor:
    fullname: Williams
– volume: 505
  start-page: 559
  year: 2014
  ident: B24
  article-title: Diet Rapidly and Reproducibly Alters the Human Gut Microbiome
  publication-title: Nature
  doi: 10.1038/nature12820
  contributor:
    fullname: David
– volume: 161
  start-page: 264
  year: 2015
  ident: B106
  article-title: Indigenous Bacteria From the Gut Microbiota Regulate Host Serotonin Biosynthesis
  publication-title: Cell
  doi: 10.1016/j.cell.2015.02.047
  contributor:
    fullname: Yano
– volume: 1072
  start-page: 242
  year: 2006
  ident: B12
  article-title: Inflammatory Bowel Disease and the Apical Junctional Complex
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1196/annals.1326.017
  contributor:
    fullname: Bruewer
– volume: 299
  start-page: 76
  year: 2003
  ident: B98
  article-title: Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform
  publication-title: Science
  doi: 10.1126/science.1078197
  contributor:
    fullname: Walther
– volume: 110
  start-page: 278
  year: 2015
  ident: B75
  article-title: Intestinal Microbiota and Diet in IBS: Causes, Consequences, or Epiphenomena
  publication-title: Am. J. Gastroenterol.
  doi: 10.1038/ajg.2014.427
  contributor:
    fullname: Rajilić-Stojanović
– volume: 293
  start-page: 6039
  year: 2018
  ident: B47
  article-title: Hypoxanthine Is a Checkpoint Stress Metabolite in Colonic Epithelial Energy Modulation and Barrier Function
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.RA117.000269
  contributor:
    fullname: Lee
– volume: 12
  start-page: 304
  year: 2010
  ident: B54
  article-title: Diversity of Human Colonic Butyrate-Producing Bacteria Revealed by Analysis of the Butyryl-CoA:acetate CoA-Transferase Gene
  publication-title: Environ. Microbiol.
  doi: 10.1111/j.1462-2920.2009.02066
  contributor:
    fullname: Louis
– volume: 81
  start-page: 288
  year: 1996
  ident: B85
  article-title: Enumeration of Human Colonic Bacteria Producing Phenolic and Indolic Compounds: Effects of Ph, Carbohydrate Availability and Retention Time on Dissimilatory Aromatic Amino Acid Metabolism
  publication-title: J. Appl. Bacteriol.
  doi: 10.1111/j.1365-2672.1996
  contributor:
    fullname: Smith
– volume: 65
  start-page: 101
  year: 2015
  ident: B10
  article-title: Randomized Withdrawal Study of Patients With Symptomatic Neurogenic Orthostatic Hypotension Responsive to Droxidopa
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.114.04035
  contributor:
    fullname: Biaggioni
– volume: 132
  start-page: 397
  year: 2007
  ident: B33
  article-title: The Serotonin Signaling System: From Basic Understanding to Drug Development for Functional GI Disorders
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2006.11.002
  contributor:
    fullname: Gershon
– volume: 31
  start-page: 356
  year: 2011
  ident: B51
  article-title: Low Intake of Vitamin B6 Is Associated With Irritable Bowel Syndrome Symptoms
  publication-title: Nutr. Res.
  doi: 10.1016/j.nutres.2011.04.001
  contributor:
    fullname: Ligaarden
– volume: 23
  start-page: 716
  year: 2018
  ident: B3
  article-title: Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2018.05.003
  contributor:
    fullname: Agus
– volume: 64
  start-page: 327
  year: 2007
  ident: B28
  article-title: The Role of Dopamine in the Pathophysiology of Depression
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.64.3.327
  contributor:
    fullname: Dunlop
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Snippet Irritable bowel syndrome (IBS) is the most common functional bowel disorder worldwide and is associated with visceral hypersensitivity, gut motility,...
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SubjectTerms amino acids
bile acids
Cellular and Infection Microbiology
gut microbiota
irritable bowel syndrome
SCFAs
tryptophan
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Title Gut Microbiota-Derived Metabolites in Irritable Bowel Syndrome
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https://pubmed.ncbi.nlm.nih.gov/PMC8495119
https://doaj.org/article/b1d18af4988f4d0f89e16248f66132f8
Volume 11
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