AKT-mediated regulation of chromatin ubiquitylation and tumorigenesis through Mel18 phosphorylation

• Published in: Oncogene Vol. 40; no. 13; pp. 2422 - 2436
• Main Authors: Mai, Jia, Peng, Xiao-Dan, Tang, Jun, Du, Tian, Chen, Yu-Hong, Wang, Zi-Feng, Zhang, Hai-Liang, Huang, Jun-Hao, Zhong, Zhuo-Yan, Yang, Dong, Li, Zhi-Ling, Huang, Yun, Feng, Gong-Kan, Zhu, Xiao-Feng, Deng, Rong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2021; Nature Publishing Group
• Subjects: 631/67; 631/80; Adult; Aged; AKT protein; Apoptosis; Bone growth; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cancer; Carcinogenesis; Carcinogenesis - genetics; Cell Biology; Cell Cycle Proteins - genetics; Cell migration; Cell Proliferation; Chromatin; Female; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Genetic aspects; Health aspects; Histone H2A; Histones - genetics; Human Genetics; Humans; Internal Medicine; Kaplan-Meier Estimate; Kinases; Medicine; Medicine & Public Health; Metastases; Middle Aged; Neoplasm Metastasis; Oncology; Oncology, Experimental; Phosphorylation; Polycomb group proteins; Polycomb Repressive Complex 1 - genetics; Post-translational modification; Progression-Free Survival; Protein kinase; Protein kinases; Proto-Oncogene Proteins c-akt - genetics; Structure; Tumorigenesis; Tumors; Ubiquitin; Ubiquitination - genetics; Zinc finger proteins; China

Polycomb repressor complex 1 (PRC1) is linked to the regulation of gene expression and histone ubiquitylation conformation, which contributes to carcinogenesis. However, the upstream regulators of PRC1 biogenesis machinery remain obscure. Here, we report that the polycomb group-related mammalian gen...