Levels of Alternatively Spliced Tissue Factor in the Plasma of Patients with Pancreatic Cancer May Help Predict Aggressive Tumor Phenotype

• Published in: Annals of surgical oncology Vol. 22; no. Suppl 3; pp. 1206 - 1211
• Main Authors: Unruh, Dusten, Sagin, Farah, Adam, Mariette, Van Dreden, Patrick, Woodhams, Barry J., Hart, Kimberly, Lindsell, Christopher J., Ahmad, Syed A., Bogdanov, Vladimir Y.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2015; Springer Nature B.V
• Subjects: Acute Coronary Syndrome - blood; Acute Coronary Syndrome - genetics; Acute Coronary Syndrome - pathology; Alternative Splicing - genetics; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Carcinoma, Pancreatic Ductal - blood; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - secondary; Case-Control Studies; Diabetes Mellitus - blood; Diabetes Mellitus - genetics; Diabetes Mellitus - pathology; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Staging; Oncology; Pancreatic cancer; Pancreatic Neoplasms - blood; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Pancreatic Tumors; Prognosis; Retrospective Studies; Surgery; Surgical Oncology; Thromboplastin - analysis; Thromboplastin - genetics; Tissue Factor; Pancreatic Cancer Patient; Pancreatic Cancer; Pancreatic Ductal Adenocarcinoma; Acute Coronary Syndrome

Background Circulating (‘blood-borne’) tissue factor (TF) is implicated in the pathogenesis of several chronic conditions, most notably cardiovascular disease, diabetes, and cancer. Full-length TF is an integral membrane protein, while alternatively spliced TF (asTF) can be secreted and, owing to it...