Icariin Alleviates Wear Particle-Induced Periprosthetic Osteolysis via Down-Regulation of the Estrogen Receptor α-mediated NF-κB Signaling Pathway in Macrophages

• Published in: Frontiers in pharmacology Vol. 12; p. 746391
• Main Authors: Guangtao, Fu, Zhenkang, Wen, Zhantao, Deng, Mengyuan, Li, Qingtian, Li, Yuanchen, Ma, Yuanfeng, Chen, Qiujian, Zheng
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 03.11.2021
• Subjects: estrogen receptor α; icariin; macrophage; osteolysis; Pharmacology; wear particle

Periprosthetic osteolysis is one of the major long-term complications following total joint replacement. Its cause is widely accepted to be wear particle-induced activation of inflammatory macrophages. No effective strategy for the prevention and treatment of periprosthetic osteolysis is yet availab...