Somatic Depolarization Enhances Hippocampal CA1 Dendritic Spike Propagation and Distal Input-Driven Synaptic Plasticity

• Published in: The Journal of neuroscience Vol. 42; no. 16; pp. 3406 - 3425
• Main Authors: Bock, Tobias, Negrean, Adrian, Siegelbaum, Steven A.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 20.04.2022
• Subjects: Action Potentials - physiology; Animals; Dendrites; Dendrites - physiology; Dendritic plasticity; Dendritic structure; Depolarization; Hippocampus; Hippocampus - physiology; Inactivation; Male; Membrane potential; Mice; Neuronal Plasticity; Plasticity; Propagation; Pyramidal Cells - physiology; Sensory perception; Spatial discrimination; Synaptic plasticity; pyramidal neuron; calcium spike; dendrite; plasticity; synaptic integration; hippocampus

Synaptic inputs that target distal regions of neuronal dendrites can often generate local dendritic spikes that can amplify synaptic depolarization, induce synaptic plasticity, and enhance neuronal output. However, distal dendritic spikes are subject to significant attenuation by dendritic cable pro...