Pro-inflammatory cytokines and leukocyte integrins associated with chronic neuropathic pain in traumatic and inflammatory neuropathies: Initial observations and hypotheses

• Published in: Frontiers in immunology Vol. 13; p. 935306
• Main Authors: Dong, Chaoling, Ubogu, Eroboghene E.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 02.08.2022
• Subjects: cytokines; Immunology; leukocyte integrins; mouse models; neuroinflammation; nociception; peripheral neuropathy

Leukocyte infiltration and persistence within peripheral nerves have been implicated in chronic nociception pathogenesis in murine peripheral neuropathy models. Endoneurial cytokine and chemokine expression contribute to leukocyte infiltration and maintenance of a pro-inflammatory state that delays...